Month: December 2022

Tong, Yu Ying published the artcileSyntheses and properties of the gold(I) complexes with bulky thiolates [Au(SR)]₆ and [Au(SR)(PPh₃)] (R = C₆H₂Me₃-2,4,6 or C₆H₂Pr₃ⁱ-2,4,6), and the molecular structure of [Au(SC₆H₂Pr₃ⁱ-2,4,6)(PPh₃)], Formula: C15H24S, the publication is Transition Metal Chemistry (London) (1995), 20(4), 372-5, database is CAplus.

[Au(SR)]₆ (R = C₆H₂Me₃-2,4,6 or C₆H₂Prⁱ₃-2,4,6) prepared by treatment of chloroauric acid in water with thiodiglycol followed by reaction with the appropriate thiol (HSR) in CHCl₃, can add PPh₃ in CH₂Cl₂ to give [Au(SR)(PPh₃)], which, alternatively, can be obtained from reaction of [AuCl(PPh₃)] in THF with HSR in the presence of KOH-EtOH. The mol. structure of [Au(SC₆H₂Prⁱ₃-2,4,6)(PPh₃)] was determined by x-ray diffraction anal.

Transition Metal Chemistry (London) published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C10H12F6N4O6PdS2, Formula: C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lipeeva, Alla V. published the artcileSynthesis of 1H-1,2,3-triazole linked aryl(arylamidomethyl) – dihydrofurocoumarin hybrids and analysis of their cytotoxicity, HPLC of Formula: 16909-09-4, the publication is European Journal of Medicinal Chemistry (2015), 119-128, database is CAplus and MEDLINE.

A series of 2-(4-R-triazolyl)substituted 3-oxo-2,3-dihydrofurocoumarins have been synthesized by a regioselective cycloaddition of 2-azidooreoselone I or 2-azido-9-[(4-methylpiperazin-1-yl)methyl]oreoselone II with various alkynes in the presence of Cu(II)/ascorbate in water/methylene chloride reaction medium. The structure of 2-azidooreoselone was established by X-ray structure anal. The cytotoxicity of 2-substituted dihydrofurocoumarins was determined against three cancer cell lines (CEM-13, MT-4, U-937) using the conventional MTT assays. Among the tested mols., most of the analogs displayed better cytotoxic activity than the parent natural furocoumarin peucedanin III. The activity and selectivity to the cell line increased even further in the series of 2-(4-{2,3-dihydrobenzo[b][1,4]dioxine}triazolyl)-3-oxo-2,3-dihydrofurocoumarins and 2-(4-aryltriazolyl)-3-oxo-2,3-dihydrofurocoumarins having the (4-methylpiperazin-1-ylmethyl) substituent in the 9-th position. The most active compound IV contain the 4-hydroxy-3-methoxybenzamidomethyl substituent in the 4-th position at the triazole ring of 2-(triazol-1-yl)dihydrofurocoumarins. The obtained 2-triazolyl substituted dihydrofurocoumarins were studied as inhibitors of phosphodiesterase (PDE-4B) using docking experiments As a result of virtual screening 3 compounds are selected based on min. binding energy. The interactions of the most active compound and amino acid residues in the binding site were studied.

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, HPLC of Formula: 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Benz, Sebastian published the artcileCatalysis with Pnictogen, Chalcogen, and Halogen Bonds, Recommanded Product: Trimethyl(perfluorophenyl)silane, the publication is Angewandte Chemie, International Edition (2018), 57(19), 5408-5412, database is CAplus and MEDLINE.

Halogen- and chalcogen-based ¦Ò-hole interactions have recently received increased interest in non-covalent organocatalysis. However, the closely related pnictogen bonds have been neglected. In this study, authors introduce conceptually simple, neutral, and monodentate pnictogen-bonding catalysts. Solution and in silico binding studies, together with high catalytic activity in chloride abstraction reactions, yield compelling evidence for operational pnictogen bonds. The depth of the ¦Ò holes is easily varied with different substituents. Comparison with homologous halogen- and chalcogen-bonding catalysts shows an increase in activity from main group VII to V and from row 3 to 5 in the periodic table. Pnictogen bonds from antimony thus emerged as by far the best among the elements covered, a finding that provides most intriguing perspectives for future applications in catalysis and beyond.

Angewandte Chemie, International Edition published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Recommanded Product: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bercher, Olivia P. published the artcileDeaminative Reductive Methylation of Alkylpyridinium Salts, Synthetic Route of 2051-95-8, the publication is Organic Letters (2021), 23(18), 7059-7063, database is CAplus and MEDLINE.

To enable efficient installation of Me groups on simple building blocks and in late-stage functionalization, a nickel-catalyzed reductive coupling of secondary Katritzky alkylpyridinium salts with Me iodide was developed. When coupled with formation of the pyridinium salt from an alkyl amine, this method allowed amino groups to be readily transformed to Me groups with broad functional group and heterocycle tolerance.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Synthetic Route of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Plate, Ralf published the artcileSynthesis, and in vitro and in vivo muscarinic pharmacological properties of a series of 1,6-dihydro-5-(4H)-pyrimidinone oximes, Recommanded Product: O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry (1998), 6(9), 1403-1420, database is CAplus and MEDLINE.

A series of 1,6-dihydro-5-(4H)-pyrimidinone oximes I [R = alkyl, alkenyl, alkynyl, aralkyl] and some of the derived hydroxylamines were synthesized and tested for muscarinic activity in receptor binding assays using [³H]-oxotremorine-M (Oxo-M) and [³H]-pirenzepine (Pz) as ligands. Potential muscarinic agonistic or antagonistic properties of the compounds were determined using binding studies that measured their potencies to inhibit the binding of Oxo-M and Pz. Preferential inhibition of Oxo-M binding was used as an indicator for potential muscarinic agonistic properties; this potential was confirmed in functional studies on isolated organs. The series produced a wide range of active compounds with differing degrees of selectivity in M₁, M₂, and M₃ functional models. Several compounds that have mixed agonist/antagonist profiles were able to reduce cholinergic-related cognitive impairments in models of mnemonic function. Substitutions (I, e.g. R² or R³ = Me) at the 1,6-dihydro-5-(4H)pyrimidine ring disrupted binding and efficacy, whereas systematic variation of the oximes substituent R¹ resulted in various degrees of potency and selectivity dependent on the nature of the substitution.

Bioorganic & Medicinal Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Recommanded Product: O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gaidukovs, Sergejs published the artcileUnderstanding the Impact of Microcrystalline Cellulose Modification on Durability and Biodegradation of Highly Loaded Biocomposites for Woody Like Materials Applications, SDS of cas: 13822-56-5, the publication is Journal of Polymers and the Environment (2022), 30(4), 1435-1450, database is CAplus.

The transition from fossil-based to bio-based materials requires in-depth environmental durability anal. for material engineering and construction applications. We report the hydrothermal aging and biodegradation effect on 6 types of compatibilized microcrystalline cellulose (MCC) and poly(butylene succinate) (PBS) composites. The prepared highly loaded systems with 70 wt% of MCC showed a strong pos. impact on the composites¡ä mech. and thermomech. properties concerning applied modifications. MCC was modified with different coupling agents, namely polyhydroxy amides (PHA), alkyl ester (EST), (3-Aminopropyl)trimethoxysilane (APTMS), maleic acid anhydride, and polymeric diphenylmethane diisocyanate (PMDI). In addition, crosslinking agent carbodiimide (CDI) was used as an alternative to MCC modification. Modification of MCC compared to unmodified composite induced the enhanced rigidity, creep properties, and thermal stability of the materials due to the crosslinking in the interface by proposed chem. treatment. PMDI and CDI chem. modification resulted in the highest elastic modulus while keeping high strength values. A significant 2.5-fold reduction of the coefficient of linear thermal expansion and decreased thermal strains for modified biocomposites were obtained. Due to the hydrophilic nature of MCC, the hydrothermal aging of the composites revealed a dramatic decrease in the elastic modulus and strength characteristics compared to neat PBS. The hydrophilicity depends on the applied surface modification as indicated by contact angle measurements and water absorption and swelling tests. EST facilitated water wetting and enhanced water penetration, and reduced material biodegradation to 30 days, a 2.5-fold improvement compared to the neat PBS polymer. In contrast, PHA, APTMS, PMDI, and CDI improved biocomposites durability while suppressing biodegradation The obtained results could be useful for selecting an optimal MCC surface modification route to design novel and perspective biocomposites with tailored durability and biodegradation and to replace polyolefin composites for wood polymer composite applications.

Journal of Polymers and the Environment published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, SDS of cas: 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

North, Michael published the artcileDiastereoselective darzens condensations of ¦Á-haloamides: influence of aryl substituents on diastereoselectivity, Related Products of catalysis-chemistry, the publication is Letters in Organic Chemistry (2009), 6(7), 552-556, database is CAplus.

N,N-Diaryl ¦Á-haloamides undergo Darzens condensations with aldehydes induced by metal hydroxides. The diastereoselectivity of epoxide formation is strongly influenced by the electronic properties of the arylamide, which can be rationalized on the basis of the acidity of the substrate hydrogens and hence on reaction occurring under kinetic or thermodn. control.

Letters in Organic Chemistry published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Shasha published the artcileMerging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening, Related Products of catalysis-chemistry, the publication is ACS Catalysis (2022), 12(5), 3201-3210, database is CAplus.

An integrated workflow is described that combines micromole-scale high-throughput experimentation (HTE) reaction screening and solid-phase peptide synthesis (SPPS) to enable rapid synthetic method development for on-resin peptide diversification. Using this new approach, we have identified several sets of robust Suzuki-Miyaura coupling conditions with complementary scope that collectively display broad coverage with respect to both resin-bound peptide substrates containing aryl halide side chains and (hetero)arylboronic acid coupling partners. We have also demonstrated the utility of this integrated SPPS/chem. diversification method by synthesizing a multidimensional library of diverse peptides in high yields.

ACS Catalysis published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Firestone, Raymond A. published the artcileSelective delivery of cytotoxic compounds to cells by the LDL pathway, HPLC of Formula: 30670-30-5, the publication is Journal of Medicinal Chemistry (1984), 27(8), 1037-43, database is CAplus and MEDLINE.

Cytotoxic compounds were prepared for reconstitution with LDL (low-d. lipoproteins) to be delivered to cancer cells that internalize LDL, and evaluated by measuring the toxicity of reconstituted LDL toward test cells, SV-589 (SV-40 transformed human fibroblasts) bearing LDL receptors. Selectivity was determined by comparison, either with mutant cells with few LDL receptors, or with reconstituted methylated LDL (not recognized by LDL receptors) or normal cells. N-[[[4-(3¦Â–(Oleoyloxy)androst-5-en-17¦Â-yl]pentyl]oxy]carbonyl]-N,N-bis(2-chloroethyl)amine (I) [90343-98-9] reconstituted well and was delivered exclusively via the LDL pathway in amounts capable of killing 100% cells.

Journal of Medicinal Chemistry published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C10H6F17N, HPLC of Formula: 30670-30-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Firestone, Raymond A. published the artcileLysosomotropic agents. 4. Carbobenzoxyglycylphenylalanyl, a new protease-sensitive masking group for introduction into cells, Safety of 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, the publication is Journal of Medicinal Chemistry (1982), 25(5), 539-44, database is CAplus and MEDLINE.

Bioactive primary and secondary amines, when acylated with the Z-Gly-Phe group, were transported into pinocytic cells, such as macrophages, P-815 mastocytoma, SV-40 3T3, and leukemia 1210, much faster than the parent compounds Amines, such as lysomotropic detergents (which are cytotoxic compounds, designed as anticancer agents, acting by selectively rupturing the membranes of liposomes) and nitrogen mustard, which are deactivated by acylation, are unmasked by enzymic action intracellularly, probably in lysosomes because an acidic pH maximum in activity exists which acts only on the L isomer. The added polarity and mol. weight brought about by acylation prevents the amines’ normally facile entry into cells by simple diffusion, restricting it to an active-transport mechanism.

Journal of Medicinal Chemistry published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C10H6F17N, Safety of 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia