Month: November 2022

Ruan, Mengyao published the artcileElectrochemical two-electron oxygen reduction reaction (ORR) induced aerobic oxidation of ¦Á-diazoesters, Synthetic Route of 104-03-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(13), 2168-2171, database is CAplus and MEDLINE.

The recent progress in the oxidation of ¦Á-diazoesters R¹C(=N₂)C(O)OR² (R¹ = Ph, 2-naphthyl, benzo[d][1,3]dioxol-5-yl, etc.; R² = Me, cyclohexyl, (tetrahydrofuran-2-yl)methyl, etc.) to ¦Á-ketoesters R¹C(O)C(O)OR² by in situ generated hydrogen peroxide via a two-electron oxygen reduction approach was described. A diverse collection of valuable ¦Á-ketoester products was obtained with moderate to high yields under an exogenous-oxidant-free and metal catalyst-free electrochem. conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Synthetic Route of 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ni, Xiu-Wen published the artcileA photocontrollable thermosensitive chemical spatiotemporally destabilizes mitochondrial membranes for cell fate manipulation, Application In Synthesis of 71989-31-6, the publication is Biomaterials Science (2022), 10(10), 2550-2556, database is CAplus and MEDLINE.

Perturbations in mitochondrial membrane stability lead to cytochrome c release and induce caspase-dependent apoptosis. Using synthetic smart chems. with changeable physicochem. properties to interfere the mitochondrial membrane stability has not yet been reported. Here we show that a thermosensitive anchor-polymer-peptide conjugate (anchor-PPC) destabilizes mitochondrial membranes upon in situ mol. changes from hydrophilic to hydrophobic, which consequently induces apoptosis in a spatiotemporally controlled manner and acts as an antitumor pharmaceutical. The anchor-PPC is composed of a thermosensitive copolymer, a photolabile linker, a hydrophilic HIV Tat-derived peptide both for cell penetration and polymer phase transition temperature (Tt) modulation, and an anchor peptide for intercalating into mitochondrial membranes. The photocontrollable anchor-PPC dehydrates and changes from being hydrophilic to hydrophobic upon photoactivation at body temperature This cell-penetrable anchor-PPC specifically targets mitochondria and destabilizes mitochondrial membranes upon irradiation, and consequently initiates apoptosis in cells and a complex 3D tumor model. This study provides the first exptl. evidence that the synthetic smart chem. can spatiotemporally control the stability of organelle membranes based on its in situ physicochem. property change.

Biomaterials Science published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Application In Synthesis of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lin, Huajian published the artcileEnhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine, Application of 1,3,5-Triazaadamantan-7-amine, the publication is Journal of Inorganic Biochemistry (2018), 192-198, database is CAplus and MEDLINE.

Antimicrobial photodynamic therapy (aPDT) is an effective way to combat infectious diseases and antibiotic resistance. Photosensitizer is a key factor of aPDT and has triggered extensive research interest. In this study, a new asym. Zn(II) phthalocyanine mono-substituted with a triazatricyclodecane moiety (compound 3) and its cationic N-methylated derivative (compound 4) were synthesized. Their photodynamic antimicrobial activities were evaluated using bioluminescent bacterial strains. Compound 3 showed phototoxicity only toward the Gram-pos. bacteria, whereas the cationic derivative compound 4 exhibited strong anti-bacterial activity against both Gram-pos. and Gram-neg. strains. These bacterial species were eradicated (>4.0 logs or 99.99% killing) at appropriate concentrations of compound 4 with 12.7 J/cm² of red light, demonstrating compound 4 as a potent aPDT agent.

Journal of Inorganic Biochemistry published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Application of 1,3,5-Triazaadamantan-7-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Yinrong published the artcileCopper-Mediated Decarboxylative Sulfonylation of Arylacetic Acids with Sodium Sulfinates, COA of Formula: C8H7NO4, the publication is Organic Letters (2020), 22(18), 7164-7168, database is CAplus and MEDLINE.

Herein, we present a copper-mediated decarboxylative sulfonylation of arylacetic acids with sodium sulfinates that provides viable access to sulfone compounds This protocol features readily available feedstocks, simple operations, high regioselectivities, and moderate to good yields. The newly obtained products could be converted to other useful compounds Importantly, the products and their derivatives exhibited potent antitumor activities in vitro, which were tested by MTT assay.

Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C13H10N2S, COA of Formula: C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Gang published the artcileDBU-Catalyzed Selective N-Methylation and N-Formylation of Amines with CO₂ and Polymethylhydrosiloxane, Product Details of C14H23N, the publication is Advanced Synthesis & Catalysis (2018), 360(12), 2364-2369, database is CAplus.

We describe herein an efficient organocatalytic system for the selective N-methylation and N-formylation of amines with carbon dioxide (CO₂) as a sustainable C1 feedstock and polymethylhydrosiloxane (PMHS) as a cost-effectvie reducing reagent. High-yielding N-methylation products are obtained with low catalyst loading (1%) of DBU. Selective N-formylation of amines is achieved using the same catalytic system at a lower reaction temperature

Advanced Synthesis & Catalysis published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Product Details of C14H23N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Yong published the artcileThree piperazine compounds as corrosion inhibitors for copper in 0.5 M sulfuric acid medium, SDS of cas: 119-80-2, the publication is Journal of the Taiwan Institute of Chemical Engineers (2021), 231-243, database is CAplus.

Searching for and developing green corrosion-resisting drugs plays an significant role in protecting Cu during its pickling treatment. The toxicities and inhibitive performances are closely correlated with their mol. formulas. Therefore, Amoxapine, Loxapine and Clozapine, all of which belong to piperazines, were assessed as inhibitive agents to protect Cu from corrosion in 0.5 M H2SO4 via electrochem. measurements, surface morphologies and theor. calculations According to the electrochem. results, the anti-corrosion efficiencies of AP, LP and CP reached their maximum at 5 mM, namely 94.0, 95.2 and 96.6, resp. They were all proved to be cathodic-type corrosion inhibitors. The morphol. anal. implied the shaping of protective films on Cu surfaces. Moreover, the absorption of AP, LP and CP on Cu surfaces deferred to the Langmuir isotherm model, confirming the anal. of Fourier transform IR spectroscopy (FT-IR) and XPS. Theor. calculations revealed their adsorption models and anti-corrosive mechanisms. Both experiment and calculation manifested favorable corrosion-proof properties of the three researched drugs. Further anal. also proved the enhanced inhibitive effect of Me that connected with benzene ring owing to its conjugative effect. Furthermore, N atom possessed higher electronegativity and accordingly stronger electron-donating ability compared to O atom. The corrosion-resisting efficiency of Clozapine was 96.6%, being higher than that of Loxapine which was 95.2%.

Journal of the Taiwan Institute of Chemical Engineers published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, SDS of cas: 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Xiaoguang published the artcileNitrogen-coupled blatter diradicals: the fused versus unfused bridges, Product Details of C12H9N3O4, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2019), 7(34), 10460-10464, database is CAplus.

We report the synthesis and characterization of nitrogen-coupled diradicals NDR (unfused) and CDR (fused). NDR has a large diradical character y of 0.89, and a small singlet-triplet energy gap ¦¤E_S-T of -1.16 kcal mol^-1 with the observation of a forbidden transition signal (¦¤m_s = ¡À2). Moreover, NDR shows very high stability. In contrast, the fused CDR has a smaller y (0.68), along with a larger ¦¤E_S-T (-2.38 kcal mol^-1).

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Product Details of C12H9N3O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

He, Jiayan published the artcileCatalytic Decarboxylative Radical Sulfonylation, Synthetic Route of 2051-95-8, the publication is Chem (2020), 6(5), 1149-1159, database is CAplus.

The decarboxylative radical sulfonylation with sulfinates were reported, with the merger of 4CzIPN and Cu(OTf)₂ as catalysts, the visible-light-induced reaction of redox-active esters of aliphatic carboxylic acids with organosulfinates at room temperature provided the corresponding sulfones in satisfactory yields. This redox-neutral protocol exhibited broad substrate scope and wide functional group compatibility, enabling the late-stage modification of complex natural products and bioactive pharmaceuticals. The synthetic utility of the method was further demonstrated by the improved synthesis of anti-prostate cancer drug bicalutamide.

Chem published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Synthetic Route of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Heng-Rui published the artcileMerging photoredox with copper catalysis: decarboxylative difluoroacetylation of ¦Á,¦Â-unsaturated carboxylic acids with ICF₂CO₂Et, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(79), 11827-11830, database is CAplus and MEDLINE.

A photoredox-/copper-catalyzed decarboxylative difluoroacetylation reaction of ¦Á,¦Â-unsaturated carboxylic acids has been developed. This reaction produces a variety of difluoroalkylated alkenes in moderate to excellent yields and exhibits satisfactory stereoselectivity and a broad substrate scope at ambient temperature Furthermore, this decarboxylative difluoroacetylation protocol provides efficient and environmentally friendly access to the difluoroalkylated alkenes.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C28H18O4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Tzu-Lun published the artcileCalcium complexes containing oxalamidinate ligands as catalysts for ¦Å-caprolactone polymerization, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride, the publication is Dalton Transactions (2013), 42(25), 9255-9262, database is CAplus and MEDLINE.

A series of calcium complexes containing oxalamidinate ligands is described. Reactions of oxalamidinate ligand precursors, [PhN:C{NH(CH₂)₂OMe}-C{NH(CH₂)₂OMe}:NPh] (1), [PhN:C{NH(CH₂)₂NMe₂}-C{NH(CH₂)₂NMe₂}:NPh] (2), [Ph^TriMeN:C{NH(CH₂)₂OMe}-C{NH(CH₂)₂OMe}:NPh^TriMe] (3), [Ph^TriMeN:C{NH(CH₂)₂SMe}-C{NH(CH₂)₂SMe}:NPh^TriMe] (4), [Ph^TriMeN:C{NHCH₂Py}-C{NHCH₂Py}:NPh^TriMe] (5), with two molar equivalents of Ca[N(SiMe₃)₂]₂(THF)₂ gave calcium oxalamidinate complexes, [Ca{N(SiMe₃)₂}(THF)(PhN)C{N(CH₂)₂OMe}-]₂ (6), [Ca{N(SiMe₃)₂}(THF)(PhN)C{N(CH₂)₂NMe₂}-]₂ (7), [Ca{N(SiMe₃)₂}(THF)(Ph^TriMeN)C{N(CH₂)₂OMe}-]₂ (8), [Ca{N(SiMe₃)₂}(THF)(Ph^TriMeN)C{N(CH₂)₂SMe}-]₂ (9), [Ca{N(SiMe₃)₂}(THF)(Ph^TriMeN)C{NCH₂Py}-]₂ (10), resp. The mol. structure of complex 7 was further characterized by the single crystal x-ray diffraction technique. The catalytic activities of complexes 6-10 toward the ring opening polymerization of ¦Å-caprolactone were studied. Complex 8 exhibited excellent activity for the polymerization of ¦Å-caprolactone with controlled mol. weights and polydispersities.

Dalton Transactions published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia