Tag: M.W=200-250

Zhang, Zhi-Qi published the artcileDifluoromethylation of Unactivated Alkenes Using Freon-22 through Tertiary Amine-Borane-Triggered Halogen Atom Transfer, Category: catalysis-chemistry, the publication is Journal of the American Chemical Society (2022), 144(31), 14288-14296, database is CAplus and MEDLINE.

The application of abundant and inexpensive fluorine feedstock sources to synthesize fluorinated compounds is an appealing yet underexplored strategy. Here, authors report a photocatalytic radical hydrodifluoromethylation of unactivated alkenes with an inexpensive industrial chem., chlorodifluoromethane (ClCF₂H, Freon-22). This protocol is realized by merging tertiary amine-ligated boryl radical-induced halogen atom transfer (XAT) with organophotoredox catalysis under blue light irradiation A broad scope of readily accessible alkenes featuring a variety of functional groups and drug and natural product moieties could be selectively difluoromethylated with good efficiency in a metal-free manner. Combined exptl. and computational studies suggest that the key XAT process of ClCF₂H is both thermodynamically and kinetically favored over the hydrogen atom transfer pathway owing to the formation of a strong boron-chlorine (B-Cl) bond and the low-lying antibonding orbital of the carbon-chlorine (C-Cl) bond.

Journal of the American Chemical Society published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H21BO3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Suzuki, Toshio published the artcileA simple and convenient preparation of triethylene tetramine dihydrochloride (trien) for the treatment of Wilson’s disease and its stability, HPLC of Formula: 38260-01-4, the publication is Byoin Yakugaku (1987), 13(6), 335-9, database is CAplus.

Treatment of triethylene tetramine with anhydrous MeOH-HCl solution derived from AcCl and MeOH at 0¡ã, followed by recrystallization provided pure triethylene tetramine di-HCl (trien di-HCl). The compound is less hygroscopic than that prepared by the preceding procedure. Examination of its stability and drug activity under various conditions suggests than an aqueous solution of trien could also be useful for the treatment of Wilson’s disease.

Byoin Yakugaku published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C28H18O4, HPLC of Formula: 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hasebe, Shigeru published the artcileRemoval of lead(2+) ion by absorbing particle flotation using zeolite, Name: Dodecylamineacetate, the publication is Iwate Daigaku Kogakubu Kenkyu Hokoku (1983), 53-9, database is CAplus.

The flotation of zeolite with dodecylamine?acetate (DAA) [2016-56-0] for the removal of Pb²⁺ was investigated. Zeolite particle can be effectively floated with DAA at pH 2-7. The suitable size of zeolite for flotation with a column type separator is 104-137¦Ì, and the recovery of zeolite is ?95% with DAA 15 kg/ton. Under the same conditions, the column flotation showed a higher recovery of zeolite and removal of Pb²⁺ than did the Denver type flotation equipment. The zeolite may be used for 3 cycles to remove Pb²⁺. Adsorbing particle flotation in the column can be treated with a higher concentration and for a shorter time than with the percolation method.

Iwate Daigaku Kogakubu Kenkyu Hokoku published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Name: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Edo, Kiyoto published the artcileExtra-weak chemiluminescence of drugs. II. Relationship between the structure and the extra-weak chemiluminescence of organic compounds, HPLC of Formula: 38260-01-4, the publication is Chemical & Pharmaceutical Bulletin (1985), 33(7), 3042-5, database is CAplus.

The extra-weak chemiluminescence was measured for 116 organic compounds with simple structures having various functional groups. Alkynes, aliphatic amines, aliphatic aldehydes, epoxides and peroxides had high emission intensities.

Chemical & Pharmaceutical Bulletin published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, HPLC of Formula: 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rahmani-Nezhad, Samira published the artcileSynthesis, in vitro cytotoxicity and apoptosis inducing study of 2-aryl-3-nitro-2H-chromene derivatives as potent anti-breast cancer agents, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Medicinal Chemistry (2014), 562-569, database is CAplus and MEDLINE.

A series of 2-aryl-3-nitro-2H-chromenes I [R¹ = H, OMe; R² = H, OMe; R³ = H, OMe; R⁴ = 4-OMe, 3,4-dimethyoxy, 4-Cl, etc.] were designed as hybrid analogs of flavanone, ¦Â-nitrostyrene and nitrovinylstilbene scaffolds. They were synthesized from the reaction of appropriate ¦Â-nitrostyrenes and salicylaldehydes in good yields. In vitro cytotoxic activities of compounds I were tested against breast cancer cell lines including MCF-7, T-47D and MDA-MB-231. Most compounds exhibited good cytotoxic activity against selected cell lines, being more potent than standard drug etoposide. Representatively, 8-methoxy-3-nitro-2-(4-chlorophenyl)-2H-chromene I (R¹=R²=H, R³=OMe, R⁴= 4-Cl) with IC₅₀ = 0.2 ¦ÌM against MCF-7 cells, was 36-times more potent than etoposide. Apoptosis as a mechanism of cell death for selected compounds I (R¹=R²=H, R³=R⁴=OMe) and I (R¹=R²=H, R³=OMe, R⁴= 4-Cl) was confirmed morphol. by acridine orange/ethidium bromide double staining and TUNEL anal., as well as caspase-3 activation assay.

European Journal of Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

De Simone, Filippo published the artcileFormal Homo-Nazarov and Other Cyclization Reactions of Activated Cyclopropanes, Formula: C11H12O4, the publication is Chemistry – A European Journal (2011), 17(51), 14527-14538, S14527/1-S14527/124, database is CAplus and MEDLINE.

The Nazarov cyclization of divinyl ketones gives access to cyclopentenones. Replacing one of the vinyl groups by a cyclopropane leads to a formal homo-Nazarov process for the synthesis of cyclohexenones. In contrast to the Nazarov reaction, the cyclization of vinyl-cyclopropyl ketones is a stepwise process, often requiring harsh conditions. Herein are described two different approaches for further polarization of the three-membered ring of vinyl-cyclopropyl ketones to allow the formal homo-Nazarov reaction under mild catalytic conditions. In the first approach, the introduction of an ester group ¦Á to the carbonyl on the cyclopropane gave a more than tenfold increase in reaction rate, allowing us to extend the scope of the reaction to non-electron-rich aryl donor substituents in the ¦Â position to the carbonyl on the cyclopropane. In this case, a proof of principle for asym. induction could be achieved using chiral Lewis acid catalysts. In the second approach, heteroatoms, especially nitrogen, were introduced ¦Â to the carbonyl on the cyclopropane. In this case, the reaction was especially successful when the vinyl group was replaced by an indole heterocycle. With a free indole, the formal homo-Nazarov cyclization on the C3 position of indole was observed using a copper catalyst. In contrast, a new cyclization reaction on the N1 position was observed with Bronsted acid catalysts. Both reactions were applied to the synthesis of natural alkaloids. Preliminary investigations on the rationalization of the observed regioselectivity are also reported.

Chemistry – A European Journal published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moorthy, Jarugu Narasimha published the artcileC₃-Symmetric Proline-Functionalized Organocatalysts: Enantioselective Michael Addition Reactions, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Organic Chemistry (2010), 6359-6365, S6359/1-S6359/55, database is CAplus.

C₃-Sym., tripodal catalyst I based on 1,3,5-triethylbenzene, which incorporates the features of a mol. receptor, is shown to catalyze Michael addition reactions ofcarbonyl compounds to ¦Â-nitrostyrenes in a high stereoselectivity (up to 99:1 dr and up to 98 % ee).

European Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Alomari, Khadra published the artcileEnantioselective ”clip-cycle” synthesis of di-, tri- and spiro-substituted tetrahydropyrans, Computed Properties of 22693-41-0, the publication is Organic & Biomolecular Chemistry (2022), 20(6), 1181-1185, database is CAplus and MEDLINE.

The ¦Ø-unsaturated alcs. e.g., C(Me)₂(OH)(CH₂)₃CHCH₂ were ‘clipped’ via alkene e.g., 1-[(2,4,6-trimethylphenyl)sulfanyl]prop-2-en-1-one metathesis to a thioester activating group, which was followed by a chiral phosphoric acid catalyzed intramol. oxa-Michael cyclization to yield tetrahydropyrans/spiro-tetrahydropyrans e.g., I with excellent enantioselectivity. The mechanism and origin of the enantioselectivity were probed by DFT calculations and kinetic isotope studies, where there was excellent correlation between the computational and synthetic investigations.

Organic & Biomolecular Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Computed Properties of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saigusa, K. published the artcileInfluence of carboxylic acid content and polymerization catalyst on hydrolytic degradation behavior of Poly(glycolic acid) fibers, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline, the publication is Polymer Degradation and Stability (2020), 109054, database is CAplus.

Poly(glycolic acid) (PGA) is an aliphatic polyester with the simplest chem. structure. Since PGA is susceptible to hydrolysis, various researchers studied the factors affecting the hydrolytic degradation behavior of PGA. The factors include the higher-order structure, pH, ionic electrolyte etc. In this study, to clarify the mechanism for the hydrolysis of PGA fibers, effect of the carboxylic acid content on the hydrolytic degradation behavior was investigated through the quant. evaluation of the amounts of the carboxylic acid end group and the PGA monomer (glycolide, GL) in the fibers. Evaluation of the hydrolysis of PGA fibers through the analyses of the mol. weight retention and tensile strength retention after immersing in the phosphate buffer solution at 37¡ãC revealed that the hydrolysis is governed by the carboxylic acid content in the PGA fibers. It was also found that the amount of GL generated during the melt spinning process is affected by the amount and type of polymerization catalyst. In addition, the exptl. results of fundamental anal. suggested that the polymerization catalyst also decomposes the GL into glycolic acid or glycolic acid dimers to generate carboxylic acid, and the rate of decomposition varies depending on the type and amount of catalyst. Based on these results, it was concluded that there is an indirect effect of the type and amount of polymerizing catalyst on the rate of hydrolysis of PGA fibers.

Polymer Degradation and Stability published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Uemura, Takahito published the artcileA Concise Enantiodivergent Synthesis of Equol, SDS of cas: 16909-09-4, the publication is Synlett (2021), 32(7), 693-696, database is CAplus.

Equol, a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein, has been synthesized as both enantioenriched forms based on MacMillan’s ¦Á-arylation of carbonyl compound mediated by amino acid derived indazolidinones and copper precatalysts. The natural form of (S)-equol and its enantiomer (R)-equol have been synthesized in 8 steps from 2,4-dimethoxybenzaldehyde with good enantiomeric purity (90% ee and 90% ee, resp.).

Synlett published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C12H23N3S, SDS of cas: 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia