Month: December 2022

Bohme, Horst published the artcileOptical studies on coumarins. II. Ultraviolet absorption of monohydroxycoumarins and derivatives, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft (1957), 405-12, database is CAplus.

cf. C.A. 51, 15270h. In comparative studies of 4 monohydroxycoumarins, the longwave absorption bands were found to be moved bathochromically by introduction of a hydroxy group in the 6 or 7 position, while the corresponding maximum of 5-and 8-hydroxycoumarins lies at shorter wave lengths. As with coumarin itself 3 bands appear with 5-, 6-, and 8-hydroxycoumarin. 7-Hydroxycoumarin does not produce the medial bands with an inflection at 240 m¦Ì. Dihydroxy-trans-cinnamic acids are optically very similar to their methylated derivatives, but big differences were noted between hydroxycoumarins and dimethoxy-cis-cinnamic acids.

Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khomutov, R. M. published the artcileHydroxylamine derivatives. IX. Synthesis of some O-substituted hydroxylamines, Computed Properties of 6084-58-8, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1967), 1820-3, database is CAplus.

Saturation of 150 g. dry MeCN in 170 ml. EtOH with HCl at 0-5¡ã and keeping 2 days in the cold gave a precipitate of Et acetimidoacetate-HCl, which was separated and treated with aqueous NaOH at -10¡ã, then with 275 g. NH2OH.HCl in C6H6-H2O and stirred 1 hr. at room temperature to yield 45-50% MeC(:NOH)OEt (I), m. 32¡ã, b12 62¡ã. I was converted to the Na salt by MeONa in MeOH and treated with an alkyl halide to give the following MeC(:NOR)OEt (II): (R, % yield, b.p., and n20D given): Et, 70, b55 60¡ã, 1.4141; iso-Pr 84, 134-6¡ã, 1.4155; iso-Bu, 81, 160¡ã, 1.4240; MeSCH2CH2, 34, b7 85-7¡ã, -; PhCH2, 75, b12 122¡ã, 1.5030. II in Et2O was treated with 1 mole H2O and HCl in Et2O to yield on standing the following RONH2.Hcl (R and m.p. given): Et, 128¡ã; iso-Pr, 85-6.5¡ã; iso-Bu 129.5-30.5¡ã; MeSCH2CH2, 96¡ã (decomposition); PhCH2, 224-6¡ã (free base b3 64-4.5¡ã). BrCH2CO2K (0.32 mole) in H2O treated with 0.32 mole KOH and 0.32 mole I 0.5 hr. at 35¡ã, then diluted at -10¡ã with (CH2Cl)2 and acidifying with HCl, then evaporating in vacuo, gave a residue that on reevapn. with HCl gave 65-70% aminoxyacetic acid-HCl, m. 150-1¡ã (iso-PrOH); heating with EtOH-HCl gave the Et ester HCl salt, m. 115-16¡ã, while heating with benzyl alc. in the presence of p-MeC6H4SO3H in C6H6 gave, after azeotropic removal of H2O, 77% benzyl aminoxyacetate, m. 135-7¡ã. Heating Me N-(ethylidenethoxy)aminoxypropionate in concentrated HCl 2.5 hrs. gave on evaporation 80% free acid-HCl, m. 151¡ã, which with benzyl alc. as above gave the benzyl ester of ¦Â-aminoxypropionic acid, m. 112-14¡ã. I and CF2:CFCl kept in an autoclave with alc. EtONa several days gave 85% MeC(OEt):NOCF2CHFCl, b12 61-2.5¡ã. CCl3CH2OH and ClNH2 in the presence of EtONa in Et2O at -10¡ã, then at room temperature 1 day, gave CCl3CH2ONH2.HCl, m. 196-7¡ã (iso-PrOH), after saturation of the crude product with dry HCl in Et2O.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Computed Properties of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Vignesh, Rajendran Babhu published the artcileCorrosion protection behaviour of sol-gel derived N,N-dimethylthiourea doped 3-glycidoxypropyltrimethoxysilane on aluminium, Recommanded Product: 1,1-Dimethylthiourea, the publication is Progress in Organic Coatings (2014), 77(1), 136-141, database is CAplus.

The present work describes the anticorrosion features of inhibitor doped sol-gel coating on Al metal. Sol-gel coatings were prepared by using 3-glycidoxypropyltrimethoxysilane (GPTMS) as parent precursor. In order to improve the corrosion resistance property of coating, N,N-dimethylthiourea was added into the sol-gel matrix. The corrosion inhibitor doped sol-gel coating on metal was characterized by Fourier transform IR anal. (FTIR) and scanning electron microscope (SEM). Inhibition effect of N,N-dimethylthiourea doped GPTMS coating on Al substrates in 1% NaCl solution was investigated using electrochem. impedance (EIS) and polarization studies. EIS results showed that the corrosion resistance of sol-gel coating significantly improved upon addition of N,N-dimethylthiourea. The study had outlined the nuances of doping an organic inhibitor to enhance the protection ability of sol-gel coating on Al metal.

Progress in Organic Coatings published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C8H10S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saha, Satyajit published the artcileFunctionalized proline with double hydrogen bonding potential: highly enantioselective Michael addition of carbonyl compounds to ¦Â-nitrostyrenes in brine, Category: catalysis-chemistry, the publication is Tetrahedron Letters (2010), 51(40), 5281-5286, database is CAplus.

Simple synthetic manipulation of S-proline allows access to prolinamides as catalysts capable of double hydrogen bonding for enantioselective Michael addition reactions of carbonyl compounds to ¦Â-nitrostyrenes. It is shown that prolinamide catalyst I leads to addition products with a high diastereo- as well as enantioselectivity. The transition state structure involving the binding of electrophilic nitrostyrene via two H-bonds is believed to be further stabilized by ¦Ð,¦Ð stacking interactions mediated by the tosyl ring.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fripiat, Jose J. published the artcileAdsorption of amines by montmorillonites. III. Nature of the aminemontmorillonite bond, Formula: C3H12Cl2N2, the publication is Bulletin de la Societe Chimique de France (1962), 635-44, database is CAplus.

The complexes formed between Macid or Msatd. and C₆H₆ solutions of BuNH₂, PrNH₂, ethylenediamine and propylenediamine were studied by infrared spectroscopy. In the Macid complexes there are alkyl mono- and alkyl diammonium cations. Since the amount of adsorption of the diamines is larger than the exchange capacity of the montmorillonite, R(NH₃⁺)₂ becomes converted to the form of (NH₂)R(NH₃⁺). Neutral amine adsorption is identified in these complexes and is similar to that observed on Msatd. Spectroscopic evidence also supports the existence of 2 orientations for the C chains, parallel and perpendicular to the plane of the silicates. Addition of NaOMe to the monoamine complexes expels the amine but MeOH is trapped inside the lattice as it contracts. The infrared spectra of this material shows a pattern characteristic of solid MeOH. When NaOMe is added to the diamine complexes, there is only a partial lattice contraction and the infrared pattern shows pure MeOH vapor characteristics.

Bulletin de la Societe Chimique de France published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ignat’eva, S. N. published the artcile[[N-(1,3,5-Triazaadamant-7-yl)amino]alkyl]phosphine oxides, Safety of 1,3,5-Triazaadamantan-7-amine, the publication is Zhurnal Obshchei Khimii (1996), 66(11), 1800-1801, database is CAplus.

Treating RCH:NR’ (R = 4-EtOC₆H₄, 4-Me₂NC₆H₄, 3,4-methylenedioxyphenyl; R’ = 1,3,5-triazaadamant-7-yl throughout this abstract) with Ph₂PH in C₆H₆ gave the corresponding R’NHCHRP(O)Ph₂.

Zhurnal Obshchei Khimii published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Safety of 1,3,5-Triazaadamantan-7-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Giessel, Josephine M. published the artcileSubstituted cinnamic anhydrides act as selective inhibitors of acetylcholinesterase, Formula: C9H7NO4, the publication is Bioorganic Chemistry (2019), 103058, database is CAplus and MEDLINE.

Cinnamic anhydrides have been shown to be more than reactive reagents, but they also act as inhibitors of the enzyme acetylcholinesterease (AChE). Thus, out of a set of 33 synthesized derivatives, several of them were mixed type inhibitors for AChE (from elec. eel). Thus, (E)-3-(2,4-dimethoxyphenyl)acrylic anhydride (2c) showed K_i = 8.30 ¡À 0.94 ¦ÌM and K_i‘ = 9.54 ¡À 0.38 ¦ÌM, and for (E)-3-(3-chlorophenyl)acrylic anhydride (2u) K_i = 8.23 ¡À 0.93 ¦ÌM and K_i‘ = 13.07 ¡À 0.46 ¦ÌM were measured. While being not cytotoxic to many human cell lines, these compounds showed an unprecedented and noteworthy inhibitory effect for AChE but not for butyrylcholinesterase (BChE).

Bioorganic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Giessel, Josephine M. published the artcileSubstituted cinnamic anhydrides act as selective inhibitors of acetylcholinesterase, Category: catalysis-chemistry, the publication is Bioorganic Chemistry (2019), 103058, database is CAplus and MEDLINE.

Cinnamic anhydrides have been shown to be more than reactive reagents, but they also act as inhibitors of the enzyme acetylcholinesterease (AChE). Thus, out of a set of 33 synthesized derivatives, several of them were mixed type inhibitors for AChE (from elec. eel). Thus, (E)-3-(2,4-dimethoxyphenyl)acrylic anhydride (2c) showed K_i = 8.30 ¡À 0.94 ¦ÌM and K_i‘ = 9.54 ¡À 0.38 ¦ÌM, and for (E)-3-(3-chlorophenyl)acrylic anhydride (2u) K_i = 8.23 ¡À 0.93 ¦ÌM and K_i‘ = 13.07 ¡À 0.46 ¦ÌM were measured. While being not cytotoxic to many human cell lines, these compounds showed an unprecedented and noteworthy inhibitory effect for AChE but not for butyrylcholinesterase (BChE).

Bioorganic Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bhela, Irene preet published the artcileTritylamine as an Ammonia Surrogate in the Ugi Reaction Provides Access to Unprecedented 5-Sulfamido Oxazoles Using Burgess-type Reagents, SDS of cas: 104-03-0, the publication is Organic Letters (2021), 23(9), 3610-3614, database is CAplus and MEDLINE.

Starting from a wide range of ¦Á-acylamino amide substructures RNHC(O)CH(R¹)NHC(O)R² (R = pentyl, Bn, [3-(1H-1,3-benzodiazol-1-ylmethyl)phenyl]methyl, etc.; R¹ = H, Me, n-Pr, hexyl; R² = Me, Ph, (4-nitrophenyl)methyl, etc.) synthesized using tritylamine as an ammonia surrogate in the Ugi reaction, Burgess-type reagents R³N^–S(O)₂N⁺(CH₂CH₃)₃ (R³ = C(O)OMe, C(O)OBn) enable cyclodehydration and afford unprecedented oxazole scaffolds I with four points of diversity, including a sulfamide moiety in the 5-position. The synthetic procedure employs readily available starting materials and proceeds smoothly under mild reaction conditions with good tolerance for a variety of functional groups, coming to fill a gap in the field of oxazole compounds

Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, SDS of cas: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lutskii, A. E. published the artcileElectron interactions in polyfunctional organic compounds, Synthetic Route of 1821-27-8, the publication is Zhurnal Fizicheskoi Khimii (1971), 45(4), 754-8, database is CAplus.

The electronic interactions between bridging (Y) and ring (X) substituents of aromatic compounds 4-X1C6H4YC6H4X2-4 (where Y = CO, NH; X1, X2 = H, NO2, MeO, Me2N) were studied by using ir spectra (¦ÍCO, ¦ÍNH) of CCl4, C2H4Cl2, and THF solutions Both ¦ÍCO and ¦ÍNH show solvent effects. The ¦¤¦Í values (referred to unsubstituted compounds) are discussed in terms of X and Y electron-donor or -acceptor capacity and the relation between X1 and X2 conjugation effects. The ¦¤¦Í values of X1 and X2 are non-additive (always less than the sum). Correlations ¦¤¦ÍCO/¦¤E1/2, ¦¤¦ÍNH/¦¤E1/2 (¦¤E1/2 = half-wave potential) and ¦¤¦ÍCO/¦Ò Jaffe are found. If X1 = X2 the ring substituent effect is concurrent with that of Y. If X1 and X2 are not the same, the predominant effect is the effect of X which has the sign for the conjugation effect opposite, to that of Y.

Zhurnal Fizicheskoi Khimii published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Synthetic Route of 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia