Month: December 2022

Ghiani, M. published the artcileMicrobial purification technique of mineral dressing plants reject waters, Quality Control of 2016-56-0, the publication is FEMS Microbiology Reviews (1993), 11(1-3), 153-7, database is CAplus and MEDLINE.

A microbial mineral reject water purification technique utilizing nonpathogenic strains was developed and is currently being implemented. Nonpathogenic strains such as Bacillus subtilis, Saccharomyces cerevisiae, Bifidobacterium bifidum, Lactobacillus acidophilus, and Acinetobacter calcoaceticus have been successfully tested for removing alkylsulfates, alkylamines and fatty acids from solutions simulating flotation plant tailings waters. Removals of ¡Ü90% in <48 h can be easily achieved with no nutrient requirements, since in most cases the flotation reagent residue to be removed is metabolized by the microorganisms themselves.

FEMS Microbiology Reviews published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Quality Control of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Castelli, Ugo published the artcileEvidence of Phosphonium-Carbenium Dication Formation in a Superacid: Precursor to Fluorinated Phosphine Oxides, Quality Control of 4141-48-4, the publication is Angewandte Chemie, International Edition (2019), 58(5), 1355-1360, database is CAplus and MEDLINE.

Unambiguously confirmed by low-temperature in situ NMR experiments, x-ray diffraction and vibrational spectroscopy, phosphonium-carbenium superelectrophiles are generated in strong acidic conditions. Representing crucial intermediates, their exploitation allows for the synthesis of unprecedented fluorinated (cyclic) phosphine oxides.

Angewandte Chemie, International Edition published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Quality Control of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fliri, Anton F. published the artcileDrug effects viewed from a signal transduction network perspective, Quality Control of 38260-01-4, the publication is Journal of Medicinal Chemistry (2009), 52(24), 8038-8046, database is CAplus and MEDLINE.

Understanding how drugs affect cellular network structures and how resulting signals are translated into drug effects holds the key to the discovery of medicines. Herein we examine this cause-effect relationship by determining protein network structures associated with the generation of specific in vivo drug-effect patterns. Medicines having similar in vivo pharmacol. have been identified by a comparison of drug-effect profiles of 1320 medicines. Protein network positions reached by these medicines were ascertained by examining the coinvestigation frequency of these medicines and 1179 protein network constituents in millions of scientific investigations. Interestingly, medicine associations obtained by comparing by drug-effect profiles mirror those obtained by comparing drug-protein coinvestigation frequency profiles, demonstrating that these drug-protein reachability profiles are relevant to in vivo pharmacol. By using protein associations obtained in these investigations and independent, curated protein interaction information, drug-mediated protein network topol. models can be constructed. These protein network topol. models reveal that drugs having similar pharmacol. profiles reach similar discrete positions in cellular protein network systems and provide a network view of medicine cause-effect relationships.

Journal of Medicinal Chemistry published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Quality Control of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ahmed, Shamshad published the artcilePurines, pyrimidines, and imidazoles. Part XLIV. Syntheses of some dihydro-1,3-oxazine derivatives and related substituted uracils, COA of Formula: C3H8N2S, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1976), 1969-75, database is CAplus and MEDLINE.

The oxazinedione I (R = Me, R1 = R2 = H, X = O) (II) was prepared from MeCOCH2CO2Et by reaction with CO(NHR3)2 (R3 = Me, Et) in AcOH-Ac2O, or by heating with H2NCO2Et in the presence or absence of solvent. II was also prepared by heating MeCOCH2CONHR3 (III; R3 = CO2Et), or by heating III (R3 = CONMe2) with AcOH-Ac2O or H2SO4; its structure was confirmed by 1H and 13C NMR spectroscopy. Similar treatment of various ¦Â-oxo esters, including C-methyl and C-benzyl derivatives, with H2NCO2Et and with CO(NHMe)2 gave 6-aryl- and 6-alkyloxazinediones and 5,6-dialkyloxazinediones. E.g. 4-FC6H4COCH2CO2Et with CO(NHMe)2 in AcOH-Ac2O at reflux for 4 hr gave I (R = 4-FC6H4, R1 = R2 = H, X = O) whereas similar treatment of H2NCO2Et with MeCOCHMeCO2Et gave I (R = R1 = Me, R2 = H, X = O). Treatment of the oxazinediones I (X = O) with ammonia and with primary amines gave substituted uracils, whereas with secondary amines, acylated ureas were obtained. E.g. II with NH3, MeNH2, and NH2OH gave the corresponding substituted uracils I (R = Me, R1 = R2 = H, X = NH, NMe, NOH, resp.) and with H2NCH2CO2H, the acylated urea I (R = Me, R1 = R2 = H, X = NCH2CO2H) was obtained. II dimerized on heating with NaOH to give (6-hydroxy-4-methyl-2-pyridyl)acetic acid.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, COA of Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nau, Heinz published the artcilePharmacologic evaluation of various metabolites and analogs of valproic acid: teratogenic potencies in mice, Related Products of catalysis-chemistry, the publication is Fundamental and Applied Toxicology (1986), 6(4), 669-76, database is CAplus and MEDLINE.

The teratogenicity of valproic?acid (VPA) [99-66-1] and its metabolites and analogs was tested in mice following a single s.c. injections of 600 mg/kg on day 8 of gestation. VPA was highly teratogenic at this dose level and >60% of live fetuses had neural tube defects (exencephaly). Homologous compounds with shorter or longer alkyl chains were less teratogenic than VPA. Substitution of the ¦Á-H atoms in related branched carboxylic acids by Me or Et groups abolished the teratogenic response. Introduction of a double bond in the ¦Ø-position of VPA (4-en-VPA [1575-72-0]) did not change the teratogenicity of VPA, while a ¦Ø-2 double bond (2-en-VPA [60218-41-9]) abolished teratogenicity. The other VPA metabolites tested as well as 2 straight-chain acids (n-octanoic?acid??[124-07-2] and 4-pentenoic?acid??[591-80-0]) and the 2 clin. used substances valpromide??[2430-27-5] and ethosuximide??[77-67-8] did not induce neural tube defects, although some of them induced slightly increased resorption rates and fetal weight retardation. The serum-protein-binding capacities of the various compounds did not correlate with the teratogenic response. Also the concentrations reached in the gestational material did not predict the teratogenicity of the substances tested. Apparently, the teratogenicity of the class of compounds studied represents a more specific effect than the anticonvulsant activity, which could lead to the development of alternative antiepileptic drugs with low embryotoxic potential.

Fundamental and Applied Toxicology published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Giessel, Josephine M. published the artcileCaffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2019), 259-268, database is CAplus and MEDLINE.

Unexpected inhibitory effects against eeAChE could be found for a newly synthesized class of caffeic acid phenethyl ester (CAPE) derivatives Thus, phenethyl-(E)-3-(3,5-dimethoxy-4-phenethoxyphenyl)-acrylate (K_i = 1.97 ¡À 0.38 ¦ÌM, K_i’ = 2.44 ¡À 0.07 ¦ÌM) and 4-(2-(((E)-3-(3,4-bis(benzyloxy)phenyl)acryloyl)oxy)ethyl)-1,2-phenylene (2E,2’E)-bis(3-(3,4-bis(benzyloxy)phenyl)acrylate) (K_i = 0.72 ¡À 0.31 ¦ÌM, K_i’ = 1.80 ¡À 0.21 ¦ÌM) showed very good inhibition of eeAChE, while being non cytotoxic for malignant human cancer cells and non-malignant mouse fibroblasts. Also, they are weak inhibitors for BChE (from equine serum).

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yagodkin, Andrey published the artcileStraightforward carbamoylation of nucleophilic compounds employing organic azides, phosphines, and aqueous trialkylammonium hydrogen carbonate, Related Products of catalysis-chemistry, the publication is Tetrahedron (2010), 66(12), 2210-2221, database is CAplus.

In the presence of aqueous trialkylammonium hydrogen carbonate, the Staudinger reaction leads to the intermediate formation of the corresponding isocyanate, which, in turn, reacts further with a nucleophilic reagent also present in the mixture and results in carbamoylation with good yield. On the basis of this reaction a practical carbamoylation procedure was devised and a comparative study on suitability of different solvents and phosphorus (III) derivatives for carbamoylation reaction was conducted. The versatility of the method was demonstrated by examples with different classes of nucleophilic compounds that included the aminomethyl resin and natural compounds that display poor solubility in organic solvents.

Tetrahedron published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C9H21NO3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lovelock, Sarah L. published the artcilePhenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway, COA of Formula: C9H7NO4, the publication is Angewandte Chemie, International Edition (2014), 53(18), 4652-4656, database is CAplus and MEDLINE.

Phenylalanine ammonia-lyases (PALs) belong to a family of 4-methylideneimidazole-5-one (MIO) cofactor-dependent enzymes which are responsible for the conversion of L-phenylalanine into trans-cinnamic acid in eukaryotic and prokaryotic organisms. Under conditions of high NH₃ concentration, this deamination reaction is reversible and hence there is considerable interest in the development of PALs as biocatalysts for the enantioselective synthesis of non-natural amino acids. Here, the discovery of a previously unobserved competing MIO-independent reaction pathway, which proceeds in a non-stereoselective manner and results in the generation of both L– and D-phenylalanine derivatives, is described. The mechanism of the MIO-independent pathway is explored through isotopic-labeling studies and mutagenesis of key active site residues. The results obtained were consistent with amino acid deamination occurring by a stepwise E₁cB elimination mechanism.

Angewandte Chemie, International Edition published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huynh, Khoi published the artcileN,N’-dibenzosuberyl-1,1′-binaphthyl-2,2′-diamine: a highly effective supporting ligand for the enantioselective cyclization of aminoalkenes catalyzed by chelating diamide complexes of La(III) and Y(III), Application of 2,2-Diallylpent-4-en-1-amine, the publication is Synlett (2014), 25(12), 1721-1724, 4 pp., database is CAplus.

Enantioselective hydroamination/cyclization of representative aminoalkenes catalyzed by chelating diamide complexes of La(III) and Y(III) are described. It is noteworthy that the La(III) complex derived from the sterically demanding (R)-N,N’-dibenzosuberyl-1,1′-binaphthyl-2,2′-diamine proligand provides enantioselectivities that are in many cases significantly higher than those obtained with the corresponding Y(III) analog. In addition, the presence of LiCl was typically found to suppress both the rates and the enantioselectivities obtained with the Y(III) complex when compared to its La(III) counterpart, in addition to completely suppressing the bicyclization of 2,2-diallylpent-4-en-1-amine. The amide complexes employed in the latter study were prepared by ‘amine elimination’ using the new, highly active bases La[N(TMS)(t-Bu)]₃ and Y[N(TMS)(t-Bu)]₃.

Synlett published new progress about 928836-00-4. 928836-00-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain, name is 2,2-Diallylpent-4-en-1-amine, and the molecular formula is C11H19N, Application of 2,2-Diallylpent-4-en-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yao, Yuqin published the artcileDesign, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy, Recommanded Product: 1,1,1-Trifluoropropan-2-amine, the publication is Acta Pharmaceutica Sinica B (2020), 10(8), 1453-1475, database is CAplus and MEDLINE.

In this study, the design, synthesis, target identification, mol. mechanism, pharmacodynamics (PD) and pharmacokinetics (PK) research of a novel triple-angiokinase inhibitor WXFL-152 is reported. WXFL-152, identified from a series of 4-oxyquinoline derivatives based on a structure-activity relationship study, inhibited the proliferation of vascular endothelial cells (ECs) and pericytes by blocking the angiokinase signals VEGF/VEGFR2, FGF/FGFRs and PDGF/PDGFRb simultaneously in vitro. Significant anticancer effects of WXFL-152 were confirmed in multiple preclin. tumor xenograft models, including a patient-derived tumor xenograft (PDX) model. Pharmacokinetic studies of WXFL-152 demonstrated high favorable bioavailability with single-dose and continuous multi-dose by oral administration in rats and beagles. In conclusion, WXFL-152, which is currently in phase Ib clin. trials, is a novel and effective triple-angiokinase inhibitor with clear PD and PK in tumor therapy.

Acta Pharmaceutica Sinica B published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C18H17N5O3, Recommanded Product: 1,1,1-Trifluoropropan-2-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia