Month: December 2022

Kooner, Anoopjit Singh published the artcileSynthesis and microbial activity of acrylamides with heteroatoms, Computed Properties of 1772-76-5, the publication is Journal of the Indian Chemical Society (2014), 91(2), 293-298, database is CAplus.

The modified condensation reaction of benzaldehyde, 2-chlorobenzaldehyde, 3-nitrobenzaldehyde, and 4-chlorobenzaldehyde with ¦Á-proton containing acids viz. acetic acid and similar reaction of propionic acid with 3-nitrobenzaldehyde and 4-chlorobenzaldehyde in the presence of sodium borohydride to afford corresponding acrylic acids I (R¹ = H, 3-O₂N, 4-Cl, 2-Cl; R² = H, CH₃) which on further reaction with amines like morpholine and 4-aminophenazone in the presence of base and thionylchloride yielded series of acrylamides II (R¹ = H, 3-O₂N, 4-Cl, 2-Cl; R² = H, CH₃) and III (R¹ = H, 3-O₂N, 4-Cl, 2-Cl; R² = H, CH₃). Phys. data (yield, m.p., state and color) of synthesized acids and amides were determined Amide derivative were tested for their microbial activity on Rhizobium sp. (LMR 07), Bradyrhizobium sp. (BJP), Pseudomonas sp. (LK 791) and Bacillus sp. (BSY 101) at different concentration Amides with morpholine moiety showed promising results.

Journal of the Indian Chemical Society published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Computed Properties of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kaur, Sandeep published the artcileConventional as well as microwave assisted synthesis and microbial effect of some new acrylamides, Related Products of catalysis-chemistry, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2013), 52B(12), 1513-1520, database is CAplus.

Knoevenagel condensation of a variety of aromatic aldehydes with acetic acid in the presence of sodium borohydride gave the corresponding cinnamic acids R¹CH:CHCO₂H (R¹ = Ph, 2-ClC₆H₄, 4-ClC₆H₄, 3-O₂NC₆H₄, 2-MeOC₆H₄, 4-MeOC₆H₄) which further reacted with furfurylamine or 2-aminopyridine either by conventional method in the presence of a catalytic amount of boric acid or using microwave irradiation to form the corresponding cinnamides R¹CH:CHC(O)NHR² (R² = 2-furylmethyl, 2-pyridyl) (I). For all the compounds, the amidation under microwave irradiation conditions gave higher yields and took less time than the reactions under conventional heating conditions. The resulting amides were screened for their antimicrobial activity against bacteria [Bacillus sp. (BSY 101), Pseudomonas sp. (LK 791) and Ensifer sp. (IND 2)], fungus (Ascochyta blight) and yeast (Sacchromyces cerevisiae). The majority of the synthesized amides showed poor inhibition against Bacillus sp., Pseudomonas sp. and Ensifer sp. The compounds I (R¹ = 4-ClC₆H₄, 4-MeOC₆H₄; R² = 2-furylmethyl) and I (R¹ = 2-ClC₆H₄, 4-MeOC₆H₄; R² = 2-pyridyl) showed the best activity against Ensifer sp. The products containing a pyridine moiety were found to be more effective against bacteria than those based on furfurylamine. All the amides were ineffective against fungus and yeast.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kaur, Gurpreet published the artcileInvestigating mixed micellar system of dodecylammonium acetate for solubilisation of curcumin, Application In Synthesis of 2016-56-0, the publication is Science of Advanced Materials (2015), 7(8), 1546-1555, database is CAplus.

The present work deals with the anal. of aggregation behavior of cationic surfactant dodecylammonium acetate (DAA) (in single and mixed micellar formulations). Thermodn. parameters reveal that the micellization of DAA is predominantly entropy driven. In mixed micellar system of DAA with dodecyltrimethylammonium bromide (DTAB), the synergistic effect dominates between two cationic surfactants mainly due to the dominance of chain-chain van der Waal interactions. Further, the micellar system has been evaluated for solubilization of curcumin. The solubilization locus, encapsulation efficiency and in vitro release mechanism have been evaluated. The distribution coefficient, binding constant, Stern-Volmer quenching constant, along with the free energy of transfer of curcumin in mixed micelles have been assessed fluorometrically. The results obtained indicate that the mixed cationic micellar system is stable and can prove to be a thriving vector for water insoluble curcumin in future.

Science of Advanced Materials published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Application In Synthesis of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Goswami, Ravi Kumar published the artcileEffect of Lemna minor supplemented diets on growth, digestive physiology and expression of fatty acids biosynthesis genes of Cyprinus carpio, Product Details of C5H11NO2S, the publication is Scientific Reports (2022), 12(1), 3711, database is CAplus and MEDLINE.

The potential nutritional value of duckweed Lemna minor (Lemnaceae) was evaluated for common carp Cyprinus carpio fry. Fish were fed diets containing five graded levels of duckweed: 0% (LM0, control), 5% (LM5), 10% (LM10), 15% (LM15) and 20% (LM20). The final weight and specific growth rate were significantly higher in LM15 and LM20 diets fed fish compared to others. Amylase activity was significantly higher in LM0 treatment. Total protease, trypsin and chymotrypsin activities showed linear relationships with the increased level of duckweed in the diet. Protein and essential amino acids contents were significantly higher in carp fed diets LM15 and LM20 compared to others. Lipid content was significantly higher in fish fed duckweed-based diets compared to control. A direct relationship was found between the inclusion level of duckweed in the diet and n-3 long-chain polyunsaturated fatty acid (LC-PUFA) content of carp. Contents of desatd. and elongated products of dietary linolenic acid (18:3n-3) including 20:4n-3, 20:5n-3, 22:5n-3 and 22:6n-3 increased in a graded manner with increasing dietary duckweed. The monounsaturated fatty acids and n-6 PUFA contents reduced significantly in fish fed duckweed. Expression of fads2d6, elovl2, elovl5 and fas were higher in carp fed diets LM10, LM15 and LM20 compared to control fish. The inclusion of L. minor in diet enhanced the nutritional value of carp by increasing protein, lipid, amino acids and n-3 PUFA contents.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Product Details of C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Goswami, Ravi Kumar published the artcileEffect of Lemna minor supplemented diets on growth, digestive physiology and expression of fatty acids biosynthesis genes of Cyprinus carpio, Name: Docosahexaenoic Acid, the publication is Scientific Reports (2022), 12(1), 3711, database is CAplus and MEDLINE.

The potential nutritional value of duckweed Lemna minor (Lemnaceae) was evaluated for common carp Cyprinus carpio fry. Fish were fed diets containing five graded levels of duckweed: 0% (LM0, control), 5% (LM5), 10% (LM10), 15% (LM15) and 20% (LM20). The final weight and specific growth rate were significantly higher in LM15 and LM20 diets fed fish compared to others. Amylase activity was significantly higher in LM0 treatment. Total protease, trypsin and chymotrypsin activities showed linear relationships with the increased level of duckweed in the diet. Protein and essential amino acids contents were significantly higher in carp fed diets LM15 and LM20 compared to others. Lipid content was significantly higher in fish fed duckweed-based diets compared to control. A direct relationship was found between the inclusion level of duckweed in the diet and n-3 long-chain polyunsaturated fatty acid (LC-PUFA) content of carp. Contents of desatd. and elongated products of dietary linolenic acid (18:3n-3) including 20:4n-3, 20:5n-3, 22:5n-3 and 22:6n-3 increased in a graded manner with increasing dietary duckweed. The monounsaturated fatty acids and n-6 PUFA contents reduced significantly in fish fed duckweed. Expression of fads2d6, elovl2, elovl5 and fas were higher in carp fed diets LM10, LM15 and LM20 compared to control fish. The inclusion of L. minor in diet enhanced the nutritional value of carp by increasing protein, lipid, amino acids and n-3 PUFA contents.

Scientific Reports published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Name: Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Yantao published the artcileHighly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids, Application In Synthesis of 118-90-1, the publication is Nature Communications (2022), 13(1), 10, database is CAplus and MEDLINE.

The synthesis of all-carbon tetrasubstituted olefins under mild reaction conditions is challenging because of the inevitable issues including significant steric hindrance and the uncontrolled Z/E stereoselectivity. In this paper, authors report the synthesis of all-carbon tetrasubstituted alkenes from readily available carboxylic acids and alkenyl triflates with the synergistic catalysis of cyclo-octa-1,5-diene(tetramethyl-1,4-benzoquinone)nickel and visible light under an air atm., thus avoiding the need for a glovebox or a Schlenk line. A wide range of aromatic carboxylic acids and cyclic and acyclic alkenyl triflates underwent the C-C coupling process smoothly, forming structurally diverse alkenes stereospecifically in moderate to good yields. The practicality of the method is further illustrated by the late-stage modification of complex mols., the one pot synthesis and gram-scale applications. This is an important step towards the valuable utilization of carboxylic acids, and it also simplifies the exptl. operation of metallophotoredox catalysis with moisture sensitive nickel(0) catalysis.

Nature Communications published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Application In Synthesis of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Balachandra, Biguvu published the artcileIodine catalyzed one-pot synthesis of highly substituted N-methyl pyrroles via [3 + 2] annulation and their in vitro evaluation as antibacterial agents, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is RSC Advances (2015), 5(79), 64781-64789, database is CAplus.

A class of highly substituted pyrroles I [R = 2-F, 3-Cl, 4-OCH₃, etc.] have been synthesized via a simple, fast, and efficient method using environmentally friendly iodine catalyzed [3 + 2] annulation. N-Methyl-N-[(E)-1-(methylsulfanyl)-2-nitro-1-ethenyl]amine (NMSM) and U+03B2-nitrostyrenes underwent cycloaddition to afford the desired products I in excellent yields under solvent and metal free conditions. All the pyrrole derivatives I were evaluated for their in vitro anti-bacterial activity. Among the synthesized pyrrole derivatives I [R = H, 3-OCH₃, 3,4,5-(OCH₃)₃, 4-F, 4-Cl, 2-Br, 3-OH, 4-NO₂, 1,2-C₄H₄] displayed good inhibitory properties against a panel of Gram pos. and neg. infectious pathogens.

RSC Advances published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reddy, Raju Jannapu published the artcileMetal-free, highly regioselective sulfonylation of NH-1,2,3-triazoles with sodium sulfinates and thiosulfonates, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Tetrahedron Letters (2018), 59(21), 2014-2017, database is CAplus.

A convenient and metal-free protocol for the highly regioselective sulfonylation of NH-1,2,3-triazoles such as 4-methyl-5-phenyl-2H-1,2,3-triazole, 4-furan-2-yl-5-methyl-2H-[1,2,3]triazole, 4-phenyl-2H-1,2,3-triazole, etc. was described. A range of readily accessible NH-1,2,3-triazoles was sulfonylated with various aryl sulfinates such as sodium p-toluenesulfinate, sodium 4-bromobenzenesulfinate, sodium benzenesulfinate, sodium 4-chlorobenzenesulfinate in the presence of mol. iodine. The scope was extended to thiosulfonates such as S-Ph 4-Me benzenesulfonothioate, S-Ph benzenesulfonothioate as an efficient sulfonylating agent and nitrochromene derived triazoles which were also explored for selective N-sulfonylation. A variety of synthetically viable N2-sulfonyl triazoles e.g., I was obtained in moderate to high yields with excellent regioselectivities via N-S bond construction under mild reaction conditions.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Amini, Nader published the artcileConstruction of a highly sensitive immunosensor based on antibody immunoglobulin G/3-(trimethoxysilyl) propylamine/graphene oxide for antigen-specific immunoglobulin G detection, Synthetic Route of 13822-56-5, the publication is Microchemical Journal (2022), 107218, database is CAplus.

The aim of this study is to develop an immunosensor that has the ability to detect antigen G with properties such as very low detection of limit, remarkable with no bifunctional crosslinking species and excellent activity at physiol. pH values. IgG (IgG) is found in all body fluids. When a specific bond occurs between the anti-IgG and the IgG (anti-IgG), the result is activation of the reaction against viral and bacterial diseases. For detection and determination of antibody-antigen (Rabbit IgG-AntiRabbit IgG) interactions, a novel electrochem. immunosensor based on antibody IgG/3-(trimethoxysilyl)propylamine/graphene oxide/glassy carbon (Ab/TMSPA/GO/GCE) was fabricated by using of carboxylic groups (-COOH) on graphene oxide (GO) and by exploiting 3-(trimethoxysilyl)propylamine (TMSPA) to covalently conjugate antibody mols. For characterization of the modification process of the surface of glassy carbon electrode(GCE), electrochem. impedance spectroscopy (EIS) and cyclic voltammetry (CV) were used. The change of impedance response was used for the monitoring of the interactions of antibody with different concentrations of antigen. Based on the results obtained, with increasing concentrations of antigen, the electron transfer resistance increased. The limit of detection (DL) and linear range 400 ng mL^-1 and 2-1500 ¦ÌmL^-1 were obtained.

Microchemical Journal published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Synthetic Route of 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shishilov, Oleg N. published the artcilePalladium Nitrosyl Complexes as Highly Versatile Catalysts for C-H/C-H Oxidative Coupling of Arenes: Application Area and Insight into Mechanism, Formula: C14H14, the publication is ChemistrySelect (2021), 6(8), 1795-1803, database is CAplus.

Palladium nitrosyl carboxylates Pd₃(NO)₂(CX₃CO₂)₄(ArH)₂ (X = Cl, Ar = Ph; X = F, Ar = Tol) were found to be effective catalysts for synthesis of biaryls Ar¹Ar² = [Ar¹ = 4-MeC₆H₄, 2-ClC₆H₄, 3-F₃CC₆H₄, etc.; Ar² = 2-MeC₆H₄, 2-ClC₆H₄, 3-F₃CC₆H₄, etc.] via C-H/C-H oxidative homocoupling of arenes bearing electron-donor as well as electron-withdrawing groups (EWG). Trifluoroacetate complex Pd₃(NO)₂(CX₃CO₂)₄(ArH)₂ (X=F, Ar=Tol) was found to be more promising due to higher stability under the reaction conditions. Trifluoroacetate complex also showed high performance in intramol. coupling in diarylsulfides, diarylethers and diarylamines gave corresponding dibenzothiophenes/dibenzofurans/carbazoles I [R¹ = H, Me; R² = H, Me, CF₃, etc.; Y = O, S, NH] with yields ranged from moderate to high. The plausible mechanism was studied by DFT computational anal. basing on Pd₃ linear complexes as major active species. It was found that two deprotonation steps proceeded in two different ways: for the first deprotonation S_EAr was most probable pathway while for the second one concerted metalation-deprotonation (CMD) was preferable. That could explain high tolerance of the system to different substrates: S_EAr was favorable in the presence of electron donor group and EWG facilitated CMD. NO group was found to be involved into the CMD pathway and that was the rate-determining step with the highest activation barrier.

ChemistrySelect published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C9H11BO4, Formula: C14H14.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia