Month: November 2022

Yamaguchi, Shigehiro published the artcilePhotophysical Properties Changes Caused by Hypercoordination of Organosilicon Compounds: From Trianthrylfluorosilane to Trianthryldifluorosilicate, Recommanded Product: Difluorodiphenylsilane, the publication is Journal of the American Chemical Society (2000), 122(28), 6793-6794, database is CAplus.

Modification of π-electron systems by the main group elements represents a new direction toward the construction of organic materials with unusual electronic structures and with unique functions such as sensory materials. One of the potential way may be to take advantage of the hypercoordination abilities of the main-group elements. The authors present the first example of controlling the photophys. properties derived from the hypercoordination of group 14 elements. As a group 14 compound having extended π-conjugated substituents, tri(9-anthryl)fluorosilane (I) with its unique photophys. properties due to the through-space interaction was used. The addition of fluoride ion to I produced tri(9-anthryl)difluorosilicate (II). The use of KF/[2.2.2]cryptand as a fluoride source made possible to isolate the silicate cryptand (IIK⁺/cryptand) in 74% yield. Tetrahedral flat geometry crystal structure of I was changed due to hypercoordination to nearly ideal trigonal bipyramidal structure in IIK⁺/cryptand. The changes in the optical absorption and fluorescence spectra were studied by addition of n-Bu₄NF as a fluoride source to I. Upon formation of silicate IIBu₄⁺ fluorescence intensity increased with âˆ?0 nm hypsochromic shifts of the maximum, its absorption band was shifted into âˆ?0 nm shorter range relative to I. The observed changes should be mainly ascribed not to the intrinsic electronic perturbation by the hypercoordination but to the decrease in the degree of the through-space interaction between the anthryl groups by the structural change from tetrahedral of I to trigonal bipyramidal of II. The large spectral change of fluorescence spectra upon transition from from I to II allowed to estimate the binding constant of I toward fluoride as to be 2.8(±0.2) x 10⁴ M^-1 at 20° C in THF. Photophys. properties of series of similar triarylfluorosilanes and corresponding silicates were also studied.

Journal of the American Chemical Society published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C18H28N2O7, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Adeyemi, Kazeem D. published the artcileGrowth Performance, Carcass Traits, Muscle Fatty Acids, Intramuscular Fat, Cholesterol, and Antioxidant Status in Rabbits Supplemented with Kigelia pinnata Leaf Meal, Quality Control of 6217-54-5, the publication is European Journal of Lipid Science and Technology (2022), 124(8), 2200014, database is CAplus.

The effects of dietary Kigelia pinnata leaf (KPL) on growth, carcass, muscle fatty acids, antioxidant status, cholesterol, physicochem. properties, and sensory profile of Longissimus thoracis et lumburum (LTL) muscle in rabbits are investigated. Seventy-two, 32 d old male New Zealand rabbits (684 ± 18 g) are randomly assigned to diets containing either no KPL (KPL-0), 5% KPL (KPL-5) or 10% KPL (KPL-10) for eight weeks, and euthanized, and the LTL is refrigerated for 6 days. Dietary KPL does not influence growth performance and carcass cuts in rabbits. Abdominal fat is lower in KPL- rabbits than in the KPL-0 rabbits. Supplemented LTL has lower i.m. fat and cholesterol, and higher crude protein, polyphenol content, glutathione reductase, and catalase compared with the control LTL. Concentration of C18:3n-3, C22:6n-3, and C20:5n-3 is higher in supplemented LTL than the control LTL. Supplemented meat has lower cook loss than the KPL-0 meat at 24 h postmortem. The KPL-10 meat has higher redness and lower malondialdehyde content than other meats on d 6 postmortem. Juiciness and overall acceptance of the supplemented meat are higher than that of the KPL-0 meat. Supplementation with KPL-10 enhances muscle n-3 fatty acids, sensorial quality, and oxidative stability of rabbit meat. Rabbit meat is replete in n-6 polyunsaturated fatty acid (PUFA) but low in n-3 PUFA, which heightens its n-6/n-3 ratio. Higher n-6/n-3 PUFA intake can pose serious health risks to consumers. This suggests a need to ameliorate the n-3 PUFA of rabbit meat. Dietary KPL causes ‘147-184% increase in n-3 PUFA and a 66-77% decrease in n-6/n-3 ratio in rabbit meat. Moreover, KPL improves sensorial quality and oxidative stability and lowers i.m. fat and cholesterol content of rabbit meat. These results support the delivery of a healthier rabbit meat that responds to consumer demands. This study explicates the potential of KPL in ameliorating the nutritional value and sensory quality of rabbit meat.

European Journal of Lipid Science and Technology published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Quality Control of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rouhi-Saadabad, Hamed published the artcileDirect, rapid and convenient synthesis of esters and thioesters using PPh₃/N-chlorobenzotriazole system, COA of Formula: C9H7NO4, the publication is Journal of the Brazilian Chemical Society (2014), 25(2), 253-263, database is CAplus.

An efficient method was developed for esterification and thioesterification of various carboxylic acids with different alcs. and thiols using PPh₃/N-chlorobenzotriazole mixed reagent in CH₂Cl₂ at room temperature

Journal of the Brazilian Chemical Society published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rouhi-Saadabad, Hamed published the artcileA One-Pot, fast, and efficient amidation of carboxylic acids, α-amino acids and sulfonic acids using PPh₃/N-chlorobenzotriazole system, SDS of cas: 1772-76-5, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2015), 190(10), 1703-1714, database is CAplus.

Triphenylphosphine (PPh₃)/N-chlorobenzotriazole (NCBT), and amine (primary and secondary aliphatic amines and also substituted anilines) in CH₂Cl₂ efficiently converted carboxylic acids, α-amino acids, and sulfonic acids to the corresponding amides and sulfonamides at room temperature Good to excellent yields, inexpensive, and fast reaction conditions are the important features of this procedure.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, SDS of cas: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Entezari, Najmeh published the artcileDirect and facile synthesis of acyl isothiocyanates from carboxylic acids using trichloroisocyanuric acid/triphenylphosphine system, Category: catalysis-chemistry, the publication is Croatica Chemica Acta (2014), 87(3), 201-206, 32 pp., database is CAplus.

A mild, efficient, and practical method for one-step synthesis of alkanoyl and aroyl isothiocyanates from carboxylic acids RCO₂H using a safe and inexpensive mixed reagent such as trichloroisocyanuric acid/triphenylphosphine is described at room temperature Availability of the reagents and easy workup of the reaction make this method attractive for organic chemists.

Croatica Chemica Acta published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kitazawa, Makio published the artcileStudies on the synthesis of antiulcer agents. VI. Synthesis and antiulcer activity of dihydrobenzofuranone derivatives, Quality Control of 16909-09-4, the publication is Yakugaku Zasshi (1989), 109(10), 718-36, database is CAplus and MEDLINE.

Dimethyldihydrobenzofuranones I [R = OH, OEt, (un)substituted amino], II (R¹ = 5-, 6-, or 7-CH:CHCOR²; R² = piperidino, morpholino; R³ = 7-, 6-, or 5-OMe, Br, NO₂, NH₂, NHAc, H, Me, CO₂Et), III (n = 0-2; R⁴ = OH, OEt, substituted amino), and IV [R⁵ = (un)substituted amino] were prepared and tested for antiulcer activity. I (R = piperidino, morpholino) showed the highest activity.

Yakugaku Zasshi published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Quality Control of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Richard-Bildstein, Sylvia published the artcileDiscovery of the Potent, Selective, Orally Available CXCR7 Antagonist ACT-1004-1239, Related Products of catalysis-chemistry, the publication is Journal of Medicinal Chemistry (2020), 63(24), 15864-15882, database is CAplus and MEDLINE.

The chemokine receptor CXCR7, also known as ACKR3, is a seven-transmembrane G-protein-coupled receptor (GPCR) involved in various pathologies such as neurol. diseases, autoimmune diseases, and cancers. By binding and scavenging the chemokines CXCL11 and CXCL12, CXCR7 regulates their extracellular levels. From an original high-throughput screening campaign emerged an arylketoamide hit among others. The hit-to-lead optimization led to the discovery of a novel chemotype series of acylaminopiperidinecarboxamides. This series provided CXCR7 antagonists that block CXCL11- and CXCL12-induced ss-arrestin recruitment. Further structural modifications on the acylaminopiperidinecarboxamide framework yielded compounds with high CXCR7 antagonistic activities and balanced ADMET properties. The effort described herein culminated in the discovery of ACT-1004-1239 I. Biol. characterization of I demonstrated that it is a potent, insurmountable antagonist. Oral administration of I in mice up to 100 mg/kg led to a dose-dependent increase of plasma CXCL12 concentration

Journal of Medicinal Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Brichard, Laurent published the artcileAn Efficient Method for Enhancing the Reactivity and Flexibility of [¹⁸F]Fluoride Towards Nucleophilic Substitution Using Tetraethylammonium Bicarbonate, Recommanded Product: Tetraethylammonium hydrogencarbonate, the publication is European Journal of Organic Chemistry (2014), 2014(28), 6145-6149, database is CAplus.

The standard method used to generate reactive [¹⁸F]fluoride for [¹⁸F]radiolabelling is to trap it on an anion-exchange cartridge then elute it with a basic aqueous solution, which is then subjected to azeotropic evaporation to remove water. A method using tetraethylammonium hydrogen carbonate in which efficient recovery of [¹⁸F]fluoride (up to 99 %), remove the requirement for the time-consuming and inefficient azeotropic evaporation process and produce a reactive [¹⁸F]fluoride that can undergo a wide range of aliphatic and aromatic [¹⁸F]nucleophilic substitutions in up to 93 % radiochem. conversion at end-of-synthesis in the presence or without water is developed.

European Journal of Organic Chemistry published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, Recommanded Product: Tetraethylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Dong Wook published the artcileA New Class of S_N2 Reactions Catalyzed by Protic Solvents: Facile Fluorination for Isotopic Labeling of Diagnostic Molecules, HPLC of Formula: 17351-62-1, the publication is Journal of the American Chemical Society (2006), 128(50), 16394-16397, database is CAplus and MEDLINE.

Aprotic solvents are usually preferred for the S_N2 reactions, because nucleophilicity and hence S_N2 reactivity are severely retarded by the influence of the partial pos. charge of protic solvents. In this work, we introduce a remarkable effect of using tertiary alcs. as a reaction medium for nucleophilic fluorination with alkali metal fluorides. In this novel synthetic method, the nonpolar protic tert-alc. enhances the nucleophilicity of the fluoride ion dramatically in the absence of any kind of catalyst, greatly increasing the rate of the nucleophilic fluorination and reducing formation of byproducts (such as alkenes, alcs., or ethers) compared with conventional methods using dipolar aprotic solvents. The great efficacy of this method is a particular advantage in labeling radiopharmaceuticals with [¹⁸F]fluorine (t_1/2 = 110 min) for positron emission tomog. (PET) imaging, and it is illustrated by the synthesis of four [¹⁸F]fluoride-radiolabeled mol. imaging probes – [¹⁸F]FDG, [¹⁸F]FLT, [¹⁸F]FP-CIT, and [¹⁸F]FMISO – in high yield and purity and in shorter times compared to conventional syntheses.

Journal of the American Chemical Society published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, HPLC of Formula: 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Juvonen, Risto O. published the artcileDevelopment of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes, COA of Formula: C15H14O3, the publication is Xenobiotica (2019), 49(9), 1015-1024, database is CAplus and MEDLINE.

Cytochrome P 450 (CYP) enzymes constitute an essential xenobiotic metabolizing system that regulates the elimination of lipophilic compounds from the body. Convenient and affordable assays for CYP enzymes are important for assessing these metabolic pathways. In this study, 10 novel profluorescent coumarin derivatives with various substitutions at carbons 3, 6 and 7 were developed. Mol. modeling indicated that 3-phenylcoumarin offers an excellent scaffold for the development of selective substrate compounds for various human CYP forms, as they could be metabolized to fluorescent 7-hydroxycoumarin derivatives Oxidation of profluorescent coumarin derivatives to fluorescent metabolites by 13 important human liver xenobiotic-metabolizing CYP forms was determined by enzyme kinetic assays. Four of the coumarin derivatives were converted to fluorescent metabolites by CYP1 family enzymes, with 6-methoxy-3-(4-trifluoromethylphenyl)coumarin being oxidized selectively by CYP1A2 in human liver microsomes. Another set of four compounds were metabolized by CYP2A6 and CYP1 enzymes. 7-Methoxy-3-(3-methoxyphenyl)coumarin was oxidized efficiently by CYP2C19 and CYP2D6 in a non-selective fashion. The advantages of the novel substrates were (1) an excellent signal-to-background ratio, (2) selectivity for CYP1 forms, and (3) convenient multiwell plate measurement, allowing for precise determination of potential inhibitors of important human hepatic forms CYP1A2, CYP2C19 and CYP2D6.

Xenobiotica published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, COA of Formula: C15H14O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia