Tag: M.W=200-250

Park, Sei-Kyoung published the artcileInhibition of A¦Â42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs, Application of N1,N2-Dibenzylethane-1,2-diamine, the publication is Microbial Cell (2016), 3(2), 53-64, database is CAplus and MEDLINE.

The formation of small A¦Â42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinositol binding clathrin assembly protein (PICALM), reduced oligomerization of A¦Â42 fused to a reporter in yeast. Thus we used the A¦Â42-reporter system to identify drugs that could be developed into therapies that prevent or arrest AD. From a screen of 1,200 FDA approved drugs and drug-like small compounds we identified 7 drugs that reduce A¦Â42 oligomerization in yeast: 3 antipsychotics (bromperidol, haloperidol and azaperone), 2 anesthetics (pramoxine HCl and dyclonine HCl), tamoxifen citrate, and minocycline HCl. Also, all 7 drugs caused A¦Â42 to be less toxic to PC12 cells and to relieve toxicity of another yeast AD model in which A¦Â42 aggregates targeted to the secretory pathway are toxic. Our results identify drugs that inhibit A¦Â42 oligomers from forming in yeast. It remains to be determined if these drugs inhibit A¦Â42 oligomerization in mammals and could be developed as a therapeutic treatment for AD.

Microbial Cell published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ouvry, Gilles published the artcileSubstituted allyl diphenylphosphine oxides as radical allylating agents, Synthetic Route of 4141-48-4, the publication is Angewandte Chemie, International Edition (2006), 45(30), 5002-5006, database is CAplus and MEDLINE.

The radical addition of dithiocarbonates to branched allyl diphenylphosphine oxides may be followed by elimination of a diphenylphosphinoyl radical, thereby giving rise to allylated products. Highly functionalized structures can thus be rapidly assembled under mild conditions and from cheap and readily available substrates and reagents.

Angewandte Chemie, International Edition published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Synthetic Route of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

DeBerardinis, Albert M. published the artcileVitamin D3 analogues that contain modified A- and seco-B-rings as hedgehog pathway inhibitors, Product Details of C15H14O3, the publication is European Journal of Medicinal Chemistry (2015), 156-171, database is CAplus and MEDLINE.

The hedgehog (Hh) signaling pathway is a developmental signaling pathway that has been implicated as a target for anti-cancer drug development in a variety of human malignancies. Several natural and synthetic vitamin D-based seco-steroids have been identified as potent inhibitors of Hh signaling with chemotherapeutic potential. These include the previously characterized analog 4, which contains the northern CD-ring/side chain region of vitamin D3 (VD3) linked to an aromatic A-ring mimic through an ester bond. To further explore structure-activity relationships for this class of VD3-based Hh pathway inhibitors, we have designed, synthesized and evaluated several series of compounds that modify the length, composition, and stereochem. orientation of the ester linker. These studies have identified compounds 54 and 55, which contain an amine linker and an aromatic A-ring incorporating a para-phenol, as new lead compounds with enhanced potency against the Hh pathway (IC₅₀ values = 0.40 and 0.32 ¦ÌM, resp.).

European Journal of Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Product Details of C15H14O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Maresh, Justin J. published the artcileChemoselective Zinc/HCl Reduction of Halogenated ¦Â-Nitrostyrenes: Synthesis of Halogenated Dopamine Analogues, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Synlett (2014), 25(20), 2891-2894, database is CAplus.

A detailed account regarding the synthesis of 2- and 5-halogenated dopamine is given. The key step is a chemoselective reduction of a nitrostyrene by Zn/HCl at 0 ¡ãC. These conditions represent a simple, low-cost alternative to reduction by water-sensitive hydride donors and two-step procedures. Under these conditions, aryl fluoride, chloride, and bromide groups are stable. However, iodine undergoes significant reductive dehalogenation.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Carreiro, Elisabete P. published the artcileChiral monooxazolines as modular copper(I)-heterocomplex building blocks: investigations on the catalytic asymmetric cyclopropanation of alkenes, Application In Synthesis of 16909-09-4, the publication is Tetrahedron (2011), 67(25), 4640-4648, database is CAplus.

Novel chiral monodentate oxazoline ligands I [R = Me, Ph, 2,4-(MeO)₂C₆H₃; R¹ = Ph, PhCH₂, i-Pr] have been synthesized in good yields. The catalytic activity of these monodentate oxazoline/Cu catalysts was evaluated in the catalytic asym. cyclopropanation of styrene and ¦Á-methylstyrene, giving moderate to good enantioselectivities (up to 74% ee for the trans-cyclopropane product) and full conversions (up to 100%). In an attempt to enhance the enantioselectivities of the cyclopropanations, heterocombinations of these ligands were used. Unfortunately, with the data set that was used in this study, no improvements were observed However, to gain an insight into the nature of the active catalyst present under these circumstances, NMR, mass spectrometric and computational studies were carried out and indicated the presence of bidentate heterocomplexes in the equilibrium mixture Anal. of the stereoselectivities (ees and des) did not prove very useful in pinpointing the identity of the active chiral catalyst and only afforded a very weak conclusion. In order to ascertain the importance of the ¦Ð-¦Ð interactions, the monodentate oxazoline ligands I [R = Me; R¹ = Ph, i-Pr] were synthesized and screened in these reactions. Their stereoselectivity was compared to the one of ligands I [R = 2,4-(MeO)₂C₆H₃; R¹ = PhCH₂, i-Pr]. The results suggest the presence of weak ¦Ð-¦Ð interactions.

Tetrahedron published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Acharya, Amitabha published the artcile1,3-diamido-calix[4]arene conjugates of amino acids: recognition of -COOH side chain present in amino acids, peptides, and proteins by experimental and computational studies, Computed Properties of 1798-04-5, the publication is Journal of Organic Chemistry (2011), 76(1), 127-137, database is CAplus and MEDLINE.

Lower rim 1,3-diamido conjugates of calix[4]arene have been synthesized and characterized, and the structures of some of these have been established by single crystal XRD. The amido-calix conjugates possessing a terminal -COOH moiety have been shown to exhibit recognition toward guest mols. possessing -COOH moiety, viz., Asp, Glu, and reduced and oxidized glutathione (GSH, GSSG), by switch-on fluorescence in aqueous acetonitrile and methanol solutions when compared to the control mols. via forming a 1:1 complex. The complex formed has been shown by mass spectrometry, and the structural features of the complexes were derived on the basis of DFT computations. The association constants observed for the recognition of Asp/Glu by Phe-calix conjugate, viz., 532/676 M^-1, are higher than that reported for the recognition of Val, Leu, Phe, His, and Trp (16-63 M^-1) by a water-soluble calixarene (Arena, G., et al. Tetrahedron Lett. 1999, 40, 1597). For this recognition, there should be a free -COOH moiety from the guest mol. AFM, SEM, and DLS data exhibited spherical particles with a hundred-fold reduction in the size of the complexes when compared to the particles of the precursors. These spherical particles have been computationally modeled to possess hexameric species reminiscent of the hexameric micellar structures shown for a Ag⁺ complex of a calix[6]arene reported in the literature (Houmadi, S., et al. Langmuir 2007, 23, 4849). Both AFM and TEM studies demonstrated the formation of nanospheres in the case of GSH-capped Ag nanoparticles in interaction with the amido-calix conjugate that possesses terminal -COOH moiety. The AFM studies demonstrated in this paper have been very well applied to albumin proteins to differentiate the aggregational behavior and nanostructural features exhibited by the complexes of proteins from those of the uncomplexed ones. To the authors’ knowledge, this is the first report wherein a amido-calix[4]arene conjugate and its amino acid/peptide/protein complexes have been differentiated on the basis of spectroscopy and microscopy studies followed by species modeling by computations.

Journal of Organic Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Joseph, Roymon published the artcileExperimental and Computational Studies of Selective Recognition of Hg²⁺ by Amide Linked Lower Rim 1,3-Dibenzimidazole Derivative of Calix[4]arene: Species Characterization in Solution and that in the Isolated Complex, Including the Delineation of the Nanostructures, Category: catalysis-chemistry, the publication is Journal of Organic Chemistry (2008), 73(15), 5745-5758, database is CAplus and MEDLINE.

Amide linked lower rim 1,3-dibenzimidazole derivative of calix[4]arene, L has been shown to be sensitive and selective to Hg²⁺ in aqueous acetonitrile solution based on fluorescence spectroscopy, and the stoichiometry of the complexed species has been found to be 1:1. The selectivity of L toward Hg²⁺ has been shown among 11 M²⁺ ions, viz., Mn²⁺, Fe²⁺, Co²⁺, Ni²⁺, Cu²⁺, Zn²⁺, Cd²⁺, Hg²⁺, Pb²⁺, Ca²⁺, and Mg²⁺ studied, including those of the mercury group and none of these ions impede the recognition of Hg²⁺ by L. Role of the solvent on the recognition of Hg²⁺ has been demonstrated. The role of calix[4]arene platform and the benzimidazole moieties in the recognition of Hg²⁺ by L has been delineated upon performing such studies with five different mols. of relevance as reference mol. systems. The binding cores formed by the receptor L and the reference compounds have been established based on the single crystal XRD structures, and the preferential metal ion binding cores have been discussed. The binding of Hg²⁺ with L has been further established based on ¹H and ¹³C NMR, ESI MS, absorption, and fluorescence lifetime measurements. Some of these techniques have been used to establish the stoichiometry of the species formed. The complex species formed between L and Hg²⁺ have been isolated and characterized and found to be 1:1 species even in the isolated complex. Whereas transmission electron microscopy (TEM), at. force microscopy (AFM), and SEM provided the nanostructural behavior of L, the TEM and SEM demonstrated that the mercury complex has different characteristics when compared to L. The TEM, SEM, and powder XRD studies revealed that whereas L is crystalline, that of the mercury complex is not, perhaps a reason for not being able to obtain single crystals of the complex. Binding characteristics of Hg²⁺ toward L have been established based on the DFT computational calculations

Journal of Organic Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gangadhara, Seelolla published the artcileSynthesis, antimicrobial and antioxidant activity of piperidine analog containing trans cinnamamides, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Indo American Journal of Pharmaceutical Research (2015), 5(3), 1280-1287, database is CAplus.

Cinnamamides were prepared by using piperidine and different cinnamicacids. The structures of the newly synthesized compounds were confirmed by their IR, LC-MS, 1H & 13C NMR spectral data and tested in vitro for antibacterial activity against Gram-pos. and Gram-neg. bacterial strains. Most of the synthesized compounds showed moderate to good activity comparable to that of the standard drugs Streptomycin and Amphotericin B as an antibacterial and antifungal strain resp. Compounds 4a and 4b exhibited good activity against Gram-pos. bacterial strains S.aureus and B.subtilis resp. Compounds 4a and 4i displayed good activity against fungal strains C.albicans and A.flavus resp.

Indo American Journal of Pharmaceutical Research published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hermann, Uwe published the artcileReaction pathways towards novel open chain and cyclic stannasilanes, Recommanded Product: Difluorodiphenylsilane, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2001), 145-150, database is CAplus.

Cyclic stannasilaalkanes were formed by rearrangement reactions of open chain and branched Si-Sn derivatives For example, ^tBu₂Sn(H)(SiMe₂)₄Sn(H)^tBu₂ reacted with LDA resulting in 2,2,3,3,4,4,5,5-octamethyl-1,1-ditert-butyl-2,3,4,5-tetrasilastannacyclopentane. First attempts for producing three membered Si-Sn rings via lithio or potassio substituted stannanes are reported.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bardin, V. V. published the artcileInteraction of polyfluoroaromatic compounds with electrophilic agents in the presence of tris(dialkylamino)phosphines. 3. Reactions of bromopentafluorobenzene with P(NEt₂)₃ and Me₂SiXY, Recommanded Product: Trimethyl(perfluorophenyl)silane, the publication is Sibirskii Khimicheskii Zhurnal (1992), 52-5, database is CAplus.

The reactions of C₆F₅Br (I) with Me₂SiXY (X = Cl, Br, I; Y = Me, Bu, Ph, C₆F₅) and P(NEt₂)₃ (II) gave C₆F₅SiMe₂Y in 60-77% yield. Me₂CHSiMe₂Cl reacted with I and II to give the analogous product in only 23% yield. PhSiMe₂F, PhSiMe₂OEt, and C₆F₅SiMe₂OEt were unreactive, and Me₂SiClOEt was converted to C₆F₅SiMe₂OEt and (C₆F₅)₂SiMe₂.

Sibirskii Khimicheskii Zhurnal published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Recommanded Product: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia