Month: December 2022

Lee, Sumin published the artcileDirect Regio- and Diastereoselective Synthesis of ¦Ä-Lactams from Acrylamides and Unactivated Alkenes Initiated by Rh^III-Catalyzed C-H Activation, Formula: C6H12F3NO5S, the publication is Angewandte Chemie, International Edition (2020), 59(12), 4965-4969, database is CAplus and MEDLINE.

Here a Rh^III-catalyzed regio- and diastereoselective synthesis of ¦Ä-lactams such as I [R = Me, F, Bn, etc.; R¹ = Me, cyclopentyl, Bn, etc.; R² = H; R¹R² = (CH₂)₃, (CH₂)₂CH=CH, (CH₂)₆, etc.] and their regioisomers I [R = Me, F, Bn, etc.; R¹ = H; R² = Me, cyclopentyl, Bn, etc.] from readily available acrylamide derivatives and unactivated alkenes was reported. The regioselectivity of the reaction with unactivated terminal alkene was significantly improved by using Cpt ligand on the Rh^III catalyst. The synthetic utility of the reaction was demonstrated by the preparation of a potential drug candidate containing a trisubstituted piperidine moiety. Mechanistic studies showed that the reversibility of the C-H activation depends on the choice of Cp ligand on the Rh^III catalyst. The irreversible C-H activation was observed and becomes turnover-limiting with [CptRhCl₂]₂ as catalyst.

Angewandte Chemie, International Edition published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, Formula: C6H12F3NO5S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zubairov, M. M. published the artcileCharacterization of chlorine-free biocidal agents based on nontoxic or slightly toxic azaadamantane compounds, SDS of cas: 14707-75-6, the publication is Russian Journal of Physical Chemistry B (2015), 9(3), 471-480, database is CAplus.

The bactericidal properties of a series of 20 chlorine-free biocidal agents based on monoaza-, diaza-, triaza-, and tetraazaadamantanes and their homo and dihomo analogs were studied. Based on the exptl. results, the most active compound 1,3,6,8-tetraazatricyclo[4.4.1.1^3.8]dodecane was chosen in order to study its biocidal activity and pharmacol. and toxicol. characteristics. Disinfection conditions for the viral and bacterial causative agents of taxonomic groups of different etiol. were determined It was found that the above compound is characterized by high bactericidal, viricidal, mycocidal, and sporicidal activities, and it is a promising agent for the development of an industrial process for the production of a safe chlorine-free disinfectant.

Russian Journal of Physical Chemistry B published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C5H6BNO2, SDS of cas: 14707-75-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Toyota, Masahiro published the artcileSynthetic approach to stemodin (I) – a novel stereocontrolled construction of the stemodane system by the successive intramolecular Diels-Alder reactions, Application In Synthesis of 4141-48-4, the publication is Tetrahedron (1994), 50(4), 1093-104, database is CAplus.

The synthesis of the A, B, C and D ring part I of the diterpene stemodin (II) from 1,4-cyclohexanedione monoethylene ketal III by use of successive intramol. Diels-Alder reactions is described.

Tetrahedron published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C6H12F3NO5S, Application In Synthesis of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Toyota, Masahiro published the artcileSynthetic approach to stemodin – a novel stereocontrolled construction of the stemodane system by successive intramolecular Diels-Alder reactions., Name: Allyldiphenylphosphine oxide, the publication is Tetrahedron Letters (1992), 33(32), 4581-4, database is CAplus.

The tetracyclic compound I, possessing the stemodane skeleton, was synthesized from 1,4-cyclohexanedione monoethylene ketal. The key steps involve intramol. Diels-Alder reactions, namely ketone II to tricycle III and triene IV to I.

Tetrahedron Letters published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C11H8ClN3, Name: Allyldiphenylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Burow, David published the artcileModifications to the silver physical developer, Related Products of catalysis-chemistry, the publication is Journal of Forensic Sciences (2003), 48(5), 1094-1100, database is CAplus and MEDLINE.

The silver phys. developer is currently the most successful reagent used for visualizing the water-insoluble components (e.g., lipids) of latent prints on porous surfaces. It is normally used after the amino acid visualizing reagents (e.g., ninhydrin and DFO) are used. This work found that the performance of the current formulation of silver phys. developer is strongly reduced when the water used is changed from the usual distilled water to the more purified reverse osmosis/deionized (RO/DI) water. Based on numerous experiments involving the systematic variation of the component concentrations, the performance was restored and even improved by reducing the concentration of all the components (except that of the ferric salt) and by including malic acid in the formulation. These modifications resulted in a new silver phys. developer formulation that performs as well as or better than the current formulation and is less expensive to make.

Journal of Forensic Sciences published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bernerd, Cyril published the artcileQuadratic nonlinear optical properties of the organic N-benzyl-2-methyl-4-nitroaniline (BNA) biaxial crystal, Formula: C14H14N2O2, the publication is Optics Letters (2018), 43(8), 1818-1821, database is CAplus and MEDLINE.

We performed the direct measurement of second harmonic generation and sum frequency generation phase-matching directions in the organic N-benzyl-2-methyl-4-nitroaniline crystal over its visible and near-IR transparency range. The fit of these data allowed us to refine the Sellmeier equations of the three principal refractive indexes in this range. With these equations, we improved the calculated tuning curves of terahertz emission from a phase-matched difference frequency process. We also determined the absolute magnitude of the d₂₄ nonlinear coefficient

Optics Letters published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C14H14N2O2, Formula: C14H14N2O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chinn, Alex J. published the artcilePhosphine/Photoredox Catalyzed Anti-Markovnikov Hydroamination of Olefins with Primary Sulfonamides via ¦Á-Scission from Phosphoranyl Radicals, Recommanded Product: 2,4,6-Triisopropylbenzenethiol, the publication is Journal of the American Chemical Society (2021), 143(43), 18331-18338, database is CAplus and MEDLINE.

A dual phosphine and photoredox catalytic system that enables direct formation of sulfonamidyl radicals from primary sulfonamides RSO₂NH₂ (R = 4-tert-butylphenyl, Me, cyclopropyl, thiophen-2-yl, etc.) was reported. Mechanistic investigations support that the N-centered radical is generated via ¦Á-scission of the P-N bond of a phosphoranyl radical intermediate, formed by sulfonamide nucleophilic addition to a phosphine radical cation. As compared to the recently well-explored ¦Â-scission chem. of phosphoranyl radicals, this strategy is applicable to activation of N-based nucleophiles and is catalytic in phosphine. The application of this activation strategy to an intermol. anti-Markovnikov hydroamination of unactivated olefins (such as cyclohexene, hex-1-ene, styrene, etc.) with primary sulfonamides RSO₂NH₂ is highlighted. A range of structurally diverse secondary sulfonamides [such as 4-(tert-butyl)-N-hexylbenzenesulfonamide, 4-(tert-butyl)-N-(3-phenylpropyl)benzenesulfonamide, 2-chloro-N-cyclohexylbenzenesulfonamide, etc.] can be prepared in good to excellent yields under mild conditions.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Recommanded Product: 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jalalzadeh-Esfahani, Mehrnoosh published the artcileImmobilization of palladium on benzimidazole functionalized mesoporous silica nanoparticles: catalytic efficacy in Suzuki-Miyaura reaction and nitroarenes reduction, HPLC of Formula: 13822-56-5, the publication is Journal of Porous Materials (2022), 29(4), 1149-1164, database is CAplus.

Benzimidazole functionalized mesoporous silica nanoparticles immobilized Pd(0)/Pd(II) has been proposed as an efficient catalyst for the one-pot preparation of biaryls via Suzuki-Miyaura cross-coupling reaction and for reduction of nitro-arenes to aromatic amines. Firstly, mesoporous silica nanoparticles (MSNs) were prepared by using soft template strategy. After template removal and subsequent functionalization by 3-aminopropyl trimethoxy silane (APS), further grafting was achieved via terephthalaldehyde (ALD) and 2-aminobenzimidazole (BzIm). Lastly palladium chloride was added to prepare the nanocatalyst. MSN-APS-ALD-BzIm-Pd has been characterized by Fourier-transform IR spectroscopy (FT-IR), Brunauer-Emmett-Teller (BET) surface area anal., powder X-Ray diffraction (PXRD), energy dispersive X-ray anal., high-resolution transmission electron microscopy, field emission scanning electron microscope, thermogravimetric anal., XPS and Inductively coupled plasma-optical emission spectroscopy (ICP-OES). After successful characterization, MSN-APS-ALD-BzIm-Pd was evaluated as a nanocatalyst in Suzuki-Miyaura cross-coupling reaction and in reduction of nitroarenes. According to the obtained results, both processes are performed in a short time and with high turnover frequency (TOF) and efficiency. Other advantages include heterogeneous and recyclable catalyst, green reaction conditions, small amounts of catalyst, facile work-up and user-friendly procedure.

Journal of Porous Materials published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, HPLC of Formula: 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Guozhang published the artcileDiscovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases, Recommanded Product: O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(12), 3495-3499, database is CAplus and MEDLINE.

We herein disclose a novel series of 4-aminopyrimidine-5-carboxaldehyde oximes that are potent and selective inhibitors of both EGFR and ErbB-2 tyrosine kinases, with IC₅₀ values in the nanomolar range. Structure-activity relationship (SAR) studies elucidated a critical role for the 4-amino and C-6 arylamino moieties. The X-ray co-crystal structure of EGFR with a (fluorobenzylindazolylamino)aminopyrimidine carboxaldehyde O-(2-methoxyethyl) oxime was determined and validated our design rationale.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is Al2H32O28S3, Recommanded Product: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shavaleev, Nail M. published the artcileNear-Infrared Luminescence of Nine-Coordinate Neodymium Complexes with Benzimidazole-Substituted 8-Hydroxyquinolines, Synthetic Route of 457-68-1, the publication is Inorganic Chemistry (2008), 47(19), 9055-9068, database is CAplus and MEDLINE.

A new class of benzimidazole-substituted 8-hydroxyquinoline ligands was prepared that contain a monoanionic tridentate N,N,O-coordinating unit. These ligands, e.g., benzimidazolyl(hydroxy)quinoline I (HL) and methylenebis(hydroxyquinolinylbenzimidazole) II (L2) form charge-neutral lanthanide complexes [Ln(L-R)₃]¡¤nH₂O or [Ln₂(L2)₃]¡¤nH₂O (n = 1-3) with early lanthanides from La^III to Gd^III inclusive. Crystallog. characterization was carried out for 11 complexes with 6 different ligands. In all of these structures, the lanthanide ion is nine-coordinated by three ligands arranged in an up-up-down fashion around the metal center. The coordination environment can be described as a tricapped trigonal prism, with N atoms of quinoline rings occupying capping positions. Upon deprotonation of the ligand and complex formation, a new absorption band appears in the visible range of the spectrum with a maximum at 466-483 nm and molar absorptivity of (7.2-18) ¡Á 10³ M^-1 cm^-1. Its origin probably is an intraligand phenolate-to-pyridyl charge transfer transition centered on the 8-hydroxyquinolate chromophore. Upon excitation in ligand absorption bands, new Nd^III complexes display characteristic metal-centered luminescence in the near-IR region from 850 to 1450 nm with quantum yields and lifetimes in solid state at room temperature ¡Ü0.34% and 1.2 ¦Ìs, resp.

Inorganic Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C7H5ClN2S, Synthetic Route of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia