Catalysis-chemistry

Nicolaou, K. C. published the artcileRapid access to complex molecular architectures via o-azaquinones, Category: catalysis-chemistry, the publication is Angewandte Chemie, International Edition (2001), 40(11), 2145-2149, database is CAplus and MEDLINE.

Complex analogs I and II of pseudopterosin and elisabethin natural products, resp., were prepared in a single step from the amidoaryldiene 4-[Me₂CHC(:O)NH]C₆H₄(CH₂)₃CH:CHCH:CH₂ (III) in a single step by oxidation with the Dess-Martin periodinane, allowing rapid access to natural product analogs from simple starting materials. E.g., III was prepared in 5 steps and 72% overall yield from 4-(4-aminophenyl)butanoic acid by LAH reduction of the acid to a primary alc., acylation of both the aniline and alc. moieties with isobutyryl chloride followed by hydrolysis of the ester with sodium hydroxide in methanol, oxidation of the primary alc. with o-iodooxybenzoic acid, and Horner-Wittig olefination of the aldehyde with di-Ph allyl phosphine oxide. E.g., treatment of III with 4 equivalent of the Dess-Martin periodinane and 2 equivalent of water presumably generated the key ortho-azaquinone moiety in situ; oxidation of the o-azaquinone followed by intramol. Diels-Alder cycloaddition gave benz[d]indene dione (and elisabethin analog) II in 25% yield, while intramol. Diels-Alder cycloaddition followed addition of water to the remaining imine moiety gave hexahydrophenalenone derivative (and pseudopterosin analog) I in 28% yield. I could be functionalized with various reagents to give various polycyclic natural product-like derivatives Condensation of I with aryl amines in the presence of pyridinium tosylate yielded aromatized derivatives IV [R = 2-HO-5-MeC₆H₃, 5-indazolyl, 2-(EtO₂C)C₆H₄, Ph] in 45-84% yields, while treatment of I with the hydrochlorides of amino acid esters R¹CH(NH₂)CO₂Me [R¹ = 4-HOC₆H₄, PhCH₂, Me₂CH, EtO₂CCH₂CH₂, Me, MeSCH₂CH₂, CbzNH(CH₂)₄] in the presence of pyridinium tosylate gave the fused oxazinones V in 49-80% yields, and condensation of I with diamines gave pyrazine derivatives such as VI in 73-94% yields. Condensation of I with nonracemic 1,2-aminoalcs. in the presence of pyridinium tosylate gave spirooxazole derivatives such as VII in 66-87% yields. Oxazinone and pyrazine fused derivatives such as VI can be aromatized by heating in air in either DMF or toluene solution The solid-phase preparation of combinatorial libraries of natural product-like compounds such as I and its functionalized derivatives is being explored (no data).

Angewandte Chemie, International Edition published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Xiaobin published the artcileSynthesis and antibacterial activity of oxime ester derivatives containing 1,2,4-triazole or 1,3,4-oxadiazole moiety, Formula: C9H7F3O3, the publication is Chemical Papers (2017), 71(10), 1953-1960, database is CAplus.

A series of 1,3,4-oxadiazolyl oxime ester derivatives I [R¹ = Me, Et; R² = 3,4-dimethoxyphenyl, (4-methoxyphenoxy)methyl, [4-(trifluoromethyl)phenoxy]methyl, etc.] and 1,2,4-triazolyl oxime esters II [R¹ = Me, Et; R² = H, F, MeO, etc.] were designed and synthesized and their antibacterial activities in-vitro against Xanthomonas axonopodis pv. citri (Xac) and Xanthomonas oryzae pv. oryzae (Xoo) were evaluated. The bioassays showed that all the title compounds I and II exhibited potent antibacterial activity against Xac and Xoo. In particular, compound I [R¹ = Me, R² = 3,4-dimethoxyphenyl] and compounds II [R¹ = Me, R² = H, F, CF₃; R¹ = Et, R² = H, F, CF₃] exhibited remarkable antibacterial activity against Xoo, with the EC₅₀ values ranging from 15.15 to 49.34 ¦Ìg/mL, which were superior to that of bismerthiazol (92.61 ¦Ìg/mL). This study indicated that oxime ester derivatives containing 1,2,4-triazole I or 1,3,4-oxadiazole II moiety were used as potential alternative templates in the search for novel antibacterial agents.

Chemical Papers published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C4H11NO, Formula: C9H7F3O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Jianguang published the artcileCorrelation between intestinal flora disruption and protein-energy wasting in patients with end-stage renal disease, COA of Formula: C5H11NO2S, the publication is BMC Nephrology (2022), 23(1), 130, database is CAplus and MEDLINE.

Different dialysis treatments may affect the composition and structure of the intestinal flora of dialysis-treated chronic kidney disease (CKD) patients. This study aimed to analyze the correlations between the different flora and the nutritional indexes and further explore the potential metabolic pathways in patients with CKD in end-stage renal disease (ESRD). Altogether, 102 patients with ESRD were recruited and categorized into the hemodialysis (HD) group (N = 49) and the peritoneal dialysis (PD) group (N = 53). Their biochem. indexes, anthropometric indicators, and inflammatory markers were determined The total genomic DNA was extracted for 16S ribosomal DNA sequencing. Furthermore, bioinformatics anal. was employed for functional anal. Anthropometric indicators, including handgrip strength, mid-upper arm circumference, mid-upper arm muscle circumference, and body mass index, in the HD and PD groups showed a pos. correlation with butyric acid-producing bacteria (Rosella and Phascolarctobacterium) and a neg. correlation with conditional pathogens (Escherichia spp.). Meanwhile, the inflammatory markers, including high-sensitivity C-reactive protein and interleukin-6, were significantly higher in the PD-protein-energy wasting (PEW) group than in the PD-non-protein-energy wasting (NPEW) group; although they showed an increasing trend in the HD-PEW group, no significant difference was noted. Rosella was considerably scarce in the HD-PEW group than in the HD-NPEW group, whereas Escherichia was substantially more abundant in the PD-PEW group than in the PD-NPEW group. Compared with the HD group, the essential amino acid synthesis pathway, amino acid metabolism-related enzyme pathways, and aminoacyl-tRNA biosynthesis pathways were weakened in the PD group. Most carbohydrate metabolic pathways were weakened, although the tricarboxylic acid cycle was slightly enhanced. Concurrently, the fatty acid metabolism was enhanced, whereas fatty acid synthesis was weakened; the metabolic pathways of B vitamins were also weakened. These potential metabolic pathways of the various compounds released by intestinal flora showed a significant correlation with blood biochem. indexes, anthropometric indicators, and inflammatory markers. In patients with ESRD, different dialysis treatments affected the abundance of butyric acid-producing bacteria (Rosella and Phascolarctobacterium) and conditional pathogens (Escherichia spp.). Butyric acid-producing bacteria showed a pos. correlation with PEW and showed a neg. correlation with Escherichia. Improving the intestinal diversity and increasing the amount of butyric acid-producing bacteria, such as Blautella, Faecococcus, and Phascolarctobacterium, are potential therapeutic approaches to enhance protein-energy consumption in patients with ESRD.

BMC Nephrology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zheng, Wei-Xiang published the artcileSynthesis of Aryl Ketones from Carboxylic Acids and Arylboronic Acids Using 2-Chloroimidazolium Chloride as a Coupling Reagent, Recommanded Product: 2-Methylbenzoic acid, the publication is Synthesis, database is CAplus.

Carboxylic acids are an abundant and structurally diverse class of com. available materials, which are commonly used as stable reagents in organic synthesis. The Suzuki-Miyaura coupling reaction directly using carboxylic acid as a substrate has been rarely reported. Here, authors report an efficient coupling reaction of carboxylic acids with arylboronic acids in toluene in the presence of IPrCl-Cl, Pd(OAc)₂, PPh₃, and K₃PO₄¡¤7H₂O at 90 ¡ãC to give the corresponding aryl ketones.

Synthesis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C7H6O3, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Shu-mei published the artcileStudy on low-grade pinnoite concentration by flotation, Name: Dodecylamineacetate, the publication is Liaoning Huagong (2010), 39(4), 356-361, database is CAplus.

Using sodium oleate and dodecylamine acetate (DAA) as compound collector, sodium metasilicate as regulator, low grade pinnoite (MgO¡¤B₂O₃¡¤3H₂O) mineral from Dachaidan areas of Qinghai province, was concentrated by reverse flotation. The results indicated that pinnoite can be separated from gypsum, basic magnesium carbonate and salt by reverse flotation. Based on experiments, suitable processing parameters were obtained as follows: collectors dodecylamine acetate 1.5 kg/t, sodium oleate 0.15kg/t, regulator sodium metasilicate 0.92kg/t, liquid-to-solid ratio 6:1, flotation temperature 30-35¡ãC and time 10 min, hydrogen ion concentration of ore pulp 9.0-9.2. Under above conditions, the mass fraction of B₂O₃ in concentrate increased from 7.82% to 12.3% by first flotation, and recovery of boron was over 60%.

Liaoning Huagong published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Name: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Guang-yi published the artcileReverse flotation separation of diaspore and kaolinite in the presence of cationic polyacrylamide polymers, HPLC of Formula: 2016-56-0, the publication is Transactions of Nonferrous Metals Society of China (2003), 13(5), 1231-1234, database is CAplus.

Based on the crystal structure and surface properties of diaspore and kaolinite, an effective diaspore depressant, CPAM (cationic polyacrylamide) was identified based on single mineral tests, separation of synthetic mixed minerals, zeta potential, and adsorption measurements. The reverse flotation separation of diaspore and kaolinite can be carried out using dodecylamine acetate as collector and CPAM depressant at pH 5.5-8.5. The diaspore particles show large amount of active aluminum atoms that can bond with -C(O)NH₂ groups in CPAM and the -CH₂N⁺(CH₃)₃ groups in CPAM orient toward the outer surfaces of diaspore and prevent a majority of dodecylamine cations from adsorbing on diaspore, enhancing hydrophilicity of diaspore, and depressing floatability of diaspore particles. As for kaolinite, CPAM polymers have little effect on floatability.

Transactions of Nonferrous Metals Society of China published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, HPLC of Formula: 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abassian, Maryam published the artcileA new class of organoplatinum-based DFNS for the production of cyclic carbonates from olefins and CO₂, SDS of cas: 140-28-3, the publication is RSC Advances (2020), 10(26), 15044-15051, database is CAplus and MEDLINE.

We studied the potential application of an efficient, reusable, and easily recoverable catalyst of dendritic fibrous nanosilica (DFNS)-supported platinum(II) complexes (DFNS/Pt(II) NPs) to form cyclic carbonates in the presence of epoxides by converting carbon dioxide. Cyclic carbonates from epoxides and carbon dioxide is proposed as the most appropriate way to synthesis this C1 building block. We performed FE-SEM, TEM, TGA, BET, VSM, and ICP-MS to thoroughly characterize DFNS/Pt(II) NPs.

RSC Advances published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, SDS of cas: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Youliang published the artcileIntramolecular Insertions into Unactivated C(sp³)-H Bonds by Oxidatively Generated ¦Â-Diketone-¦Á-Gold Carbenes: Synthesis of Cyclopentanones, HPLC of Formula: 1237588-12-3, the publication is Journal of the American Chemical Society (2015), 137(16), 5316-5319, database is CAplus and MEDLINE.

Generation of reactive ¦Á-oxo gold carbene intermediates via gold-catalyzed oxidation of alkynes has become an increasing versatile strategy of replacing hazardous diazo carbonyl compounds with benign and readily available alkynes in the development of efficient synthetic methods. However, one of the hallmarks of metal carbene/carbenoid chem., i.e., insertion into an unactivated C(sp³)-H bond, has not be realized. This study reveals for the first time that this highly valuable transformation can be readily realized intramolecularly by oxidatively generated ¦Â-diketone-¦Á-gold carbenes using ynones as substrates. Substrate conformation control via the Thorpe-Ingold effect is the key design feature that enables generally good to excellent efficiencies, and synthetically versatile cyclopentanones including spiro-, bridged, and fused bicyclic ones can be readily accessed.

Journal of the American Chemical Society published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C10H12O5, HPLC of Formula: 1237588-12-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ding, Xiumin published the artcileBottom-up synthetic biology approach for improving the efficiency of menaquinone-7 synthesis in Bacillus subtilis, Product Details of C5H11NO2S, the publication is Microbial Cell Factories (2022), 21(1), 101, database is CAplus and MEDLINE.

Menaquinone-7 (MK-7), which is associated with complex and tightly regulated pathways and redox imbalances, is produced at low titers in Bacillus subtilis. Synthetic biol. provides a rational engineering principle for the transcriptional optimization of key enzymes and the artificial creation of cofactor regeneration systems without regulatory interference. This holds great promise for alleviating pathway bottlenecks and improving the efficiency of carbon and energy utilization. We used a bottom-up synthetic biol. approach for the synthetic redesign of central carbon and to improve the adaptability between material and energy metabolism in MK-7 synthesis pathways. First, the rate-limiting enzymes, 1-deoxyxylulose-5-phosphate synthase (DXS), isopentenyl-diphosphate delta-isomerase (Fni), 1-deoxyxylulose-5-phosphate reductase (DXR), isochorismate synthase (MenF), and 3-deoxy-7-phosphoheptulonate synthase (AroA) in the MK-7 pathway were sequentially overexpressed. Promoter engineering and fusion tags were used to overexpress the key enzyme MenA, and the titer of MK-7 was 39.01 mg/L. Finally, after stoichiometric calculation and optimization of the cofactor regeneration pathway, we constructed two NADPH regeneration systems, enhanced the endogenous cofactor regeneration pathway, and introduced a heterologous NADH kinase (Pos5P) to increase the availability of NADPH for MK-7 biosynthesis. The strain expressing pos5P was more efficient in converting NADH to NADPH and had excellent MK-7 synthesis ability. Following three Design-Build-Test-Learn cycles, the titer of MK-7 after flask fermentation reached 53.07 mg/L, which was 4.52 times that of B. subtilis 168. Addnl., the artificially constructed cofactor regeneration system reduced the amount of NADH-dependent byproduct lactate in the fermentation broth by 9.15%. This resulted in decreased energy loss and improved carbon conversion. In summary, a “high-efficiency, low-carbon, cofactor-recycling” MK-7 synthetic strain was constructed, and the strategy used in this study can be generally applied for constructing high-efficiency synthesis platforms for other terpenoids, laying the foundation for the large-scale production of high-value MK-7 as well as terpenoids.

Microbial Cell Factories published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Product Details of C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Yan published the artcileA comparative study between freeze-dried and spray-dried goat milk on lipid profiling and digestibility, Quality Control of 6217-54-5, the publication is Food Chemistry (2022), 132844, database is CAplus and MEDLINE.

Different drying techniques impart distinguishing characteristics to goat milk, particularly to its fat globules. Here, we investigated the difference between freeze-dried and spray-dried goat milk (FGM and SGM) fat globules on lipid profiling and in vitro infant gastrointestinal digestibility. The former presented higher levels of MUFA (31.76%) and lower cholesterol content (1.20 ¡À 0.02 mg/g). Some important long-chain polyunsaturated triacylglycerols such as POL (16:0/18:1/18:2), PSL (16:0/18:0/18:2), and POO (16:0/18:1/18:1), also had better preservation in FGM. Moreover, we detected more species of lysophospholipid in FGM than SGM, accounting for 2.51% and 0.71% of total phospholipids, resp. More intriguingly, FGM, which has better membrane integrity and larger particle size, showed longer lag during gastric digestion and lower level of final lipolysis throughout gastrointestinal digestion. Therefore, our results showed the effects of different drying techniques on lipid profiling and digestibility of goat milk, providing significant insight for appropriate utilization of goat milk in infant nutrition.

Food Chemistry published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C6H13N3O2, Quality Control of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia