Tag: M.W=200-250

Sakuma, Shinji published the artcileEffect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal, Synthetic Route of 38260-01-4, the publication is Journal of Controlled Release (2007), 118(1), 59-64, database is CAplus and MEDLINE.

Food-drug interactions may reduce the bioavailability of drugs taken after meals (neg. food effect). In order to develop pharmaceutical technologies that overcome this problem, the effect of administration site within the gastrointestinal tract on the bioavailability of several model drugs was examined in rats. Bioavailability after oral administration to fed animals was one-fifth to one-tenth of that in the fasted animals because of interactions between drugs and large amounts of food components remaining in the stomach. This strong neg. food effect was reduced when drugs were administered directly into any site of the small intestine. Bioavailability was maximized when the drug administration site was the middle small intestine. On the other hand, intracolonic administration did not result in the reduction of the neg. food effect. Site-specific drug delivery to the middle small intestine could be a useful approach for reducing the neg. food effect on drug absorption with maximized bioavailability.

Journal of Controlled Release published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Synthetic Route of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Jiaxing published the artcileIn vitro and in vivo evaluation of benzathine foscarnet microcrystals as a potential intravitreal drug depot, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is RSC Advances (2019), 9(37), 21318-21322, database is CAplus and MEDLINE.

Sodium foscarnet is an antiviral drug against cytomegalovirus retinitis, and clin. it is used via frequent intravitreal injection which causes various ocular complications. Here we propose to use benzathine foscarnet in a new salt form with much lower aqueous solubility, and as a potential long-acting intravitreally injectable solid form for foscarnet. Benzathine foscarnet (1 : 1) microcrystals were synthesized and evaluated both in vitro and in vivo. The aqueous solubility of benzathine foscarnet was 14.2 mM, which is in between those of the currently-used sodium foscarnet and our previously-reported calcium foscarnet salt. In a rabbit model, the injected microcrystals last for about 3 wk in the vitreous, suggesting its solubility and dissolution profile is appropriate for its intended use. However, the injected benzathine foscarnet microcrystals also caused adverse effects in vivo.

RSC Advances published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C25H47NO8, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fujito, Hiroshi published the artcileA study of efficient preparation of triethylenetetramine dihydrochloride for the treatment of Wilson’s disease and hygroscopicity of its capsule, Synthetic Route of 38260-01-4, the publication is Yakuzaigaku (1990), 50(4), 402-8, database is CAplus.

Triethylenetetramine-2HCl (I) for the treatment of Wilson’s disease is generally prepared by the reaction of triethylenetetramine (trien) and concentrated HCl. Using this method, the yield of I was 46.2% and trien-4HCl was obtained in a 21.3% yield as a byproduct. On the other hand, I was obtained in a 88.5% yield without formation of trien-4HCl by the reaction of trien and HCl gas in absolute EtOH. Capsules packed with I could stock for 30 days under 53% relative humidities of 25¡ã.

Yakuzaigaku published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Synthetic Route of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ranjbari, Mohammad A. published the artcileRegioselective and solvent-free arylation of ¦Â-nitrostyrenes with mono- and dialkyl anilines, Category: catalysis-chemistry, the publication is Research on Chemical Intermediates (2021), 47(2), 709-721, database is CAplus.

A green and solvent-free method was developed for alkylation of N,N-dialkylanilines with substituted ¦Â-nitrostyrenes using 10 mol% of choline chloride-zinc chloride deep eutectic solvent at 70¡ã. The reaction was highly regioselective and only para-substituted products have been prepared Despite the sensitivity and weak reactivity of the aniline derivatives for the Friedel-Crafts reaction in acidic media, the presented procedure was successfully carried out this transformation. The synthetic protocol was expanded for the alkylation of pyrrole and indole to produce pharmaceutically active compounds The reduction of the nitro group of the product to amine was performed using Pd/C and hydrazine to produce amphetamine structure.

Research on Chemical Intermediates published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Leibler, Isabelle Nathalie-Marie published the artcileA general strategy for C(sp³)-H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor, HPLC of Formula: 457-68-1, the publication is Nature Communications (2021), 12(1), 6950, database is CAplus and MEDLINE.

A strategy that transforms C(sp³)-H bonds into carbocations via sequential hydrogen atom transfer (HAT) and oxidative radical-polar crossover were discussed. The resulting carbocation was functionalized by a variety of nucleophiles-including halides, water, alcs., thiols, an electron-rich arene and an azide-to effect diverse bond formations. Mechanistic studies indicated that HAT was mediated by Me radical-a previously unexplored HAT agent with differing polarity to many of those used in photoredox catalysis-enabling new site-selectivity for late-stage C(sp³)-H functionalization.

Nature Communications published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, HPLC of Formula: 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Hang published the artcileEfficient broadband terahertz generation from organic crystal BNA using near infrared pump, Application of N-Benzyl-2-methyl-4-nitroaniline, the publication is Applied Physics Letters (2019), 114(24), 241101/1-241101/4, database is CAplus.

We report on terahertz (THz) generation from organic crystal N-benzyl-2-methyl-4-nitroaniline using a 1.15-1.55 ¦Ìm near IR pump. We observed a very large emission spectrum extending up to 7 THz, compared to 2.5 THz from a Ti:Sa pump in previous reports. The maximum optical-to-THz conversion efficiency in our experiment was 0.8% at a repetition rate of 1 kHz and without saturation, leading to a peak elec. field of 1 GV/m. Our results show pronounced phase matching privilege for intense terahertz generation using a pump in the 1.15-1.25 ¦Ìm range where high energy near IR pump sources operate. (c) 2019 American Institute of Physics.

Applied Physics Letters published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C4HN5, Application of N-Benzyl-2-methyl-4-nitroaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ohshita, Joji published the artcileSynthesis and Chromic Behaviors of Dithienosiloles with Push-Pull Substituents Toward VOC Detection, Related Products of catalysis-chemistry, the publication is Molecular Crystals and Liquid Crystals (2010), 1-9, database is CAplus.

2-Methylthio- and 2-n-hexylthienyl-6-(tricyanoethenyl)-4,4-diphenyldithienosilole were prepared as novel push-pull type compounds These compounds exhibit solvatochromic behaviors with respect to their UV-vis absorption and emission spectra. Clear vapor chromism is also observed for their thin solid films and the color changed clearly on exposure of the films to organic solvent vapors, indicating the potential applications to VOC sensors.

Molecular Crystals and Liquid Crystals published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kashiwabara, Taigo published the artcileDecarbonylative Coupling of Fluorobenzoyl Chlorides with Hexamethyldisilane in the Presence of a Palladium Complex Catalyst: Extremely Facile Decarbonylation of Pentafluorobenzoyl-Pd Complex Relevant to C₆F₅SiMe₃ Formation, Application of Trimethyl(perfluorophenyl)silane, the publication is Organometallics (2006), 25(19), 4648-4652, database is CAplus.

Pd-phosphite complexes (PdCl₂(PhCN)₂ + P(OEt₃)₃ or P(OPr)₃ most effective) catalyze the reaction of pentafluorobenzoyl chloride with hexamethyldisilane to selectively form pentafluorophenyltrimethylsilane as virtually the sole product. The reaction of 3,5-difluoro- or 4-fluorobenzoyl chloride was less selective, giving a mixture of corresponding benzoyl- and phenylsilanes. Oxidative addition of pentafluorobenzoyl chloride with Pd(PPh₃)₄ or with Pd[P(OEt)₃]₂ generated in situ proceeds readily, but decarbonylation occurs, giving trans-C₆F₅PdClL₂ (L = PPh₃, P(OEt)₃), selectively. The crystal and mol. structures of trans-C₆F₅PdCl(PPh₃)₂ were determined by x-ray crystallog.

Organometallics published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Application of Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kashiwabara, Taigo published the artcilePd-catalyzed desulfonylative homocoupling of arenesulfonyl chlorides in the presence of hexamethyldisilane forming biaryls, COA of Formula: C9H9F5Si, the publication is Tetrahedron Letters (2005), 46(42), 7125-7128, database is CAplus.

Arenesulfonyl chlorides undergo desulfonylative homo-coupling upon heating with hexamethyldisilane in the presence of Pd₂(dibenzylideneacetone)₃.CHCl₃ as a precatalyst to afford biaryls. Diaryl sulfides are occasionally formed as byproducts.

Tetrahedron Letters published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, COA of Formula: C9H9F5Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Haraguchi, Ryosuke published the artcilePalladium-Catalyzed Formylation of Arylzinc Reagents with S-Phenyl Thioformate, Application In Synthesis of 77189-99-2, the publication is Organic Letters (2017), 19(7), 1646-1649, database is CAplus and MEDLINE.

In the presence of Pd(OAc)₂ and tri(2-furyl)phosphine in toluene/THF, arylzinc reagents derived from aryl iodides and an alkenylzinc reagent were chemoselectively formylated with S-Ph thioformate PhSCHO to yield aryl aldehydes ArCHO (Ar = 4-NCC₆H₄, 4-EtO₂CC₆H₄, 4-i-Pr₂NCOC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 3-ClC₆H₄, 3-BrC₆H₄, 4-MeOC₆H₄, 1,3-benzodioxol-5-yl, 4-HOC₆H₄, 4-Me₂NC₆H₄, 2-MeC₆H₄, 2-MeOC₆H₄, 2,4,6-Me₃C₆H₂, 2-naphthyl, 1-naphthyl, 2-thienyl, 2-benzofuranyl, 1-Me-5-indolyl) and trans-cinnamaldehyde in 56-97% yields. Using deuterated and ¹³C-labeled deuterated and ¹³C-labeled S-Ph thioformate, 4-DCOC₆H₄CN and 4-BrC₆H₄¹³CH:CH₂ were prepared in high isotopic purities by this method.

Organic Letters published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Application In Synthesis of 77189-99-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia