Catalysis-chemistry

Aydin, Ahmet published the artcileThe synthesis of mono- and triglycerides of branched fatty acids and physical properties of the synthesized glycerides, Quality Control of 3115-28-4, the publication is Chimica Acta Turcica (1977), 5(1), 93-101, database is CAplus.

Nine 1-monoglycerides of BuCHRCO₂H (I; R = C_2-10–n-alkyl) were prepared by heating 2,3-O-isopropylideneglycerol with I in xylene in the presence of p-MeC₆H₄SO₃H with azeotropic distillation of water of reaction, and the corresponding triglycerides were prepared by similar treatment of glycerol. The refractive indexes, dielec. constants and dipole moments of all the glycerides and the surface tension of aqueous solutions of the monoglycerides were determined

Chimica Acta Turcica published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Quality Control of 3115-28-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tosa, Monica Ioana published the artcileThe Interaction of Nitrophenylalanines with Wild Type and Mutant 4-Methylideneimidazole-5-one-less Phenylalanine Ammonia Lyase, Computed Properties of 1772-76-5, the publication is ChemCatChem (2013), 5(3), 779-783, database is CAplus.

Racemic nitrophenylalanines and (E)-nitrophenylacrylates are synthesized from the corresponding aldehydes. Both products are important for the examination of the mechanism of action of phenylalanine ammonia lyase (PAL). For the reaction of the rac-nitrophenylalanines with both wild type (wt) PAL and an 4-methylideneimidazole-5-one (MIO)-less mutant, the kinetic constants K_m and V_max are determined and compared with those of the natural substrate L-phenylalanine: the K_m values for the racemic nitrophenylalanines with wt PAL are up to 9 times higher, however, the V_max values are up to 5 times lower. Compared to wt PAL, the catalytic activity of MIO-less PAL mutant for the deamination of L-phenylalanine is approx. 400 times, while that for 3-nitrophenylalanine is approx. 50 times lower. Both wt and MIO-less PALs are enantioselective for L-nitrophenylalanines. Thus, enantiopure D-nitrophenylalanines can be biosynthesized from racemic substrates. The biocatalytic synthesis of the corresponding L-enantiomers is achieved by the reverse reaction, starting from (E)-nitrophenylacrylates. Both enantiomeric products obtained with wt and MIO-less PAL are spectroscopically and chromatog. characterized and their optical rotations measured.

ChemCatChem published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C15H21BO2, Computed Properties of 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Winget, Paul published the artcileGround-State Electronic Structure in Charge-Transfer Complexes Based on Carbazole and Diarylamine Donors, Category: catalysis-chemistry, the publication is Journal of Physical Chemistry C (2011), 115(21), 10823-10835, database is CAplus.

The geometries, binding energies, and amounts of charge transferred in the ground state for a series of donor/acceptor organic ¦Ð-¦Ð complexes have been characterized at the d. functional theory level. We find that these compounds exhibit important changes in geometry upon complexation that is accompanied by a large binding energy. The amount of charge transferred from the donor to the acceptor depends highly on the substitution of the donor and can be roughly described by the electron donating or withdrawing ability of the substituent. Interestingly, there is a significant difference in the behavior of carbazoles and diarylamines upon substitution.

Journal of Physical Chemistry C published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C9H9F5Si, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pien, Nele published the artcileProteomics as a tool to gain next level insights into photo-crosslinkable biopolymer modifications, Product Details of C5H11NO2S, the publication is Bioactive Materials (2022), 204-220, database is CAplus and MEDLINE.

The distribution of photo-crosslinkable moieties onto a protein backbone can affect a biomaterials crosslinking behavior, and therefore also its mech. and biol. properties. A profound insight in this respect is essential for biomaterials exploited in tissue engineering and regenerative medicine. In the present work, photo-crosslinkable moieties have been introduced on the primary amine groups of: (i) a recombinant collagen peptide (RCPhC1) with a known amino acid (AA) sequence, and (ii) bovine skin collagen (COL BS) with an unknown AA sequence. The degree of substitution (DS) was quantified with two conventional techniques: an ortho-phthalic dialdehyde (OPA) assay and 1H NMR spectroscopy. However, neither of both provides information on the exact type and location of the modified AAs. Therefore, for the first time, proteomic anal. was evaluated herein as a tool to identify functionalized AAs as well as the exact position of photo-crosslinkable moieties along the AA sequence, thereby enabling an in-depth, unprecedented characterization of functionalized photo-crosslinkable biopolymers. Moreover, our strategy enabled to visualize the spatial distribution of the modifications within the overall structure of the protein. Proteomics has proven to provide unprecedented insight in the distribution of photo-crosslinkable moieties along the protein backbone, undoubtedly contributing to superior functional biomaterial design to serve regenerative medicine.

Bioactive Materials published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Product Details of C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lopez-Lopez, Maria published the artcileDiphenylamine and derivatives as predictors of gunpowder age by means of HPLC and statistical models, Formula: C12H9N3O4, the publication is Talanta (2013), 214-220, database is CAplus and MEDLINE.

The gunpowder age is information of great importance that could help to establish safety regulations related to the propellants use and manipulation. In this work, a forced aging treatment (65¡ã for 120 days) was applied to four gunpowders stabilized with diphenylamine (DPA). The evolution of DPA and derivatives (N-nitroso-DPA, 2-nitro-DPA, 4-nitro-DPA, and 4-4′-dinitro-DPA) concentration during the days was leaded by high performance liquid chromatog. (HPLC). The variation with time of the peak areas of these compounds was used to construct different statistical models that could predict the gunpowders age. These models were validated using nitrocellulose-based gunpowders of known manufacture date. Models that best predicted the gunpowder age provided prediction errors lower than 6, 4, and 2 years for single-base gunpowders with dinitrotoluene (¡Ý 10% (m/m)), single-base gunpowders and double-base gunpowders, resp.

Talanta published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Formula: C12H9N3O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Valles-Miret, Mariona published the artcileA generic small-molecule microarray immobilization strategy, Recommanded Product: 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, the publication is Tetrahedron Letters (2011), 52(50), 6819-6822, database is CAplus.

Small-mol. microarrays are often limited by the requirement for each compound undergoing immobilization to contain a common functional group or by the need to prepare glass slides containing photo-reactive groups. Herein, the authors present a generic strategy that allows any compound library to be immobilized. This was achieved by printing a fluorous-tagged photo-reactive 3-aryl-3-trifluoromethyldiazirine, which undergoes nonselective insertion into compounds following UV-activation, onto fluorous-functionalized glass slides. The arrays could be reused following aqueous stripping and re-assessment of the compounds with the same protein or another target of interest.

Tetrahedron Letters published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C11H10O, Recommanded Product: 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cordonnier, Axel published the artcileSynthesis and in vitro preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer, HPLC of Formula: 1395786-30-7, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2021), 9(36), 7423-7434, database is CAplus and MEDLINE.

Over the last decade, upconversion nanoparticles (UCNP) have been widely investigated in nanomedicine due to their high potential as imaging agents in the near-IR (NIR) optical window of biol. tissues. Here, we successfully develop active targeted UCNP as potential probes for dual NIR-NIR fluorescence and radioactive-guided surgery of prostate-specific membrane antigen (PSMA)(+) prostate cancers. We designed a one-pot thermolysis synthesis method to obtain oleic acid-coated spherical NaYF₄:Yb,Tm@NaYF₄ core/shell UCNP with narrow particle size distribution (30.0 ¡À 0.1 nm, as estimated by SAXS anal.) and efficient upconversion luminescence. Polyethylene glycol (PEG) ligands bearing different anchoring groups (phosphate, bis- and tetra-phosphonate-based) were synthesized and used to hydrophilize the UCNP. DLS studies led to the selection of a tetra-phosphonate PEG(2000) ligand affording water-dispersible UCNP with sustained colloidal stability in several aqueous media. PSMA-targeting ligands (i.e., glutamate-urea-lysine derivatives called KuEs) and fluorescent or radiolabeled prosthetic groups were grafted onto the UCNP surface by strain-promoted azide-alkyne cycloaddition (SPAAC). These UCNP, coated with 10 or 100% surface d. of KuE ligands, did not induce cytotoxicity over 24 h incubation in LNCaP-Luc or PC3-Luc prostate cancer cell lines or in human fibroblasts for any of the concentrations evaluated. Competitive binding assays and flow cytometry demonstrated the excellent affinity of UCNP@KuE for PSMA-pos. LNCaP-Luc cells compared with non-targeted UCNP@CO₂H. Furthermore, the binding of UCNP@KuE to prostate tumor cells was pos. correlated with the surface d. of PSMA-targeting ligands and maintained after ¹²⁵I-radiolabelling. Finally, a preliminary biodistribution study in LNCaP-Luc-bearing mice demonstrated the radiochem. stability of non-targeted [^125I]UCNP paving the way for future in vivo assessments.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C25H21N3O4, HPLC of Formula: 1395786-30-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wichmann, Kathrin A. published the artcileCharacterization of Dicarboxylic Salts of Protonated Triethylenetetramine Useful for the Treatment of Copper-Related Pathologies, Related Products of catalysis-chemistry, the publication is Crystal Growth & Design (2007), 7(9), 1844-1850, database is CAplus.

X-ray crystal structures of three salts of protonated triethylenetetramine, (H₄TETA)⁴⁺, with succinate, maleate, and fumarate anions are reported. Structures of the complexes (H₄-triethylenetetramine)(hydrogenmaleate)₄¡¤2H₂O [(H₄TETA)(Hmal)₄¡¤2H₂O], (H₄-triethylenetetramine)(hydrogenfumarate)₄¡¤3.3H₂O [(H₄TETA)(Hfum)₄¡¤3.3H₂O], and (H₄-triethylenetetramine)(succinate)₂ [(H₄TETA)(suc)₂] all form assemblies of alternating two-dimensional layers of (H₄TETA)⁴⁺ and the anionic species via hydrogen-bond networks. Both classical and nonclassical hydrogen bonds between the protonated amine groups, anions, and water mols. were observed X-ray powder diffraction measurements, DTA/thermogravimetry, d. vapor sorption, and Karl Fischer titration measurements were performed to obtain confirmatory information about the water content in the structures [(H₄TETA)(Hmal)₄¡¤2H₂O] and [(H₄TETA)(Hfum)₄¡¤3.3H₂O] and to examine polymorphism within the salts. The nonhydrated salt [(H₄TETA)(suc)₂] was determined to be the most favorable salt formulation for use in medicinal applications.

Crystal Growth & Design published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C11H12O4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Voronkov, M. G. published the artcileReaction of organyltrifluorosilanes with dimethylsulfoxide and dimethylformamide and its spectroscopic investigation, Related Products of catalysis-chemistry, the publication is Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) (2001), 71(12), 1865-1868, database is CAplus.

Reaction of organotrifluorosilanes RSiF₃ (R = C₆H₅, 3-O₂NC₆H₄, and C₆H₅CH₂) with DMSO and DMF (B) gave the complexes 2B¡¤SiF₄ and R₂SiF₂. Besides, biphenyl, benzene, Me(fluoromethyl)sulfoxide, and S,S’-dimethyldisulfide-S,S’-dioxide CH₃S(O)S(O)CH₃ were either isolated or identified by chromatomass-spectrometry. Speculative mechanism of the reaction proceeding is discussed. IR spectra of the reaction mixtures and those of 2B¡¤SiF₄ adduct were studied in details; they indicate octahedron structure of the complex with cis arrangement of B ligands.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C9H12O, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Heald, Robert published the artcileNoncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study, Category: catalysis-chemistry, the publication is Journal of Medicinal Chemistry (2015), 58(22), 8877-8895, database is CAplus and MEDLINE.

Because of their increased activity against activating mutants, first-generation epidermal growth factor receptor (EGFR) kinase inhibitors have had remarkable success in treating non-small-cell lung cancer (NSCLC) patients, but acquired resistance, through a secondary mutation of the gatekeeper residue, means that clin. responses only last for 8-14 mo. Addressing this unmet medical need requires agents that can target both of the most common double mutants: T790M/L858R (TMLR) and T790M/del(746-750) (TMdel). Herein we describe how a noncovalent double mutant selective lead compound was optimized using a strategy focused on the structure-guided increase in potency without added lipophilicity or reduction of three-dimensional character. Following successive rounds of design and synthesis it was discovered that cis-fluoro substitution on 4-hydroxy- and 4-methoxypiperidinyl groups provided synergistic, substantial, and specific potency gain through direct interaction with the enzyme and/or effects on the proximal ligand oxygen atom. Further development of the fluorohydroxypiperidine series resulted in the identification of a pair of diastereomers that showed 50-fold enzyme and cell based selectivity for T790M mutants over wild-type EGFR (wtEGFR) in vitro and pathway knock-down in an in vivo xenograft model.

Journal of Medicinal Chemistry published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia