Month: November 2022

Cho, Hong Je published the artcileSelective Synthesis of 4,4′-Dimethylbiphenyl from 2-Methylfuran, Synthetic Route of 613-33-2, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(8), 3316-3323, database is CAplus.

4,4′-Dimethylbiphenyl (DMBP) is a promising platform chem. for the production of polymer precursors, plasticizers, and metal-organic frameworks among other materials. We report a two-step process to produce DMBP from 2-methylfuran (MF) via the formation of the intermediate 5,5′-dimethyl-2,2′-bifuran (DMBF). DMBF is generated from the Pd-catalyzed oxidative coupling of MF in the presence of trifluoroacetic acid (TFA) with high selectivity (94%). Optimization of reaction conditions yields a 20-fold increase in site-time-yield (STY = 6.99 h^-1) compared with a previously reported protocol. High O₂ pressure (7 bar) and a high TFA concentration (3 M) are critical to improve the DMBF formation rate. For the conversion of DMBF to DMBP, we show that phosphoric acid supported on silica (P-SiO₂) catalyzes tandem Diels-Alder and dehydration reactions of DMBF with ethylene to produce DMBP (83% yield). The high yield and selectivity are a consequence of the weak Bronsted acid sites in P-SiO₂ that dehydrate furan-ethylene cycloadducts without substantial formation of carbon deposits.

ACS Sustainable Chemistry & Engineering published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Synthetic Route of 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nagase, Masahiro published the artcile4-Position-Selective C-H Perfluoroalkylation and Perfluoroarylation of Six-Membered Heteroaromatic Compounds, Computed Properties of 1206-46-8, the publication is Journal of the American Chemical Society (2016), 138(19), 6103-6106, database is CAplus and MEDLINE.

The first 4-position-selective C-H perfluoroalkylation and perfluoroarylation of six-membered heteroaromatic compounds were achieved using nucleophilic perfluoroalkylation and perfluoroarylation reagents. The regioselectivity was controlled by electrophilically activating the heteroaromatic rings, while sterically hindering the 2-position, with a sterically bulky borane Lewis acid. The reaction proceeded in good yield, even in gram scale, and by a sequential reaction without isolating the intermediates. This reaction could be applied to late-stage trifluoromethylation of a bioactive compound

Journal of the American Chemical Society published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Computed Properties of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Weis, Robert published the artcileSynthesis of new analogs of diphenylpyraline, Application In Synthesis of 6972-05-0, the publication is Tetrahedron (2003), 59(9), 1403-1411, database is CAplus.

1-Unsubstituted 4-dimethylamino-5,6-dihydropyridine-2(1H)-thiones were converted to isomeric piperidin-4-ols which were separated and N-methylated to 2-substituted 1-methylpiperidin-4-ols. Their 1-Ph analogs were prepared from 4-dimethylamino-5,6-dihydro-1-phenylpyridine-2(1H)-thiones. After their conversion to dihydro-1-phenylpyridin-4(1H)-ones the hydrogenation gave isomeric 1-phenylpiperidin-4-ols, which were separated O-Alkylation of the 1-substituted piperidin-4-ols by various methods yielded 2-substituted analogs of diphenylpyraline. Their antimycobacterial activity was examined The configurations and conformations of the piperidine derivatives were investigated by NMR spectroscopy.

Tetrahedron published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C18H35NO, Application In Synthesis of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ni, Feng published the artcileRemarkably Stereospecific Utilization of ATP ¦Á,¦Â-Halomethylene Analogues by Protein Kinases, COA of Formula: C17H37NO3, the publication is Journal of the American Chemical Society (2017), 139(23), 7701-7704, database is CAplus and MEDLINE.

ATP analogs containing a CXY group in place of the ¦Á,¦Â-bridging oxygen atom are powerful chem. probes for studying ATP-dependent enzymes. A limitation of such probes has been that conventional synthetic methods generate a mixture of diastereomers when the bridging carbon substitution is nonequivalent (X ¡Ù Y). We report here a novel method based on derivatization of a bisphosphonate precursor with a D-phenylglycine chiral auxiliary that enables preparation of the individual diastereomers of ¦Á,¦Â-CHF-ATP and ¦Á,¦Â-CHCl-ATP, which differ only in the configuration at the CHX carbon. When tested on a dozen divergent protein kinases, these individual diastereomers exhibit remarkable diastereospecificity (up to over 1000-fold) in utilization by the enzymes. This high selectivity can be exploited in an enzymic approach to obtain the otherwise inaccessible diastereomers of ¦Á,¦Â-CHBr-ATP. The crystal structure of a tyrosine kinase Src bound to ¦Á,¦Â-CHX-ADP establishes the absolute configuration of the CHX carbon and helps clarify the origin of the remarkable diastereospecificity observed We further synthesized the individual diastereomers of ¦Á,¦Â-CHF-¦Ã-thiol-ATP and demonstrated their utility in labeling a wide spectrum of kinase substrates. The novel ATP substrate analogs afforded by these two complementary strategies should have broad application in the study of the structure and function of ATP-dependent enzymes.

Journal of the American Chemical Society published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, COA of Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Singh, Vikramjeet published the artcileRedox noninnocence of the formazanate ligand applied to catalytic formation of ¦Á-ketoamides, Application In Synthesis of 118-90-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(46), 6630-6633, database is CAplus and MEDLINE.

An iron-formazanate mol. I (X = pyridine-1-yl) for efficiently preparing ¦Á-keto amides R(R¹)NC(O)R² [R = Me, Et, 2-(4-chlorophenyl)ethyl; R¹ = Et, Ph, 4-bromophenyl, etc.; RR¹ = -(CH₂)₄-, -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-; R² = benzoyl, (thiophen-2-yl)carbonyl, cyclohexyl, etc.] is crucial reductive cleavage of the substrate mol. and tightly regulated by the electron donation from the formazanate, in a reversible manner.

Chemical Communications (Cambridge, United Kingdom) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C36H45ClN3O8P, Application In Synthesis of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Krishna published the artcileCu (II) Schiff base complex grafted guar gum: Catalyst for benzophenone derivatives synthesis, Application of Bis(4-fluorophenyl)methane, the publication is Applied Catalysis, A: General (2020), 117529, database is CAplus.

Guar gum based Cu(II) Schiff’s base complex (GG-Cu) has been synthesized and characterized by FT-IR, PXRD, UV-vis, TGA, XPS, FESEM, TEM, EDAX, solid-state NMR, Elemental mapping, CHNS and AAS anal. This moiety has been found to be an efficient heterogeneous catalyst for selective oxidation reactions. Fifteen model reactions have been carried to establish the catalytic behavior of GG-Cu, and five of these yield novel products. The ease of separation of catalyst from the reaction mixture simply by filtration is an added advantage; furthermore the catalyst can be reused up to five times without significant loss of catalytic activity. The overall concept of developing newer, efficient and environmental benign catalysts with ease of separation and recycling ability has been successfully demonstrated. All of the isolated products were fully characterized on the basis of their phys. and spectral data.

Applied Catalysis, A: General published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Application of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yadav, Sudha published the artcileNonlinear optical single crystals for terahertz generation and detection, SDS of cas: 201157-13-3, the publication is Journal of Nonlinear Optical Physics & Materials (2022), 31(2), 2230001, database is CAplus.

A review. Nonlinear optical (NLO) single crystals with high quality are the pillars for the development of new devices that fulfil the demands of society. Nowadays, NLO single crystals are very attractive for the photonic applications particularly for terahertz (THz) photonics. The reason for their popularity is that these crystals can produce very powerful and ultra wideband THz waves due to their high nonlinear susceptibility. In this review paper, we deal with the challenges and progresses in the evolution of NLO single crystals for THz wave generation and detection. Here, we review the single crystal growth that how and by which method single crystal is grown. We summarize the structures, intermol. and intramol. interactions, their properties and how they generate and detect the THz waves. Widely used single crystals at present are DAST, BNA, OH1, amino acid-based single crystals, etc.

Journal of Nonlinear Optical Physics & Materials published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C13H19Br2ClN2O, SDS of cas: 201157-13-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Amaravathi, M. published the artcileOxidation of 1-benzyl-3,4-dihydroisoquinolines using active manganese dioxide, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1983), 22B(12), 1246-7, database is CAplus.

Oxidation of benzyldihydroisoquinolines I [R, R¹, R² = H, H, H; MeO, PhCH₂O, H; H, MeO, H; H, H, NO₂ (II), H, H, Cl] by active MnO₂ gave benzoyldihydroisoquinolines III in yields >80%, except in the case of II which gave the oxidation product in 46% yield.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Talluri, Thirumala Rao published the artcileIntegrated multi-omics analyses reveals molecules governing sperm metabolism potentially influence bull fertility, Product Details of C5H11NO2S, the publication is Scientific Reports (2022), 12(1), 10692, database is CAplus and MEDLINE.

Bull fertility is of paramount importance in bovine industry because semen from a single bull is used to breed several thousands of cows; however, so far, no reliable test is available for bull fertility prediction. In the present study, spermatozoa from high- and low-fertility bulls were subjected to high-throughput transcriptomic, proteomic and metabolomic anal. Using an integrated multi-omics approach the mol. differences between high- and low-fertility bulls were identified. We identified a total of 18,068 transcripts, 5041 proteins and 3704 metabolites in bull spermatozoa, of which the expression of 4766 transcripts, 785 proteins and 33 metabolites were dysregulated between high- and low-fertility bulls. At transcript level, several genes involved in oxidative phosphorylation pathway were found to be downregulated, while at protein level genes involved in metabolic pathways were significantly downregulated in low-fertility bulls. We found that metabolites involved in Taurine and hypotaurine metabolism were significantly downregulated in low-fertility bulls. Integrated multi-omics anal. revealed the interaction of dysregulated transcripts, proteins and metabolites in major metabolic pathways, including Butanoate metabolism, Glycolysis and gluconeogenesis, Methionine and cysteine metabolism, Phosphatidyl inositol phosphate, pyrimidine metabolism and saturated fatty acid beta oxidation These findings collectively indicate that mols. governing sperm metabolism potentially influence bull fertility.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C3H12Cl2N2, Product Details of C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sharma, Abhishek published the artcileUnique versatility of ionic liquids as clean decarboxylation catalyst cum solvent: a metal- and quinoline-free paradigm towards synthesis of indoles, styrenes, stilbenes and arene derivatives under microwave irradiation in aqueous conditions, Application In Synthesis of 16909-09-4, the publication is Advanced Synthesis & Catalysis (2008), 350(18), 2910-2920, database is CAplus.

Ionic liquids have been found to provide a new platform for metal- and quinoline-free decarboxylation of various N-heteroaryl and aryl carboxylic acids under microwave irradiation in aqueous condition. The method was found to possess a wide substrate scope towards the synthesis of various pharmacol. and industrially important aromatic compounds including indoles, styrenes, stilbenes, and nitro- or hydroxyarene derivatives The decarboxylation of indole and ¦Á-phenylcinnamic acids proceeded well without addition of any catalyst in neat 1-hexyl-3-methylimidazolium bromide ([hmim]Br) and 1-methylimidazolium p-toluenesulfonic acid ([Hmim]PTSA), resp., while addition of a mild base like aqueous sodium hydrogen carbonate to [hmim]Br further improved the decarboxylation of hydroxylated cinnamic and aromatic acid substrates. The developed methodol. not only precludes the usage of toxic metal/quinoline and harsh organic bases but also offers several inherent benefits like recyclability of reagent system, reduction in waste and hazards, short reaction time besides ease of product recovery.

Advanced Synthesis & Catalysis published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C5H5F3O2, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia