Catalysis-chemistry

Yu, Haiyang published the artcileRhodium(I)-Catalyzed C2-Selective Decarbonylative C-H Alkylation of Indoles with Alkyl Carboxylic Acids and Anhydrides, Safety of 3-Benzoylpropionicacid, the publication is Asian Journal of Organic Chemistry (2021), 10(4), 879-885, database is CAplus.

A Rh(I)-catalyzed chelation-assisted C2-selective C-H decarbonylative alkylation of indoles with readily available, cheap, safe and structurally diverse alkyl carboxylic acids or anhydrides has been developed. A wide variety of primary and secondary alkyl carboxylic acids and differently substituted indoles are compatible with this transformation, allowing facile synthesis of various C2-alkylated indoles with high efficiency and broad tolerance of diverse functional groups. The reaction proceeds in the absence of any external oxidant, and the presence of readily installable and removable N-pyrimidyl directing group is critical for catalysis. The process is convenient and scalable, and avoids the use of a dried solvent and an inert atm. Moreover, selective C7-alkylation and C2, C7-dialkylation have also been achieved by slightly modifying the reaction conditions.

Asian Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C7H13NO2, Safety of 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Haiyang published the artcileRhodium(I)-Catalyzed C2-Selective Decarbonylative C-H Alkylation of Indoles with Alkyl Carboxylic Acids and Anhydrides, Category: catalysis-chemistry, the publication is Asian Journal of Organic Chemistry (2021), 10(4), 879-885, database is CAplus.

A Rh(I)-catalyzed chelation-assisted C2-selective C-H decarbonylative alkylation of indoles with readily available, cheap, safe and structurally diverse alkyl carboxylic acids or anhydrides has been developed. A wide variety of primary and secondary alkyl carboxylic acids and differently substituted indoles are compatible with this transformation, allowing facile synthesis of various C2-alkylated indoles with high efficiency and broad tolerance of diverse functional groups. The reaction proceeds in the absence of any external oxidant, and the presence of readily installable and removable N-pyrimidyl directing group is critical for catalysis. The process is convenient and scalable, and avoids the use of a dried solvent and an inert atm. Moreover, selective C7-alkylation and C2, C7-dialkylation have also been achieved by slightly modifying the reaction conditions.

Asian Journal of Organic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C24H29N5O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Chen-Ran published the artcileOrganocatalytic silyl transfer from silylborane to nitroalkenes for the synthesis of ¦Â-silyl nitroalkanes and ¦Â-silyl amines, SDS of cas: 4230-93-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(50), 7862-7865, database is CAplus and MEDLINE.

The silylation of a wide array of nitroalkenes is achieved by organocatalysts in yields up to 93%. The reaction is carried out in a toluene/water biphasic solvent under operationally simple conditions. Reduction of the nitro group provides efficient access to functionalized ¦Â-silyl amines.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, SDS of cas: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Li-Biao published the artcileStereospecific Addition of H-P Bond to Alkenes: A Simple Method for the Preparation of (R_P)-Phenylphosphinates, Related Products of catalysis-chemistry, the publication is Journal of Organic Chemistry (2005), 70(24), 10121-10123, database is CAplus and MEDLINE.

Functionalized chiral at phosphorus optically pure (R_P)-alkylphenylphosphinates were prepared by stereospecific radical or base-catalyzed additions of the easily available (R_P)-menthyl phenylphosphinate to 1-alkenes. Addition of (R_P)-(RO)PO(H)Ph [1, R = (-)-menthyl] to alkenes CH₂:CHR¹ gave (R_P)-(RO)PO(CH₂CH₂R¹)Ph [2a, 2c–l; R¹ = C₆H₁₃, (CH₂)₄OH, OBu, SPh, PPh₂, POPh₂, PO(OEt)₂, Si(OEt)₃, SnBu₃, CH₂POPh₂, 3-cyclohexen-1-yl], the same reaction conditions applied to internal alkenes gave (R_P)-(RO)POR²Ph (2m–r; R² = 3-tetrahydrofuranyl, 3-tetrahydropyranyl, CH₂CHMeOAc, 2-norbornyl, cyclohexyl, cyclopentyl). Stereospecific Michael addition of 1 to electroneg. alkenes CH₂:CHR³ was achieved in the presence of R⁴OMgCl (R⁴ = Et, ⁱPr, ^tBu, (-)-menthyl) as base catalysts, affording (R_P)-(RO)PO(CH₂CH₂R³)Ph [2h, 2s,t; R³ = PO(OEt)₂, CN, CO₂Me]. Absolute phosphorus configuration of the products 2 was determined by addition of 1 with (R_P)-(RO)PO(CH:CH₂)Ph, which gave (R_P,R_P)-(RO)POPhCH₂CH₂POPh(OR).

Journal of Organic Chemistry published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Caiyou published the artcileEnzyme-Inspired Chiral Secondary-Phosphine-Oxide Ligand with Dual Noncovalent Interactions for Asymmetric Hydrogenation, Formula: C11H10O3, the publication is Angewandte Chemie, International Edition (2017), 56(24), 6808-6812, database is CAplus and MEDLINE.

Inspired by the unique character of enzymes, we developed novel chiral SPO (secondary-phosphine-oxide) ligand (SPO-Wudaphos) which can enter into both ion pair and H-bond noncovalent interactions. The novel chiral SPO-Wudaphos exhibited excellent results in the asym. hydrogenation of ¦Á-methylene-¦Ã-keto carboxylic acids, affording the chiral ¦Ã-keto acids with up to over 99 % ee. A series of control experiments and DFT calculations were conducted to illustrate the critical roles of both the ion pair and H-bond noncovalent interactions.

Angewandte Chemie, International Edition published new progress about 15732-75-9. 15732-75-9 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ketone, name is 2-Methylene-4-oxo-4-phenylbutanoic acid, and the molecular formula is C11H10O3, Formula: C11H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Prakash, G. K. Surya published the artcileN,N-Dimethyl-S-difluoromethyl-S-phenylsulfoximinium tetrafluoroborate: A versatile electrophilic difluoromethylating reagent, Product Details of C14H23N, the publication is Journal of Fluorine Chemistry (2011), 132(10), 792-798, database is CAplus.

Over the past decade, sulfur-based fluoromethyl containing compounds have been exhaustively investigated as versatile fluoroalkylating reagents by our research laboratory as well as many others. Lately, we have designed a novel electrophilic difluoromethylating protocol employing in situ prepared N,N-dimethyl-S-difluoromethyl-S-phenylsulfoximinium salt. The present reagent provides excellent reactivity toward a broad spectrum of nucleophilic species (N-, P-, S-, and O-nucleophiles) to yield the corresponding difluoromethylated products with high efficacy under mild conditions. Addnl. studies have been performed to elucidate the mechanistic fundamentals of the reactions.

Journal of Fluorine Chemistry published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Product Details of C14H23N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Peng-Wei published the artcileCobalt-Catalyzed Intermolecular Hydroamination of Unactivated Alkenes Using NFSI as Nitrogen Source, Computed Properties of 2051-95-8, the publication is Chinese Journal of Chemistry (2022), 40(9), 1066-1072, database is CAplus.

Comprehensive Summary : Cheap metal (Fe, Mn, and Co)-catalyzed hydroamination of alkenes has been an attractive method for synthesis of amines because of biocompatibility of metal, excellent Markovnikov selectivity and chemoselectivity. However, most reports are limited to unsaturated nitrogen sources (nitric oxide, azos, azides, cyano, etc.), for which aminated products are very limited. Notably, while used widely for fluorinating reaction, N-fluorobenzenesulfonimide (NFSI) as amine source for hydroamination has seldom been reported. Here authors developed a cobalt-catalyzed intermol. hydroamination of unactivated alkenes using NFSI as nitrogen source under mild conditions. The reaction exhibits excellent chemo- and regio-selectivity with no hydrofluorination or linear-selectivity products. Notably, the reaction proceeded with excellent yield even though the amount of Co(salen) catalyst was reduced to 0.2 mol%. Recently, a similar work was also reported by Zhang and coworkers (reference 19).

Chinese Journal of Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C9H6N2O2, Computed Properties of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wen, Si published the artcileRuthenium(II)-catalyzed synthesis of CF₃-isoquinolinones via C-H activation/annulation of benzoic acids and CF₃-imidoyl sulfoxonium ylides, Safety of 2-Methylbenzoic acid, the publication is Organic Chemistry Frontiers (2022), 9(16), 4388-4393, database is CAplus.

A ruthenium(II)-catalyzed C-H activation/annulation reaction of benzoic acids and CF₃-imidoyl sulfoxonium ylides enabled by weak O-coordination was achieved. A series of 3-trifluoromethyl-isoquinolinones I [R = Ph, 2-MeC₆H₄, CH₂CH₂Ph, etc.; R¹ = 8-Me, 7-F, 6-I, etc.; R² = F, CF₂CF₃, CF₂CF₂CF₃] were synthesized in 37-75% yields under redox-neutral reaction conditions.

Organic Chemistry Frontiers published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C4H6BrFO2, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Yong-Jin published the artcileSynthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE, Related Products of catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(10), 2654-2660, database is CAplus and MEDLINE.

A series of N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)-butan-2-yl)benzamides, i.e. I, has been synthesized as BACE inhibitors. A variety of P2 and P3 substituents has been explored, and these efforts have culminated in the identification of several 1,3,5-trisubstituted phenylcarboxyamides with potent BACE inhibitory activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C25H23NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dong, Xiao-Yang published the artcileA general asymmetric copper-catalysed Sonogashira C(sp³)-C(sp) coupling, Recommanded Product: 3-Benzoylpropionicacid, the publication is Nature Chemistry (2019), 11(12), 1158-1166, database is CAplus and MEDLINE.

Continued development of the Sonogashira coupling has made it a well established and versatile reaction for the straightforward formation of C-C bonds, forging the carbon skeletons of broadly useful functionalized mols. However, asym. Sonogashira coupling, particularly for C(sp³)-C(sp) bond formation, has remained largely unexplored. Here the authors demonstrate a general stereoconvergent Sonogashira C(sp³)-C(sp) cross-coupling of a broad range of terminal alkynes and racemic alkyl halides (>120 examples) that are enabled by copper-catalyzed radical-involved alkynylation using a chiral cinchona alkaloid-based P,N-ligand. Industrially relevant acetylene and propyne are successfully incorporated, laying the foundation for scalable and economic synthetic applications. The potential utility of this method is demonstrated in the facile synthesis of stereoenriched bioactive or functional mol. derivatives, medicinal compounds and natural products that feature a range of chiral C(sp³)-C(sp/sp²/sp³) bonds. This work emphasizes the importance of radical species for developing enantioconvergent transformations.

Nature Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia