Month: November 2022

Yang, Pu published the artcileChiral Nanostructured Bimetallic Au-Ag Films for Enantiomeric Discrimination, Related Products of catalysis-chemistry, the publication is Advanced Materials Interfaces (2022), 9(19), 2200369, database is CAplus.

Herein, the chiral nanostructured bimetallic Au-Ag films (CNAAFs) with both photomagnetic-chiral anisotropy to enantiomers (PM-ChA_C-E) and surface-enhanced Raman scattering-chiral anisotropy to enantiomers (SERS-ChA_C-E) for efficient enantiomeric discrimination are reported. The CNAAFs are synthesized by electrodeposition on n-type Si (n-Si) substrates with the assistance of N-acetyl-L/D-cysteine (S/R-NAC) as symmetry-breaking agents, which are consisted of polycrystalline Boerdijk-Coxeter-Bernal (BCB) tetrahelical structured Au-Ag alloy nanowires grown on n-Si substrates perpendicularly. The anisotropic factors of PM-ChA_C-E (g_PM-ChA) and SERS-ChA_C-E (g_SERS-ChA) of CNAAFs in the range of 0.68-1.12 and 1.45-1.89 are obtained, resp. Considering the increase of magnetic fields and SERS intensities with enantiomeric excess (ee) values of adsorbed enantiomers on the CNAAFs are higher than that of pure chiral nanostructure Au films, the enhancement of PM-ChAC-E and SERS-ChAC-E effects of CNAAFs can be attributed to the enhanced selective spin polarization coupling between CNAAFs and enantiomers. It is predicted to be due to the strong surface plasmon resonance generated by the active electrons of Ag under laser irradiation

Advanced Materials Interfaces published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H12O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ma, Sheng published the artcileDevelopment of Second-Generation Small-Molecule RhoA Inhibitors with Enhanced Water Solubility, Tissue Potency, and Significant in vivo Efficacy, Safety of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is ChemMedChem (2015), 10(1), 193-206, database is CAplus and MEDLINE.

RhoA, a member of the Rho GTPases, is involved in a variety of cellular functions and could be a suitable therapeutic target for the treatment of cardiovascular diseases. However, few small-mol. RhoA inhibitors have been reported. Based on the previously reported lead compounds, 32 new 2-substituted quinoline (or quinoxaline) derivatives were synthesized and tested in biol. assays. Six compounds showed high RhoA inhibitory activities, with IC₅₀ values of 1.17-1.84 ¦ÌM. Among these, I and II demonstrated noticeable vasorelaxation effects against phenylephrine-induced contraction in thoracic aorta artery rings, and compound I had good water solubility and showed significant in vivo efficacy, which was similar to that of 5-(1,4-diazepane-1-sulfonyl)isoquinoline (fasudil) in a subarachnoid hemorrhage-cardiovascular model. To the best of the knowledge, compound I is the first example of a small- mol. RhoA inhibitor with potent in vivo efficacy, which could serve as a good lead for designing cardiovascular agents.

ChemMedChem published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Safety of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Deng, Chen-Qiang published the artcileNi-Catalyzed Asymmetric Hydrogenation of Aromatic Ketoacids for the Synthesis of Chiral Lactones, Related Products of catalysis-chemistry, the publication is Organic Letters (2022), 24(13), 2494-2498, database is CAplus and MEDLINE.

A highly efficient Ni-catalyzed asym. hydrogenation of aromatic ¦Ã- and ¦Ä-ketoacids has been developed, affording a series of ¦Ã- and ¦Ä-aryl lactones in high yields and excellent enantioselectivities (¡Ü98% ee). The hydrogenation could occur smoothly on a gram scale with 0.05 mol % catalyst loading (S/C = 2000). This protocol provides an efficient and practical approach for accessing chiral lactones with important potential applications in organic synthesis and the pharmaceutical industry.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Potapov, V. M. published the artcileEffect of the relative position of chromophores on the chiroptical properties of aralkanoic acids with an asymmetrical atom in the ¦Á-position to the carboxylic group, Recommanded Product: 2-Methyl-4-phenylbutanoic acid, the publication is Zhurnal Organicheskoi Khimii (1981), 17(11), 2329-33, database is CAplus.

The CD spectra of (R)-(-)-Ph(CH₂)_nCHMeCO₂H (n = 0, 1, 2) were recorded. As n increased, the Cotton effect curve at ?220 nm exhibited a hypochromic shift and a decrease in intensity.

Zhurnal Organicheskoi Khimii published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Recommanded Product: 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Roos, Casey B. published the artcileEnantioselective Hydroamination of Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer, Recommanded Product: 2,4,6-Triisopropylbenzenethiol, the publication is Journal of the American Chemical Society (2020), 142(13), 5974-5979, database is CAplus and MEDLINE.

An enantioselective, radical-based method for the intramol. hydroamination of alkenes with sulfonamides to afford pyrrolidines I [R¹ = Ph, 2-thienyl, 2,4,6-tri-MeC₆H₂, etc.; R² = H, Me; R³ = Me, t-Bu, CH₂CH₂CH=CMe₂; R²R³ = (CH₂)₂, (CH₂)₅, CH₂CH₂NBocCH₂CH₂] was reported. These reactions were proposed to proceed via N-centered radicals formed by proton-coupled electron transfer (PCET) activation of sulfonamide N-H bonds. Noncovalent interactions between the neutral sulfonamidyl radical and a chiral phosphoric acid generated in the PCET event were hypothesized to serve as the basis for asym. induction in a subsequent C-N bond forming step, achieving selectivities of up to 98:2 er. These results offer further supported for the ability of noncovalent interactions to enforce stereoselectivity in reactions of transient and highly reactive open-shell intermediates.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Recommanded Product: 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Botta, Bruno published the artcileSynthesis of C-Alkylcalix[4]arenes. 4. Design, Synthesis, and Computational Studies of Novel Chiral Amido[4]resorcinarenes, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Journal of Organic Chemistry (1997), 62(4), 932-938, database is CAplus.

In extending our studies involving BF₃¡¤Et₂O-catalyzed reaction of cinnamic acid analogs, we have shown that amido derivatives also can afford [4]resorcinarene octamethyl ethers. Subsequently, chiral monomeric amides, derived from the mixed anhydride of cinnamic acid and L– or D-valine, upon treatment with BF₃¡¤Et₂O, yielded for the first time chiral amido[4]resorcinarenes in enantiomerically pure forms. Four stereoisomers were isolated, and three of them were assigned the flattened-cone, chair, and 1,2-alternate conformations. The major product was assigned a novel chairlike structure, namely, flattened partial cone 1. The flattened-cone stereoisomer, which was indicated by mol. modeling studies to be the most stable, became the major product under more drastic exptl. conditions. Chromatog. studies on chiral phases revealed that the above tetramers could be used for the enantiodiscrimination of racemic mols.

Journal of Organic Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cauquis, G. published the artcileElectrochemical properties of diphenylamines and of their oxidation products in organic media. III. p,p’-Disubstituted diphenylamines and production of their primary cation radicals, SDS of cas: 1821-27-8, the publication is Electrochimica Acta (1976), 21(8), 557-65, database is CAplus.

The electrochem. oxidation of 2,2′,4,4′-tetramethoxydiphenylamine [7093-78-9] on bright Pt in neutral media, studied by cyclic voltammetry, ESR, and uv spectroscopy, gives 3 waves. The 1st wave corresponds to formation of the stable radical cation [54323-77-2], the 2nd wave to further oxidation to the nitrenium ion [61236-17-7] via the dication, and the final step results in formation of the aryl p-benzoquinoneimine. In 2,6-lutidine the nitrenium ion is observed before conversion to a heptamethoxydihydrophenazine, the exact formula of which is unknown. Oxidation of p,p’-disubstituted diphenylamines, e.g. p,p’-diaminodiphenylamine [537-65-5] in basic media gives the corresponding radical cations. In strong base, these lead to tetraarylhydrazines but in pyridine-like bases and, in some cases, H2O diaryldihydrophenazines are formed.

Electrochimica Acta published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, SDS of cas: 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Vermeulen, Nicolaas A. published the artcileSynthesis of Complex Allylic Esters via C-H Oxidation vs C-C Bond Formation, Product Details of C11H12O4, the publication is Journal of the American Chemical Society (2010), 132(32), 11323-11328, database is CAplus and MEDLINE.

A highly general, predictably selective C-H oxidation method for the direct, catalytic synthesis of complex allylic esters is introduced. This Pd(II)/sulfoxide-catalyzed method allows a wide range of complex aryl and alkyl carboxylic acids R¹CO₂H [R¹ = Me, Ph, (E)-2,4-(MeO)₂C₆H₃CH:CH, 3,4-F₂C₆H₃CH₂, BocNHCH₂CH₂, etc.] to couple directly with terminal olefins R²CH₂CH:CH₂ (R² = Ph, benzodioxolan-5-yl, t-BuSiMe₂CH₂CH₂, etc.) to furnish (E)-allylic esters R²CH:CHCH₂OCOR¹ in synthetically useful yields and selectivities (16 examples, E/Z ¡Ý 10:1) and without the use of stoichiometric coupling reagents or unstable intermediates. Strategic advantages of constructing allylic esters via C-H oxidation vs C-C bond-forming methods are evaluated and discussed in four “case studies”.

Journal of the American Chemical Society published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C15H21BO2, Product Details of C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

De Bruycker, Kevin published the artcileCovalent Fluorination Strategies for the Surface Modification of Polydienes, Synthetic Route of 30670-30-5, the publication is Macromolecular Rapid Communications (2017), 38(11), n/a, database is CAplus and MEDLINE.

Nonreactive additives are widely applied to enhance polymer properties but can leach out of the material over time. In this work, two essentially different fluorinated additives bearing a triazolinedione moiety are synthesized and grafted on several polydiene backbones (acrylonitrile-butadiene-styrene, styrene-butadiene, and styrene-isoprene-styrene (SIS) copolymers), either by dip-coating or by reaction in solution The resulting polymers are analyzed by contact angle goniometry, size exclusion chromatog., and NMR, IR, and XPS. Independent of the modification procedure, the fluorophilic perfluoroalkyl additive is found at the material surface, thereby yielding a more hydrophobic surface. For SIS thermoplastic elastomers, for example, contact angles up to 125¡ã can be obtained.

Macromolecular Rapid Communications published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C10H6F17N, Synthetic Route of 30670-30-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hevesi, L. published the artcilePeculiarities in the cleavage by methyllithium of unsymmetrical disilanes, Application of Trimethyl(perfluorophenyl)silane, the publication is Tetrahedron Letters (1994), 35(43), 8031-2, database is CAplus.

The title reactions did not produce the more stable silyl anions from the disilanes studied. These reactions either occurred by attack at the more electrophilic Si atom, or led to unexpected products. Three different reaction pathways were observed, depending on the substituents. Thus, treating Me₃SiSiMe₂C₆H_nX_5-n (X = H; X = 4-Cl, n = 4; X = 3-CF₃, 4-Cl, n = 3 1a–c) with MeLi in HMPA gave predominantly Me₃SiC₆H_nX_5-n. Similar reaction of 1d (X = 3,5-Cl₂, n = 3) gave almost quant. m-Cl₂C₆H₄, whereas 1e (X = F₅, n = 0) gave C₆HF₅ and polymeric -(Me₂Si)-_n.

Tetrahedron Letters published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Application of Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia