Tag: M.W=200-250

Blodgett, Jordan published the artcileThe 4-tert-butylphenyl group as a simple tag for solution phase synthesis, Formula: C12H16O3, the publication is Tetrahedron Letters (2004), 45(35), 6649-6652, database is CAplus.

A solution phase synthesis strategy was investigated using 4-tert-butylphenyl group as the tag and a beta-cyclodextrin column as the affinity chromatog. support for the isolation of compounds containing the tag. It was found that compounds containing the tag have significantly longer retention times on the beta-cyclodextrin column than those compounds that do not have such a tag. The tag is chem. inert and can be introduced onto and removed from target compounds readily. This solution phase synthesis method was applied to the synthesis of some simple amino acid derivatives

Tetrahedron Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Jiu-ling published the artcilePalladium(II)-catalyzed C-C and C-O bond formation for the synthesis of C₁-benzoyl isoquinolines from isoquinoline N-oxides and nitroalkenes, Computed Properties of 4230-93-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(65), 10028-10031, database is CAplus and MEDLINE.

C₁-Benzoyl isoquinolines I [R = H, CH₃; R¹ = 6-CH₃, 5-Cl, 5-NO₂, etc.; R² = 4-H₃COC₆H₄, 4-(CH₃)₂CHC₆H₄, naphthalen-2-yl, etc.] can be generated via a palladium(II)-catalyzed C-C and C-O coupling of isoquinoline N-oxides II with aromatic nitroalkenes R²C=CHNO₂. The reaction proceeds through remote C-H bond activation and subsequent intramol. oxygen atom transfer (OAT). In this reaction, the N-O bond was designed as a directing group in the C-H bond activation as well as the source of an oxygen atom.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Computed Properties of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Jun published the artcileStructural diversity and properties of six coordination polymers derived from 1,2/1,3-phenylenedioxydiacetic acids and varied N-donor co-ligands, HPLC of Formula: 5411-14-3, the publication is Inorganica Chimica Acta (2014), 6-15, database is CAplus.

Based on two positional isomers of phenylenedioxydiacetate ligands and different N-containing co-ligands, six novel coordination polymers, formulated as {[Zn(o-PDOA)(bpp)]¡¤2H₂O}_n (1), {[Cd(o-PDOA)(bix)]¡¤3H₂O}_n (2), [Cd(m-PDOA)(bix)]_n (3), [Cd(m-PDOA)(bib)]_n (4), [Zn(m-PDOA)(bix)]_n (5), {[Zn(m-PDOA)(bib)]¡¤2H₂O}_n (6), (o/m-H₂PDOA = 1,2/1,3-phenylenedioxydiacetic acid; bix = 1,4-bis(imidazolylmethyl)benzene; bib = 1,4-bis(1H-imidazol-1-yl)-butane; bpp = 1,3-bis(4-pyridyl)propane), were prepared under hydrothermal conditions. 1 Features a three-dimensional (3D) 2-fold interpenetrating cds topol. In 2, the (H₂O)₆ clusters interlink the 1-dimensional double [Cd₂(o-PDOA)₂(bix)₂]_n chains into a 3-dimensional supramol. network. 3 Is a (3,5)-connected 2-dimensional layer with (4².6)(4².6⁷.8) topol. Compound 4 exhibits a 3-fold interpenetrating pcu topol. network, while, 5 is a 2-dimensional puckered meso-helical 4⁴-sql layer built by alternately arranged right-handed and left-handed helical chains. In contrast to 1–5, compound 6 possesses a 1-dimensional loop-like chain and rare D4 tetrameric (H₂O)₄ cluster extends the chains into a 3-dimensional supramol. framework. Also, the thermal stabilities and luminescent properties of compounds 1–6 also were studied.

Inorganica Chimica Acta published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C5H5N3S, HPLC of Formula: 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Mianmian published the artcileTotal syntheses of benzylisoquinoline alkaloids Neolitacumoine, Mollinedine and Papaverine, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Youji Huaxue (2020), 40(1), 149-155, database is CAplus.

A new general synthetic route towards benzylisoquinoline alkaloids was developed. The key step of this route is Cu-catalyzed cascade oxidation-aromatization of 1-benzyl-3,4-dihydroisoquinolines. The three benzylisoquinoline alkaloids such as Neolitacumoine, Mollinedine and Papaverine were synthesized starting from piperonaldehyde and 3,4-dimethoxybenzaldehyde by 8 steps in 42%, 37% and 37% overall yields, resp.

Youji Huaxue published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C16H24BNO2, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Lei published the artcileOrganocatalytic asymmetric Michael reaction with acylsilane donors, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Organic & Biomolecular Chemistry (2013), 11(3), 443-447, database is CAplus and MEDLINE.

Authors have developed an organocatalytic asym. Michael reaction of acylsilane through the selection of acylsilane substrates and organocatalysts, thus creating a rare example of acylsilane ¦Á-alkylation with a chiral guanidine catalyst, which afforded products in good yields and high stereoselectivity. The corresponding adducts described here have also been demonstrated to be useful in the synthesis of unnatural amino acids and biol. active compounds

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C18H24N6O6S4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Yi published the artcileThe protecting group enabled para-selective C-H benzylation of anilides via iron(II) catalysis: a convenient approach for the synthesis of triarylmethanes, Formula: C13H10F2, the publication is Organic Chemistry Frontiers (2020), 7(14), 1823-1827, database is CAplus.

A series of triarylmethanes I [R = H, 2-Me, 3-Cl, etc.; R¹ = NHC(O)Me, NHC(O)C(Me)₃, NHCO₂CH₂CH(Me)₂, etc.; R² = Me, Ph, 2-MeC₆H₄, etc.; Ar = Ph, 4-FC₆H₄, 4-EtC₆H₄, etc.] was synthesized via iron catalyzed para-selective C-H benzylation of iso-Bu Ph carbamates with diarylmethanes. Iso-Bu Ph carbamates were prepared using reaction of anilines and iso-Bu chloroformate. Preliminary mechanistic studies revealed that the iron(II) catalyst was essential and the use of the sterically demanding isobutoxy group led to high para-selectivity.

Organic Chemistry Frontiers published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Formula: C13H10F2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Haikong published the artcileHigh frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilis, Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Emerging Microbes & Infections (2015), 4(2), e10, database is CAplus and MEDLINE.

The preferred drugs for the treatment of syphilis, benzathine and procaine penicillin, have not been available in Shanghai for many years, and currently, the incidence of syphilis is increasing. Alternative antibiotics for patients with syphilis during the benzathine and procaine penicillin shortage include macrolides. The failure of macrolide treatment in syphilis patients has been reported in Shanghai, but the reason for this treatment failure remains unclear. The authors used polymerase chain reaction technol. to detect a 23S rRNA A2058G mutation in Treponema pallidum in 109 specimens from syphilis patients. The use of azithromycin/erythromycin in the syphilis patients and the physicians’ prescription habits were also assessed based on two questionnaires regarding the use of macrolides. A total of 104 specimens (95.4%) were pos. for the A2058G mutation in both copies of the 23S rRNA gene, indicating macrolide resistance. A questionnaire provided to 122 dermatologists showed that during the penicillin shortage, they prescribed erythromycin and azithromycin for 8.24 ¡À 13.95% and 3.21 ¡À 6.37% of their patients, resp., and in the case of penicillin allergy, erythromycin and azithromycin were prescribed 15.24 ¡À 22.89% and 7.23 ¡À 16.60% of the time, resp. A second questionnaire provided to the syphilis patients showed that 150 (33.7%), 106 (23.8%) and 34 (7.6%) individuals had used azithromycin, erythromycin or both, resp., although the majority did not use the drugs for syphilis treatment. The authors’ findings suggest that macrolide resistance in Treponema pallidum is widespread in Shanghai. More than half of the syphilis patients had a history of macrolide use for other treatment purposes, which may led to the high prevalence of macrolide resistance. Physicians in China are advised to not use azithromycin for early syphilis.

Emerging Microbes & Infections published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Seeling, Andreas published the artcilePhysico-chemical, pharmacological, and toxicological properties of fomocaine metabolites, Category: catalysis-chemistry, the publication is Arzneimittel-Forschung (2001), 51(1), 7-17, database is CAplus and MEDLINE.

Fomocaine (4-[3-(4-phenoxymethylphenyl)-propyl]-morpholine, CAS 17692-39-6) is a highly effective local anesthetic of low toxicity. The drug, which causes no allergic response, was introduced in the German Extrapharmacopoeia (DAC). 14 Metabolites are formed after oral administration to rat and beagle dog. Less than 5 % fomocaine are excreted unchanged. The metabolites were synthesized and their physico-chem. properties were investigated. No metabolite caused a surface or conduction anesthesia with the exception of 2-hydroxyfomocaine (O/Se 4). After topical and parenteral administration irritation could not be observed All metabolites except O/Se 10 and O/Se 11 showed a lower toxicity than fomocaine. In both species O/Se 10 and O/Se 11 are formed only in a small amount and are detoxified by conjugation.

Arzneimittel-Forschung published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C9H5ClO4S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dilman, Alexander D. published the artcileSynthesis of C₆F₅-substituted amines containing quaternary carbon atoms, Synthetic Route of 1206-46-8, the publication is Synthesis (2006), 447-450, database is CAplus.

The reaction of enamines and methyltris(pentafluorophenyl)silane in the presence of acetic acid affording C₆F₅-substituted amines is described. The proposed mechanism features a transfer of the C₆F₅ group from the five-coordinate silicate intermediate onto an iminium cation resulting in the generation of a quaternary carbon atom in the C-C bond forming event.

Synthesis published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Synthetic Route of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dilman, Alexander D. published the artcileNucleophilic trifluoromethylation of arylidenemalononitriles, COA of Formula: C9H9F5Si, the publication is Tetrahedron Letters (2008), 49(28), 4352-4354, database is CAplus.

A method for the nucleophilic trifluoromethylation of arylidenemalononitriles using Me₃SiCF₃ is described. The reaction is carried out in DMF in the presence of AcONa as a Lewis base, and affords Michael addition products in high yield.

Tetrahedron Letters published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, COA of Formula: C9H9F5Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia