Month: December 2022

Focsaneanu, Kathy-Sarah published the artcilePotential analytical applications of differential fluorescence quenching: Pyrene monomer and excimer emissions as sensors for electron deficient molecules, Safety of 2,6-Diisopropyl-N,N-dimethylaniline, the publication is Photochemical & Photobiological Sciences (2005), 4(10), 817-821, database is CAplus and MEDLINE.

Quenching of the monomer and excimer emissions from pyrene allows excellent discrimination in the detection of electron-deficient mols.; this characteristic could be used to detect explosives and for rapid screening of complex samples suspected of containing explosives. The method responds to electron deficient mols. other than nitro compounds (e.g., 1,4-dicyanobenzene), giving some false positives; in this case, however, the method is unlikely to lead to false negatives, a desirable characteristic in security-related applications.

Photochemical & Photobiological Sciences published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Safety of 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhun’, V. I. published the artcileReaction of Germanium Tetrachloride with Chloro(phenyl)silanes in the Presence of Aluminum Chloride, Recommanded Product: Difluorodiphenylsilane, the publication is Russian Journal of General Chemistry (2005), 75(6), 867-869, database is CAplus.

The effect of the quantity of AlCl₃ on the direction and depth of reaction of GeCl₄ with chloro(phenyl)silanes Ph_nSiCl_4-n (n = 1-3) was studied to show that radical exchange between Ge and Si is initiated only if the mixture contains ¡Ý2.5-5% of AlCl₃. With trichloro(phenyl)silane, the radical exchange is initiated at 5% of AlCl₃ and results in exclusive formation of trichloro(phenyl)germane. The reactions of GeCl₄ with dichlorodiphenylsilane and chlorotriphenylsilane in the presence = 2.5-7.5% of AlCl₃ give dichlorodiphenylgermane as the major product, and at AlCl₃ concentrations of >10% the major product becomes trichloro(phenyl)germane.

Russian Journal of General Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C23H20BN, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yavari, Issa published the artcileA one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from thioamides or thioureas and 2-chloro-1,3-dicarbonyl compounds in an ionic liquid, Computed Properties of 6972-05-0, the publication is Monatshefte fuer Chemie (2009), 140(2), 209-211, database is CAplus.

A simple one-pot synthesis of functionalized Et 1,3-thiazole-5-carboxylates from the reaction of 2-chloro-1,3-dicarbonyl compounds with thioureas or thioamides in the presence of 1-butyl-3-methylimidazolium trifluoromethanesulfonate was described.

Monatshefte fuer Chemie published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C30H24BrCuN2P, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Isiklan, Muhammet published the artcileSynthesis, structural characterization, and cytotoxic activity of new spirocyclic octachlorocyclotetraphosphazenes, Quality Control of 140-28-3, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2016), 191(9), 1216-1222, database is CAplus.

Octachlorocyclotetraphosphazene, N₄P₄Cl₈, (1) was reacted with N,N’-dibenzylethylenediamine to synthesize partially substituted monospiro- (2), dispiro- (5) and tetraspirocyclotetraphosphazene (8) derivatives The reactions of and with excess pyrrolidine and morpholine produced fully substituted pyrrolidino (3 and 6) morpholino (4 and 7) spirocyclotetraphosphazenes. The structures of the compounds were determined with 1D (¹H, ¹³C, ³¹P, and DEPT) NMR, 2D (HSQC) NMR, ESI-MS, FTIR, and elemental anal. The solid-state structures of and were examined by x-ray crystallog. In 7, intramol. C-H¡¤¡¤¡¤O hydrogen bonds link the mols. into centrosym. dimmers. The cytotoxic activity of all the compounds against human cervix carcinoma cell lines (HeLa) was investigated. The study showed that these compounds exert limited cytotoxic, apoptotic and necrotic effects on HeLa cancer cell lines.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Triandafillidi, Ierasia published the artcileSynthesis of ¦Ã-Lactones Utilizing Ketoacids and Trimethylsulfoxonium Iodide, Related Products of catalysis-chemistry, the publication is Organic Letters (2019), 21(14), 5533-5537, database is CAplus and MEDLINE.

¦Ã-Ketoacids, a ¦Ä-ketoacid, and a ¦Ã-ketoamide underwent Johnson-Corey-Chaykovsky epoxidation with trimethylsulfoxonium iodide and NaH in DMSO to yield ¦Ã-(hydroxymethyl)-¦Ã-lactones, a ¦Ä-(hydroxymethyl)-¦Ä-lactone, and a ¦Ã-(hydroxymethyl)-¦Ã-lactam in 22-76% yields. The method was used in an attempted synthesis of (+)-asperolide C; (-)-epi-asperolide C was obtained in two steps from (+)-podocarpic acid.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C23H43NP2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Verdoliva, Valentina published the artcileZeolites employed as basic catalyst for nucleophilic substitution reactions: An analysis of the adopted approach and hypothesized new perspectives, Application of Fmoc-Pro-OH, the publication is Inorganica Chimica Acta (2021), 120630, database is CAplus.

The present article reports on an excursus of substitution reactions performed on different halo-compounds and several cyclic sulfamidates that are readily accessible to nucleophilic attack. Essentially, a cysteine sulfhydryl group is employed as nucleophile and the process is promoted by the basic sites of activated Zeolites A (4 ? mol. sieves). The catalysis occurs on the external surface of the zeolite, as also assessed by the FT-IR anal. executed on mols. adsorbed on the catalyst. The moderate basicity of the zeolite lattice surface is the prerequisite for conducting chemoselective and in some case stereoselective peptide modifications. The developed methodol. allows an efficient one-pot introduction of exogenous moieties into peptides, useful for developing peptidomimetic and/or peptide-based probes.

Inorganica Chimica Acta published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C18H10, Application of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Garrigou, Michael published the artcileAccelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology, Safety of Fmoc-Pro-OH, the publication is Journal of Medicinal Chemistry (2022), 65(13), 8961-8974, database is CAplus and MEDLINE.

Macrocyclic peptides can disrupt previously intractable protein-protein interactions (PPIs) relevant to oncol. targets such as KRAS. Early hits often lack cellular activity and require meticulous improvement of affinity, permeability, and metabolic stability to become viable leads. We have validated the use of the Automated Ligand Identification System (ALIS) to screen oncogenic KRAS^G12D (GDP) against mass-encoded mini-libraries of macrocyclic peptides and accelerate our structure-activity relationship (SAR) exploration. These mixture libraries were generated by premixing various unnatural amino acids without the need for the laborious purification of individual peptides. The affinity ranking of the peptide sequences provided SAR-rich data sets that led to the selection of novel potency-enhancing substitutions in our subsequent designs. Addnl. stability and permeability optimization resulted in the identification of peptide 7 (I) that inhibited pERK activity in a pancreatic cancer cell line. More broadly, this methodol. offers an efficient alternative to accelerate the fastidious hit-to-lead optimization of PPI peptide inhibitors.

Journal of Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Safety of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Truong, Ngoc published the artcileDirect carbon-carbon bond formation via reductive soft enolization: a syn-selective Mannich addition of ¦Á-iodo thioesters, Category: catalysis-chemistry, the publication is Organic & Biomolecular Chemistry (2016), 14(33), 7864-7868, database is CAplus and MEDLINE.

The ¦Â-amino carboxylic acid moiety is a key feature of numerous important biol. active compounds We describe a syn-selective direct Mannich addition reaction that uses ¦Á-iodo thioesters and sulfonyl imines and produces ¦Â-amino thioesters. Enolate formation is achieved by reductive soft enolization. The products of the reaction provide straightforward access to biol. important ¦Â-lactams through a variety of known reactions.

Organic & Biomolecular Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C7H10O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Edo, Kiyoto published the artcileExtra-weak chemiluminescence of drugs. II. Relationship between the structure and the extra-weak chemiluminescence of organic compounds, HPLC of Formula: 38260-01-4, the publication is Chemical & Pharmaceutical Bulletin (1985), 33(7), 3042-5, database is CAplus.

The extra-weak chemiluminescence was measured for 116 organic compounds with simple structures having various functional groups. Alkynes, aliphatic amines, aliphatic aldehydes, epoxides and peroxides had high emission intensities.

Chemical & Pharmaceutical Bulletin published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, HPLC of Formula: 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hasebe, Shigeru published the artcileRemoval of lead(2+) ion by absorbing particle flotation using zeolite, Name: Dodecylamineacetate, the publication is Iwate Daigaku Kogakubu Kenkyu Hokoku (1983), 53-9, database is CAplus.

The flotation of zeolite with dodecylamine?acetate (DAA) [2016-56-0] for the removal of Pb²⁺ was investigated. Zeolite particle can be effectively floated with DAA at pH 2-7. The suitable size of zeolite for flotation with a column type separator is 104-137¦Ì, and the recovery of zeolite is ?95% with DAA 15 kg/ton. Under the same conditions, the column flotation showed a higher recovery of zeolite and removal of Pb²⁺ than did the Denver type flotation equipment. The zeolite may be used for 3 cycles to remove Pb²⁺. Adsorbing particle flotation in the column can be treated with a higher concentration and for a shorter time than with the percolation method.

Iwate Daigaku Kogakubu Kenkyu Hokoku published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Name: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia