Tag: M.W=200-250

Farkas, Edit published the artcileEquilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATA^m and DATA^5m Ligands, Related Products of catalysis-chemistry, the publication is Chemistry – A European Journal (2017), 23(43), 10358-10371, database is CAplus and MEDLINE.

The development of ⁶⁸Ge/⁶⁸Ga generators has made the positron-emitting ⁶⁸Ga isotope widely accessible and raised interest in new chelate complexes of Ga³⁺. The hexadentate 1,4-di(acetate)-6-methyl[amino(methyl)acetate]perhydro-1,4-diazepane (DATA^m) ligand and its bifunctional analog, 1,4-di(acetate)-6-pentanoic acid-6-[amino(methyl)acetate]perhydro-1,4-diazepane (DATA^5m), rapidly form complexes with ⁶⁸Ga in high radiochem. yield. The stability constants of DATA^m and DATA^5m complexes formed with Ga³⁺, Zn²⁺, Cu²⁺, Mn²⁺ and Ca²⁺ were determined by using pH potentiometry, spectrophotometry (Cu²⁺) and ¹H and ⁷¹Ga NMR spectroscopy (Ga³⁺). The stability constants of Ga(DATA^m) and Ga(DATA^5m) complexes are slightly higher than those of Ga(AAZTA). The species distribution calculations indicated the predominance of Ga(L)OH mixed-hydroxo complexes at physiol. pH. The ¹H and ⁷¹Ga NMR spectroscopy studies provided information about the coordinated functional groups of ligands and on the kinetics of exchange between the Ga(L) and Ga(L)OH complexes. The transmetalation reactions between the Ga(L) complexes and Cu²⁺ citrate (6 < pH < 8.5) occur through both spontaneous and OH^–-assisted dissociation of the Ga(L)OH species. At pH 7.4 and 25¡ã, the half-lives of the dissociation of Ga(DATA^m), Ga(DATA^5m) and Ga(AAZTA) were 11, 44 and 24 h, resp. Similar half-lives were obtained for the ligand-exchange reactions between the Ga(L)OH complexes and transferrin. The equilibrium and kinetic data indicate that the Ga(DATA^5m) complex is a good ⁶⁸Ga-based radiodiagnostic candidate.

Chemistry – A European Journal published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sankara Rao, N. published the artcileDesign and synthesis of DNA-intercalative naphthalimide-benzothiazole/cinnamide derivatives: cytotoxicity evaluation and topoisomerase-IIa inhibition, SDS of cas: 16909-09-4, the publication is MedChemComm (2019), 10(1), 72-79, database is CAplus and MEDLINE.

A new series of different naphthalimide-benzothiazole/cinnamide derivatives were designed, synthesized and tested for their in vitro cytotoxicity on selected human cancer cell lines. Among them, derivatives 4a and 4b with the 6-aminobenzothiazole ring and 5g with the cinnamide ring displayed potent cytotoxic activity against colon (IC₅₀: 3.715 and 3.467 uM) and lung cancer (IC₅₀: 4.074 and 3.890 uM) cell lines when compared to amonafide (IC₅₀: 5.459 and 7.762 uM). Later, the DNA binding studies for these selected derivatives (by CD, UV/vis, fluorescence spectroscopy, DNA viscosity, and mol. docking) suggested that these new derivatives significantly intercalate between two strands of DNA. In addition, the most potent derivatives 4a and 4b were also found to inhibit DNA topoisomerase-II.

MedChemComm published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, SDS of cas: 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Santoro, Orlando published the artcileSynthesis, characterization and catalytic activity of stable [(NHC)H][ZnXY₂] (NHC = N-Heterocyclic carbene, X, Y = Cl, Br) species, Category: catalysis-chemistry, the publication is Journal of Molecular Catalysis A: Chemical (2016), 85-91, database is CAplus.

The synthesis and characterization of imidazol(in)ium-based zinc(II) halide salts are reported. These compounds present interesting structural features and exhibit high stability. Their catalytic activity was explored in the methylation of amines with CO₂ and PhSiH₃. CCDC-1447299 (1), CCDC-1447302 (2), CCDC-1447301 (3), CCDC-1447298 (4a) and CCDC-1447300 (5b).

Journal of Molecular Catalysis A: Chemical published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yamazaki, Shoko published the artcileSynthesis of Piperidines via Intramolecular Hydride Transfer from ¦Á-Amino sp³ Carbon Atoms to Ethenetricarboxylate-Derived Fragments and Further Cyclization, Application In Synthesis of 140-28-3, the publication is ChemistrySelect (2018), 3(16), 4505-4511, database is CAplus.

The cyclization of amides derived from ethenetricarboxylic acid bearing tert-amino groups wsa examined The amides were efficiently converted to piperidine derivatives (2-piperidones) upon heating in a polar solvent (e. g., DMSO or DMF) via intramol. hydride transfer and subsequent ring closure. The reaction was less efficient in the presence of a Lewis acid. The reactivity varies depending on the alkyl substituents of tert-amino groups, probably due to steric effects. The hydride transfer/cyclization mechanism was investigated by DFT calculations The reaction of the carboxylic acid and relatively bulky diamines such as diisopropyl-substituted diamine in the presence of amide condensation reagents at 60 ¡ã gave the piperidine derivatives in a one-pot reaction. The reaction of the diisopropylamine substituted piperidine product with primary amines gave secondary amine-substituted piperidines.

ChemistrySelect published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H4ClN3S, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, B. published the artcileA study on the separation of fine cassiterite and quartz by liquid-liquid extraction, Application In Synthesis of 2016-56-0, the publication is Publications of the Australasian Institute of Mining and Metallurgy (1993), 3/93(XVIII International Mineral Processing Congress), 727-33, database is CAplus.

Fine cassiterite and quartz were separated by liquid-liquid extraction using iso-octane as an oil phase, dodecylamine acetate (DAA) as a collector, and sodium chloride as a depressant. With regard to the distribution of fine cassiterite and quartz between oil and aqueous phases, the effect of DAA was investigated in terms of pH, DAA and NaCl concentrations, zeta potential, and adsorption d. A maximum recovery of cassiterite in the oil phase was obtained with pH around 6.0, DAA concentration of 1.0 ¡Á 10^-5 mol/L, and NaCl addition of 0.1 mol/L. In these conditions of liquid-liquid extraction, most of the fine quartz remained in the aqueous phase. Thus NaCl was an effective depressant for fine quartz under optimum conditions. A series of separation tests by liquid-liquid extraction was then conducted for the mixed samples (6.0% Sn) of cassiterite and quartz. By a single separating process, the recovery of cassiterite in the oil phase was about 92% with a grade of 27% Sn. The same results could also be obtained by using kerosine in place of iso-octane as the oil phase.

Publications of the Australasian Institute of Mining and Metallurgy published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Application In Synthesis of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, B. published the artcileThe effect of organic solvents on the recovery of fine mineral particles by liquid-liquid extraction, Product Details of C14H31NO2, the publication is Minerals Engineering (1993), 6(7), 731-42, database is CAplus.

The cooperative effect of organic solvents in recovering fine mineral particles by liquid-liquid extraction was studied. With dodecylamine acetate as a collector, iso-octane as the main oil phase, and n-butanol and Me iso-Bu ketone as sub-oil phases, the cooperative effect between polar neutral organic mols. and non-polar hydrocarbon oil droplets on the extraction of fine quartz from the aqueous phase into the oil phase was estimated The oil/water interfacial tensions and contact angles of oil droplets on a quartz surface in water were measured. The neutral organic mols. made extraction of the fine quartz particles more efficient, i.e., by increasing the recovery of quartz in the oil phase and decreasing the collector addition Co-adsorption of the neutral organic mols. with collector ions plays the most important role.

Minerals Engineering published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Product Details of C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Bo published the artcileRecovery of fine mineral particles by liquid-liquid extraction, Computed Properties of 2016-56-0, the publication is Shigen to Sozai (1993), 109(1), 17-22, database is CAplus.

The effect of organic phases on the recovery of fine quartz particles was studied using dodecylamine acetate (DAA) as a collector in a liquid-liquid extraction process at various pH values. Three kinds of organic solvents, i.e., BuOH, MeCOCH₂CHMe₂, and isooctane, were used as the oil phase. The interactions between the oil droplets and the quartz surface at different pH values and DAA concentrations were examined through related experiments on oil/water interfacial tension, contact angle, and interfacial free energy for contact. Good correlation was obtained between the quartz recovery and these variables. The recovery depended not only on the pH and the collector concentration, but also on the properties of the oil phase.

Shigen to Sozai published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Computed Properties of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kusaka, Eishi published the artcileRecovery of fine particles of rare earth minerals by liquid-liquid extraction method, Safety of Dodecylamineacetate, the publication is Sozai Busseigaku Zasshi (1992), 5(1), 63-73, database is CAplus.

Fine particles of monasite, xenotime, and zircon were recovered from beach sand by liquid-liquid extraction in an isooctane-water system in the presence of surfactants (Na oleate, Na dodecylbenzenesulfonate, Na dodecylsulfate, dodecylammonium acetate and dodecylammonium chloride). Zeta potential variations were measured as a function of pH for each of these minerals to determine its isoelec. point for selecting the optimum mineral recovery conditions.

Sozai Busseigaku Zasshi published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Safety of Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kamata, Ryo published the artcileAgonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay, Application In Synthesis of 1798-04-5, the publication is Toxicology In Vitro (2018), 335-349, database is CAplus and MEDLINE.

The constitutive androstane receptor (CAR) is a nuclear receptor and transcription factor regulating proteins involved in xenobiotic metabolism Agonist activation of the CAR can trigger metabolic activation and toxification as well as detoxification and clearance; accordingly, xenobiotic substances acting as CAR ligands may pose a threat to human and animal health. The authors used yeast cells transduced with the human CAR and the response pathway to measure the CAR-agonistic activities of 549 synthetic or natural compounds: 216 of the tested compounds exhibited CAR-agonistic effects. Eighty-four percent of CAR-activating compounds were aromatic compounds, and >65% of these active compounds were aromatic hydrocarbons, bisphenols, monoalkyl phenols, phthalates, styrene dimers, di-Ph ethers, organochlorines, and organophosphates. The ten most potent compounds were 4-tert-octylphenol (4tOP; reference substance), 4-nonylphenol, diethylstilbestrol, benzyl Bu phthalate, 2-(4-hydroxyphenyl)-2,4,4-trimethylchroman, o,p’-DDT, methoxychlor, di-Pr phthalate, hexestrol, and octachlorostyrene. The activities of these nine non-reference compounds exceeded 10% of the 4tOP activity. Anal. of para-monoalkyl phenols suggests that branching of the alkyl group and chlorination at the ortho position raises potency. This study provides critical information for identifying the potential of CAR-mediated toxic hazards and for understanding the relevant mechanism.

Toxicology In Vitro published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Application In Synthesis of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moriguchi, Michihisa published the artcileThe copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production, Synthetic Route of 38260-01-4, the publication is International Journal of Cancer (2002), 102(5), 445-452, database is CAplus and MEDLINE.

Recent studies have revealed that copper is an important cofactor for several angiogenic agents. We examined the antiangiogenic effect against hepatocellular carcinoma (HCC) of the copper chelator trientine, especially focusing on the relationship between copper and interleukin-8 (IL-8), a potent angiogenic factor produced by hepatoma cells. HuH-7 hepatoma cells were transplanted into nude mice and the growth of xenograft tumors was compared to and without administration of trientine. Using the resected tumor, microvessel d., apoptotic potential and proliferative activity were analyzed histol. and IL-8 mRNA was semiquantified by RT-PCR. In addition, HuH-7 cells were cultured in control medium, medium supplemented with copper, medium supplemented with trientine and medium supplemented with both copper and trientine. Human IL-8 levels were measured in the supernatants by ELISA. Using the extracts from cultured cells, IL-8 mRNA was semiquantified by RT-PCR. Trientine suppressed the growth of xenograft tumors significantly. Histol., apoptotic potential was increased significantly and microvessel d., decreased. The production of IL-8 from the tumor was suppressed by trientine. In vitro, IL-8 production by HuH-7 cells in copper-containing medium was significantly greater than that in copper-free medium, and this effect was weakened when trientine was added. However, no significant change was apparent when trientine was added to the medium alone. In conclusion, the chelating effect of trientine prevented copper from functioning as a cofactor in angiogenesis, which resulted in reduced IL-8 production from HuH-7 cells.

International Journal of Cancer published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Synthetic Route of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia