Month: November 2022

Lim, Ae Ran published the artcilePhysicochemical properties and structural dynamics of organic-inorganic hybrid [NH₃(CH₂)₃NH₃]ZnX₄ (X = Cl and Br) crystals, Related Products of catalysis-chemistry, the publication is Scientific Reports (2021), 11(1), 8408, database is CAplus and MEDLINE.

The phys. properties of the organic-inorganic hybrid crystals having the formula [NH₃(CH₂)₃NH₃]ZnX₄ (X = Cl, Br) were investigated. The phase transition temperatures (TC; 268K for Cl and 272K for Br) of the two crystals bearing different halogen atoms in their skeletons were determined through differential scanning calorimetry. The thermodn. properties of the two crystals were investigated through thermogravimetric anal. The structural dynamics, particularly the role of the [NH₃(CH₂)₃NH₃] cation, were probed through ¹H and ¹³C magic-angle spinning NMR spectroscopy as a function of temperature The ¹H and ¹³C NMR chem. shifts did not show any changes near TC. In addition, the ¹H spin-lattice relaxation time (T_1¦Ñ) varied with temperature, whereas the ¹³C T_1¦Ñ values remained nearly constant at different temperatures The T_1¦Ñ values of the atoms in [NH₃(CH₂)₃NH₃]ZnCl₄ were higher than those in [NH₃(CH₂)₃NH₃]ZnBr₄. The observed differences in the structural dynamics obtained from the chem. shifts and T_1¦Ñ values of the two compounds can be attributed to the differences in the bond lengths and halogen atoms. These findings can provide important insights or potential applications of these crystals.

Scientific Reports published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gunathilaka, Buddhi E. published the artcileMarine protein hydrolysates as a substitute of squid-liver powder in diets for Pacific white shrimp (Litopenaeus vannamei), Formula: C22H32O2, the publication is Aquaculture Research (2022), 53(11), 4059-4068, database is CAplus.

This study was conducted to examine the supplementary effects of tuna hydrolyzate (TH) and shrimp hydrolyzate (SH) as squid-liver powder (SLP) replacers in a high soybean meal diet for Pacific white shrimp (Litopenaeus vannamei). A diet containing 4.49% SLP was regarded as the control diet and two other diets were prepared by supplementing 1.14% tuna hydrolyzate (TH) and 0.94% shrimp hydrolyzate (SH) (designated as SLP, TH and SH, resp.). Five replicate groups of shrimp (initial mean body weight, 0.35 ¡À 0.002 g) were fed one of the exptl. diets for 52 days. Final body weight and weight gain of shrimp fed SH and TH diets were significantly higher than those of shrimp fed SLP diet (p < 0.05). Feed conversion ratio was lower in SH group compared to that of shrimp fed other diets. Total antioxidant capacity and catalase activity were significantly higher in TH or SH group than SLP group (p < 0.05). Hemolymph glucose and triglyceride levels of shrimp fed SLP were significantly lower than those of shrimp fed TH and SH (p < 0.05). Shrimp-fed TH or SH exhibited significantly higher carcass lipid composition than shrimp-fed SLP (p < 0.05). Dry matter and protein digestibility were significantly higher in SH diet (p < 0.05). The findings in this study indicate that SH and TH can be used as beneficial feed supplements or ingredients that could replace SLP in L. vannamei diet. Optimum inclusion level of SH would be approx. 1% to completely replace SLP in L. vannamei diet containing high level of soybean meal.

Aquaculture Research published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Formula: C22H32O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Hee Oon published the artcileDesign and synthesis of oxime ethers of ¦Á-acyl-¦Â-phenylpropanoic acids as PPAR dual agonists, Safety of O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(4), 937-941, database is CAplus and MEDLINE.

Oxime ethers of ¦Á-acyl-¦Â-phenylpropanoic acids, e.g., I, were prepared to apply as PPAR¦Á and ¦Ã dual agonists. Among them, I proved to exhibit potent in vitro activities with EC₅₀ of 19 and 13 nM in PPAR¦Á and ¦Ã, resp. It showed better glucose lowering effects than rosiglitazone and ameliorated the lipid profile like plasma triglyceride in db/db mice model.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Safety of O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, Jee-Hyun published the artcileSynthesis and evaluation of (+)-decursin derivatives as inhibitors of the Wnt/¦Â-catenin pathway, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(15), 3529-3532, database is CAplus and MEDLINE.

We synthesized (+)-decursin derivatives substituted with cinnamoyl- and Ph propionyl groups originating from (+)-CGK062 and screened them using a cell-based assay to detect relative luciferase reporter activity. Of this series, compound I, in which a 3-acetoxy cinnamoyl group was introduced, most potently inhibited (97.0%) the Wnt/¦Â-catenin pathway. Specifically, compound I dose-dependently inhibited Wnt3a-induced expression of the ¦Â-catenin response transcription (CRT) and increased ¦Â-catenin degradation in HEK293 reporter cells. Furthermore, compound I suppressed expression of the downstream ¦Â-catenin target genes cyclin D1 and c-myc and suppressed PC3 cell growth in a concentration-dependent manner.

Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Daniel, Alyssa published the artcileAbraham model correlations for solute transfer into cyclopentanone, Product Details of C8H8O2, the publication is Physics and Chemistry of Liquids, database is CAplus.

Mole fraction solubilities have been measured for anthracene, benzoic acid, 4-tert-butylbenzoic acid, 3-chlorobenzoic acid, 2-hydroxybenzoic acid, 2-methylbenzoic acid, 3-methylbenzoic acid, 3-nitrobenzoic acid and pyrene dissolved in cyclopentanone at 298.15 K using either spectrophotometric or acid-base titrimetric methods. Results of our exptl. measurements, combined with published solubility data for several inorganic and organic gases, solubility data for several important crystalline pharmaceutical intermediates and activity coefficient data taken from the published literature, were used to derive Abraham model correlations for solute transfer into anhydrous cyclopentanone solvent from both water and from the gas phase. The derived Abraham model correlations back-calculate the observed exptl. data to within 0.10 log units (or less). Reported for the first time are solute descriptor values for several important pharmaceutical intermediates.

Physics and Chemistry of Liquids published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Product Details of C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Seo, Seon-Mi published the artcileStructure-Activity Relationship of Aliphatic Compounds for Nematicidal Activity against Pine Wood Nematode (Bursaphelenchus xylophilus), Product Details of C10H15NS, the publication is Journal of Agricultural and Food Chemistry (2010), 58(3), 1823-1827, database is CAplus and MEDLINE.

Nematicidal activity of aliphatic compounds was tested to determine a structure-activity relationship. There was a significant difference in nematicidal activity among functional groups. In a test with alkanols and 2E-alkenols, compounds with C₈-C₁₁ chain length showed 100% nematicidal activity against pine wood nematode, Bursaphelenchus xylophilus, at 0.5 mg/mL concentration C₆-C₁₀ 2E-alkenals exhibited >95% nematicidal activity, but the other compounds with C₁₁-C₁₄ chain length showed weak activity. Nematicidal activity of alkyl acetates with C₇-C₁₁ chain length was strong. Compounds belonging to hydrocarbons, alkanals, and alkanoic acetates showed weak activity at 0.5 mg/mL concentration Nematicidal activity of active compounds was determined at lower concentrations At 0.25 mg/mL concentration, whole compounds except C₈ alkanol, C₈ 2E-alkenol, and C₇ alkanoic acid showed >80% nematicidal activity. C₉-C₁₁ alkanols, C₁₀-C₁₁ 2E-alkenols, C₈-C₉ 2E-alkenals, and C₉-C₁₀ alkanoic acids showed >80% nematicidal activity at 0.125 mg/mL concentration Only C₁₁ alkanol exhibited strong nematicidal activity at 0.0625 mg/mL concentration, the lowest concentration that was tested.

Journal of Agricultural and Food Chemistry published new progress about 19117-31-8. 19117-31-8 belongs to catalysis-chemistry, auxiliary class Oxidant, name is N-(tert-Butyl)-S-phenylthiohydroxylamine, and the molecular formula is C18H20N2O12, Product Details of C10H15NS.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Park, Seol Rin published the artcile2-Methylacrylamide as a bioisoster of thiourea group for 1,3-dibenzylthioureido TRPV1 receptor antagonists, HPLC of Formula: 1798-04-5, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(11), 2080-2083, database is CAplus and MEDLINE.

In order to replace thiourea group with the more drug-like moiety for 1,3-dibenzylthioureas having TRPV1 antagonist activity, we introduced a set of functional groups between the two aromatic rings based on bioisosteric replacement. The synthesized bioisosteres of 1,3-dibenzylthioureas were tested for their antagonist activities on TRPV1 by ⁴⁵Ca²⁺-influx assay using neonatal rat cultured spinal sensory neurons. Among the tested 14 kinds of bioisosters, 2-methylacrylamide group was the best candidate to replace thiourea group. Compound 7c, 2-methylacrylamide analog of ATC-120, showed as potent as ATC-120 in its antagonist activity. In addition, 2-methylacrylamide analog 7e having vinyl moiety showed the most potent activity with 0.022¦ÌM of IC₅₀ value, indicating that thiourea group of 1,3-dibenzylthioureas could be replaced to 2-methylacrylamide without loss of their potencies.

Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ha, Eun Kyo published the artcilePersonal exposure to total VOC is associated with symptoms of atopic dermatitis in schoolchildren, Safety of 2-Methylbenzoic acid, the publication is Journal of Korean Medical Science (2022), 37(8), e63, database is CAplus and MEDLINE.

The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren. Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children. Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with pos. SCORAD index values (defined as SCORAD ¡Ý 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and pos. SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and pos. SCORAD results. Conclusion: Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value.

Journal of Korean Medical Science published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Jimin published the artcileBoron Lewis Acid-Catalyzed Hydrophosphinylation of N-Heteroaryl-Substituted Alkenes with Secondary Phosphine Oxides, Related Products of catalysis-chemistry, the publication is Journal of Organic Chemistry (2020), 85(23), 15476-15487, database is CAplus and MEDLINE.

The authors report the B-catalyzed hydrophosphinylation of N-heteroaryl-substituted alkenes with secondary phosphine oxides that furnishes various P-containing N-heterocycles. This process proceeds under mild conditions and enables the introduction of a P atom into multisubstituted alkenylazaarenes. The available mechanistic data can be explained by a reaction pathway wherein the C-P bond is created by the reaction between the activated alkene (by coordination to a B catalyst) and the P(III) nucleophile (in tautomeric equilibrium with phosphine oxide).

Journal of Organic Chemistry published new progress about 23897-16-7. 23897-16-7 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Dimesitylphosphine oxide, and the molecular formula is C18H23OP, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Taelim published the artcileIdentification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism, Category: catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(7), 1844-1848, database is CAplus and MEDLINE.

In this study, a series of bis(4-hydroxy)benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have addnl. and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia