Tag: M.W=200-250

Hatanaka, Yasuo published the artcileSelective synthesis of unsymmetrical biaryls via palladium-catalyzed cross-coupling of arylfluorosilanes with aryl iodides, HPLC of Formula: 312-40-3, the publication is Chemistry Letters (1989), 1711-14, database is CAplus.

In the presence of KF, arylfluorosilanes readily participate in Pd-catalyzed cross-coupling reaction with aryl iodides to give unsym. biaryls in good yields. Thus the coupling of PhSiEtF₂ with 4-IC₆H₄OEt gave 81% 4-PhC₆H₄OEt.

Chemistry Letters published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, HPLC of Formula: 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Atmaram Upare, Abhay published the artcileDesign, synthesis and biological evaluation of (E)-5-styryl-1,2,4-oxadiazoles as anti-tubercular agents, Application In Synthesis of 16909-09-4, the publication is Bioorganic Chemistry (2019), 507-512, database is CAplus and MEDLINE.

The present study reports the synthesis of cinnamic acid derivatives via bioisosteric replacement of terminal carboxylic acid with “oxadiazole”. A series of cinnamic acid derivatives (styryl oxadiazoles) were designed and synthesized in good yields by reaction of substituted cinnamic acids with amidoximes. The synthesized styryl oxadiazoles were evaluated in vitro for anti-tubercular activity against Mycobacterium tuberculosis (Mtb) H37Ra strain. The structure-activity relationship (SAR) study has identified several compounds with mixed anti-tubercular profiles. The compound I displayed potent anti-tubercular activity (IC₅₀ = 0.045 ¦Ìg/mL). Mol. docking studies on mycobacterial enoyl-ACP reductase enzyme corroborated well with the exptl. findings providing a platform for structure based hit-to-lead development.

Bioorganic Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nasveschuk, Christopher G. published the artcileDiscovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2, Application In Synthesis of 31719-76-3, the publication is ACS Medicinal Chemistry Letters (2014), 5(4), 378-383, database is CAplus and MEDLINE.

The identification and development of a novel series of small mol. Enhancer of Zeste Homolog 2 (EZH2) inhibitors is described. A concise and modular synthesis enabled the rapid development of structure-activity relationships, which led to the identification of I as a potent, SAM-competitive inhibitor of EZH2 that dose-dependently decreased global H3K27me3 in KARPAS-422 lymphoma cells.

ACS Medicinal Chemistry Letters published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Application In Synthesis of 31719-76-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Das, Suven published the artcileFacile synthesis of 3-(diarylmethylene)isobenzofuranones, 4-(diarylmethyl)-1(2H)-phthalazinones, and diarylmethanes, Safety of Bis(4-fluorophenyl)methane, the publication is Journal of Chemical Research (2006), 84-86, database is CAplus.

Reflux of 2,2-diaryl-1,3-indandiones in ethyleneglycol with a catalytic amount of triethylamine affords 3-(diarylmethylene)isobenzofuranones in very good yields. The latter produces 4-diarymethyl-1(2H)-phthalazinones under reflux in hydrazine hydrate (99%), and diarylmethanes upon stirring in ethylenediamine. The formation of 3-(diarylmethylene)isobenzofuranones was established on the basis of spectroscopic data and confirmed by x-ray diffraction studies on single crystal of 3-(di-(p-iodophenyl)methylene)isobenzofuranone [orthorhombic, Pna2₁, a 14.996(1), b 13.667(1), c 9.254(1) ?, V 1896.6(3) ?³, Z 4].

Journal of Chemical Research published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bardin, V. V. published the artcileFluorination of trimethylsilylfluoro- and (trimethylsilyl)tetrafluorobenzenes with xenon difluoride, Related Products of catalysis-chemistry, the publication is Journal of Fluorine Chemistry (1998), 90(1), 93-96, database is CAplus.

Replacement of hydrogen or trimethylsilyl group by fluorine and the addition of two fluorine atoms to the aromatic ring were found in the reaction of XeF₂ with 1-trimethylsilyl-2,3,5,6-tetrafluorobenzene (I), 1-trimethylsilyl-2,3,4,6-tetrafluorobenzene, and 1-trimethylsilyl-2,3,4,5-tetrafluorobenzene in CH₂Cl₂ containing BF₃.OEt₂. Only addition of two fluorine atoms took place in the case of I. The three isomers of (Me₃Si)C₆H₄F underwent fluorodesilylation, fluorodeprotonation and protodesilylation to give complex product mixtures The assumed reaction pathways include both cation radicals and arylxenon(II) species as reactive intermediates.

Journal of Fluorine Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bardin, V. V. published the artcileFluorination of C₆F₅MX₃ compounds (M = Si, Ge; X = F, Cl, Br, alk) with xenon difluoride and XeF⁺ Y^– salts, Synthetic Route of 1206-46-8, the publication is Journal of Fluorine Chemistry (1993), 60(2-3), 141-51, database is CAplus.

Compounds C₆F₅MX₃ (M = Si, Ge; X = Cl, Br) react with XeF₂, exchanging chlorine (bromine) atoms for fluorine. Interaction of C₆F₅MX₃ (X = F, alkyl) with XeF₂ in the presence of BF₃¡¤OEt₂ or with XeF⁺ NbF₆^– proceeds by the addition of two fluorine atoms to the pentafluorophenyl ring.

Journal of Fluorine Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Synthetic Route of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Breuer, W. published the artcileChemistry of bromine pentafluoride. 3. Reactions of bromine pentafluoride and arylbromine tetrafluoride with N-bases, of arylbromine tetrafluoride with fluoride ions, and the fluorine-aryl monosubstitution reactions on the hexafluorobromate(V) anion, Name: Trimethyl(perfluorophenyl)silane, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1992), 85-91, database is CAplus.

BrF₅ forms 1:1 adducts with pyridines in organic solvents. In BrF₅-N-base adducts the axial Br-F bond is activated for F-aryl substitution reactions. Arylbromine tetrafluorides resulting from F-aryl monosubstitutions also yield 1:1 adducts with pyridines; in contrast to BrF₅ they react with F^– under reductive elimination. F-aryl substitutions on [BrF₆]^– are presented and the influence of the Lewis-acidity of the aryl transfer reagent and its coproduct is discussed.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Name: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abo-Amer, Anwar published the artcileFrom hypervalent xenon difluoride and aryliodine(III) difluorides to onium salts: Scope and limitation of acidic fluoroorganic reagents in the synthesis of fluoroorgano xenon(II) and iodine(III) onium salts, Quality Control of 1206-46-8, the publication is Journal of Fluorine Chemistry (2006), 127(10), 1311-1323, database is CAplus.

Fluorinated organodifluoroboranes R_fBF₂ (R_f = fluorinated alkyl, aryl) are in general suitable reagents to transform XeF₂ and RIF₂ (R = alkyl, aryl) into the corresponding onium tetrafluoroborate salts [R_fXe][BF₄] and [R(R_f)I][BF₄], resp. (4-C₅F₄N)BF₂ (C₅F₄N = tetrafluoropyridyl) and trans-CF₃CF:CFBF₂ which represent boranes of high acidity form no Xe-C onium salts in reactions with XeF₂ but give the desired iodonium salts with RIF₂ (R = C₆F₅, o-, m-, p-C₆FH₄). The reaction of (4-C₅F₄N)BF₂ with XeF₂ ends with a XeF₂-borane adduct. The solid product is shock sensitive. Furthermore cooled (¡Ü -60 ¡ãC) samples in FEP tubes exploded several times during the alignment in the Raman spectrometer. C₆F₅Xe(4-C₅F₄N), the 1st Xe-(4-C₅F₄N) compound, was obtained when C₆F₅XeF was reacted with Cd(4-C₅F₄N)₂. (4-C₅F₄N)IF₂ was prepared in 84% yield from XeF₂ and (4-C₅F₄N)I. Reactions of (4-C₅F₄N)IF₂ and C₆F₅IF₂ with (4-C₅F₄N)BF₂ gave [(4-C₅F₄N)₂I][BF₄] and [C₆F₅(4-C₅F₄N)I][BF₄] in 88% and quant. yields, resp. Analogously, aryl(perfluoroalkenyl)iodonium salts [R(R’)I][BF₄] (R = C₆F₅, o-, m-, p-C₆FH₄, R’ = trans-CF₃CF:CF, CF₂:CF) were obtained from RIF₂ and R’BF₂ in 75% to 94% yields. The gas phase fluoride affinities pF^– of selected fluoroorganodifluoroboranes R_fBF₂ and their hydrocarbon analogs were calculated (B3LYP/6-31+G^*) and discussed with respect to their potential to introduce R_f-groups into hypervalent EF₂ (E = Xe, RI; R = organic group) bonds. Four aspects which influence the transformation of hypervalent EF₂ bonds under the action of Lewis acidic reagents RAF_n-1 (A = B, P; n = 3, 5) into the corresponding [RE][AF_n+1] salts are presented and the important role of the acidity is emphasized. Fluoride affinities may help to plan the introduction of organo groups into EF₂ moieties and to expand the types of acidic reagents. Thus C₆H₅PF₄ with a pF^– value comparable to that of R_fBF₂ compounds is able to introduce the Ph group into RIF₂ (R = C₆F₅ (94% yield), p-C₆FH₄ (93%)).

Journal of Fluorine Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Quality Control of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Picheng published the artcileThe effect of hydrophobicity of silicate minerals on the adsorption of dodecylammonium acetate, Computed Properties of 2016-56-0, the publication is Materials Research Society Symposium Proceedings (1997), 351-356, database is CAplus.

The interaction between hydrophobic species plays an important role in the adsorption of surfactants. In this paper, naturally hydrophilic quartz and naturally hydrophobic talc were selected as model minerals for studying the adsorption of the cationic surfactant, dodecylammonium acetate (DAA). The effect of the hydrophobicity of minerals on the adsorption of DAA was investigated by measuring zeta potentials, adsorption densities and suspension stabilities as a function of pH in the presence of DAA.

Materials Research Society Symposium Proceedings published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Computed Properties of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shimizu, Norikazu published the artcileAge-related copper, zinc, and iron metabolism in Long-Evans cinnamon rats and copper-eliminating effects of D-penicillamine and trienthine-2HCl, Name: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Journal of Trace Elements in Experimental Medicine (1997), 10(2), 49-59, database is CAplus.

The Long-Evans cinnamon (LEC) rat is an animal model of human Wilson’s disease. The hepatic copper content of LEC rats increased in an age-dependent manner from 4-5 days of age and was maintained at a high level from 15-16 wk of age. The renal copper content of LEC rats showed a tendency to increase from 10 wk of age and increased rapidly from 15 wk of age. No difference in whole-brain copper concentration was observed between LEC and Long-Evans agouti (LEA) rats. LEC rats treated with D-penicillamine and trienthine-2HCl had reduced liver dysfunction. These agents reduced the hepatic copper content by ?1/2-2/3 and the renal copper content to within the normal range. They also decreased the copper content of hair and nails, and there was also a good correlation between the copper content of liver and white hair.

Journal of Trace Elements in Experimental Medicine published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C10H14BNO3, Name: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia