Month: December 2022

Kuboyama, Takeshi published the artcileStoichiometry-focused ¹⁸F-labeling of alkyne-substituted oligodeoxynucleotides using azido([¹⁸F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction, Synthetic Route of 17351-62-1, the publication is Bioorganic & Medicinal Chemistry (2011), 19(1), 249-255, database is CAplus and MEDLINE.

A novel method for ¹⁸F-radiolabeling of oligodeoxynucleotides (ODNs) by a Cu-catalyzed Huisgen reaction has been developed by using the lowest possible amount of the precursor biomol. for the realization of stoichiometry-oriented PET (positron emission tomog.) chem. Under the optimized cyclization conditions of p- or m-azido([¹⁸F]fluoromethyl)benzene and alkyne-substituted ODN (20 nmol) at 40 ¡ãC for 15 min in the presence of CuSO₄, TBTA [tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine], and sodium ascorbate (2:1:2), the synthesis of ¹⁸F-labeled ODNs with sufficiently high radioactivities of 2.1-2.5 GBq and specific radioactivities of 1800-2400 GBq/¦Ìmol have been accomplished for use in animal and human PET studies.

Bioorganic & Medicinal Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Synthetic Route of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tachihara, Yoshihiro published the artcileMechanically interlocked molecular architectures of valinomycin as cancer targeted prodrugs, Category: catalysis-chemistry, the publication is Nano Select (2022), 3(8), 1242-1251, database is CAplus.

Macrocyclic drugs are promising agents for treating a variety of diseases. However, these compounds usually present delivery limitations, such as low tissue selectivity and poor cellular uptake, which may impair efficacy and clin. translation. Here, we propose a mol. machine approach for delivering macrocyclic drugs based on their assembly into bioactive rotaxanes. To prove this concept, we use the extremely toxic macrocycle valinomycin (Val) as the host mol., and identify dihydralazine (Dihyd) as a guest mol. after screening several guest compounds The Val-Dihyd complex is mech. interlocked by capping one hydrazide group in Dihyd with fluorescein isothiocyanate (FITC) and the other with a Y-shape branched poly(ethylene glycol) (PEG) via a pH-sensitive hydrazone bond. Thus, the Val-loaded rotaxanes (Vrot) are stable at physiol. pH, but release Val at mild acidic conditions mimicking intratumoral and endosomal environments. In vitro studies revealed Vrot is less cytotoxic than free Val in pancreatic cancer cells, while modifying Vrot with cyclic arginine-glycine-aspartic acid (cRGD) peptides promotes the cytotoxicity by enhancing cellular uptake. These results indicate the potential of rotaxanes of macrocyclic drugs for generating cancer targeted prodrugs.

Nano Select published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C4Br2N2O4S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yamazaki, Shoko published the artcileSynthesis of Piperidines via Intramolecular Hydride Transfer from ¦Á-Amino sp³ Carbon Atoms to Ethenetricarboxylate-Derived Fragments and Further Cyclization, Application In Synthesis of 140-28-3, the publication is ChemistrySelect (2018), 3(16), 4505-4511, database is CAplus.

The cyclization of amides derived from ethenetricarboxylic acid bearing tert-amino groups wsa examined The amides were efficiently converted to piperidine derivatives (2-piperidones) upon heating in a polar solvent (e. g., DMSO or DMF) via intramol. hydride transfer and subsequent ring closure. The reaction was less efficient in the presence of a Lewis acid. The reactivity varies depending on the alkyl substituents of tert-amino groups, probably due to steric effects. The hydride transfer/cyclization mechanism was investigated by DFT calculations The reaction of the carboxylic acid and relatively bulky diamines such as diisopropyl-substituted diamine in the presence of amide condensation reagents at 60 ¡ã gave the piperidine derivatives in a one-pot reaction. The reaction of the diisopropylamine substituted piperidine product with primary amines gave secondary amine-substituted piperidines.

ChemistrySelect published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H4ClN3S, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Santoro, Orlando published the artcileSynthesis, characterization and catalytic activity of stable [(NHC)H][ZnXY₂] (NHC = N-Heterocyclic carbene, X, Y = Cl, Br) species, Category: catalysis-chemistry, the publication is Journal of Molecular Catalysis A: Chemical (2016), 85-91, database is CAplus.

The synthesis and characterization of imidazol(in)ium-based zinc(II) halide salts are reported. These compounds present interesting structural features and exhibit high stability. Their catalytic activity was explored in the methylation of amines with CO₂ and PhSiH₃. CCDC-1447299 (1), CCDC-1447302 (2), CCDC-1447301 (3), CCDC-1447298 (4a) and CCDC-1447300 (5b).

Journal of Molecular Catalysis A: Chemical published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Al-Hamdani, Yasmine S. published the artcileInteractions between large molecules pose a puzzle for reference quantum mechanical methods, HPLC of Formula: 191-07-1, the publication is Nature Communications (2021), 12(1), 3927, database is CAplus and MEDLINE.

Quantum-mech. methods are used for understanding mol. interactions throughout the natural sciences. Quantum diffusion Monte Carlo (DMC) and coupled cluster with single, double, and perturbative triple excitations [CCSD(T)] are state-of-the-art trusted wavefunction methods that have been shown to yield accurate interaction energies for small organic mols. These methods provide valuable reference information for widely-used semi-empirical and machine learning potentials, especially where exptl. information is scarce. However, agreement for systems beyond small mols. is a crucial remaining milestone for cementing the benchmark accuracy of these methods. We show that CCSD(T) and DMC interaction energies are not consistent for a set of polarizable supramols. While there is agreement for some of the complexes, in a few key systems disagreements of up to 8 kcal mol^-1 remain. These findings thus indicate that more caution is required when aiming at reproducible non-covalent interactions between extended mols.

Nature Communications published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, HPLC of Formula: 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Al-Wasidi, Asma S. published the artcileModification of Silica Nanoparticles with 4,6-Diacetylresorcinol as a Novel Composite for the Efficient Removal of Pb(II), Cu(II), Co(II), and Ni(II) Ions from Aqueous Media, HPLC of Formula: 13822-56-5, the publication is Journal of Inorganic and Organometallic Polymers and Materials (2022), 32(6), 2332-2344, database is CAplus.

Due to the danger of heavy metals such as Pb(II), Cu(II), Co(II), and Ni(II) ions to the environment and humans, the world needs to develop new effective adsorbents to get rid of them. Many Schiff bases can form chelates with most heavy metal ions. Hence, loading them on supports like silicon oxide as new composites help to solve the pollution problem. So, in this work, a new composite based on the formation of Schiff base on silica nanoparticles was facilely synthesized. (3-aminopropyl)trimethoxysilane was used to modify silica nanoparticles with silanol groups (Si-OH). Then, the modified silica was then combined with 4,6-diacetylresorcinol to create a new Schiff base/silica composite. XRD, FE-SEM, FT-IR, CHN analyzer, and N2 adsorption/desorption analyzer were used to characterize the synthesized composite. The formation of the Schiff base results in a significant drop in the intensity of the composite XRD peak at 2 = 21.9¡ã. In addition, the FT-IR bands at 3443 and 1606 cm-1 are due to the stretching and bending vibrations of OH and/or C=N, resp. The FE-SEM images confirmed that the silica has uneven forms while the composite has a flaky surface due to the formation of the Schiff base. According to an elemental anal. of the composite, the percentages of C, H, and N are 15.26, 3.24, and 1.65%, resp. The produced Schiff base restricts the pores of silica and hence the composite BET surface area and total pore volume were lowered. The synthesized composite was used to remove Pb(II), Cu(II), Co(II), and Ni(II) ions from aqueous solutions with high efficiency. The maximum uptake capacity of the composite toward Pb(II), Cu(II), Co(II), or Ni(II) ions is 107.066, 89.767, 80.580, and 70.972 mg/g, resp. The adsorption processes of the investigated metal ions were chem., spontaneous, and well fitted with the Langmuir equilibrium isotherm and pseudo-second-order kinetic model. The synthesized composite can be successfully regenerated and utilized various times in the removal of investigated metal ions from aqueous solutions

Journal of Inorganic and Organometallic Polymers and Materials published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, HPLC of Formula: 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sankara Rao, N. published the artcileDesign and synthesis of DNA-intercalative naphthalimide-benzothiazole/cinnamide derivatives: cytotoxicity evaluation and topoisomerase-IIa inhibition, SDS of cas: 16909-09-4, the publication is MedChemComm (2019), 10(1), 72-79, database is CAplus and MEDLINE.

A new series of different naphthalimide-benzothiazole/cinnamide derivatives were designed, synthesized and tested for their in vitro cytotoxicity on selected human cancer cell lines. Among them, derivatives 4a and 4b with the 6-aminobenzothiazole ring and 5g with the cinnamide ring displayed potent cytotoxic activity against colon (IC₅₀: 3.715 and 3.467 uM) and lung cancer (IC₅₀: 4.074 and 3.890 uM) cell lines when compared to amonafide (IC₅₀: 5.459 and 7.762 uM). Later, the DNA binding studies for these selected derivatives (by CD, UV/vis, fluorescence spectroscopy, DNA viscosity, and mol. docking) suggested that these new derivatives significantly intercalate between two strands of DNA. In addition, the most potent derivatives 4a and 4b were also found to inhibit DNA topoisomerase-II.

MedChemComm published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, SDS of cas: 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Farkas, Edit published the artcileEquilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATA^m and DATA^5m Ligands, Related Products of catalysis-chemistry, the publication is Chemistry – A European Journal (2017), 23(43), 10358-10371, database is CAplus and MEDLINE.

The development of ⁶⁸Ge/⁶⁸Ga generators has made the positron-emitting ⁶⁸Ga isotope widely accessible and raised interest in new chelate complexes of Ga³⁺. The hexadentate 1,4-di(acetate)-6-methyl[amino(methyl)acetate]perhydro-1,4-diazepane (DATA^m) ligand and its bifunctional analog, 1,4-di(acetate)-6-pentanoic acid-6-[amino(methyl)acetate]perhydro-1,4-diazepane (DATA^5m), rapidly form complexes with ⁶⁸Ga in high radiochem. yield. The stability constants of DATA^m and DATA^5m complexes formed with Ga³⁺, Zn²⁺, Cu²⁺, Mn²⁺ and Ca²⁺ were determined by using pH potentiometry, spectrophotometry (Cu²⁺) and ¹H and ⁷¹Ga NMR spectroscopy (Ga³⁺). The stability constants of Ga(DATA^m) and Ga(DATA^5m) complexes are slightly higher than those of Ga(AAZTA). The species distribution calculations indicated the predominance of Ga(L)OH mixed-hydroxo complexes at physiol. pH. The ¹H and ⁷¹Ga NMR spectroscopy studies provided information about the coordinated functional groups of ligands and on the kinetics of exchange between the Ga(L) and Ga(L)OH complexes. The transmetalation reactions between the Ga(L) complexes and Cu²⁺ citrate (6 < pH < 8.5) occur through both spontaneous and OH^–-assisted dissociation of the Ga(L)OH species. At pH 7.4 and 25¡ã, the half-lives of the dissociation of Ga(DATA^m), Ga(DATA^5m) and Ga(AAZTA) were 11, 44 and 24 h, resp. Similar half-lives were obtained for the ligand-exchange reactions between the Ga(L)OH complexes and transferrin. The equilibrium and kinetic data indicate that the Ga(DATA^5m) complex is a good ⁶⁸Ga-based radiodiagnostic candidate.

Chemistry – A European Journal published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nouzaki, Katsuya published the artcileTreatment by low pressure type reverse osmosis membranes for recovery of plating rinse wastewater for recycling, Name: Sodium 2,2′,2”,2”’-(ethane-1,2-diylbis(azanetriyl))tetraacetate xhydrate, the publication is Maku (2003), 28(6), 288-295, database is CAplus.

For the purpose of recycling of wastewater from plating rinse process, we studied low pressure reverse osmosis membranes (effective membrane area 1.7 m²). In the case of 50% recovery of permeate water from feed, the membrane showed a stable performance, but in the case of 80% recovery, the membrane performance decreased gradually with the formation of silica scale on the membrane surface. In order to recover the membrane performance, we studied washing the membrane surface with ethylene-diamine-tetraacetic acid, tetrasodium salt hydrate (EDTA-4Na) aqueous solutions The membranes treated with these solutions showed the same performance as the initial ones. In a pilot plant (effective membrane area 36 m²), the membrane showed a stable performance with an every 200 h wash cycle using EDTA-4Na aqueous solutions

Maku published new progress about 194491-31-1. 194491-31-1 belongs to catalysis-chemistry, auxiliary class Carboxylic Acid Salts,Amine,Aliphatic hydrocarbon chain, name is Sodium 2,2′,2”,2”’-(ethane-1,2-diylbis(azanetriyl))tetraacetate xhydrate, and the molecular formula is C10H14N2Na4O9, Name: Sodium 2,2′,2”,2”’-(ethane-1,2-diylbis(azanetriyl))tetraacetate xhydrate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Paplal, Banoth published the artcileRegioselective synthesis of functionalized 1,2,3-triazoles via oxidative [3+2]-cycloaddition using Zn(OAc)₂ – ^tBuOOH or ZnO nanoparticle as catalyst system in aqueous medium, Synthetic Route of 4230-93-7, the publication is Catalysis Communications (2017), 115-120, database is CAplus.

The regioselective synthesis of functionalized pyrazole-1,2,3-triazoles is reported via oxidative [3 + 2]-cycloaddition reactions of azides with ¦Â-nitrostyrenes and chalcone derivatives using Zn(OAc)₂ – ^tBuOOH or ZnO nanoparticles as catalyst system in aqueous medium. The catalyst dependent product selectivity was observed with ¦Â-nitrostyrenes to give the triazoles with and without -NO₂ group Zn(OAc)₂ and ZnO nanoparticles. The chalcones gave the triazoles selectively as sole products with good regioselectivity. The resulting products were further converted into sulfonamides and oxazoles resp.

Catalysis Communications published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia