Month: December 2022

Bagheri, Sepideh published the artcileCopper(I)-creatine complex on magnetic nanoparticles as a green catalyst for N- and O-arylation in deep eutectic solvent, Safety of Bis(4-nitrophenyl)amine, the publication is Applied Organometallic Chemistry (2020), 34(3), e5447, database is CAplus.

Immobilization of copper(I) ions on magnetic nanoparticles was performed using surface modification of Fe₃O₄ with creatine. Fe_3O4@creatine-Cu(I) magnetic catalyst was synthesized and applied in C-X cross-coupling reactions with aryl halides in a deep eutectic as a green solvent. The results indicate that the Fe3O4@creatine-Cu(I) magnetic nanoparticles showed excellent activity and high stability. In addition, it was revealed that this catalyst can be recycled five times without significant loss in catalytic activity.

Applied Organometallic Chemistry published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Safety of Bis(4-nitrophenyl)amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fathalla, Walid published the artcileNovel domino synthesis of 2-(2,3,4-substituted phenyl)quinazolin-4-amine, Formula: C8H8O2, the publication is Journal of Heterocyclic Chemistry (2022), 59(5), 933-942, database is CAplus.

Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with iso-Pr amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives

Journal of Heterocyclic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Paquette, Andre R. published the artcileRpoN-Based stapled peptides with improved DNA binding suppress Pseudomonas aeruginosa virulence, Application In Synthesis of 71989-31-6, the publication is RSC Medicinal Chemistry (2022), 13(4), 445-455, database is CAplus and MEDLINE.

Stapled peptides have the ability to mimic ¦Á-helixes involved in protein binding and have proved to be effective pharmacol. agents for disrupting protein-protein interactions. DNA-binding proteins such as transcription factors bind their cognate DNA sequences via an ¦Á-helix interacting with the major groove of DNA. We previously developed a stapled peptide based on the bacterial alternative sigma factor RpoN capable of binding the RpoN DNA promoter sequence and inhibiting RpoN-mediated expression in Escherichia coli. We have elucidated a structure-activity relationship for DNA binding by this stapled peptide, improving DNA binding affinity constants in the high nM range. Lead peptides were shown to have low toxicity as determined by their low hemolytic activity at 100 ¦ÌM and were shown to have anti-virulence activity in a Galleria mellonella model of Pseudomonas aeruginosa infection. These findings support further preclin. development of stapled peptides as antivirulence agents targeting P. aeruginosa.

RSC Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Application In Synthesis of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tsirigotis-Maniecka, Marta published the artcileThe polyphenolic-polysaccharide complex of Agrimonia eupatoria L. as an indirect thrombin inhibitor – isolation and chemical characterization, Category: catalysis-chemistry, the publication is International Journal of Biological Macromolecules (2019), 124-132, database is CAplus and MEDLINE.

The polyphenolic-polysaccharide complex was isolated from the dried aerial parts of the medicinal plant Agrimonia eupatoria L. using a multi-step process involving the degreasing of the plant material by extraction with organic solvents, followed by extraction with hot alkali, neutralization, further separation with organic solvents and dialysis. The complex was homogeneous with a mol. weight of about 55 ¡Á 103 g/mol and consisted mainly of carbohydrates and polyphenols matrix, composed of lignin-related units, with the dominance of dimethoxyphenyl structures. The carbohydrate moiety consists mostly of arabinogalactan associated with highly esterified rhamnogalacturonan. In vitro anticoagulant studies revealed the ability of the A. eupatoria complex to inhibit plasma clot formation, mainly in the intrinsic pathway of the blood coagulation cascade. Further studies on the mechanisms of this anticoagulant activity revealed that the isolate was primarily an indirect inhibitor of thrombin, mediated by antithrombin or by heparin cofactor II. Such mechanism of action is characteristic for highly sulfated glycosaminoglycans.

International Journal of Biological Macromolecules published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C7H5Cl2NO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mhaldar, Pradeep M. published the artcileMagnetically Recoverable Palladium Nanocatalyst [Pd(II)-Benz-Am-Fe₃O₄@SiO₂] for Ullmann Type Homocoupling of Aryl halides with N₂H₄ as an Efficient Reductant, Name: 4,4′-Dimethyldiphenyl, the publication is Journal of Inorganic and Organometallic Polymers and Materials, database is CAplus.

A highly efficient and sustainable ferrite supported palladium nanocatalyst (Pd(II)-Benz-Am-Fe₃O₄@SiO₂) has been prepared and characterized by diverse microscopic and spectroscopic techniques. The Pd(II)-Benz-Am-Fe₃O₄@SiO₂ was employed as magnetically recoverable nanocatalyst in the synthesis of sym. biaryls by reductive homocoupling of haloarenes (I, Br and Cl) using hydrazine hydrate (N₂H₄) as reducing agent. The Pd-Benz-Am-Fe₃O₄@SiO₂ nanocatalyst exhibited high surface area and efficient magnetization as 45.25 m²/g and 34 emu/g, resp. The Electron Dispersive X-ray (EDX) anal. confirmed 3.9 mol % loading of Pd in Pd-Benz-Am-Fe₃O₄@SiO₂. Moverever, high turnover number (TON) and turnover frequency (TOF), operational simplicity and facial recyclability and reusability (up to eight runs) are the remarkable advantages of the nanocatalyst. The catalytic activity and stability of recycled Pd(II)-Benz-Am-Fe₃O₄@SiO₂ catalyst was comprehensively studied from X-ray diffraction (XRD), SEM (SEM), Transmission Electron Microscopic (TEM) and EDX anal.

Journal of Inorganic and Organometallic Polymers and Materials published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Name: 4,4′-Dimethyldiphenyl.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Manna, Surya Sekhar published the artcilePyrrolidinium-Based Organic Cation (BMP)-Intercalated Organic (Coronene) Anode for High-Voltage Dual-Ion Batteries: A Comparative Study with Graphite, Quality Control of 191-07-1, the publication is Journal of Physical Chemistry C (2022), 126(22), 9264-9274, database is CAplus.

Among the post-lithium-ion batteries, rechargeable dual-ion batteries (DIBs) have bright opportunities for the development of cheap and safe batteries possessing a good electrochem. performance. The DIBs with pure ionic liquid (IL) electrolytes featuring a high voltage, sustainability, and environmental friendliness have received attention from researchers. Owing to intercalation/deintercalation of large size IL cations, the conventional dual-graphite batteries (DGBs) have suffered from severe volume expansion, thus limiting the overall reversibility of the DGBs. Herein, we have modeled two DIBs, introducing an organic cation-intercalated polycyclic aromatic hydrocarbon anode (coronene) coupled with a graphite cathode and a DGB in the other case. Pyrrolidinium-based IL, N-butyl-N-Me pyrrolidinium chloride (BMP-Cl) with the AlCl₃ salt has been employed as an electrolyte. Applying the first-principles calculation, we have investigated the systematic intercalation of the BMP cation into the coronene and graphite anodes. The BMP-intercalated graphite anode shows a higher binding energy (2.36 eV) compared to that of the coronene anode (1.71 eV). In the fully charged state, a calculated discharge voltage of 3.1 and 3.05 V and a maximum capacity of 116 and 130 mA h g^-1 have been observed for the graphite coronene dual-ion battery (GCDIB) and DGB, resp. However, the percentage of volume expansion of the graphite anode is higher (148%) compared to that of the coronene anode (53%) upon a full intercalation of BMP cations, indicating more exfoliation-prone nature of graphite compared to coronene. The d. of states and Bader charge anal. reveal that the BMP cation is intercalated successfully, indicating a reduction of electrode materials during the charging process. Furthermore, we have explained the merits of choosing the AlCl₄ anion compared to other commonly used anions such as TFSI in DIBs. These results support a clear understanding of BMP cation intercalation into both coronene and graphite anodes and motivate the fabrication of a new class of low-cost organic anode DIBs with an optimum electrochem. performance.

Journal of Physical Chemistry C published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Quality Control of 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Patel, Dushyant V. published the artcileNovel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents, Related Products of catalysis-chemistry, the publication is Bioorganic Chemistry (2020), 103977, database is CAplus and MEDLINE.

Mols. capable of engaging with multiple targets associated with pathol. condition of Alzheimer’s disease have proved to be potential anti-Alzheimer’s agents. The goal to develop multitarget-directed ligands for the treatment of Alzheimer’s disease, a novel series of carbazole-based stilbene derivatives (E)-I [R = H, NH₂, 4-chlorobutanamidyl, 4-(pyrrolidin-1-yl)butanamidyl, ([3-(piperidin-1-yl)propyl]carbamoyl)azanyl, etc.; R¹ = H, NO₂, NH₂, 2-chloroacetamidyl, ([2-(pyrrolidin-1-yl)ethyl]carbamothioyl)azanyl, etc.] was designed by the fusion of carbazole ring with stilbene scaffold. The designed compounds (E)-I were synthesized and evaluated for their anti-AD activities including cholinesterase inhibition, A¦Â aggregation inhibition, antioxidant and metal chelation properties. Amongst them, (E)-I [R = H; R¹ = ([2-(pyrrolidin-1-yl)ethyl]carbamothioyl)azanyl, (A)] appeared to be the best candidate with good inhibitory activities against AChE (IC₅₀ value of 2.64¦ÌM) and BuChE (IC₅₀ value of 1.29¦ÌM), and significant inhibition of self-mediated A¦Â_1-42 aggregation (51.29% at 25¦ÌM concentration). The metal chelation study showed that compound (A) possessed specific copper ion chelating property. Addnl., compound (A) exhibited moderate antioxidant activity. To understand the binding mode of (A), mol. docking studies were performed, and the results indicated strong non-covalent interactions of (A) with the enzymes in the active sites of AChE, BuChE as well as of the A¦Â_1-42 peptide. Addnl., it showed promising in silico ADMET properties. Putting together, these findings evidently showed compound (A) as a potential multitarget-directed ligand in the course of developing novel anti-AD drugs.

Bioorganic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Heathcote, Dean A. published the artcileA Novel Pyrazolo[1,5-a]pyrimidine is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2, and 9, Which Demonstrates Antitumor Effects in Human Tumor Xenografts Following Oral Administration, Name: 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, the publication is Journal of Medicinal Chemistry (2010), 53(24), 8508-8522, database is CAplus and MEDLINE.

Cyclin-dependent protein kinases (CDKs) are central to the appropriate regulation of cell proliferation, apoptosis, and gene expression. Abnormalities in CDK activity and regulation are common features of cancer, making CDK family members attractive targets for the development of anticancer drugs. Here, we report the identification of a pyrazolo[1,5-a]pyrimidine derived compound, 4k (BS-194, I), as a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9 (IC₅₀ = 3, 30, 30, 250, and 90 nmol/L, resp.). Cell-based studies showed inhibition of the phosphorylation of CDK substrates, Rb and the RNA polymerase II C-terminal domain, down-regulation of cyclins A, E, and D1, and cell cycle block in the S and G₂/M phases. Consistent with these findings, 4k demonstrated potent antiproliferative activity in 60 cancer cell lines tested (mean GI₅₀ = 280 nmol/L). Pharmacokinetic studies showed that 4k is orally bioavailable, with an elimination half-life of 178 min following oral dosing in mice. When administered at a concentration of 25 mg/kg orally, 4k inhibited human tumor xenografts and suppressed CDK substrate phosphorylation. These findings identify 4k as a novel, potent CDK selective inhibitor with potential for oral delivery in cancer patients.

Journal of Medicinal Chemistry published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Name: 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lenin, Dandamudi V. published the artcile¦Â-Nitrostyrenes as a valuable precursor for the synthesis of ¦Â-aryl-¦Ã-lactam and 2-oxo-1,2-dihydroquinoline derivatives, Formula: C10H11NO4, the publication is Journal of Heterocyclic Chemistry (2022), 59(3), 588-596, database is CAplus.

Two different reaction pathways for the synthesis of ¦Â-aryl-¦Ã-lactam and 2-oxo-1,2-dihydroquinoline derivatives I (R = H, 2-Cl, 3,4-dimethoxy, 4-Et, etc.) and II (R¹ = H, Cl, Br) using ¦Â-nitrostyrenes R²CH=CHNO₂ (R² = Ph, 3,4-dimethoxyphenyl, 2-nitrophenyl, etc.) were successfully demonstrated. The reaction strategy involves the Michael addition followed by reduction and cyclization reactions. Michael adducts containing two different nitro group such as one on aryl ring and another on side chain, selectively take the path to involve nitro group on aryl to form 2-oxo-1,2-dihydroquinoline derivatives II as cyclized product. Michael adducts with nitro group on side chain alone forms ¦Â-aryl-¦Ã-lactam derivatives I as cyclized product. This methodol. is appealing with reliability and scalability with gram scale products that can be synthesized. These heterocyclic compounds can be exploited for their biol. activity.

Journal of Heterocyclic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ducker, W. A. published the artcileForces between mica surfaces in the presence of rod-shaped divalent counterions, Related Products of catalysis-chemistry, the publication is Langmuir (1992), 8(1), 109-12, database is CAplus.

Recent theor. and exptl. studies have shown that the swelling of some common clay minerals (e.g., montmorillonite) is limited on addition of Ca²⁺ salts because of ion-ion correlation forces. This effect gives rise to strong, short-range attractive forces completely unexpected from classical DLVO theory. The effect was investigated of a rod-shaped divalent ion on the long-range double-layer and short-range solvation forces between mica surfaces in aqueous solution At a concentration of 3 mM this ion both reduces the diffuse double-layer repulsion and creates a strong adhesive min. at a mica-mica separation of about 0.8-0.9 nm, probably because the ion acts as a bridging agent between the facing surfaces. The force measurements are compared with the coagulation behavior of Na⁺-montmorillonite.

Langmuir published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia