Month: December 2022

Pei, Jingyan published the artcileTransport, Stability, and In Vivo Hypoglycemic Effect of a Broccoli-Derived DPP-IV Inhibitory Peptide VPLVM, Quality Control of 71989-31-6, the publication is Journal of Agricultural and Food Chemistry (2022), 70(16), 4934-4941, database is CAplus and MEDLINE.

Diabetes is a major metabolic disease that requires long-term pharmacotherapy. Bioactive peptides have unique advantages such as higher potency, selectivity, and safety over small mols. and have achieved great success in the treatment of diabetes. We previously isolated a dipeptidyl peptidase-IV (DPP-IV) inhibitory peptide VPLVM with IC₅₀ = 99.68¦ÌM from the protein hydrolyzates of broccoli stems and leaves. Here, we evaluated the interaction with DPP-IV, transport, stability, and in vivo hypoglycemic effects of VPLVM. VPLVM interacted closely and steadily with DPP-IV at S1 and S2 pockets. VPLVM had a good gastrointestinal enzyme resistance and was transported through the Caco-2 cell monolayer via paracellular diffusion and by the PepT1 with a P_app of 6.96 x 10^-7 cm/s. VPLVM has a t_1/2 of 12.56 ¡À 0.41 min in vitro plasma stability. In the oral glucose tolerance test, VPLVM showed an excellent hypoglycemic effect at 30 min after administration. VPLVM has potential as a candidate for the treatment of hyperglycemia.

Journal of Agricultural and Food Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Quality Control of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tan, Xinqiang published the artcileSilver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids, Formula: C11H14O2, the publication is Journal of the American Chemical Society (2017), 139(36), 12430-12433, database is CAplus and MEDLINE.

The silver-catalyzed decarboxylative trifluoromethylation of aliphatic carboxylic acids is described. With AgNO₃ as the catalyst and K₂S₂O₈ as the oxidant, the reactions of aliphatic carboxylic acids with (bpy)Cu(CF₃)₃ (bpy = 2,2′-bipyridine) and ZnMe₂ in aqueous acetonitrile at 40 ¡ãC afford the corresponding decarboxylative trifluoromethylation products in good yield. The protocol is applicable to various primary and secondary alkyl carboxylic acids and exhibits wide functional group compatibility. Mechanistic studies reveal the intermediacy of ^–Cu(CF₃)₃Me, which undergoes reductive elimination and subsequent oxidation to give Cu(CF₃)₂ as the active species responsible for the trifluoromethylation of alkyl radicals.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C9H7NO2, Formula: C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Mei published the artcileBiomimetic synthesis and anti-inflammatory effects of horsfiequinone A, Related Products of catalysis-chemistry, the publication is Tetrahedron Letters (2021), 152756, database is CAplus.

Inspired by the oxy-tyrosinase type II copper enzyme, a biomimetic synthesis of the natural product horsfiequinone A (I) has been achieved using CuOTf/DBED/O₂ catalyzed oxidation as a key step. The synthetic route furnished 1 in 33% overall yield (64% brsm) from com. available para-hydroxybenzaldehyde. Moreover, revisiting the biol. activity of 1 resulted in the discovery of its in vitro inhibitory activity towards nitric oxide (NO) production in LPS-induced RAW264.7 cells with an IC₅₀ value of 4.42 ¡À 0.81¦ÌM. The anti-inflammatory effect of 1 was further supported by an iNOS expression inhibition assay and mol. docking simulation.

Tetrahedron Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H9N3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Haiyao published the artcileHydrophobic carbon dots with blue dispersed emission and red aggregation-induced emission, Application In Synthesis of 119-80-2, the publication is Nature Communications (2019), 10(1), 1-11, database is CAplus and MEDLINE.

Carbon dots (CDs) have been studied for years as one of the most promising fluorescent nanomaterials. However, CDs with red or solid-state fluorescence are rarely reported. Herein, through a one-pot solvothermal treatment, hydrophobic CDs (H-CDs) with blue dispersed emission and red aggregation-induced emission are obtained. When water is introduced, the hydrophobic interaction leads to aggregation of the H-CDs. The formation of H-CD clusters induces the turning off of the blue emission, as the carbonized cores suffer from ¦Ð-¦Ð stacking interactions, and the turning on of the red fluorescence, due to restriction of the surfaces’ intramol. rotation around disulfide bonds, which conforms to the aggregation-induced-emission phenomenon. This on-off fluorescence of the H-CDs is reversible when the H-CD powder is completely dissolved. Moreover, the H-CD solution dispersed in filter paper is nearly colorless. Finally, we develop a reversible two switch-mode luminescence ink for advanced anti-counterfeiting and dual-encryption.

Nature Communications published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H24N2O2, Application In Synthesis of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Chung-Hao published the artcilePhotoaccelerated Suzuki-Miyaura and Sonogashira coupling reactions catalyzed by an Ir-Pd binuclear complex, HPLC of Formula: 613-33-2, the publication is Molecular Catalysis (2022), 112232, database is CAplus.

Reaction of iridium complex [Ir(N,C-dFppy)₂(L)Cl] [L = 5-phenyl-2,8-di-2-pyridinyl-anthyridine] with (CH₃CN)PdCl₂ to yield a hetero-binuclear complex Ir-Pd via ortho-metalation. Complexes were characterized by spectroscopic and crystallog. methods. Complex Ir-Pd showed an excellent catalytic activity for both Suzuki-Miyaura and Sonogashira cross coupling reactions under blue LED irradiation at ambient temperature This catalytic system was operated via light energy harvested by the Ir center, which was able to cooperate with Pd center for the coupling reactions to take place. Effects on these coupling reactions catalyzed by Ir-Pd under photochem. conditions were studied.

Molecular Catalysis published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C15H20O6, HPLC of Formula: 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Bo published the artcileSyntheses and structure-activity relationship studies of N-substituted-¦Â-D-glucosaminides as selective cytotoxic agents, Application In Synthesis of 16909-09-4, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(23), 7110-7113, database is CAplus and MEDLINE.

Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone groups, e.g. I (R = H, R¹ = Me, OMe; R = OMe, R¹ = H), were synthesized concisely. The cytotoxicities of the synthetic compounds on six human caner cell lines were evaluated employing MTT method. Structure-activity relationship could be observed, and two of the synthesized compounds I (R = H, R¹ = Me, OMe) exhibited selective inhibition on HeLa and MCF-7 cells, while three of them, e.g. I (R = OMe, R¹ = H), showed strong inhibition against HT1080.

Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C7H10O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Jianglong published the artcileCu(II)-Catalyzed Ligand-Free Oxidation of Diarylmethanes and Second Alcohols in Water, Safety of Bis(4-fluorophenyl)methane, the publication is Chinese Journal of Chemistry (2017), 35(9), 1391-1395, database is CAplus.

A simple and efficient Cu(II)-catalyzed ligand-free oxidation of diarylmethanes, e.g., 9H-xanthene and secondary alcs., e.g., 2,3-dihydro-1H-Inden-1-ol using 70% tert-Bu hydroperoxide (TBHP) in water were developed. A series of diarylmethanes were directly oxidized into diaryl ketones, e.g., 9H-xanthen-9-one in 67%-98% yields. Addnl., various secondary alcs. were also transformed into the desired products in 48%-98% yields. Importantly, the catalytic system in the absence of any organic solvent, surfactant, or phase transfer agent, had a wide substrate scope and a high tolerance for various functional groups.

Chinese Journal of Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C25H47NO8, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Lin published the artcileAn improved radiosynthesis of [¹⁸F]AV-133: a PET imaging agent for vesicular monoamine transporter 2, SDS of cas: 17351-62-1, the publication is Nuclear Medicine and Biology (2010), 37(2), 133-141, database is CAplus and MEDLINE.

Recently, a PET tracer, 9-[¹⁸F]fluoropropyl-(+)-dihydrotetrabenazine ([¹⁸F]AV-133), targeting vesicular monoamine transporter 2 (VMAT2) in the central nervous system was reported. It is currently under Phase II clin. trials to establish its usefulness in the diagnosis of neurodegenerative diseases including dementia with Lewy bodies and Parkinson’s disease. The radiolabeling of [¹⁸F]AV-133, nucleophilic fluorination reaction and potential effects of pseudo-carrier were evaluated by in vivo biodistribution. The preparation of [¹⁸F]AV-133 was evaluated under different conditions, specifically by employing different precursors (-OTs or -Br as the leaving group at the 9-propoxy position), reagents (K222/K₂CO₃ vs. tributylammonium bicarbonate) and solvents (acetonitrile vs. DMSO), reaction temperature and reaction time. With optimized conditions from these experiments, radiosynthesis and purification with solid-phase extraction (SPE) of [¹⁸F]AV-133 were performed by an automated nucleophilic [¹⁸F]fluorination module. In vivo biodistribution in mice on [¹⁸F]AV-133 purified by either HPLC (no-carrier-added) or the SPE method (containing a pseudo-carrier) was performed and the results compared. Under a mild fluorination condition (heating at 115¡ãC for 5 min in DMSO), [¹⁸F]AV-133 was obtained in a high yield using either -OTs or -Br as the leaving group. However, the -OTs precursor gave better radiochem. yields (>70%, thin layer chromatog. anal.) compared to those of the -Br precursor. The optimized reaction conditions were successfully implemented to an automated nucleophilic fluorination module. Labeling and purification of [¹⁸F]AV133 were readily achieved via this automatic module in good radiochem. yield of 21-41% (n=10) in 40 min. The radiochem. purity was larger than 95%. Biodistribution of SPE-purified product (containing a pseudo-carrier) in mice showed a high striatum/cerebellum ratio (4.18¡À0.51), which was comparable to that of HPLC-purified [¹⁸F]AV-133 (4.51¡À0.10). The formation of [¹⁸F]AV-133 was evaluated under different labeling conditions. These improved labeling conditions and SPE purification were successfully implemented into an automated synthesis module. This offers a short preparation time (about 40 min), simplicity in operation and ready applicability for routine clin. operation.

Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C12H9N3O4, SDS of cas: 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Yong published the artcileAn Efficient Synthesis of N,N,N-Substituted 1,4,7-Triazacyclononane, HPLC of Formula: 140-28-3, the publication is European Journal of Organic Chemistry (2018), 2018(13), 1546-1551, database is CAplus.

A new and efficient synthetic approach is reported for various N,N,N-substituted 1,4,7-triazacyclononanes (TACN) in moderate to excellent yields, with optimization of the reaction sequences and conditions of the intermediate 1,4,7-tribenzyl-1,4,7-triazonane-2,6-dione reduction with LiAlH₄, removal of benzyl with Pd/C, and alkylation reactions. This reaction scheme provides a convenient and flexible method to prepare various N,N,N-substituted TACN derivatives

European Journal of Organic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, HPLC of Formula: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tang, Ni published the artcileAmine- and thiol-bifunctionalized mesoporous silica material for immobilization of Pb and Cd: Characterization, efficiency, and mechanism, Safety of 3-(Trimethoxysilyl)propan-1-amine, the publication is Chemosphere (2022), 291(Part_1), 132771, database is CAplus and MEDLINE.

In this study, a two-step functionalizing strategy by combining co-condensation with grafting procedures was employed to synthesize well-ordered Amino- and Thiol-Bifunctionalized SBA-15 (ATBS) mesoporous silica. Its physicochem. properties, performance, and mechanisms in immobilization of toxic metals Pb and Cd in water and soil were investigated. After bi-functionalization, X-ray diffractometer, transmission electron microscope, and N₂ adsorption-desorption measurements confirmed that the ATBS maintained a highly-ordered mesoporous structure, large surface area and pore volume The elemental anal., Fourier transform IR spectroscopy and XPS evidenced the successful incorporation of amine and thiol groups into ATBS. These structure and functional characteristics of ATBS benefited Pb and Cd sorption. Sorption isotherms of Pb and Cd were better fit with Sips and Redlich-Peterson models. Sorption kinetics suggested that Pb sorption was mainly regulated by chem. reactions, whereas both diffusion process and chem. reactions were rate-regulating steps in Cd sorption. ATBS showed the maximum sorption capacities for Pb and Cd at 120 and 38 mg g-1, resp. The sorption mechanisms revealed by XPS measurements suggested that Cd sorption was mainly attributed to thiol groups while Pb was efficiently bond to both thiol and amino groups. High and stable sorption efficiencies were attained in the pH range of 4-6, with a higher affinity towards Pb than Cd. Furthermore, its ability to immobilize Pb and Cd in soils was examined with an incubation experiment, which showed that ATBS reduced 30-56% of MgCl2-extractable Pb and Cd in a contaminated soil. The synthesized sorbent via the two-step functionalizing strategy shows high sorption efficiency towards Pb and Cd, and thus it has potential application in remediating Pb and Cd contaminated water and soils.

Chemosphere published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C22H21N3O3S, Safety of 3-(Trimethoxysilyl)propan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia