Month: November 2022

Armitage, D. A. published the artcileSulfur(II)-nitrogen bond. III. Synthesis of the sulfur(II)-nitrogen from sulfenates, Formula: C10H15NS, the publication is Journal of the Chemical Society [Section] C: Organic (1971), 3867-9, database is CAplus.

PhSOMe reacted with primary and secondary amines (e.g. MeNH2, Pr2NH) to give sulfenamides (e.g., PhSNHMe, PhSNPr2), and with Me3SiNMe2, Me3SiNEt2, and Me3SiNSO to give PhSNMe2, Ph-SNEt2, and PhSNSO, resp.; with Me3SiNHEt or Me3SiNHPr a mixture of PhSNHEt or PhSNHPr and PhSNEtSiMe3 or PhSNPrSiMe3 was obtained. PhSOMe reacted with MeN(SiMe3)2 to give PhSNMeSiMe3 and with PhSNHMe to give (PhS)2NMe. N2H4 reduced PhSOMe to Ph2S2.

Journal of the Chemical Society [Section] C: Organic published new progress about 19117-31-8. 19117-31-8 belongs to catalysis-chemistry, auxiliary class Oxidant, name is N-(tert-Butyl)-S-phenylthiohydroxylamine, and the molecular formula is C10H15NS, Formula: C10H15NS.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Arienzo, Rosa published the artcileStructure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists, Recommanded Product: 2-(4-(Trifluoromethyl)phenoxy)acetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(15), 4099-4102, database is CAplus and MEDLINE.

A new series of 2-aminoquinolines, e.g. I [R¹R²N = N-methylpiperazino, morpholino, piperidino, etc.; R¹ = Me₂CH, cyclopentyl, R² = H; R¹ = Me, PhCH₂, R² = Me; R³ = Ph, 4-ClC₆H₄, 4-F₃CC₆H₄, 2,4-Cl₂C₆H₃, etc.] has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors.

Bioorganic & Medicinal Chemistry Letters published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Recommanded Product: 2-(4-(Trifluoromethyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Brousseau, Margaret E. published the artcileIdentification of a PCSK9-LDLR disruptor peptide with in vivo function, Quality Control of 71989-31-6, the publication is Cell Chemical Biology (2022), 29(2), 249-258.e5, database is CAplus and MEDLINE.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-d. lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-C concentrations and cardiovascular disease risk. The epidermal growth factor precursor homol. domain A (EGF-A) of the LDLR serves as a primary contact with PCSK9 via a flat interface, presenting a challenge for identifying small mol. PCSK9-LDLR disruptors. We employ an affinity-based screen of 1013in vitro-translated macrocyclic peptides to identify high-affinity PCSK9 ligands that utilize a unique, induced-fit pocket and partially disrupt the PCSK9-LDLR interaction. Structure-based design led to mols. with enhanced function and pharmacokinetic properties (e.g., ₁₃PCSK9i). In mice, ₁₃PCSK9i reduces plasma cholesterol levels and increases hepatic LDLR d. in a dose-dependent manner. ₁₃PCSK9i functions by a unique, allosteric mechanism and is the smallest mol. identified to date with in vivo PCSK9-LDLR disruptor function.

Cell Chemical Biology published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Quality Control of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gawryszewska, P. published the artcileStructure and optical spectroscopy of Yb(III) complex with o-phenylenedioxydiacetic acid, HPLC of Formula: 5411-14-3, the publication is Journal of Molecular Structure (2011), 988(1-3), 59-64, database is CAplus.

The Na[Ln(C₁₀H₈O₆)₂(H₂O)₂]¡¤2H₂O (Ln = Yb(III), Lu(III)) monocrystals were obtained and the crystal structure was solved. The Yb(III) complex forms a structure with the space group P2₁/c and a 15.528(1), b 21.098(1), c 7.766(1) ?, and ¦Â 92.58(2)¡ã. Optical properties of this complex were studied using the methods of absorption (293 K, 4 K), luminescence (77 K) and IR spectroscopy. The ligand-field splitting in the relevant states can be determined from low-temperature high-resolution absorption and luminescence. The split of ²F_5/2 and ²F_7/2 was determined as 540 and 592 cm^-1, resp. The f-f luminescence was not induced by exciting into the ¹¦Ð-¹¦Ð^* absorption band of the ligand but only by exciting into Yb(III) level with a very short ²F_5/2 level decay time equal to 0.32 and 0.69 ¦Ìs at 293 and 77 K, resp.

Journal of Molecular Structure published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, HPLC of Formula: 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rosenau, Simon published the artcileFeeding green: Spirulina (Arthrospira platensis) induced changes in production performance and quality of salmonid species, Application In Synthesis of 6217-54-5, the publication is Aquaculture Research (2022), 53(12), 4276-4287, database is CAplus.

Spirulina is an interesting candidate for fish nutrition. This study aims to investigate the effect of the complete replacement of fishmeal with spirulina (Arthrospira platensis) in the diets of brook trout (Salvelinus fontinalis), rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta fario), in relation to growth and product quality. Two isoenergetic and isonitrogenous exptl. diets containing either fishmeal or spirulina as a main source of protein were used for a 10-wk feeding trial. Differences in the spirulina acceptance and conversion between species were observed The exptl. diets were well accepted except for brown trout. A species-diet interaction was observed, which led to a reduction in final body weight due to the spirulina supplementation for brook and rainbow trout (p$$ p $$ < 0.05). Parallel, the feed conversion ratio increased to the same extent in the spirulina-fed fish (p$$ p $$ < 0.05), fostering the assumption, that both species did not differ in converting the spirulina diet. Spirulina led to a significant increase (p$$ p $$ < 0.05) in yellow and red coloration in both raw and cooked fillets. The diet had a significant effect on the fatty acid profile, resulting in an increase in SFA and MUFA, while PUFA levels decreased significantly in spirulina-fed fish (p$$ p $$ < 0.05). Overall, total replacement of fishmeal with Spirulina goes along with a reduced production performance and effects on major product quality traits such as fillet color and fatty acid pattern. In particular, consumer acceptance of the yellow fillet color should be further investigated.

Aquaculture Research published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Application In Synthesis of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rapsomanikis, Spyridon published the artcileMethylation of lead(II) and methyllead(IV) compounds in water by a trans-dimethylcobalt(III) complex, Recommanded Product: Propane-1,3-diamine dihydrochloride, the publication is Inorganica Chimica Acta (1984), 89(3), 179-83, database is CAplus.

The Me cobalamin model and carbanion donor [CoLMe₂]ClO₄ (I) was prepared by the reaction of H₂N(CH₂)₃NH₂, MeCOCOMe, and Co(OAc)₂ to give [CoLCl₂]ClO₄, which was methylated with MeI to give I. I methylated Pb²⁺(aq) to give 0.12% PbMe₄ and 14.2% CH₄; in the Pb^2-I-MnO₂-MeI system, only Pb⁺² and I were necessary for PbMe₄ formation. I also methylated low concentrations of aqueous Me₂PbCl₂ and Me₃PbCl giving 12-22% CH₄ and 33.3-65.0% PbMe₄. Thus aqueous Pb⁺² and partially methylated Pb compounds were methylated by a Me cobalamin model to give toxic, air-transportable PbMe₄ in environmentely significant yields.

Inorganica Chimica Acta published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Recommanded Product: Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zelenina, L. N. published the artcileThe thermodynamic properties of talyl- and phenylsilanes, Safety of Trimethyl(perfluorophenyl)silane, the publication is Russian Journal of Physical Chemistry (2006), 80(2), 139-142, database is CAplus.

The enthalpies of fusion of C₆H₅SiH₃, C₆F₅SiMe₃, and (C₆F₅)₄Si were obtained in scanning calorimetry measurements. Pressure over the condensed talylsilane 4-CF₃C₆F₄SiCH₃, phenylsilane C₆H₅SiH₃, and pentafluorophenylsilane C₆F₅SiCH₃, (C₆F₅)₂SiMe₂, and (C₆F₅)₄Si phases was measured by the static method using membrane null manometers. Equations approximating the dependences of saturated vapor pressures on temperature and the enthalpy and entropy of vaporization were obtained.

Russian Journal of Physical Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C19H15NO3, Safety of Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zelenina, L. N. published the artcileFluorophenyl derivatives of elements II-VI groups. Phase transitions thermodynamics and growing films by CVD, Category: catalysis-chemistry, the publication is Journal of Thermal Analysis and Calorimetry (2008), 92(3), 723-727, database is CAplus.

The enthalpies and temperatures of melting of RSi(CH₃)₃, R₄Si, R₃P, R₃As, R₃Sb, R₃Bi, R₂Te, and R₂Hg (R = C₆F₅) were obtained by scanning calorimetry measurements. The pressure of the saturated and unsaturated vapors of RSi(CH₃)₃, R₂Si(CH₃)₂, R₄Si, R₃Ga, R₃P, R₃As, R₃Sb, R₃Bi, R₂Te, and R₂Hg was measured by the static method with a membrane-gauge manometer. All investigated substances proceeded to vapor as monomers. Equations approximating the dependences of saturated vapor pressures on temperature and the enthalpies and entropies of vaporization were obtained. Graphite films with silicon intercalated up to 25 at.% were grown by CVD using R₄Si as a precursor. These films showed semiconductor properties in the temperature interval 80-300 K.

Journal of Thermal Analysis and Calorimetry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C17H18N3NaO3S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Go, Su Yong published the artcileA Unified Synthetic Strategy to Introduce Heteroatoms via Electrochemical Functionalization of Alkyl Organoboron Reagents, Recommanded Product: 3-Benzoylpropionicacid, the publication is Journal of the American Chemical Society (2022), 144(20), 9149-9160, database is CAplus and MEDLINE.

Based on systematic electrochem. anal., an integrated synthetic platform of C(sp³)-based organoboron compounds was established for the introduction of heteroatoms. The electrochem. mediated bond-forming strategy is highly effective for the functionalization of sp³-hybridized C atoms with significant steric hindrance. Also, virtually all the nonmetallic heteroatoms could be used as reaction partners using one unified protocol. The observed reactivity stems from the two consecutive single-electron oxidations of the substrate, which eventually generates an extremely reactive carbocation as the key intermediate. The detailed reaction profile could be elucidated through multifaceted electrochem. studies. Ultimately, a new dimension in the activation strategies for organoboron compounds was accomplished through the electrochem. driven reaction development.

Journal of the American Chemical Society published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tadpetch, Kwanruthai published the artcileCytotoxic naphthoquinone and a new succinate ester from the soil fungus Fusarium solani PSU-RSPG227, Product Details of C15H14O3, the publication is Phytochemistry Letters (2015), 106-110, database is CAplus.

A new naphthoquinone, solaninaphthoquione (1), and a new succinate ester derivative, 4-(4-hydroxyphenethoxy)-4-oxobutanoic acid (2), were isolated from the soil fungus Fusarium solani PSU-RSPG227 together with five previously reported compounds; javanicin (3), monaspilosin (4), aspergillol B (5), tyrosol (6) and 4-hydroxyphenylacetic acid (7). Their structures were elucidated primarily by NMR spectroscopic data. Due to paucity of materials, compounds 2, 4 and 5 as well as analogs of 5 were prepared for biol. activity evaluation. Compound 1 showed significant cytotoxic activity against breast cancer (MCF-7) cells and mild cytotoxic activity against oral human carcinoma (KB) cells (IC₅₀ values of 21.3 and 22.6 ¦ÌM, resp.) compared to standard compounds Compound 1 also displayed weak antimalarial activity (IC₅₀ of 26.1 ¦ÌM).

Phytochemistry Letters published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C11H10N4, Product Details of C15H14O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia