Tag: M.W=200-250

Paplal, Banoth published the artcileRegioselective synthesis of functionalized 1,2,3-triazoles via oxidative [3+2]-cycloaddition using Zn(OAc)₂ – ^tBuOOH or ZnO nanoparticle as catalyst system in aqueous medium, Synthetic Route of 4230-93-7, the publication is Catalysis Communications (2017), 115-120, database is CAplus.

The regioselective synthesis of functionalized pyrazole-1,2,3-triazoles is reported via oxidative [3 + 2]-cycloaddition reactions of azides with ¦Â-nitrostyrenes and chalcone derivatives using Zn(OAc)₂ – ^tBuOOH or ZnO nanoparticles as catalyst system in aqueous medium. The catalyst dependent product selectivity was observed with ¦Â-nitrostyrenes to give the triazoles with and without -NO₂ group Zn(OAc)₂ and ZnO nanoparticles. The chalcones gave the triazoles selectively as sole products with good regioselectivity. The resulting products were further converted into sulfonamides and oxazoles resp.

Catalysis Communications published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Hao published the artcileApproach to Vicinal t-Boc-amino Dibromides via Catalytic Aminobromination of Nitrostyrenes without Using Chromatography and Recrystallization, Application In Synthesis of 4230-93-7, the publication is Journal of Organic Chemistry (2013), 78(3), 1171-1175, database is CAplus and MEDLINE.

In the presence of tripotassium phosphate trihydrate, tert-Bu N,N-dibromocarbamate (prepared from tert-Bu carbamate) added regioselectively to ¦Â-nitrostyrenes RCH:CHNO₂ [R = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, 2-ClC₆H₄, 4-MeC₆H₄, 4-F₃CC₆H₄, 4-NCC₆H₄, 2-naphthyl, 1-naphthyl, 2-PhCH₂OC₆H₄, 2,6-Cl₂C₆H₃, 3,4-Cl₂C₆H₃, 4-FC₆H₄, 4-BrC₆H₄, 3-FC₆H₄, 3-Br-4-MeOC₆H₃, 2-MeOC₆H₄, 3,4-(MeO)₂C₆H₃, 4-Me₃CC₆H₄] in 1,2-dichloroethane to give tert-Bu ¦Á-(dibromonitromethyl)benzylcarbamates RCH(NHBoc)C(NO₂)Br₂ [R = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, 2-ClC₆H₄, 4-MeC₆H₄, 4-F₃CC₆H₄, 4-NCC₆H₄, 2-naphthyl, 1-naphthyl, 2-PhCH₂OC₆H₄, 2,6-Cl₂C₆H₃, 3,4-Cl₂C₆H₃, 4-FC₆H₄, 4-BrC₆H₄, 3-FC₆H₄, 3-Br-4-MeOC₆H₃, 2-MeOC₆H₄, 3,4-(MeO)₂C₆H₃, 4-Me₃CC₆H₄] in 82-99% yields. The solubility of the products allowed them to be isolated in pure form by extraction with hexanes rather than requiring chromatog. or recrystallization for purification

Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H14O, Application In Synthesis of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ceban, Victor published the artcileThree-component diastereoselective cascade synthesis of thiohydantoins, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Tetrahedron Letters (2013), 54(52), 7183-7187, database is CAplus.

A new three-component cascade reaction for the synthesis of thiohydantoins is reported. The reaction between ¦Á-amino esters, nitrostyrenes, and aromatic isothiocyanates is efficiently promoted by organic bases to afford highly substituted thiohydantoins e. g., I in moderate to good yields and diastereoselectivities.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sarges, Reinhard published the artcileGlucose transport-enhancing and hypoglycemic activity of 2-methyl-2-phenoxy-3-phenylpropanoic acids, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of Medicinal Chemistry (1996), 39(24), 4783-4803, database is CAplus and MEDLINE.

A series of 2-phenoxy-3-phenylpropanoic acids has been prepared which contains many potent hypoglycemic agents as demonstrated by assessing glucose lowering in ob/ob mice. Some compounds normalize plasma glucose in this diabetic model at doses of approx. 1 mg/kg. The mechanism of action of these drugs may involve enhanced glucose transport, especially in fat cells, but the compounds do not stimulate GLUT4 translocation and do not increase the levels of GLUT1 or GLUT4 in vivo. Thus, these compounds may enhance the intrinsic activity of the glucose transporter GLUT1 or GLUT4. Some compounds also modestly decrease hepatocyte gluconeogenesis in vitro, but this is not likely to be a major contributor to the hypoglycemic effect observed in vivo. Likewise, a modest decrease in food consumption observed with some of these compounds was shown by a pair-feeding experiment not to be the primary cause of the hypoglycemia observed

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Goess, Brian C. published the artcileSynthesis of a 10,000-Membered Library of Molecules Resembling Carpanone and Discovery of Vesicular Traffic Inhibitors, Formula: C10H25NO2Si, the publication is Journal of the American Chemical Society (2006), 128(16), 5391-5403, database is CAplus and MEDLINE.

Split-and-pool synthesis of a 10,000-membered library of mols. resembling the natural product carpanone has been achieved. The synthesis features development of solid-phase multicomponent reactions between nitrogen nucleophiles, enones, and hydroxylamines, and a solid-phase application of the Huisgen cycloaddition affording substituted triazoles. The synthesis was performed in high-capacity (500 ¦Ìm) polystyrene beads using a one bead-one stock solution strategy that enabled phenotypic screens of the resulting library. Using whole-cell fluorescence imaging, we discovered a series of mols. from the carpanone-based library that inhibit exocytosis from the Golgi apparatus The most potent member of this series (I; CLL-19) has an IC₅₀ of 14 ¦ÌM. We also report structure-activity relationships for the mols. exhibiting this interesting phenotype. These inhibitors of exocytosis may be useful reagents for the study of vesicular traffic.

Journal of the American Chemical Society published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Formula: C10H25NO2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Goldberg, Daniel R. published the artcileThe tandem intramolecular Diels-Alder reaction, SDS of cas: 4141-48-4, the publication is Tetrahedron Letters (1993), 34(50), 8003-6, database is CAplus.

The tandem intramol. Diels-Alder (TIMDA) reaction of ketone I is reported to give tetracyclic ketone II. The reaction proceeds under mild conditions (BF₃¡¤Et₂O, 0¡ãC) and affords two tetracyclic products diastereoselectively. TIMDA substrate I is prepared in a convergent manner from 1,5-pentanediol.

Tetrahedron Letters published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, SDS of cas: 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Danda, Hidenori published the artcileAcyclic stereoselection. 48. Reversal of stereochemistry in the aldol reactions of a chiral boron enolate, SDS of cas: 22693-41-0, the publication is Journal of Organic Chemistry (1990), 55(1), 173-81, database is CAplus.

A route to optically active anti aldols of certain aldehydes is presented. The boron enolate derived from oxazolidinone I reacts with various aldehydes to give either syn or anti aldols, depending on the amount of dibutylboron triflate used in the enolization of I. The amine [(Me₂CH₂)₂NEt or Et₃N] used in the enolization is also found to have a dramatic effect on the subsequent aldol reaction. High anti selectivity is observed when I and 3-(arylthio)propenals, e.g., PhSCH:CHCHO, are used whereas moderate selectivity is observed when I and aromatic aldehydes, e.g., PhCHO, are used. An open transition state is suggested to account for the formation of the anti aldols. NMR studies provide support for the suggested mechanism. Although findings are at present limited to a few specific aldehydes, the ability to obtain either syn or anti aldols from the same chiral enolate by a choice of reagent and stoichiometry could have significant synthetic applicability.

Journal of Organic Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, SDS of cas: 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ge, Weizhi published the artcileSynthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents, SDS of cas: 16909-09-4, the publication is European Journal of Medicinal Chemistry (2019), 445-469, database is CAplus and MEDLINE.

Triple-neg. breast cancer (TNBC) is the most aggressive cancers with a high recurrence rate and rapidly acquired drug resistance among various breast cancer subtypes. There is no specific drug for treatment of TNBC. Discovery of therapeutic agents with unique modes of actions is urgently needed. In this study, a series of seventy parthenolide derivatives was designed, synthesized, and evaluated for their anti-TNBC activities. Compound I exhibited the most potent activity against different breast cancer cells with IC₅₀ values ranging from 0.20 ¦ÌM to 0.27 ¦ÌM, which demonstrated 11.6- to 18.6-fold improvement comparing to that of the parent compound parthenolide with IC₅₀ values of 2.68-4.63 ¦ÌM. It is worth to note that I was more active than the pos. control drug ADR. Moreover, compound I could induce apoptosis of SUM-159 cells through mitochondria pathway and cause G1 phase arrest of SUM-159 cells. These findings indicate that compound I deserves further studies as a lead compound for ultimate discovery of effective anti-TNBC drug.

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, SDS of cas: 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Adhikari, Birendra Babu published the artcileExtraction of Pb²⁺ with p-tert-butylcalix [4]-, [5]-, [6]Arene Carboxylic Acid Ligands and their Monomeric Counterpart: A Thermodynamic Approach, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Solvent Extraction and Ion Exchange (2013), 31(5), 483-498, database is CAplus.

Studies on extraction equilibrium constants at different temperatures and thermodn. parameters of solvent extraction of Pb²⁺ ion with carboxylic acid derivatives of different ring size calixarenes and structure related monomeric compound have been carried out. The extraction equilibrium constants corresponding to calix[n]arene (n = 4, 5, 6) derivatives decrease in the order [5]arene > [6]arene > [4]arene. In all cases, the complexation process is primarily enthalpy driven. The favorable enthalpic contribution for extraction of Pb²⁺ is in the order hexamer ¡Ö monomer > tetramer > pentamer. However, the unfavorable entropic loss follows the order: monomer > hexamer > tetramer > pentamer. Overall stability of the host-guest complex is the function of entropy-enthalpy compensation and the free energy of complexation is min. for the pentamer, followed by tetramer ¡Ö hexamer and monomer. Although the carboxylic acid derivative of calix[4]arene is more preorganized than the calix[5]arene derivative, extraction of Pb²⁺ ion with the tetramer passes through greater entropic loss than that with the pentamer and the degree of preorganization of calix[4]arene derivative is far from perfect for the complexation and extraction of Pb²⁺ ion. As compared to tetrameric and hexameric counterparts, the structural features of the carboxylic acid derivative of calix[5]arene prior to complexation contribute much to interact with the Pb²⁺ ion and form a thermodynamically stable complex. Supplementary materials are available for this article. Go to the publisher’s online edition of Solvent Extraction and Ion Exchange to view the supplemental file.

Solvent Extraction and Ion Exchange published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Adhikari, Birendra Babu published the artcileMultiple proton ionizable calixarene derivatives with different ring sizes and complexation ability as efficient ionophores for complexation and solvent extraction of trivalent indium, Category: catalysis-chemistry, the publication is Analyst (Cambridge, United Kingdom) (2011), 136(21), 4570-4579, database is CAplus and MEDLINE.

The solvent extraction behavior of multiple proton ionizable p-tert-butylcalix[4]arene and [6]arene carboxylic acid derivatives towards indium was studied along with an acyclic monomeric analog from weakly acidic media into chloroform. The extraction mechanism is ion exchange and carboxylic acid groups are adequate ligating sites for extraction The cyclic structure of calixarene ligands to accommodate the potential guest species and the cooperativity effect of multifunctional groups significantly affect the complexation behavior and calixarene derivatives are excellent extractants over the monomeric analog. The composition of the extracted complex depends on the solution pH and attempts to determine the composition of the extracted complex for the extraction of indium were stymied by complications arising from the formation of polynuclear species of indium and bridged polymeric species of calixarene carboxylic acid derivatives One mole of calix[4]arene derivative extracts 2.5 mol of indium whereas the calix[6]arene derivative tends to extract 4.0 mol of indium. The loaded indium is back extracted with 1 mol dm^-3 hydrochloric acid solution Though quant. back extraction of indium was achieved from the fully loaded calix[6]arene derivative, it was only achieved up to 85% in the case of the calix[4]arene derivative

Analyst (Cambridge, United Kingdom) published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia