Tag: M.W=200-250

Yue, Fuyang published the artcileLight-Mediated Defluorosilylation of ¦Á-Trifluoromethyl Arylalkenes through Hydrogen Atom Transfer, Product Details of C15H24S, the publication is Organic Letters (2022), 24(22), 4019-4023, database is CAplus and MEDLINE.

Herein, the authors report a direct, light-mediated defluorosilylation protocol for converting ¦Á-trifluoromethyl arylalkenes and alkyl silanes into ¦Ã,¦Ã-difluoroallylic compounds via a combination of photoredox catalysis and H atom transfer. The clean, convenient protocol can be scaled to the gram level, and its mild conditions make it very suitable for late-stage functionalization of complex natural products and drugs.

Organic Letters published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C5H9IO2, Product Details of C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, David Y. W. published the artcileAsymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(6), 1437-1440, database is CAplus and MEDLINE.

Cocaine addiction remains a serious challenge for clin. and medical research because there is no effective pharmacol. treatment. L-THP I, a natural product isolated from Corydalis yanhusuo W. T. Wang, is one of the most frequently used traditional herbs to treat drug addiction in China. Our laboratory first reported that its demethylated metabolites had high affinity at dopamine D1, D2, and D5 receptors. Here we report the chem. synthesis of these metabolites and other derivatives and their binding affinities at dopamine receptors. The synthesis of these bioactive metabolites will allow further in vivo study of their potential in treating cocaine addiction.

Bioorganic & Medicinal Chemistry Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Elsby, Matthew R. published the artcileInfluence of N-Heterocyclic Carbene Steric Bulk on Selectivity in Nickel Catalyzed C-H Bond Silylation, Germylation, and Stannylation, Safety of Trimethyl(perfluorophenyl)silane, the publication is Organometallics (2019), 38(2), 436-450, database is CAplus.

A series of Ni(0) compounds supported by electronically similar N-heterocyclic carbene (NHC) ancillary ligands with a range of %V_bur were used as catalysts for aryl C-H bond silylation, germylation, and stannylation. The NHC steric bulk strongly influenced the selectivity of C-H functionalization to give new carbon-heteroatom bonds vs. alkene hydroarylation, despite little structural change in the resting state of the catalysts. Studies were performed by reacting C₆F₅H and H₂C:CHER₃ (ER₃ = SnBu₃, GePh₃, SiMe₃) using catalytic amounts of Ni(COD)₂ and NHC ligands IPr, IMes, IBn, and ⁱPr₂Im. Catalytic C-H stannylation to give C₆F₅SnBu₃ was facile with all ligands. The catalytic C-H germylation reaction was more difficult than stannylation but was demonstrated using H₂C:CHGePh₃ to give C₆F₅GePh₃ for all but the largest NHC. The bulkiest NHC, IPr, gave a 96:4 ratio of the hydroarylation product C₆F₅CH₂CH₂GePh₃ vs. C₆F₅GePh₃. The C-H silylation reactions required the highest temperatures and gave selective silylation product C₆F₅SiMe₃ only for the smallest IBn and ⁱPr₂Im NHC ligands. Using the larger IMes carbene resulted in a 66:34 mixture of silylation and hydroarylation products, and the largest NHC, IPr, gave exclusive conversion to the hydroarylation product, C₆F₅CH₂CH₂SiMe₃. DFT calculations are provided that give insight into the mechanism and key reaction steps, such as the relative difficulty of the critical ¦Â-Sn, Ge, and Si elimination steps.

Organometallics published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Safety of Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tai, Xi-Shi published the artcileSynthesis, spectral characterization, and electrochemical property of Cu(II) complex with 1,2-phenylenedioxydiacetic acid and 1,10-phenanthroline, Category: catalysis-chemistry, the publication is Research on Chemical Intermediates (2015), 41(11), 8279-8287, database is CAplus.

A novel dinuclear Cu(II) complex, [Cu₂L(phen)₄]¡¤L (1) [H₂L (2) = 1,2-phenylenedioxydiacetic acid], was obtained by the self-assembly of 1,2-phenylenedioxydiacetic acid, phen and Cu(CH₃COO)₂¡¤H₂O in CH₃OH/H₂O (v:v = 1:1) solution containing MgCl₂. The Cu(II) complex was characterized by elemental anal., IR, UV, and x-ray single-crystal diffraction anal. The crystal belongs to triclinic, space group P – 1 with a 13.090(3), b 14.211(3), c 19.255(4) ?, ¦Á 92.91(3), ¦Â 91.29(3), ¦Ã 110.01(3)¡ã, V = 3358.2(13) ?³, Z = 2, d_c = 1.282 g cm^-3, ¦Ì = 0.698 mm^-1, F (000) = 1332, and final R = 0.0744, ¦ØR = 0.2109. In the crystal structure, each Cu(II) atom is five-coordinated in a distorted square pyramid coordination environment. The mols. form one-dimensional chain structure by ¦Ð-¦Ð stack. The electrochem. properties of the Cu(II) complex were studied.

Research on Chemical Intermediates published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C14H26O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Xing published the artcileFacile one-pot palladium-catalyzed sequential coupling to diarylmethanes by using aryl methyl ketones as the methylene donors, Category: catalysis-chemistry, the publication is European Journal of Organic Chemistry (2013), 2013(30), 6870-6877, database is CAplus.

A novel palladium-catalyzed coupling reaction of an aryl Me ketone with two mols. of an aryl halide to yield sym. diarylmethanes is described. In the facile one-pot reaction, the aryl Me ketone acts as a formal methylene donor. The exptl. facts, including TLC monitoring, speculated intermediates as the raw materials, anal. of the cesium benzoate coproduct by ex situ IR spectroscopy, and the cross-coupling reactions of two different aryl halides, indicate a mechanism involving a palladium-catalyzed sequential two-step coupling process, in which the presence of a trace amount of H₂O is indispensable. The reaction is applicable to a broad spectrum of substrates and delivers the products in good to excellent yields. Access to unsym. diarylmethanes with this method is also explored and various factors are discussed.

European Journal of Organic Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C6H10O7, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Su, Mingyue published the artcileSynthesis and fluorescence spectrum of Eu complex and Eu-L (L=La, Y, Yb and Nd) complex with 1,2-phenylenedioxydiacetic acid and dibenzoylmethane, Quality Control of 5411-14-3, the publication is Fenzi Kexue Xuebao (2012), 28(3), 227-231, database is CAplus.

A new ternary rare earth complex Eu-BDDA-DBM and the one with 1/2 Eu³⁺ ions and 1/2 L ions (L=La³⁺, Y³⁺, Yb³⁺, and Nd³⁺) were synthesized in the alc. solution using the reaction of rare earth chloride 1,2-phenylenedioxydiacetic acid and dibenzoylmethane as raw materials. The complexes were characterized by IR spectra, UV spectra, TG anal., fluorescence excitation, and emission spectra. The IR spectra indicate that the white complex has a similar coordination structure with the doped complex. The fluorescence spectra show that the fluorescence intensity of complexes of europium is increased after doped by La³⁺ and Nd³⁺, and among them the La³⁺ containing complex has the strongest fluorescence intensity.

Fenzi Kexue Xuebao published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C15H24O2, Quality Control of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Hanyun published the artcileSynthesis of diamides containing of 2-aryloxyacetyl and meta-trifluoromethylphenyl moieties and their herbicidal activity, Quality Control of 1798-04-5, the publication is Yingyong Huaxue (2016), 33(6), 668-676, database is CAplus.

Based on the combination of different active groups with different herbicidal modes of action, a series of diamide compounds containing 2-(aryloxy)acetyl and meta-trifluoromethylphenyl moieties were designed and synthesized via the four-component Ugi reaction. Their structures were characterized by IR, ¹H NMR, EI-MS, and elemental analyses. The glass house bioassay (in vivo) shows that some of compounds 3 exhibit moderate to good herbicidal activities against B. campestris, A. retroflexus, E. crusgalli, and D. sanguinalis at a dose of 1.5 kg/ha. For example, compound 3r displays 100% inhibition against both of A. retroflexus and D. sanguinalis in the pre-emergence treatment, it also exhibits 100% inhibition against D. sanguinalis in the post-emergence treatment. In addition, the preliminary structure-activity relationships are also discussed.

Yingyong Huaxue published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C15H24S, Quality Control of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Xiaolu published the artcileCu(I) Coordination Polymers as the Green Heterogeneous Catalysts for Direct C-H Bonds Activation of Arylalkanes to Ketones in Water with Spatial Confinement Effect, Safety of Bis(4-fluorophenyl)methane, the publication is Inorganic Chemistry (2017), 56(21), 13329-13336, database is CAplus and MEDLINE.

To develop coordination polymers (CPs) as catalysts to selectively catalyze the reaction of C-H bond activation of arylalkanes to their homologous ketones, three new Cu(I)-based coordination polymers (Cu^I-CPs) [CuI(aas-TPB)]_n (1), [CuBr(ass-TPB)CH₃CN]_n (2), and {[Cu(ass-TPB)]Cl}_n (3) (TPB = N,N,N-tris(3-pyridinyl)-1,3,5-benzenetricarboxamide) were synthesized. Structural variations from a herringbone fashion 1-dimensional framework of 1 to a two-dimensional framework of 2 containing a 48-membered macrocycle and a cationic three-dimensional framework of 3 filled with Cl^– anions were observed arising from the different halogen ions (I^–, Br^–, and Cl^–). 1–3 Were used as the green heterogeneous catalysts to catalyze direct C-H bond activation reactions of arylalkanes to ketones under mild reaction conditions with H₂O as solvent. Handy product separation, convenient reaction procedures, and recyclability of these catalysts make the catalytic system fascinating. Also, the Cu^I-CPs performed the reaction with high regioselectivity due to the unique spatial confinement effect of CPs.

Inorganic Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C7H5Br2I, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ji, Jing published the artcilePeroxide promoted tunable decarboxylative alkylation of cinnamic acids to form alkenes or ketones under metal-free conditions, Formula: C11H12O4, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(35), 7546-7549, database is CAplus and MEDLINE.

A tunable decarboxylative alkylation of cinnamic acids with alkanes was developed to form alkenes or ketones under transition metal-free conditions. In the presence of DTBP or DTBP/TBHP, the reaction gave alkenes and ketones resp. via a radical mechanism in moderate to good yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Jiaqiang published the artcileEthers as hydrogen sources in BF₃¡¤OEt₂ promoted reduction of diphenylmethyl alcohols, ethers and esters to hydrocarbons, Quality Control of 457-68-1, the publication is RSC Advances (2015), 5(104), 85291-85295, database is CAplus.

A novel ether/BF₃ reductive system has been described, in which diphenylmethanols and their ether and ester derivatives are used as starting materials. Reductions are performed in ether under reflux and an argon atm., and the addition of extra water is beneficial to this reduction A series of alkanes are able to be prepared with good to excellent yields. A deuterated experiment exhibits that the reductive hydrogen is generated from ether. The mechanism is discussed in detail to explain the observed reactivity.

RSC Advances published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Quality Control of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia