Month: December 2022

Usui, Shinnosuke published the artcileThe effect of grade of quartz on the cationic flotation of quartz from hematite, Recommanded Product: Dodecylamineacetate, the publication is Tohoku Daigaku Senko Seiren Kenkyusho Iho (1980), 36(1), 17-22, database is CAplus.

Flotation experiments were carried out with quartz [14808-60-7] and hematite [1317-60-8] (44-53 ¦Ì), sep. and mixed, using a Denver-type laboratory floatator, at various values of pH and collector (dodecyl ammonium acetate DAA [2016-56-0]) concentration, with special reference to the effect of the grade of quartz on the reverse flotation of quartz. The individual flotation indicated that complete flotation of quartz was obtained at a DAA concentration of (5 ¡Á 10^-5)-(1 ¡Á 10^-4)M (0.25-0.5 kg/ton) and at pH 5-5.4, midpoint of isoelec. points of resp. minerals, while no flotation of hematite took place under corresponding conditions. In the flotation of the mixed sample an incomplete separation was obtained under the same conditions; the floatability of quartz decreased while that of hematite increased. The floatability of quartz decreased with decrease in grade, indicating that the reverse flotation of low-grade quartz from hematite becomes difficult. The poor separation of quartz described above was improved considerably by the addition of 1 ¡Á 10^-4M sodium gluconate [527-07-1].

Tohoku Daigaku Senko Seiren Kenkyusho Iho published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H10O4, Recommanded Product: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yasukawa, Tomohiro published the artcileHomologation of Aryl Aldehydes Using Nitromethane as a C1 Source Enabled by Nitrogen-Doped Carbon-Supported Palladium Catalysts, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is ACS Catalysis (2022), 12(10), 5887-5893, database is CAplus.

Homologation of aryl aldehydes provides useful synthetic intermediates, but it requires multistep reactions and generates significant amounts of waste. Herein, such reactions using nitromethane as a C1 source through nitroolefin formation, partial hydrogenation to oximes, and hydration of oximes were considered; however, the control of selectivity in the second reaction was challenging. To achieve this pathway, nitrogen-doped carbon-incarcerated palladium nanoparticle catalysts were developed for selective hydrogenation. The presence of nitrogen dopants effectively tuned the catalytic activity to show almost perfect selectivity, high activity, and reusability under ambient pressure. Then a three-step homologation reaction was performed in both batch and flow systems with only one purification step. The sequential continuous-flow system worked efficiently for more than 2 days to afforded the product in a high yield.

ACS Catalysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C11H10ClNO, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Inaba, Masanori published the artcileNucleophilic fluoroalkylation/cyclization route to fluorinated phthalides, Name: Trimethyl(perfluorophenyl)silane, the publication is Beilstein Journal of Organic Chemistry (2018), 182-186, database is CAplus and MEDLINE.

A versatile and practical method for the synthesis of C3-perfluoroalkyl-substituted phthalides in a one-pot manner was described. Upon treatment of KF or triethylamine, 2-cyanobenzaldehyde reacted with (perfluoroalkyl)trimethylsilanes via nucleophilic addition and subsequent intramol. cyclization to give perfluoroalkylphthalides in good yields.

Beilstein Journal of Organic Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Name: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Watanabe, Hiroyuki published the artcileSynthesis and biological evaluation of radioiodinated 3-phenylcoumarin derivatives targeting myelin in multiple sclerosis, Product Details of C8H7NO4, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(24), 127562, database is CAplus and MEDLINE.

Myelin is a lipid multilayer involved in the rate of nerve transmission, and its loss is a pathol. feature of multiple sclerosis in brains. Since in vivo imaging of myelin may be useful for drug development, early diagnosis, and monitoring the disease stage, the authors designed, synthesized, and evaluated eight novel radioiodinated 3-phenylcoumarin derivatives as imaging probes targeting myelin. In the biodistribution study using normal mice, all compounds displayed sufficient brain uptake, ranging from 2.5 to 5.0% ID/g, at 2 min postinjection. On ex vivo autoradiog., 6-[¹²⁵I]- and 7-[¹²⁵I]-labeled (dimethylaminophenyl)coumarins showed high binding affinity for myelin in the normal mouse brain. In addition, the radioactivity accumulation of the 7-[¹²⁵I]-labeled (dimethylaminophenyl)coumarin in the white matter of the spinal cord in the exptl. autoimmune encephalomyelitis mice was lower than that in naive mice. These results suggest that a 7-[¹²³I]-labeled (dimethylaminophenyl)coumarin shows potential as a single photon emission computed tomog. probe targeting myelin.

Bioorganic & Medicinal Chemistry Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C6H13I, Product Details of C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Murafuji, Hidenobu published the artcileDiscovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors, Application In Synthesis of 6084-58-8, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(23), 5272-5276, database is CAplus and MEDLINE.

Compound I, composed of a 1,3,6-trisubstituted 1,4-diazepane-7-one, was discovered as a novel human kallikrein 7 (KLK7, stratum corneum chymotryptic enzyme, SCCE) inhibitor, and its derivatives were synthesized and evaluated. Structure-activity relationship studies of the amidoxime unit and benzoic acid part of this new scaffold led to the identification of compounds II (R = CO₂H and R = Ms), which were more potent than the hit compound, I. The X-ray co-crystal structure of compound II (R = CO₂H) and human KLK7 revealed the characteristic interactions and enabled explanations of the structure-activity relationship.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Application In Synthesis of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nishihata, Toshiaki published the artcileIntestinal absorption of N,N’-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulfonate in rats, Synthetic Route of 71079-09-9, the publication is Chemical & Pharmaceutical Bulletin (1988), 36(7), 2544-50, database is CAplus and MEDLINE.

The intestinal absorption of N,N‘-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulfonate (FOY305) in rats was investigated using a rat intestinal loop method. Plasma drug concentrations and the disappearance of the drug from the intestinal lumen were measured. The absorption of FOY305 after administration into a rectal loop was greater than those after administration into variously positioned small intestinal loops. The low absorption of FOY305 after administration into the small intestine was due to the rapid degradation of FOY305 by esterase activity in the small intestinal lumen. The results are discussed with respect to the development of an oral or rectal dosage form of FOY305.

Chemical & Pharmaceutical Bulletin published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, Synthetic Route of 71079-09-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Uemura, Takahito published the artcileA Concise Enantiodivergent Synthesis of Equol, SDS of cas: 16909-09-4, the publication is Synlett (2021), 32(7), 693-696, database is CAplus.

Equol, a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein, has been synthesized as both enantioenriched forms based on MacMillan’s ¦Á-arylation of carbonyl compound mediated by amino acid derived indazolidinones and copper precatalysts. The natural form of (S)-equol and its enantiomer (R)-equol have been synthesized in 8 steps from 2,4-dimethoxybenzaldehyde with good enantiomeric purity (90% ee and 90% ee, resp.).

Synlett published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C12H23N3S, SDS of cas: 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Ru-Yi published the artcileLigand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp³)-H Bonds, Quality Control of 1949-41-3, the publication is Journal of the American Chemical Society (2017), 139(16), 5724-5727, database is CAplus and MEDLINE.

We herein report the palladium(II)-catalyzed bromination and iodination of a variety of ¦Á-hydrogen-containing carboxylic acid and amino acid-derived amides. These reactions are exclusively enabled by quinoline-type ligands. The halogenated products obtained in this reaction are highly versatile and rapidly undergo further diversification. Further, we report the first example of a free carboxylic acid-directed Pd(II)-catalyzed C(sp³)-H bromination, enabled by quinoline ligands.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C15H21BO2, Quality Control of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bhat, Rayees Ahmad published the artcileAnalysis of fatty acids and sex steroid hormones in rainbow trout testes (Oncorhynchus mykiss) during the reproductive process, Computed Properties of 6217-54-5, the publication is Aquaculture Research (2022), 53(12), 4426-4436, database is CAplus.

In the present study, we aimed to examine the cellular structure of the testes, the hormonal changes occurring throughout the reproductive cycle, and the fatty acid composition in rainbow trout. An electron microscopic anal. was conducted to investigate the morphol. and cellular changes during the development of the testes. Germ cells were observed in different stages of differentiation: primary spermatogonia (PSGs), secondary spermatogonia (SSGs), primary spermatocytes (PSCs), secondary spermatocytes (SSCs), spermatids (SPDs) and spermatozoa (SZs). Differentiated spermatozoa were observed within the cysts. Regarding steroid hormones, the maximum level of testosterone was in the mature stage, and the min. level was in the spent stage; for 11-ketotestosterone, the highest level was in the maturing stage and the lowest level was in the spent stage. In terms of the fatty acid composition, the levels of C14, C15, C16, C18, C16:1n7, C18:1n7, C18:1n9, C20:4n6, n-3 PUFAs, n-6 PUFAs, C20:5n-3 (EPA), C22:5n-3 (DPA) and C22:6n3 (DHA) (g^-1 of gonad wet weight) were the lowest during the immature stage and the highest during the mature stage of the testes. The major significance of the study is the sex steroid hormonal profile, the primary regulators of spermatogenesis and the fatty acid composition, which is important for the development of gonads and sperm. These data should contribute to the knowledge regarding the reproductive biol. of male rainbow trout, for which research data remain scarce.

Aquaculture Research published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Computed Properties of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saigusa, K. published the artcileInfluence of carboxylic acid content and polymerization catalyst on hydrolytic degradation behavior of Poly(glycolic acid) fibers, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline, the publication is Polymer Degradation and Stability (2020), 109054, database is CAplus.

Poly(glycolic acid) (PGA) is an aliphatic polyester with the simplest chem. structure. Since PGA is susceptible to hydrolysis, various researchers studied the factors affecting the hydrolytic degradation behavior of PGA. The factors include the higher-order structure, pH, ionic electrolyte etc. In this study, to clarify the mechanism for the hydrolysis of PGA fibers, effect of the carboxylic acid content on the hydrolytic degradation behavior was investigated through the quant. evaluation of the amounts of the carboxylic acid end group and the PGA monomer (glycolide, GL) in the fibers. Evaluation of the hydrolysis of PGA fibers through the analyses of the mol. weight retention and tensile strength retention after immersing in the phosphate buffer solution at 37¡ãC revealed that the hydrolysis is governed by the carboxylic acid content in the PGA fibers. It was also found that the amount of GL generated during the melt spinning process is affected by the amount and type of polymerization catalyst. In addition, the exptl. results of fundamental anal. suggested that the polymerization catalyst also decomposes the GL into glycolic acid or glycolic acid dimers to generate carboxylic acid, and the rate of decomposition varies depending on the type and amount of catalyst. Based on these results, it was concluded that there is an indirect effect of the type and amount of polymerizing catalyst on the rate of hydrolysis of PGA fibers.

Polymer Degradation and Stability published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia