Month: December 2022

Radke, Joshua B. published the artcileBicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase, SDS of cas: 63-68-3, the publication is Nature Communications (2022), 13(1), 459, database is CAplus and MEDLINE.

Toxoplasma gondii commonly infects humans and while most infections are controlled by the immune response, currently approved drugs are not capable of clearing chronic infection in humans. Hence, approx. one third of the world¡äs human population is at risk of reactivation, potentially leading to severe sequelae. To identify new candidates for treating chronic infection, we investigated a series of compounds derived from diversity-oriented synthesis. Bicyclic azetidines are potent low nanomolar inhibitors of phenylalanine tRNA synthetase (PheRS) in T. gondii, with excellent selectivity. Biochem. and genetic studies validate PheRS as the primary target of bicyclic azetidines in T. gondii, providing a structural basis for rational design of improved analogs. Favorable pharmacokinetic properties of a lead compound provide excellent protection from acute infection and partial protection from chronic infection in an immunocompromised mouse model of toxoplasmosis. Collectively, PheRS inhibitors of the bicyclic azetidine series offer promise for treatment of chronic toxoplasmosis.

Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, SDS of cas: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chapman, Astrid G. published the artcileAcute anticonvulsant activity of structural analogs of valproic acid and changes in brain GABA and aspartate content, Computed Properties of 3115-28-4, the publication is Life Sciences (1983), 32(17), 2023-31, database is CAplus and MEDLINE.

Ten analogs of valproic acid (substituted butyric, pentanoic and hexanoic acids) were tested for anticonvulsant activity against audiogenic seizures in DBA/2 mice. There is a consistent correlation between the structure of these branched-chain fatty acids and their anticonvulsant potency, the larger mols. being the more active. There is also a strong correlation between the anticonvulsant potency of these compounds and their ability to reduce cerebral aspartate??[56-84-8] levels. Cerebral GABA??[56-12-2] levels are elevated by most, but not all, of the actively anticonvulsant valproate analogs.

Life Sciences published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Computed Properties of 3115-28-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mallepalli, Raghu published the artcilePolyethylene glycol (PEG-400) as an efficient and recyclable reaction medium for catalyst-free benzyl C-H functionalization of methyl quinoline and Michael addition to beta-nitro styrene, Synthetic Route of 4230-93-7, the publication is Pharmacia Lettre (2013), 5(3), 201-205, database is CAplus.

Polyethylene glycol (PEG-400) was found to be an effective reaction medium for C-H activation of Me quinolines and additions to various ¦Â-nitro styrenes were executed in PEG-400 under mild reaction conditions. PEG-400 is a recyclable and eco-friendly solvent.

Pharmacia Lettre published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Badawi, A. M. published the artcileSurface and biological activity of some novel cationic surfactants, Application of Dodecylamineacetate, the publication is Journal of Surfactants and Detergents (2007), 10(4), 243-255, database is CAplus.

In this study, steps were taken toward the development of bactericidal and fungicidal synthetic cationic surfactants by reacting decyl-, dodecyl- or tetradecylamine with acetic or hydrochloric acid to produce a series of amine salts which consequently converted to copper or cobalt cationic complexes via complexing the first series compounds with copper (II) or cobalt (II) ions. Surface properties such as interfacial tension and emulsifying power of these surfactants were investigated. The surface parameters including critical micelle concentration (CMC), maximum surface excess (¦£_max) and min. surface area (A_min) were studied. Free energy of micellization (¦¤G^o_mic) and adsorption (¦¤G^o_ads) were calculated The antimicrobial activity was determined via the inhibition zone diameter of the prepared compounds, which measured against five strains of a representative group of microorganisms. FTIR spectra, elemental anal. and H¹ NMR spectrum were performed to confirm compound structure and purity.

Journal of Surfactants and Detergents published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Application of Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Wenfeng published the artcileInsights into ammonia borane enabled green synthesis of N-substituted lactams from biomass-derived keto-acids and amines, COA of Formula: C10H10O3, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(12), 4377-4382, database is CAplus.

The reductive amination/cyclization of biomass-based keto-acids and amines to lactams under mild condition with ammonia borane (NH₃-BH₃) as hydrogen donor in the absence of additives was reported herein for the first time and was demonstrated with 22 examples affording lactams in moderate to excellent yield. A combination of in situ NMR and control experiments indicated that reductive amination occurs via imine formation and double hydrogen transfer from NH₃-BH₃ during the reaction.

ACS Sustainable Chemistry & Engineering published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C12H15NO, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Al-Horani, Rami A. published the artcilePotent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold, Application In Synthesis of 16909-09-4, the publication is European Journal of Medicinal Chemistry (2012), 771-783, database is CAplus and MEDLINE.

Direct inhibition of coagulation factor Xa (FXa) carries significant promise for developing effective and safe anticoagulants. Although a large number of FXa inhibitors have been studied, each can be classified as either possessing a highly flexible or a rigid core scaffold. The authors reasoned that an intermediate level of flexibility would provide high selectivity for FXa, considering that its active site is less constrained in comparison to thrombin and more constrained as compared to trypsin. They studied several core scaffolds including 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid for direct FXa inhibition. Using a genetic algorithm-based docking and scoring approach, a promising candidate I was identified, synthesized, and found to inhibit FXa with a K_i of 28 ¦ÌM. Optimization of derivative I resulted in the design of a potent dicarboxamide II, which displayed a K_i of 135 nM. Dicarboxamide II displayed at least 1852-fold selectivity for FXa inhibition over other coagulation enzymes and doubled PT and aPTT of human plasma at 17.1 ¦ÌM and 20.2 ¦ÌM, resp., which are comparable to those of clin. relevant agents. Dicarboxamide II is expected to serve as an excellent lead for further anticoagulant discovery.

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tamoradi, Taiebeh published the artcileImmobilization of a nickel complex onto functionalized Fe₃O₄ nanoparticles: a green and recyclable catalyst for synthesis of 5-substituted 1H-tetrazoles and oxidation reactions, Product Details of C14H10O4S2, the publication is Research on Chemical Intermediates (2018), 44(2), 1363-1380, database is CAplus.

In the present research, a magnetically recoverable catalyst was easily prepared by anchoring nickel onto the surface of organically modified magnetite nanoparticles. Characterization of the prepared nanostructure was performed by various physicochem. techniques such as FTIR spectroscopy, SEM, TEM, energy-dispersive x-ray spectroscopy, inductively coupled plasma optical emission spectroscopy, X-ray diffraction, TGA and vibrating sample magnetometer measurements. The catalytic behavior of the prepared nanohybrid as an efficient catalyst was successfully probed in the oxidation of sulfides, oxidative coupling of thiols and synthesis of 5-substituted 1H-tetrazoles. This method has significant advantages, including high yield, green reaction conditions, short reaction time, easy separation and workup, as well as the ability to tolerate a wide variety of substitutions in the reagents.

Research on Chemical Intermediates published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C8H5IO, Product Details of C14H10O4S2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bateni, Fatemeh published the artcileDistribution, source and ecological risk assessment of polycyclic aromatic hydrocarbons in the sediments of northern part of the Persian Gulf, Recommanded Product: Coronene, the publication is Chemosphere (2022), 133859, database is CAplus and MEDLINE.

Distribution, sources, and ecol. risk of 43 compounds of polycyclic aromatic hydrocarbons (PAHs) in surficial sediments of the Persian Gulf were investigated. The sediments were sampled from 60 offshore stations during an oceanog. cruise in the winter of 2012. Gas chromatog. high-resolution mass spectrometry was used for the PAHs determinations in sediment samples. The concentrations of 21 parent PAHs, 7 methylated PAHs, 11 oxygenated PAHs and 4 nitrated PAHs were 9.0-201.5 ng g^-1 dw, 3.3-60.3 ng g^-1 dw, 15.2-172.7 ng g^-1 dw and 0.1-8.3 ng g^-1 dw, resp. Among 21 parental PAHs, naphthalene (29.35 ng g-1 dw), phenanthrene (4.6 ng g-1 dw), and pyrene (3.18 ng g-1 dw) were the most abundant compound 1-acenaphthenone (43.41 ng g-1 dw) and 2-methylnaphthalene (7.15 ng g-1 dw) showed the highest concentration in the oxy- and methyl-PAHs, resp. The concentrations of nitro-PAHs were between not detected to 4 ng g-1 dw. According to the ecol. risk assessment, the calculated total toxicity of PAHs was at below the lethal level on benthic organisms in all stations in the Persian Gulf, but there is risk of toxicity for the benthic organism in the Gulf of Oman (from the Strait of Hormuz to Jask). In general, nitrogenated and oxygenated derivatives did not show a significant risk in the study area. Based on the diagnostic ratios, the mixed sources (both petrogenic and pyrogenic) and pyrogenic sources have been identified for PAHs. Biomass combustion source has been identified for the stations near flares and gas fields. Principle component anal.-multivariate linear regression anal. for source identification shows that maritime traffic, abundant flares that burn the gas in oil, gas fields and dust storms have a major impact on the production of PAHs in this area.

Chemosphere published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Peterse, Evert published the artcileSolid-phase synthesis of macrocyclic peptides via side-chain anchoring of the ornithine ¦Ä-amine, Recommanded Product: Fmoc-Pro-OH, the publication is European Journal of Organic Chemistry (2022), 2022(11), e202101341, database is CAplus.

Cyclic peptides represent a popular class of macrocyclic drug candidates and therefore their solid phase synthesis has attracted much attention. In this contribution we present an efficient method of side-chain anchoring for ornithine and lysine residues to be used in the standard Fmoc-based (Fmoc = 9-fluorenylmethoxycarbonyl) synthesis of cyclic peptides via on-resin cyclization. We demonstrate that the side chain of ornithine and lysine protected with N-Boc-group (Boc = tert-butoxycarbonyl) can efficiently be converted to the isocyanate which is then immobilized on Wang-type resin in almost quant. yield. We further show the synthesis of four biol. active cyclic peptides employing the side chain ornithine anchoring. Our method is at least on a par with the previously reported methodologies in terms of yield and the purity of the final products and is arguably operationally more straightforward.

European Journal of Organic Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reddy, K. Paul published the artcileRapid gram-scale synthesis of Au/chitosan nanoparticles catalysts using solid mortar grinding, HPLC of Formula: 613-33-2, the publication is New Journal of Chemistry (2021), 45(1), 438-446, database is CAplus.

Owing to the abundant functional groups present in the chitosan polymer, high d. catalytic tiny gold particles with greater dispersion can be anchored on the chitosan powder using simple mortar and pestle. Chitosan-supported gold nanoparticles (NPs) with excellent control of size and shape were rapidly synthesized in gram-scale by solid-grinding without the need of any toxic solvents. The structure of catalysts and products was established by advanced instrumental and spectroscopic methods. The supported gold NPs functions as a heterogeneous catalyst for the homocoupling of phenylboronic acid and the aerobic oxidation of benzyl alc. in water. The catalytic behavior and activity of supported gold NPs was tuned/modulated by varying the ratio of chitosan polymer and gold precursor. Comparative studies showed that the solid chitosan supported gold catalyst exhibits superior catalytic activity and selectivity than the well known hydrophilic polymer-stabilized gold NPs catalysts prepared by the conventional solution-based methods.

New Journal of Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, HPLC of Formula: 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia