Month: November 2022

Bausinger, Tobias published the artcileDetermination of nitrodiphenylamines and related compounds in the leachate water of a military contaminated site, Product Details of C12H9N3O4, the publication is Umweltwissenschaften und Schadstoff-Forschung (2005), 17(1), 7-12, database is CAplus.

Nitrodiphenylamines can be found at abandoned military sites where the explosive 2,2′,4,4′,6,6′-hexanitrodiphenylamine (hexyl) or diphenylamine as a stabilizer of smokeless powder was handled. Aim of the present study is the development of HPLC methods for the anal. of contaminants which can be expected in particular under aerobic conditions at premises which are contaminated by nitrodiphenylamines and related compounds A list of 13 compounds which can be expected at these explosives factories was deduced from literature studies. HPLC methods were developed for the analytes. Water samples from the unsaturated zone of a former hexyl-producing factory were collected by suction cups and the material was analyzed according to these procedures to demonstrate the practicability of the new methods and to verify the existence of the postulated compounds in the environment of the former nitration plant. The new HPLC methods are suitable for the exploration of sites contaminated by nitrodiphenylamines. Beside some hexyl its intermediates 1-chloro-2,4-dinitrobenzene, 2,4-dinitrodiphenylamine and 2,2′,4,4′-tetranitrodiphenylamine were identified in the leachate water. It is advisable to include at least these 4 compounds in the examination of former hexyl-producing plants. Several unknown peaks were observed in the HPLC-chromatogram. It is recommendable to perform further investigations of the unidentified compounds to compile a final list of analytes for military sites polluted by nitrodiphenylamines.

Umweltwissenschaften und Schadstoff-Forschung published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Product Details of C12H9N3O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rabinovitch, Michel published the artcileDestruction of Leishmania mexicana amazonensis amastigotes within macrophages in culture by phenazine methosulfate and other electron carriers, Synthetic Route of 10510-54-0, the publication is Journal of Experimental Medicine (1982), 155(2), 415-31, database is CAplus and MEDLINE.

Exposure of macrophages infected with L. mexicana?amazonensis to phenazine?methosulfate (PMS) [299-11-6] resulted in rapid damage and disappearance of the intracellular amastigotes without obvious ill effects to the host cells. The reduction of the percent infection was related to the concentration of PMS and to the duration of the pulse. Most Leishmania disappeared within 2 h of a 2-h pulse with 10 ¦ÌM of the drug. In contrast, pretreatment of the macrophages with PMS followed by removal of the drug before infection did not result in disappearance of the parasites. The pH of the PMS medium markedly influenced the disappearance of Leishmania: maximum effect was observed at pH 8.0, while the effect was negligible at pH 6.3. The pH effect may be related to pseudobase formation by the PMS cation. Dose-response curves for PMS were similar for resident, elicited, or activated macrophages. Observations by time-lapse cinemicrog. documented the explosion-like fragmentation of the amastigotes within 1-2 h of exposure of infected macrophages to the drug. Parasite-derived granules and vacuoles were seen to scatter within the parasitophorous vacuoles. This early damage to the parasites was confirmed by transmission electron microscopic observations. Infected macrophages incubated with PMS displayed detectable vacuolar fluorescence, indicating that PMS or a metabolite of PMS had access to the vacuoles. A series of other electron carriers, including phenylmethanes, phenazines, oxazines, a xanthene, and a naphthoquinone, given continuously for 18 h, also induced the disappearance of the Leishmania. The most potent was crystal?violet??[548-62-9], active at 70 nM. The presence of apolar substituents enhanced activity and this is probably related to increased permeation of the dyes. Finally, PMS, as well as other electron carriers examined, also reduced the growth of Leishmania promastigotes in culture. The results are compatible with a direct effect of the drugs on the intracellular amastigotes, involving only a permissive participation of the macrophages. The diverse agents may destroy the amastigotes by redox-cycling generation of active O metabolites at or near the parasites. Alternatively, the effect of the drugs could be mediated by toxic free radical reduction species of the drugs or by interference with electron flow or with the intermediary metabolism of Leishmania.

Journal of Experimental Medicine published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Synthetic Route of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chattopadhyay, Swarup published the artcileSteric Titration of Arylthiolate Coordination Modes at Pseudotetrahedral Nickel(II) Centers, Synthetic Route of 22693-41-0, the publication is Inorganic Chemistry (2010), 49(2), 457-467, database is CAplus and MEDLINE.

Several derivatives of the pseudotetrahedral phenylthiolate complex Tp^Me,MeNi-SPh (1), Tp^Me,Me- = hydrotris(3,5-dimethyl-1-pyrazolyl)borate, were prepared incorporating substituted arylthiolates, including ortho-substituted ligands Tp^Me,MeNi-SR (R = 2,6-Me₂C₆H₃, 2; 2,4,6-Me₃C₆H₂, 3; 2,4,6- ⁱPr₃C₆H₂, 4; and 2,6-Ph₂C₆H₃, 5) and para-substituted complexes (R = C₆H₄-4-OMe, 6; C₆H₄-4-Me, 7; and C₆H₄-4-Cl, 8). The products were characterized by ¹H NMR and UV-visible spectroscopy. Spectra of 6–8 were consistent with retention of a common structure across the para-substituted series with modest perturbation of the spectral features of 1 assisting their assignment. In contrast, spectra of 2–5 were indicative of a significant change in configuration across the ortho-disubstituted series. The structure of 5 was determined by x-ray crystallog. and a distinctive arylthiolate ligation mode was found, in which the N₃S ligand field was significantly distorted toward a sawhorse, compared to a more common trigonal pyramidal shape (e.g., 1). Also, the arylthiolate substituent rotated from a vertical orientation co-directional with the pyrazole rings and disposed between two of them in 1, to a horizontal orientation perpendicular to and over a single pyrazole ring in 5. This reorientation is necessary to accommodate the large ortho substituents of 5. The divergent Ni-S coordination modes result in distinct ¹H NMR and electronic spectra that were rationalized by d. functional theory (DFT) and time-dependent DFT (TD-DFT) calculations These results demonstrate rich coordination chem. for arylthiolates that can be elicited by steric manipulation at the periphery of pseudotetrahedral ligand fields.

Inorganic Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Synthetic Route of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Patra, Tuhin published the artcileIron-Mediated Decarboxylative Trifluoromethylation of ¦Á,¦Â-Unsaturated Carboxylic Acids with Trifluoromethanesulfinate, Quality Control of 1772-76-5, the publication is European Journal of Organic Chemistry (2013), 2013(24), 5247-5250, database is CAplus.

A sustainable FeCl₃-mediated method has been developed for the decarboxylative trifluoromethylation of ¦Á,¦Â-unsaturated carboxylic acids by using NaSO₂CF₃ as an economic and stable CF₃ source. The reaction proceeds under mild condition and tolerates various functional groups. Advantageously, this method does not require an inert atm. and proceeds well in air at ambient temperature

European Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Quality Control of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Behrsing, Thomas published the artcileHydrated Rare Earth Structural Networks containing the Phenylene-1,2-dioxydiacetate (PDDA) Ligand, Synthetic Route of 5411-14-3, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (2013), 639(1), 41-48, database is CAplus.

Reaction of LnCl₃ with Na₂(PDDA) (PDDA = phenylene-1,2-dioxydiacetate) in a 1 to 2 mol ratio in aqueous solution yielded [Ln₂(PDDA)₃(H₂O)₆]¡¤2H₂O, structurally characterized for Ln = Ce (1), Sm (2) (redetn.), Tb (3) and Y (4) in a monoclinic C2/c array, a second related structural form [orthorhombic, Pbcn] being obtained for Tb (5), Ho (6) and Er (7). The ‘domains of existence’ of these two previously described forms are now extended to Ce-Dy, Y, and Eu-Er, resp. Reaction under the same conditions for the heavier Yb³⁺ ion yielded [Yb₂(PDDA)₃(H₂O)₆]_(¡Þ|¡Þ)¡¤4H₂O (8), orthorhombic, Pbca. In the case of Ln = La the bimetallic species [NaLa(PDDA)₂(H₂O)₂]_(¡Þ|¡Þ)¡¤4H₂O (9) was obtained, while reaction of LnCl₃ with Na₂(PDDA) in a 1 to 3 mol ratio led to the isolation of the isotypic (monoclinic, P2₁/c) [NaLn(PDDA)₂(H₂O)₂]_(¡Þ|¡Þ)¡¤4H₂O for Ln = Ce (10) and Sm (12). With the smaller Ln = Yb, the more definitively bimetallic [NaYb(PDDA)₂(H₂O)₂]_(¡Þ|¡Þ)¡¤3H₂O (13) (triclinic, P1?) was obtained, the trihydrate solvation ascribed differing from that recorded (dihydrate) in a cosynchronous report.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Synthetic Route of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Grollier, Kevin published the artcile(Trifluoromethylselenyl)methylchalcogenyl as Emerging Fluorinated Groups: Synthesis under Photoredox Catalysis and Determination of the Lipophilicity, Synthetic Route of 5411-14-3, the publication is Chemistry – A European Journal (2021), 27(19), 6028-6033, database is CAplus and MEDLINE.

The synthesis of mols. bearing (trifluoromethylselenyl)methylchalcogenyl groups ArXCH₂COOH (Ar = 4-methylphenyl, 2-methoxy-4-(prop-2-en-1-yl)phenyl, naphthalen-1-yl, etc.; X = O, S, Se) via an efficient two-step strategy based on a metal-free photoredox catalyzed decarboxylative trifluoromethylselenolation with good yields up to 88%, which raised to 98% in flow chem. conditions was described. The flow methods allowed also to scale up the reaction. The mechanism of this key reaction was studied. The physicochem. characterization of these emerging groups was performed by determining their Hansch-Leo lipophilicity parameters with high values up to 2.24. This reaction was also extended to perfluoroalkylselenolation with yields up to 95%. Finally, this method was successfully applied to the functionalization of relevant bioactive mols. such as tocopherol I or estrone derivatives II (R¹ = CF₃, C₆F₁₃).

Chemistry – A European Journal published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Synthetic Route of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chao, Rebecca R. published the artcileThe efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is RSC Advances (2016), 6(60), 55286-55297, database is CAplus.

The oxidation of cinnamic acid derivatives, e.g., 3-(2H-1,3-benzodioxol-5-yl)prop-2-enoic acid, was investigated in order to determine the potential of CYP199A4 to act as a biocatalyst for this important class of biol. mols. The compounds such as 4-methoxy- and 4-methyl-cinnamic acids bound tightly to CYP199A4 and were better substrates for CYP199A4 than cinnamic acid itself. The oxidations of both 4-methoxy- and 4-methyl-cinnamic acids was 100% selective for attack at the para substituent. Certain dimethoxy substituted cinnamic acids were demethylated more efficiently than 4-methoxycinnamic acid and retained the selectivity for the para-methoxy substituent. Only very low product turnover was observed with 3,5-dimethoxycinnamic acid. The compound, 4-isopropylcinnamic acid was hydroxylated and desatd. by CYP199A4 at the iso-Pr group. Cinnamic acids with a para-substituted alkyl- and alkyloxy-cinnamic acid framework were a good fit for the active site of the CYP199A4 enzyme and as a consequence were efficiently and selectively oxidized. Whole-cell oxidations resulted in high yields of product and CYP199A4 could be developed for applications in the biocatalytic oxidation of cinnamic acid derivatives and related phenylpropanoids.

RSC Advances published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Howell, Barbara F. published the artcilePigmented coatings cured with visible light, HPLC of Formula: 2909-77-5, the publication is ACS Symposium Series (1997), 219-232, database is CAplus.

Use of photobleaching photoinitiators in an environmentally friendly, visible light curable, pigmented coating which can be applied for touch up purposes to minimally prepared steel surfaces, was studied. Addnl. requirements are that the coating does not yellow during aging and that it can be applied to a cold surface. Photoinitiators containing BAPO [bis(2,6-dimethoxybenzoyl)-2,4,4-trimethylpentyl-phosphine oxide] and DIBF (5,7-diiodo-3-butoxy-6-fluorone) were tested. DIBF can initiate curing by free radical reactions and by cationic means. DIBF is used with an amine and the cationic photoinitiator OPPI (4-octyloxyphenylphenyl-iodonium hexafluoroantimonate) for radical initiation, but for cationic initiation only OPPI and DIBF are needed. Resins used were: Ebecryl 3700 epoxy acrylate, Unicarb, and Heloxy 505 modifier; monomers were: isobornyl acrylate, trimethylol propane triacrylate, tripropylene glycol trimethacrylate, Photomer 4017 [1,6-hexanediol diacrylate], and Epon 828. Addnl. photoinitiators used were: Darocur 1173, Darocur 4265, Irgacure 907, CGI 1700, FX-512, H-Nu 470, and DIDMA [N,N-dimethyl-2,6-diisopropylaniline]. The photosensitizer used was ITX [isopropylthioxanthone] and the pigments include TiONa, TiO₂, Lampblack, manganese ferrite, and copper chromite. A cycloaliphatic epoxy coating formulation, was rapidly cured cationically with OPPI and DIBF and only a small amount (0.1%) of DIBF photoinitiator was required, to achieve through cure. The use of borate photoinitiators with DIBF, OPPI, and DIDMA was also studied.

ACS Symposium Series published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, HPLC of Formula: 2909-77-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Galaco, Ayla Roberta Borges da Silva published the artcileIon-exchange resin as a new tool for characterisation of coordination compounds and MOFs by NMR spectroscopy, Computed Properties of 5411-14-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(56), 8106-8109, database is CAplus and MEDLINE.

¹H and ¹³C NMR spectroscopy was used to investigate the organic constituents of metal complexes, MOFs and coordination compounds synthesized under solvothermal and precipitation conditions. The elucidation of the ligands in paramagnetic compounds bearing Cu²⁺ (d⁹), Gd³⁺ (f⁷), Eu³⁺ (f⁶), Fe³⁺ (d⁵), ions after treatment with a cationic exchange resin is possible. The authors prove the efficiency of two post-synthesis linker modifications on diamagnetic IRMOF-3 Zn²⁺ (d¹⁰) with Et isocyanate and benzyl bromide.

Chemical Communications (Cambridge, United Kingdom) published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Computed Properties of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dalpozzo, Renato published the artcileSynthesis of phosphine oxides and phosphonates by cerium-mediated addition of organolithium compounds to chloro-phosphorus compounds, Recommanded Product: Allyldiphenylphosphine oxide, the publication is European Journal of Organic Chemistry (1999), 2299-2301, database is CAplus.

The addition of organocerium reagents RCeCl₂ (R = Me, Bu, CHMeEt, hexyl, Ph, allyl, CH₂SiMe₃) to R¹₂P(O)Cl (R¹ = Ph, EtO) leads to the corresponding phosphine oxides and phosphonates, R¹₂P(O)R, in good to high (40-85%) yields. The reaction can be extended to Ce enolates from ketones or nitriles except when a benzyl group bound to the carbonyl moiety should be metalated.

European Journal of Organic Chemistry published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Recommanded Product: Allyldiphenylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia