Tag: M.W=200-250

Qian, Wangke published the artcileDesign, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D₁ receptor, Quality Control of 4230-93-7, the publication is Bioorganic & Medicinal Chemistry (2012), 20(15), 4862-4871, database is CAplus and MEDLINE.

A series of new tetrahydroprotoberberine (THPB) derivatives were designed, synthesized, and tested for their binding affinity towards dopamine (D₁ and D₂) and serotonin (5-HT_1A and 5-HT_2A) receptors. Many of the THPB compounds exhibited high binding affinity and activity at the dopamine D₁ receptor, as well as high selectivity for the D₁ receptor over the D₂, 5-HT_1A, and 5-HT_2A receptors. Among these, compound I exhibited a promising D₁ receptor binding affinity (K_i = 2.53 nM) and remarkable selectivity vs. D₂R (inhibition = 81.87%), 5-HT_1AR (inhibition = 61.70%), and 5-HT_2AR (inhibition = 24.96%). Compared with l-(S)-stepholidine (l-SPD) (D₁K_i = 6.23 nM, D₂K_i = 56.17 nM), compound I showed better binding affinity for the D₁ receptor (2.5-fold higher) and excellent D₂/D₁ selectivity. Functional assays found compounds II, III, and I are pure D₁ receptor antagonists. These results indicate that removing the C10 hydroxy group and introducing a methoxy group at C11 of the pharmacophore of l-SPD can reverse the function of THPB compounds at the D₁ receptor. These results are in accord with mol. docking studies.

Bioorganic & Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Quality Control of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Lixin published the artcileCopolymerization of ethylene and butadiene with supported titanium catalyst, Application In Synthesis of 312-40-3, the publication is Journal of Polymer Science, Part B: Polymer Physics (1988), 26(10), 2113-26, database is CAplus.

The copolymerization of ethylene and butadiene with a supported titanium catalyst (TiCl₄/MgCl₂/Et benzoate/Ph₂SiCl₂/AlEt₃) was described. The resulting products were characterized by IR, ¹³C NMR, x-ray diffraction, differential thermal anal., electron microscopy, and solvent extraction The butadiene units were substantially in trans-1,4-configuration and blocked sequences. Both ethylene and butadiene blocks formed crystalline phases. The presence of unsaturated bonds made it possible to graft Me methacrylate and maleic anhydride. The influences of monomer composition, temperature, Al/Ti ratio, catalyst concentration, and solvents on the copolymerization were investigated.

Journal of Polymer Science, Part B: Polymer Physics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C6H3ClFNO2, Application In Synthesis of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fan, Shuang published the artcileMonodispersed poly(4-vinylpyridine) spheres supported Fe(III) material: An efficient and reusable catalyst for benzylic oxidation, Quality Control of 457-68-1, the publication is Journal of Molecular Catalysis A: Chemical (2015), 186-192, database is CAplus.

A novel ferric chloride immobilized poly(4-vinylpyridine) (P4VP) catalyst was developed via a coordination chem.-based approach. The pyridine moiety of poly(4-vinylpyridine) spheres functioned as the nitrogen donor to bind iron ions, as well as to decrease the amount of pyridine used in the catalytic reaction system. The monodispersed catalyst was well dispersed in the organic solvent during the catalytic procedure, taking advantage of its nanomorphol. and uniform size. The catalytic activity of various monodispersed catalysts based different mass fractions of the divinylbenzene (DVB) was investigated, meanwhile the capacities of supported Fe(III) in the various catalysts were also discussed. The P4VPDVB_10%-Fe(III) catalyst exhibited high catalytic activity in the benzylic oxidation of benzylic methylenes and secondary benzylic alcs. It was easily separated from the reaction system and reused several times without obvious degradation of catalytic activity. Moreover, leaching tests suggested that the as-synthesized P4VPDVB_10%-Fe(III) catalyst was a true heterogeneous catalyst without significant metal leaching.

Journal of Molecular Catalysis A: Chemical published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Quality Control of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lickiss, Paul D. published the artcileRate increases in the fluorination of bulky chlorosilanes caused by ultrasound or by water, HPLC of Formula: 312-40-3, the publication is Journal of Organometallic Chemistry (1996), 510(1-2), 167-72, database is CAplus.

The conversion of bulky chlorosilanes to fluorosilanes under anhydrous conditions with hexafluorosilicate salts is accelerated by ultrasound. The fluorination of sterically hindered chlorosilanes such as ^tBuPh₂SiCl, in the absence of ultrasound, is greatly accelerated by the addition of H₂O to the reaction mixture

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, HPLC of Formula: 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Giessel, Josephine M. published the artcileCaffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2019), 259-268, database is CAplus and MEDLINE.

Unexpected inhibitory effects against eeAChE could be found for a newly synthesized class of caffeic acid phenethyl ester (CAPE) derivatives Thus, phenethyl-(E)-3-(3,5-dimethoxy-4-phenethoxyphenyl)-acrylate (K_i = 1.97 ¡À 0.38 ¦ÌM, K_i’ = 2.44 ¡À 0.07 ¦ÌM) and 4-(2-(((E)-3-(3,4-bis(benzyloxy)phenyl)acryloyl)oxy)ethyl)-1,2-phenylene (2E,2’E)-bis(3-(3,4-bis(benzyloxy)phenyl)acrylate) (K_i = 0.72 ¡À 0.31 ¦ÌM, K_i’ = 1.80 ¡À 0.21 ¦ÌM) showed very good inhibition of eeAChE, while being non cytotoxic for malignant human cancer cells and non-malignant mouse fibroblasts. Also, they are weak inhibitors for BChE (from equine serum).

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fliri, Anton F. published the artcileDrug effects viewed from a signal transduction network perspective, Quality Control of 38260-01-4, the publication is Journal of Medicinal Chemistry (2009), 52(24), 8038-8046, database is CAplus and MEDLINE.

Understanding how drugs affect cellular network structures and how resulting signals are translated into drug effects holds the key to the discovery of medicines. Herein we examine this cause-effect relationship by determining protein network structures associated with the generation of specific in vivo drug-effect patterns. Medicines having similar in vivo pharmacol. have been identified by a comparison of drug-effect profiles of 1320 medicines. Protein network positions reached by these medicines were ascertained by examining the coinvestigation frequency of these medicines and 1179 protein network constituents in millions of scientific investigations. Interestingly, medicine associations obtained by comparing by drug-effect profiles mirror those obtained by comparing drug-protein coinvestigation frequency profiles, demonstrating that these drug-protein reachability profiles are relevant to in vivo pharmacol. By using protein associations obtained in these investigations and independent, curated protein interaction information, drug-mediated protein network topol. models can be constructed. These protein network topol. models reveal that drugs having similar pharmacol. profiles reach similar discrete positions in cellular protein network systems and provide a network view of medicine cause-effect relationships.

Journal of Medicinal Chemistry published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Quality Control of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Castelli, Ugo published the artcileEvidence of Phosphonium-Carbenium Dication Formation in a Superacid: Precursor to Fluorinated Phosphine Oxides, Quality Control of 4141-48-4, the publication is Angewandte Chemie, International Edition (2019), 58(5), 1355-1360, database is CAplus and MEDLINE.

Unambiguously confirmed by low-temperature in situ NMR experiments, x-ray diffraction and vibrational spectroscopy, phosphonium-carbenium superelectrophiles are generated in strong acidic conditions. Representing crucial intermediates, their exploitation allows for the synthesis of unprecedented fluorinated (cyclic) phosphine oxides.

Angewandte Chemie, International Edition published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Quality Control of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ghiani, M. published the artcileMicrobial purification technique of mineral dressing plants reject waters, Quality Control of 2016-56-0, the publication is FEMS Microbiology Reviews (1993), 11(1-3), 153-7, database is CAplus and MEDLINE.

A microbial mineral reject water purification technique utilizing nonpathogenic strains was developed and is currently being implemented. Nonpathogenic strains such as Bacillus subtilis, Saccharomyces cerevisiae, Bifidobacterium bifidum, Lactobacillus acidophilus, and Acinetobacter calcoaceticus have been successfully tested for removing alkylsulfates, alkylamines and fatty acids from solutions simulating flotation plant tailings waters. Removals of ¡Ü90% in <48 h can be easily achieved with no nutrient requirements, since in most cases the flotation reagent residue to be removed is metabolized by the microorganisms themselves.

FEMS Microbiology Reviews published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Quality Control of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Marino, Thomas published the artcilePostcure Effects on Photopolymerization Using Visible Light Initiators, Application In Synthesis of 2909-77-5, the publication is Industrial & Engineering Chemistry Research (1995), 34(12), 4549-52, database is CAplus.

In a continuing study of the visible light initiator 5,7-diiodo-3-butoxy-6-fluorone, significant postcure is observed in propylene glycol-maleic anhydride-terephthalic acid-styrene copolymer formed under both aerobic and anaerobic conditions either in the presence or absence of ambient light. The extent of postcure varies with the test conditions. A tentative explanation is proposed.

Industrial & Engineering Chemistry Research published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Application In Synthesis of 2909-77-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Steinberg, Ilya Sh. published the artcileTwo-photon recording of microholograms in photopolymer materials with new cationic thioxanthone photoinitiators, HPLC of Formula: 2909-77-5, the publication is Optics Communications (2008), 281(17), 4297-4301, database is CAplus.

The authors have demonstrated two-photon induced recording of the microholograms at an arbitrary point within thick (?100 ¦Ìm) photopolymer material using photoinitiators on a basis of new cationic thioxanthone derivatives Such material provides high values of refractive index change ¦¤n = 4.8 ¡Á 10^-3, and holog. recording sensitivity S = 1.2 cm/J. A nanosecond laser pulse at a wavelength of 532 nm was used for recording. For the selective on the depth reading of the microholograms the method of collinear heterodyning was applied.

Optics Communications published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C27H39ClN2, HPLC of Formula: 2909-77-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia