Month: December 2022

Thomas, Jennifer L. published the artcileSeparation and detection of smokeless powder additives by ultra performance liquid chromatography with tandem mass spectrometry (UPLC/MS/MS), Application In Synthesis of 1821-27-8, the publication is Journal of Forensic Sciences (2013), 58(3), 609-615, database is CAplus and MEDLINE.

A reversed phase gradient ultra performance liquid chromatog. tandem mass spectrometry (UPLC/MS/MS) method has been developed for the anal. of smokeless powders. A total of 20 different components were separated by UPLC and detected by MS/MS in multiple reaction monitoring (MRM) mode. These compounds included diphenylamines, centralites, nitrotoluenes, nitroglycerin, and various phthalates. Simultaneous pos. and neg. electrospray ionization (ESI) was used along with neg. atm. pressure chem. ionization (APCI) to detect all compounds in a single anal. Anal. times were under 8 min with a gradient of 10-73% organic at a flow rate of 0.500 mL/min. With this method, UV and MRM limits of detection ranging from 0.08 to 2.6 ng and 0.4-64 ng injected were achieved. Com. available smokeless powders were also extracted with methylene chloride and characterized using the developed UPLC/MS/MS method. The procedure permits the determination of compositional differences between different brands as well as lot-to-lot variations.

Journal of Forensic Sciences published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C7H5Br2F, Application In Synthesis of 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shan, Shijie published the artcileStretchable, robust and reprocessable poly(siloxane-urethanes) elastomers based on exchangeable aromatic disulfides, Category: catalysis-chemistry, the publication is Polymer (2021), 123588, database is CAplus.

The rapid expansion of dynamic covalent chem. world urges for materials not only possessing high mech. properties and stretchability, but also including high reprocessability and reforming. Herein, aromatic disulfide-containing polysiloxanes elastomers with modified urea as chain-extender and crosslinker were first designed and fabricated. Dynamic crosslinks, including hydrogen bonding formed between urea and amide bonds, and aromatic disulfide are connected with polysiloxanes backbones through isocyanate (DTSA-HDI) reacted with systematically controlled aminopropyl groups in the side chains. Consequently, a series of ATPx-SS elastomers with polysiloxanes of different mol. weight and APPx-SS elastomers with different crosslinking densities are developed. The molar amount of DTSA-HDI has been proved to play a crucial role in adjusting the mech. and thermal properties of the networks. Among all, ATP3-SS showed the best stretchability, of which the elongation at break was as high as 780%. APP1-SS achieved the highest tensile strength of 2.60 MPa. Besides, it has outstanding reprocessability and can be reprocessed and reformed without much decline of tensile strength after several cycles of hot-pressing. These remarkable properties demonstrate that the aromatic disulfide-containing elastomers are competitive to those un-filled polysiloxanes elastomers based on dynamic bonds ever reported.

Polymer published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C7H10O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Lianbin published the artcileMetabolic profilings of rat INS-1 ¦Â-cells under changing levels of essential amino acids, Application In Synthesis of 63-68-3, the publication is Scientific Data (2022), 9(1), 299, database is CAplus and MEDLINE.

Application of mass spectrometry enables the detection of metabolic differences between organisms with different nutritional settings. Divergence in the metabolic fingerprints of rat pancreatic INS-1 ¦Â-cells were systematically captured with regard to ten individual essential amino acid (EAA) availability. A high-resolution tandem mass spectrometry system coupled to liquid chromatog. produced a horizontal comparison of metabolic profilings of ¦Â-cells with individual EAA elevated to 10 mmol/L by turn or removal individual EAA from the medium one by one. Quality control samples were injected at regular intervals throughout the anal. run to monitor and evaluate the stability of the system. The raw data of samples and reference compounds including study protocols have been deposited in the open metabolomics database MetaboLights to enable efficient reuse of the datasets, such as investigating the difference in metabolic process between diverse EAAs as well as screening and verifying potential metabolites affecting insulin secretion and ¦Â-cell function.

Scientific Data published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H13Cl2N, Application In Synthesis of 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Ya published the artcileStructural basis of FPR2 in recognition of A¦Â₄₂ and neuroprotection by humanin, HPLC of Formula: 63-68-3, the publication is Nature Communications (2022), 13(1), 1775, database is CAplus and MEDLINE.

Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the ¦Â amyloid peptide A¦Â42 and serves as a receptor for humanin, a peptide that protects neuronal cells from damage by A¦Â42, implying its involvement in the pathogenesis of Alzheimers disease (AD). However, the interaction pattern between FPR2 and A¦Â42 or humanin remains unknown. Here we report the structures of FPR2 bound to Gi and A¦Â42 or N-formyl humanin (fHN). Combined with functional data, the structures reveal two critical regions that govern recognition and activity of A¦Â42 and fHN, including a polar binding cavity within the receptor helical bundle and a hydrophobic binding groove in the extracellular region. In addition, the structures of FPR2 and FPR1 in complex with different formyl peptides were determined, providing insights into ligand recognition and selectivity of the FPR family. These findings uncover key factors that define the functionality of FPR2 in AD and other inflammatory diseases and would enable drug development.

Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C7H8O3, HPLC of Formula: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Altoe, Antonio P. published the artcileIonophoric neutral diamides. Phenylenedioxydiacetamides, Quality Control of 5411-14-3, the publication is Quimica Nova (1984), 7(1), 4-6, database is CAplus.

o-C₆H₄(OCH₂CONRR¹)₂ [I, R = H, R¹ = H, Et, Bu, CMe₃, cyclopentyl, cyclohexyl, CH₂CH(OMe)₂, Ph, 1-naphthyl, CMe:CHCO₂Me, 2-AcC₆H₄; R = Et, R¹ = Et, Ph; R = Me, R¹ = CONHMe; NRR¹ = piperidino, morpholino] were prepared by treating o-C₆H₄(OH)₂ with BrCH₂CO₂Et in aqueous NaOH, chelating the diacid, and amidating. I, except I (R = H, R¹ = Ph, 1-naphthyl, CMe:CHCO₂Me, 2-AcC₆H₄) complexed alk. earth metals.

Quimica Nova published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Quality Control of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liao, Wei-Jr published the artcileSite-Selective Acylation of Phenols Mediated by a Thioacid Surrogate through Sodium Thiosulfate Catalysis, Computed Properties of 118-90-1, the publication is Organic Letters (2022), 24(23), 4207-4211, database is CAplus and MEDLINE.

Sodium thiosulfate was used as the sulfur source that reacts with anhydrides to generate acyl-Bunte salts, after which a reaction with phenols was induced. This protocol can be applied for the site-selective acylation of the phenolic hydroxyl group in the presence of other alc. groups. The advantages of this acylation method are operational simplicity, high efficiency, and the use of odorless reagents with low toxicity.

Organic Letters published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Liwei published the artcileA nanomedicine enables synergistic chemo/photodynamic therapy for pancreatic cancer treatment, Category: catalysis-chemistry, the publication is Biomaterials Science (2022), 10(13), 3624-3636, database is CAplus and MEDLINE.

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Gemcitabine (Gem) has been a key chemotherapy agent for pancreatic cancer treatment by suppressing cell proliferation and inducing apoptosis. However, the overexpression of inhibitors of apoptosis (IAP) family of proteins during the carcinogenesis of pancreatic cancer can develop resistance to chemotherapy treatment and result in poor efficacy. To achieve the synergistic combinations of multiple strategies for this dismal disease, we developed a robust nanomedicine system, consisting of a photodynamic therapeutic agent (chlorine e6, Ce6) and a pro-apoptotic peptide-Gem conjugate. To have spatiotemporally controlled drug release, the pro-apoptotic peptide-Gem conjugate was designed to have a vinyldithioether linker that was sensitive to reactive oxygen species (ROS). The nanomedicine was fabricated by the direct self-assembly of the pro-apoptotic peptide-Gem conjugate with Ce6. After being delivered into tumors, the nanomedicine disassembled and rapidly released Gem, Ce6, and the pro-apoptotic peptide upon light illumination (660 nm). Both in vitro and in vivo studies in pancreatic cancer models confirmed the tumor inhibition efficacy with low systemic toxicity to animals.

Biomaterials Science published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C17H16O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Luo, Jinyun published the artcileThe organocatalytic synthesis of perfluorophenylsulfides via the thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates, Quality Control of 1206-46-8, the publication is Organic & Biomolecular Chemistry (2021), 19(42), 9237-9241, database is CAplus and MEDLINE.

The organic superbase t-Bu-P₄-catalyzed direct thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates was developed. Yields of perfluorophenylsulfides of up to 97% under catalysis of 5 mol% t-Bu-P₄ were achieved. This method was shown to provide an efficient way to construct the perfluorophenyl-sulfur bond under mild metal-free reaction conditions.

Organic & Biomolecular Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Quality Control of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Xinfei published the artcileAerobic Oxidation of Benzylic sp³ C-H Bonds through Cooperative Visible-Light Photoredox Catalysis of N-Hydroxyimide and Dicyanopyrazine, Formula: C13H10F2, the publication is Asian Journal of Organic Chemistry (2017), 6(4), 422-425, database is CAplus.

A visible-light-driven cooperative catalysis between dicyanopyrazine-derived chromophore (DPZ) and N-hydroxyimide has been developed. Under irradiation with a low-energy and operationally convenient visible light, the cooperative catalytic system could facilitate the aerobic oxygenation of a series of benzylic sp³ C-H bonds through a photoredox pathway. The method provides a novel approach to access valuable carbonyls from benzylic methylenes and benzylic alcs. in moderate to excellent yields (up to 93 %).

Asian Journal of Organic Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Formula: C13H10F2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Da-Wei published the artcileAn Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors, Computed Properties of 163839-73-4, the publication is Journal of Agricultural and Food Chemistry (2016), 64(47), 8986-8993, database is CAplus and MEDLINE.

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. To search for novel HPPD inhibitors, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using of N,N’-Carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH₂Cl₂. A total of 58 triketone compounds were prepared in good to excellent yields. Some of the synthesized compounds displayed potent Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one (I) displayed high, broad-spectrum and post-emergent herbicidal activity at the rate of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, I showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that I might have the potential as herbicide for the weed control in maize and canola fields. I is the first HPPD inhibitor showing good crop safety towards canola.

Journal of Agricultural and Food Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C15H12O8, Computed Properties of 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia