Month: December 2022

Dwarakanath, K. published the artcileAssignments for the fundamental vibrations of N,N-dimethylthiourea and N,N-dimethylselenourea, Synthetic Route of 6972-05-0, the publication is Indian Journal of Pure and Applied Physics (1979), 17(3), 171-5, database is CAplus.

The IR spectra of Me₂NC(S)NH₂ (I) and Me₂NC(Se)NH₂ (II) and their N-deuterated and S-Me derivatives were measured between 4000 and 30 cm^-1. The fundamental frequencies of I and II were assigned and supported by normal coordinate calculations for the in-plane and out-of-plane modes of I–d₀ and –d₂. The coordinate treatment was extended to the in-plane vibrations of I–d₀ and –d₂ by introducing min. changes in transferring the force constants from I.

Indian Journal of Pure and Applied Physics published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Synthetic Route of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shechter, Yoram published the artcileNewly Designed Modifier Prolongs the Action of Short-Lived Peptides and Proteins by Allowing Their Binding to Serum Albumin, Name: Propane-1,3-diamine dihydrochloride, the publication is Bioconjugate Chemistry (2012), 23(8), 1577-1586, database is CAplus and MEDLINE.

We found that human serum albumin (HSA) contains a single binding domain for derivatives of long-chain fatty acid (LCFA)-like mols. in which the carboxylate is replaced by sulfonate. Accordingly, we have synthesized 16-sulfo-hexadecanoic acid-N-hydroxysuccinimide ester [HO₃S-(CH₂)₁₅-CONHS], an agent that reacts selectively with the amino side chains of peptides and proteins. A macromol. containing a single 16-sulfohexadecanoate moiety associating with albumin with a K_a value of 0.83¡À0.08¡Á10⁶ M^-1, a sufficient affinity to extend the actions in vivo of such short-lived peptides and proteins. S.c. administration of insulin-NHCO-(CH₂)₁₅-SO₃^– into mice facilitated a glucose-lowering effect 4.3 times in duration and 6.6 times in area under the curve (AUC) as compared to an in vitro equipotent amount of Zn²⁺-free insulin. Similarly, s.c. and i.v. administration of exendin-4-NHCO-(CH₂)₁₅-SO₃^– to mice yielded prolonged and stable reduction in glucose level, 5-9-fold longer than that of exendin-4. Also, a single s.c. administration of human interferon-¦Á2-[NH-CO-(CH₂)₁₅-SO₃^–]₃ to mice yielded circulating antiviral activity over a period of 40 h. In conclusion, a simple, hydrophilic reagent has been engineered, synthesized, and studied. Its linkage to peptides and proteins in a mono-modified fashion yielded hydrophilic, prolonged acting derivatives, due to their acquired ability to associate with serum albumin after administration.

Bioconjugate Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C20H28B2O4S2, Name: Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Suzuki, Toshio published the artcileA simple and convenient preparation of triethylene tetramine dihydrochloride (trien) for the treatment of Wilson’s disease and its stability, HPLC of Formula: 38260-01-4, the publication is Byoin Yakugaku (1987), 13(6), 335-9, database is CAplus.

Treatment of triethylene tetramine with anhydrous MeOH-HCl solution derived from AcCl and MeOH at 0¡ã, followed by recrystallization provided pure triethylene tetramine di-HCl (trien di-HCl). The compound is less hygroscopic than that prepared by the preceding procedure. Examination of its stability and drug activity under various conditions suggests than an aqueous solution of trien could also be useful for the treatment of Wilson’s disease.

Byoin Yakugaku published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C28H18O4, HPLC of Formula: 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kocabas, Erdal published the artcileA rapid and high-yielding synthesis of thiazoles and aminothiazoles using tetrabutylammonium salts, Category: catalysis-chemistry, the publication is Heterocycles (2010), 81(12), 2849-2854, database is CAplus.

A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of Bu₄NPF₆ at room temperature was developed. The products were formed rapidly within 15 min in high yields. The method is simple, rapid, and practical, generating thiazoles in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, ¹H NMR, ¹³C NMR, and elemental anal.

Heterocycles published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Barut, Burak published the artcileAzole antifungal compounds could have dual cholinesterase inhibitory potential according to virtual screening, enzyme kinetics, and toxicity studies of an inhouse library, Related Products of catalysis-chemistry, the publication is Journal of Molecular Structure (2021), 130268, database is CAplus.

Recent advances in cholinesterase inhibitors opened new venues for the treatment of cognitive disorders like Alzheimer’s disease. Certain azole antifungals like miconazole were reported to have cholinesterase inhibitory effects and hence ameliorate cognitive deficits. In this study, we tested a set of azole antifungal derivatives selected through virtual screening of an inhouse library for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory effects. Compound 61 showed potent and selective AChE inhibition (IC50 = 8.77¦ÌM). The study also yielded dual AChE/BChE inhibitors in addition to a number of potent AChE inhibitors. Enzyme kinetics assays revealed that AChE inhibitors were competitive inhibitors. All the active compounds were imidazole derivatives and the modeling study showed that imidazole at protonated state contributed greatly to the binding interactions with some key residues of AChE and BChE active site. The active derivatives had negligible cytotoxic effects on murine fibroblast viability. According to our results, compounds featuring the classical scaffold of azole antifungal drugs could hold high potential for anticholinesterase drug design.

Journal of Molecular Structure published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Farrell, David P. published the artcileAnion binding by fluorescent Fmoc-protected amino acids, SDS of cas: 17351-61-0, the publication is Supramolecular Chemistry (2016), 28(1-2), 45-52, database is CAplus.

Two non-natural amino acids with fluorescent urea side-chains were prepared from Fmoc-protected aspartic and glutamic acids. In acetonitrile solution, the emission of the Asp derivative is strongly quenched by HCO₃^– or H₂PO₄^– (K = 10⁴ M^-1) but not by less-basic Cl^– or NO₃^–. Solutions containing excess bicarbonate ion appear peach-colored, with gamma_abs at 394 and 495 nm ascribed to the anion complex and urea-deprotonated sensor, resp. Corresponding fluorescence bands are observed at 475 and 579 nm. Dihydrogenphosphate is not sufficiently basic to remove H⁺ from the ground state of the fluorophore. However, deprotonation of the excited state occurs in the presence of>1 equiv of H₂PO₄^–. According to ¹H NMR in DMSO-d₆, recognition of H₂PO₄^– occurs at the urea N-H groups and the amino acid backbone N-H. DFT techniques further predict that the backbone C = O group accepts an H-bond from the anion. The Glu derivative has lower affinity for anions; the addnl. CH₂ group in its side-chain apparently sets the backbone N-H and C = O too far from the urea to contribute significantly to binding. To demonstrate suitability for standard Fmoc-based solid-phase peptide synthesis, the Asp derivative was incorporated into a 12-residue peptide.

Supramolecular Chemistry published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, SDS of cas: 17351-61-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Canonica, L. published the artcileThe hypocholesterolemic action of some synthetic compounds, SDS of cas: 1949-41-3, the publication is Drugs Affecting Lipid Metab., Proc. Symp., Milan (1961), 328-35, database is CAplus.

The anti-cholesterolemic effect of some phenylsubstituted aliphatic carboxylic acids was examined by their effect on the hyper-cholesterolemia induced in rats by intraperitoneal injection of 500 mg./kg. of Triton WR 1339, blood cholesterol being determined 22 hrs. after injection by Bloor’s method and the effect evaluated statistically. Toxicity of the compounds in mice and the min. dose giving a significant reduction in blood cholesterol were determined Thirty-four compounds were synthesized and tested; these were in 6 groups in which a phenyl group was introduced in various positions along an aliphatic C chain. The groups were: butyric acids; valeric and isovaleric acids; methylbutyric acids; unsaturated acids with isoprenoid structures; diand tetrahydrogeranic acids; and mevalonic acids. Among ¦Á-phenylbutyric acids, para substitution of OH and NH₂ resulted in inactive compounds whereas the p-Cl, -Me, and -OMe compounds were active. Phenyltetrahydrogeranic acid and phenylmevalonic acid derivatives were inactive. Phenyl derivatives of C₅ acids with a branched chain were active, particularly ¦Â-benzylidenebutyric (I), ¦Á-methyl-¦Ã-phenylbutyric (II), ¦Á-benzylbutyric (III), ¦Á-phenyldimethylacrylic (IV), and ¦Â-phenylisovaleric (V) acids. The L.D.₅₀ (mice mg./kg.), min. effective dose (mg./kg.), and therapeutic index of these were: I, 520, 130, 4; II, 712, 71, 10; III, 1068, 215, 4; IV, 1700, 340, 5; V, 1550, 387, 4. The only active straight-chain compound was ¦Â-phenylvaleric acid (748, 249, 3).. Biosynthesis of fatty acids from acetate-1-C¹⁴ was inhibited by I, IV, and V to varying degrees; cholesterol synthesis was similarly inhibited by I and cholesterol synthesis from mevalonate-2-C¹⁴ was inhibited by all except II. The anticholestcrolemic effect of I was confirmed clin. with doses of 200 mg./day.

Drugs Affecting Lipid Metab., Proc. Symp., Milan published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, SDS of cas: 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lunn, George published the artcileDecontamination of aqueous solutions of biological stains, Quality Control of 10510-54-0, the publication is Biotechnic & Histochemistry (1991), 66(6), 307-15, database is CAplus and MEDLINE.

Aqueous solutions of a number of biol. stains were completely decontaminated to the limit of detection using Amberlite resins. Amberlite XAD-16 was the most generally applicable resin but Amberlite XAD-2, Amberlite XAD-4, and Amberlite XAD-7 could be used to decontaminate some solutions Solutions of Acridine Orange, Alcian Blue 8GX, Alizarine Red S, azure A, azure B, congo red, cresyl violet acetate, crystal violet, eosin B, erythrosin B, ethidium bromide, Janus Green B, methylene blue, Neutral Red, nigrosin, orcein, propidium iodide, Rose Bengal, safranine O, Toluidine Blue O, and trypan blue could be completely decontaminated to the limit of detection and solutions of eosin Y and Giemsa stain were decontaminated to very low levels (<0.02 ppm) using Amberlite XAD-16. Fourteen of the 23 stains tested were mutagenic to Salmonella?typhimurium. None of the completely decontaminated solutions were mutagenic.

Biotechnic & Histochemistry published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Quality Control of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Zhi-Qi published the artcileDifluoromethylation of Unactivated Alkenes Using Freon-22 through Tertiary Amine-Borane-Triggered Halogen Atom Transfer, Category: catalysis-chemistry, the publication is Journal of the American Chemical Society (2022), 144(31), 14288-14296, database is CAplus and MEDLINE.

The application of abundant and inexpensive fluorine feedstock sources to synthesize fluorinated compounds is an appealing yet underexplored strategy. Here, authors report a photocatalytic radical hydrodifluoromethylation of unactivated alkenes with an inexpensive industrial chem., chlorodifluoromethane (ClCF₂H, Freon-22). This protocol is realized by merging tertiary amine-ligated boryl radical-induced halogen atom transfer (XAT) with organophotoredox catalysis under blue light irradiation A broad scope of readily accessible alkenes featuring a variety of functional groups and drug and natural product moieties could be selectively difluoromethylated with good efficiency in a metal-free manner. Combined exptl. and computational studies suggest that the key XAT process of ClCF₂H is both thermodynamically and kinetically favored over the hydrogen atom transfer pathway owing to the formation of a strong boron-chlorine (B-Cl) bond and the low-lying antibonding orbital of the carbon-chlorine (C-Cl) bond.

Journal of the American Chemical Society published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H21BO3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sanchez-Carnerero, Esther M. published the artcileSpeeding up heterogeneous catalysis with an improved highly reusable catalyst for the preparation of enantioenriched secondary alcohols, COA of Formula: C16H20N2, the publication is Reactive & Functional Polymers (2017), 23-30, database is CAplus.

A new catalytic heterogeneous system, very efficient and highly reusable, for the preparation of enantioenriched secondary alcs. through the addition of diethylzinc to benzaldehyde has been developed. This system is based on a chiral bis(hydroxyamide) ligand supported on crosslinked polystyrene. The catalyst has been shown to be very efficient, leading to the corresponding secondary alc. with an enantiomeric excess of 93% in a time as short as 2 h and using just 4% of the heterogeneous catalyst and just 1.5 equiv of the organozinc reagent. We have demonstrated that the new catalyst is very stable and can be efficiently recycled with no decrease in yield or enantioselectivity. The presented system has an unquestionable interest for the potential transfer of the reaction to the industry by using catalytic fluidized-bed reactors.

Reactive & Functional Polymers published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia