Tag: M.W=200-250

Helmer, Bradley J. published the artcileSilicon-29 NMR of pentacoordinate silicon derivatives, Product Details of C12H10F2Si, the publication is Journal of Organometallic Chemistry (1983), 251(3), 295-8, database is CAplus.

The temperature dependence of chem. shifts in o-(Me₂NCH₂)C₆H₄SiRR¹R² (I; R, R¹, R² = Me, Ph, 1-C₁₀H₇, H, F, Cl, OMe, OEt) and PhSiRR¹R² indicated the existence of an equilibrium between tetra- and penta-coordinate forms. I (R = 1-C₁₀H₇, R¹ = R² = H) is the 1st Si derivative without halogen or chalcogen to show intramol. pentacoordination. This coordination may account for the reactivity of the Si-H bond in this compound

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Product Details of C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liaw, Joshua Y published the artcileLessons to be learned: Using National Immunisation strategies to improve adherence to acute rheumatic fever secondary prophylaxis., Formula: C16H20N2, the publication is Journal of paediatrics and child health (2019), 55(10), 1170-1176, database is MEDLINE.

Rheumatic heart disease, as a result of a single or recurrent episode of acute rheumatic fever (ARF), remains a significant cause of morbidity and mortality in northern and remote Australia; ARF has a peak incidence among 5-14-year-old Aboriginal and Torres Strait Islander children. Long-term regular benzathine penicillin G injections are the only currently successful secondary prevention strategy; however, rates of adherence remain critically low. In contrast, rates of adherence to immunisations on the National Immunisation Program (NIP) Schedule are high, even among this target population. This article compares strategies used to implement and improve ARF secondary prophylaxis with those used in the NIP. Some successful NIP strategies, such as Service Incentive Payment for health providers, home-visiting delivery models and integration into the National Immunisation Register, if applied to ARF secondary prophylaxis have the potential to improve benzathine penicillin G adherence.

Journal of paediatrics and child health published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tyrra, Wieland published the artcileA facile preparative route for pentafluorophenylsilver, AgC₆F₅ and its use as an oxidative pentafluorophenyl group transfer reagent in reactions with group 12 to 16 elements – the single crystal structure of AgC₆F₅¡¤EtCN, the first arylsilver derivative crystallizing in infinite chains, Recommanded Product: Trimethyl(perfluorophenyl)silane, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (2002), 628(8), 1841-1847, database is CAplus.

AgC₆F₅ is directly and quant. formed from room temperature reactions of AgF and Me₃SiC₆F₅ in N-donor solvents, particularly EtCN. Solutions of AgC₆F₅ prepared by this method exhibit excellent oxidative properties in reactions with a variety of groups 12 to 16 elements giving the corresponding pentafluorophenyl element compounds in moderate to excellent yields. AgC₆F₅-EtCN crystallizes with monoclinic symmetry (C2/c, Z = 8, a = 2301.4(5) pm, b = 1078.8(4) pm, c = 948.0(2) pm, ¦Â = 113.19(1)¡ã) and exhibits chains of silver atoms with bridging C₆F₅ groups.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C37H30ClIrOP2, Recommanded Product: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lim, Booyong S. published the artcileMonodithiolene Molybdenum(V,VI) Complexes: A Structural Analogue of the Oxidized Active Site of the Sulfite Oxidase Enzyme Family, HPLC of Formula: 22693-41-0, the publication is Journal of the American Chemical Society (2001), 123(34), 8343-8349, database is CAplus and MEDLINE.

The active sites of the xanthine oxidase and sulfite oxidase enzyme families contain one pterin-dithiolene cofactor ligand bound to a Mo atom. Consequently, monodithiolene Mo complexes were sought by exploratory synthesis for structural and reactivity studies. Reaction of [MoO(S₂C₂Me₂)₂]^1- or [MoO(bdt)₂]^1- with PhSeCl results in removal of one dithiolate ligand and formation of [MoOCl₂(S₂C₂Me₂)]^1- (1) or [MoOCl₂(bdt)]^1- (2), which undergoes ligand substitution reactions to form other monodithiolene complexes [MoO(2-AdS)₂(S₂C₂Me₂)]^1- (3), [MoO(SR)₂(bdt)]^1- (R = 2-Ad (4), 2,4,6-Prⁱ₃C₆H₂ (5)), and [MoOCl(SC₆H₂-2,4,6-Prⁱ₃)(bdt)]^1- (6) (Ad = 2-adamantyl, bdt = benzene-1,2-dithiolate). These complexes have square pyramidal structures with apical oxo ligands, exhibit rhombic EPR spectra, and 3–5 are electrochem. reducible to Mo^IVO species. Complexes 1–6 constitute the 1st examples of five-coordinate monodithiolene Mo^VO complexes; 6 approaches the proposed structure of the high-pH form of sulfite oxidase. Treatment of [MoO₂(OSiPh₃)₂] with Li₂(bdt) in THF affords [MoO₂(OSiPh₃)(bdt)]^1- (8). Reaction of 8 with 2,4,6-Prⁱ₃C₆H₂SH in MeCN gives [MoO₂(SC₆H₂-2,4,6-Prⁱ₃)(bdt)]^1- (9, 55%). Complexes 8 and 9 are square pyramidal with apical and basal oxo ligands. With one dithiolene and one thiolate ligand of a square pyramidal Mo^VIO₂S₃ coordination unit, 9 closely resembles the oxidized sites in sulfite oxidase and assimilatory nitrate reductase as deduced from crystallog. (sulfite oxidase) and Mo EXAFS. The complex is the 1st structural analog of the active sites in fully oxidized members of the sulfite oxidase family. This work provides a starting point for the development of both structural and reactivity analogs of members of this family.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, HPLC of Formula: 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ai, Teng published the artcileN-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides: Antiproliferative Activity and Effects on mTORC1 and Autophagy, Formula: C14H12O3, the publication is ACS Medicinal Chemistry Letters (2017), 8(1), 90-95, database is CAplus and MEDLINE.

Guided by antiproliferative activity in MIA PaCa-2 cells, the authors have performed preliminary structure-activity relationship studies on N-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides. Two selected compounds showed submicromolar antiproliferative activity and good metabolic stability. Both compounds reduced mTORC1 activity and increased autophagy at the basal level. In addition, they disrupted autophagic flux by interfering with mTORC1 reactivation and clearance of LC3-II under starvation/re-feed conditions, as evidenced by accumulation of LC3-II and abnormal LC3 labeled punctae. Therefore, N-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides may represent a new class of autophagy modulators that possesses potent anticancer activity and potentially a novel mechanism of action.

ACS Medicinal Chemistry Letters published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fuerstenau, D. W. published the artcileThe recedence of thick aqueous films in the dewetting of solid surfaces, Application of Dodecylamineacetate, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (1994), 89(2/3), 193-204, database is CAplus.

The recedence of relatively thick aqueous films from flat solid surfaces was investigated exptl. for two different substrates: paraffin wax and polished Pyrex glass. The wettability of Pyrex was controlled by the addition of dodecylammonium acetate. Using the conservation of energy principle, a model was developed to analyze steady state recedence velocity in terms of the surface free energy change, kinetic energy of the receding liquid, friction loss, kinetic energy loss and gravitational potential energy of the system. A numerical solution of the model was utilized and compared with the exptl. data. The model indicates an insensitivity to viscous dissipation and corroborates not only the thermodn. theory for film recedence, but also the general conceptions of other workers on film movement.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Application of Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fuerstenau, D. W. published the artcileThe effect of non-equilibrium adsorption at the solid-vapor interface on the recedence of aqueous films and dewetting of solid surfaces, Safety of Dodecylamineacetate, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (1994), 89(2/3), 205-12, database is CAplus.

Phenomena involving the recedence of relatively thick films were investigated in the paraffin-water and Pyrex-dodecylammonium acetate-water systems. Non-equilibrium adsorption was found to enhance the dewetting or recedence velocity of aqueous films from the surface of Pyrex glass. An explanation, based on the enhanced zipper-like adsorption at the solid-vapor interface as the liquid-vapor interface is destroyed, is presented to explain in existence of a maximum recedence velocity. These effects are absent in the paraffin-water system. This work reflects recedence behavior in practical non-quiescent systems.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Safety of Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jones, Mark M. published the artcileCharacteristics of chelate antidotes for acute copper(II) intoxication, Application In Synthesis of 38260-01-4, the publication is Journal of Inorganic and Nuclear Chemistry (1981), 43(9), 2175-81, database is CAplus.

Twenty-five chelating agents were exptl. screened to determination the structural features characteristic of antidotes for acute Cu(II) intoxication in mice. Four structural classes of antidote were identified: vicinal dithiols, polyaminocarboxylates, polyethyleneamines and their derivatives, and compounds derived from the ¦Â-mercaptoethylamine structure. The most effective antidote of the compounds examined was HSCH₂CH(SH)CH₂SO₂Na [4076-02-2], with a survival ratio in mice of 37:45 when given at a 10:1 mol ratio with CuSO₄ at a dosage of 10 mg/kg i.p.

Journal of Inorganic and Nuclear Chemistry published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Montagnat, Oliver D. published the artcileLessons learned in development of sustained release penicillin drug delivery systems for prophylactic treatment of rheumatic heart disease (RHD), Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Drug Delivery and Translational Research (2018), 8(3), 729-739, database is CAplus and MEDLINE.

The current prophylactic treatment to prevent rheumatic heart disease requires four-weekly i.m. injection of a suspension of the poorly soluble benzathine salt form of penicillin G (BPG) often for more than 10 years. In seeking to reduce the frequency of administration to improve adherence, biodegradable polymer matrixes have been investigated. Poly(lactide-co-glycolide) (PLGA)-based in situ forming precursor systems containing N-methyl-2-pyrrolidone as solvent and PLGA-based monolithic implants for surgical implantation containing BPG were developed. Long-term release studies indicated low and plateaued release of penicillin G, but continual favorable release profiles for the benzathine counterion, indicating degradation of the polymer and generation of acidic microenvironment being detrimental to penicillin stability. In order to avoid the issue of the acidic product, poly(caprolactone)(PCL) implants were also investigated, with favorable penicillin G release behavior being achieved, and slow release over 180 days. However, when taking into account the mass of polymer, and the total dose of drug calculated from literature pharmacokinetic parameters for penicillin G, we concluded that an implant size of over 7 g would still be required. This may preclude clin. deployment of a polymer matrix type delivery system for this indication in children and adolescents. Therefore, we have learned that biodegradable PLGA-type systems are not suitable for development of sustained release BPG treatments and that although the PCL system provides favorable release behavior, the total size of the implant may still present a hurdle for future development.

Drug Delivery and Translational Research published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Maruizumi, Takuya published the artcileNeutral carrier-based sodium(1+)-selective electrode for application in blood serum, Quality Control of 5411-14-3, the publication is Mikrochimica Acta (1986), 1(5-6), 331-6, database is CAplus.

The ionophore N,N,N‘,N‘-tetracyclohexyl-1,2-phenylenedioxydiacetamide shows higher lipophilicity and superior Na⁺/K⁺ selectivity than the previously described N,N‘-dibenzyl-N,N‘-diphenyl-1,2-phenylenedioxydiacetamide. It is a suitable component of Na⁺-selective liquid membrane electrodes for the assay of Na⁺ in clin. analyzers.

Mikrochimica Acta published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Quality Control of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia