Month: December 2022

Han, Yi published the artcileThe protecting group enabled para-selective C-H benzylation of anilides via iron(II) catalysis: a convenient approach for the synthesis of triarylmethanes, Formula: C13H10F2, the publication is Organic Chemistry Frontiers (2020), 7(14), 1823-1827, database is CAplus.

A series of triarylmethanes I [R = H, 2-Me, 3-Cl, etc.; R¹ = NHC(O)Me, NHC(O)C(Me)₃, NHCO₂CH₂CH(Me)₂, etc.; R² = Me, Ph, 2-MeC₆H₄, etc.; Ar = Ph, 4-FC₆H₄, 4-EtC₆H₄, etc.] was synthesized via iron catalyzed para-selective C-H benzylation of iso-Bu Ph carbamates with diarylmethanes. Iso-Bu Ph carbamates were prepared using reaction of anilines and iso-Bu chloroformate. Preliminary mechanistic studies revealed that the iron(II) catalyst was essential and the use of the sterically demanding isobutoxy group led to high para-selectivity.

Organic Chemistry Frontiers published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Formula: C13H10F2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Lei published the artcileOrganocatalytic asymmetric Michael reaction with acylsilane donors, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Organic & Biomolecular Chemistry (2013), 11(3), 443-447, database is CAplus and MEDLINE.

Authors have developed an organocatalytic asym. Michael reaction of acylsilane through the selection of acylsilane substrates and organocatalysts, thus creating a rare example of acylsilane ¦Á-alkylation with a chiral guanidine catalyst, which afforded products in good yields and high stereoselectivity. The corresponding adducts described here have also been demonstrated to be useful in the synthesis of unnatural amino acids and biol. active compounds

Organic & Biomolecular Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C18H24N6O6S4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Mianmian published the artcileTotal syntheses of benzylisoquinoline alkaloids Neolitacumoine, Mollinedine and Papaverine, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Youji Huaxue (2020), 40(1), 149-155, database is CAplus.

A new general synthetic route towards benzylisoquinoline alkaloids was developed. The key step of this route is Cu-catalyzed cascade oxidation-aromatization of 1-benzyl-3,4-dihydroisoquinolines. The three benzylisoquinoline alkaloids such as Neolitacumoine, Mollinedine and Papaverine were synthesized starting from piperonaldehyde and 3,4-dimethoxybenzaldehyde by 8 steps in 42%, 37% and 37% overall yields, resp.

Youji Huaxue published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C16H24BNO2, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Jun published the artcileStructural diversity and properties of six coordination polymers derived from 1,2/1,3-phenylenedioxydiacetic acids and varied N-donor co-ligands, HPLC of Formula: 5411-14-3, the publication is Inorganica Chimica Acta (2014), 6-15, database is CAplus.

Based on two positional isomers of phenylenedioxydiacetate ligands and different N-containing co-ligands, six novel coordination polymers, formulated as {[Zn(o-PDOA)(bpp)]¡¤2H₂O}_n (1), {[Cd(o-PDOA)(bix)]¡¤3H₂O}_n (2), [Cd(m-PDOA)(bix)]_n (3), [Cd(m-PDOA)(bib)]_n (4), [Zn(m-PDOA)(bix)]_n (5), {[Zn(m-PDOA)(bib)]¡¤2H₂O}_n (6), (o/m-H₂PDOA = 1,2/1,3-phenylenedioxydiacetic acid; bix = 1,4-bis(imidazolylmethyl)benzene; bib = 1,4-bis(1H-imidazol-1-yl)-butane; bpp = 1,3-bis(4-pyridyl)propane), were prepared under hydrothermal conditions. 1 Features a three-dimensional (3D) 2-fold interpenetrating cds topol. In 2, the (H₂O)₆ clusters interlink the 1-dimensional double [Cd₂(o-PDOA)₂(bix)₂]_n chains into a 3-dimensional supramol. network. 3 Is a (3,5)-connected 2-dimensional layer with (4².6)(4².6⁷.8) topol. Compound 4 exhibits a 3-fold interpenetrating pcu topol. network, while, 5 is a 2-dimensional puckered meso-helical 4⁴-sql layer built by alternately arranged right-handed and left-handed helical chains. In contrast to 1–5, compound 6 possesses a 1-dimensional loop-like chain and rare D4 tetrameric (H₂O)₄ cluster extends the chains into a 3-dimensional supramol. framework. Also, the thermal stabilities and luminescent properties of compounds 1–6 also were studied.

Inorganica Chimica Acta published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C5H5N3S, HPLC of Formula: 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zeng, Xiao-Xiao published the artcilePd-NHCs Enabled Suzuki-Miyaura Cross-Coupling of Arylhydrazines via C-N Bond Cleavage, HPLC of Formula: 613-33-2, the publication is Journal of Organometallic Chemistry (2021), 121749, database is CAplus.

Author describe a highly efficient protocol for cross-coupling of phenylhydrazines with arylboronic acids by Pd-NHCs under aerobic reaction condition. A series of well-defined Pd-NHCs complexes were evaluated and the relationship between the structure and the catalytic properties was investigated. It was disclosed that the Pd-PEPPSI-IPr proved to be the robust precatalyst, providing access to a range of (hetero)biaryls in good to excellent yields.

Journal of Organometallic Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C11H19BO2S, HPLC of Formula: 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Shen published the artcileDetermination of tipping point in course of PM_2.5 organic extracts-induced malignant transformation by dynamic network biomarkers, Quality Control of 191-07-1, the publication is Journal of Hazardous Materials (2022), 128089, database is CAplus and MEDLINE.

The dynamic network biomarkers (DNBs) are designed to identify the tipping point and specific mols. in initiation of PM_2.5-induced lung cancers. To discover early-warning signals, we analyzed time-series gene expression datasets over a course of PM_2.5 organic extraction-induced human bronchial epithelial (HBE) cell transformation (0th?16th week). A composition index of DNB (CIDNB) was calculated to determine correlations and fluctuations in mol. clusters at each timepoint. We identified a group of genes with the highest CI_DNB at the 10th week, implicating a tipping point and corresponding DNBs. Functional experiments revealed that manipulating resp. DNB genes at the tipping point led to remarkable changes in malignant phenotypes, including four promoters (GAB2, NCF1, MMP25, LAPTM5) and three suppressors (BATF2, DOK3, DAP3). Notably, co-altered expression of seven core DNB genes resulted in an enhanced activity of malignant transformation compared to effects of single-gene manipulation. Perturbation of pathways (EMT, HMGB1, STAT3, NF-¦ÊB, PTEN) appeared in HBE cells at the tipping point. The core DNB genes were involved in regulating lung cancer cell growth and associated with poor survival, indicating their synergistic effects in initiation and development of lung cancers. These findings provided novel insights into the mechanism of dynamic networks attributable to PM_2.5-induced cell transformation.

Journal of Hazardous Materials published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Quality Control of 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dai, Chaoyang published the artcile2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors, Computed Properties of 6972-05-0, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(10), 3172-3176, database is CAplus and MEDLINE.

TNF-¦Á converting enzyme (TACE) inhibitors are promising agents to treat inflammatory disorders and cancer. We have investigated novel tartrate diamide TACE inhibitors where the tartrate core binds to zinc in a unique tridentate fashion. Incorporating (R)-2-(2-N-alkylaminothiazol-4-yl)pyrrolidines into the left hand side amide of the tartrate scaffold led to the discovery of potent and selective TACE inhibitors, some of which exhibited good rat oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wei, Wei published the artcilePhospholipid composition and fat globule structure II: Comparison of mammalian milk from five different species, Quality Control of 6217-54-5, the publication is Food Chemistry (2022), 132939, database is CAplus and MEDLINE.

We compared phospholipids (PLs) content, their mol. species, and milk fat globules size and microstructure in the milk of five mammalian species, including human, cow, goat, yak, and donkey. The absolute quantification of major PLs was determined using 31P NMR and their fatty acid composition with GC. The mol. species of PLs were analyzed using LC-MS where a total of 9 PL species, including one sphingomyelin (SM), six glycerophospholipid (GPL), and two lysoglycerophospholipids (lyso-GPLs), were identified. PLs profile shows an obvious difference among the species, with human milk showing higher SM content and more unsaturated fatty acyls than other mammalian milk. The mammalian milk show a similar core-membrane lipid structure but obvious different size distribution. These data provide a basis for better construction of infant formulas to provide PLs requirements and a similar milk fat globule structure for infants.

Food Chemistry published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C10H11NO4, Quality Control of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Fu-Peng published the artcileCarbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals, Formula: C11H14O2, the publication is Organic Letters (2019), 21(14), 5699-5703, database is CAplus and MEDLINE.

In this communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

Organic Letters published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C15H12O6, Formula: C11H14O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Peng, Ming published the artcileInsights into methionine S-methylation in diverse organisms, Safety of (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Nature Communications (2022), 13(1), 2947, database is CAplus and MEDLINE.

Abstract: Dimethylsulfoniopropionate (DMSP) is an important marine anti-stress compound, with key roles in global nutrient cycling, chemotaxis and, potentially, climate regulation. Recently, diverse marine Actinobacteria, ¦Á- and ¦Ã-proteobacteria were shown to initiate DMSP synthesis via the methionine (Met) S-methyltransferase enzyme (MmtN), generating S-methyl-Met (SMM). Here we characterize a roseobacterial MmtN, providing structural and mechanistic insights into this DMSP synthesis enzyme. We propose that MmtN uses the proximity and desolvation mechanism for Met S-methylation with two adjacent MmtN monomers comprising the Met binding site. We also identify diverse functional MmtN enzymes in potentially symbiotic archaeal Candidatus Woesearchaeota and Candidate Phyla Radiation (CPR) bacteria, and the animalcule Adineta steineri, not anticipated to produce SMM and/or DMSP. These diverse MmtN enzymes, alongside the larger plant MMT enzyme with an N-terminus homologous to MmtN, likely utilize the same proximity and desolvation mechanism. This study provides important insights into the catalytic mechanism of SMM and/or DMSP production, and proposes roles for these compounds in secondary metabolite production, and SMM cycling in diverse organisms and environments.

Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Safety of (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia