Catalysis-chemistry

Xu, Shengtao published the artcileA Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Medicinal Chemistry (2017), 60(4), 1449-1468, database is CAplus and MEDLINE.

The cytotoxicity of the natural ent-kaurene diterpenoid, oridonin, has been extensively studied. However, the application of oridonin for cancer therapy was hampered primarily by its moderate potency. In this study, a series of oridonin A-ring modified analogs, and their derivatives bearing various substituents on 14-OH position, were designed, synthesized and evaluated for anticancer efficacy. Some of the derivatives were significantly more potent than oridonin against both drug-sensitive and drug-resistant cancer cells. The most potent compound, I, was 200-fold more efficacious than oridonin in MCF-7 cancer cells. Furthermore, I induced apoptosis and cell cycle arrest at the G2/M phase. A decrease in mitochondrial membrane potential and increased Bax/Bcl-2 ratio, accompanied by activated caspase-3 cleavage, were observed in MCF-7 cells after treatment with I, suggesting that the mitochondrial pathway was involved in the I-mediated apoptosis. Moreover, I significantly inhibited tumor growth in mouse xenograft models and had no observable toxic effect.

Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C20H18BrN3, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Feng, Zhen published the artcileTwo-dimensional metal-organic framework Mo₃(C₂O)₁₂ as a promising single-atom catalyst for selective nitrogen-to-ammonia conversion, Recommanded Product: Coronene, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2022), 10(9), 4731-4738, database is CAplus.

The development of single-atom catalysts (SACs) for the electrocatalytic nitrogen reduction reaction (NRR) remains a great challenge. Using d. functional theory calculations, we design a new family of two-dimensional metal-organic frameworks [TM₃(C₂O)₁₂, TM = Sc-Au] and explore their feasibility as SACs for the NRR. The calculated adsorption Gibbs free energies of N₂ and NNH species demonstrate that only the Mo₃(C₂O)₁₂ monolayer could both activate the NN bond and stabilize the adsorbed NNH intermediate. The Mo₃(C₂O)₁₂ metal-organic framework not only possesses sufficient stability, but also exhibits high nitrogen fixation activity and substantial selectivity. The NRR distal pathway could achieve this sufficient goal with a low limiting potential of -0.36 V and a promising theor. faradaic efficiency value of 100%. This work could give guidance to develop more effective NRR SACs using 2D metal-organic frameworks under ambient conditions.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fan, Tian-Yun published the artcileStructure-activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Bioorganic Chemistry (2021), 104994, database is CAplus and MEDLINE.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency markedly enhances the survival rate of patients with cardiovascular diseases (CVDs). Forty berberine (BBR) derivatives I (R¹ = H, MeO, R² = MeO, OH, PhCH₂O, EtO, R³ = MeO, OH, EtO, R²R³ = OCH₂O, R⁴ = H, MeO, R⁵ = H, Cl, MeO, PhCH₂O, cyclobutylmethoxy, etc., R⁶ = MeO, OH, R⁷ = MeO, EtO, H) were synthesized and evaluated for their activity on down-regulating the transcription of PCSK9 in HepG2 cells, taking BBR as the lead. Structure-activity relationship (SAR) anal. revealed that the 2,3-dimethoxy moiety might be beneficial for activity. Among them, I (R¹ = R⁴ = R⁷ = H, R² = R³ = R⁶ = MeO, R⁵ = p-F₃CSC₆H₄CH₂O) (II) displayed the most potent activity with an IC₅₀ value of 9.5 ¡À 0.5¦ÌM, better than that of BBR. Also, it significantly decreased the PCSK9 protein level at the cellular level, as well as in the liver and serum of mice in vivo. Furthermore, II markedly increased LDLR expression and LDL-C clearance via down-regulating PCSK9 protein. The mechanism of action of II is targeting HNF1¦Á and/or Sp1 cluster modulation upstream of PCSK9, a different one from BBR. Therefore, II might have the potential to be a novel PCSK9 transcriptional inhibitor for the treatment of atherosclerosis, worthy for further investigation.

Bioorganic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Bo-Sheng published the artcileReductive Coupling of Aryl Halides via C-H Activation of Indene, Recommanded Product: 4,4′-Dimethyldiphenyl, the publication is Chinese Journal of Chemistry (2021), 39(6), 1573-1579, database is CAplus.

A reductive coupling reaction with indene, a non-heteroatom olefin used as a reducing agent. The scope of the substrate was wide. The homo-coupling, cross-coupling, and synthesis of 12 and 14-membered rings were realized. The control experiment, indene-product curve and d. functional theory calculations showed that the ¦Ç³-palladium indene intermediate was formed by C-H activation in the presence of cesium carbonate. The final product was obtained through a Pd (IV) intermediate or aryl ligand exchange. In addition, it was excluded the formation of palladium anion (Pd(0)^–) intermediates.

Chinese Journal of Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C10H17N3O2, Recommanded Product: 4,4′-Dimethyldiphenyl.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhou, Jiahui published the artcileRobust Poly(urethane-amide) Protective Film with Fast Self-Healing at Room Temperature, Name: 2,2′-Dithiodibenzoic acid, the publication is ACS Applied Polymer Materials (2020), 2(2), 285-294, database is CAplus.

Simultaneous optimization of the mech. strength and self-healing cycles of polymers at ambient temperature has long been considered a great challenge because it is difficult to strike a balance between intermol. interactions and segment/chain mobility. Here, we synthesized a unique class of amide-based polyurethanes incorporated with an unreported low-cost carboxylic-acid-type aromatic disulfide, which exhibits an amazing integration of mech. robustness and fast self-healing ability, and a ready healing efficiency of 98% can be achieved when healed for only 30 s at ambient temperature, as calculated using Young’s modulus (pristine: 59.4 MPa). As a result of hierarchical structure tuning, the target poly(urethane-amide) exhibits relatively fast segment movements but slow chain diffusion dynamics, thus facilitating rapid recombination of H-bonding as well as disulfide metathesis between fractured surfaces with a small degree of both microphase separation and crystallization This easily processable poly(urethane-amide) has the potential to be widely used in various industries as a high value-added film.

ACS Applied Polymer Materials published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C44H28ClFeN4, Name: 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cui, De-Yun published the artcileSystematic research of H₂dedpa derivatives as potent inhibitors of New Delhi Metallo-¦Â-lactamase-1, Quality Control of 140-28-3, the publication is Bioorganic Chemistry (2020), 103965, database is CAplus and MEDLINE.

New Delhi Metallo-¦Â-lactamase-1 (NDM-1), a Zn (II)-dependent enzyme, can catalyze the hydrolysis of almost all ¦Â-lactam antibiotics including carbapenems, resulting in bacterial antibiotic resistance, which threatens public health globally. Based on our finding that H2dedpa is as an efficient NDM-1 inhibitor, a series of H2dedpa derivatives was systematically prepared These compounds exhibited significant activity against NDM-1, with IC50 values 0.06-0.94 ¦ÌM. In vitro, compounds 6k and 6n could restore the activity of meropenem against Klebsiella pneumoniae, Escherichia coli and Proteus mirabilis possessing either NDM or IMP. In particular, the activity of meropenem against E. coli producing NDM-4 could be improved up to 5333 times when these two compounds were used. Time-kill cell-based assays showed that 99.9% of P. mirabilis were killed when treated with meropenem in combination with compound 6k or 6n. Furthermore, compounds 6k and 6n were nonhemolytic (HC50 > 1280 ¦Ìg/mL) and showed low toxicity toward mammalian (HeLa) cells. Mechanistic studies indicated that compounds 6k and 6n inhibit NDM-1 by chelating the Zn2+ ion of the enzyme.

Bioorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cai, Shi published the artcileDesign, synthesis and biological evaluation of bicyclic carboxylic acid derivatives as IDO1 inhibitors, Category: catalysis-chemistry, the publication is Bioorganic Chemistry (2020), 103356, database is CAplus and MEDLINE.

Indoleamine 2,3-dioxygenase 1 (IDO1) plays a vital role in tumor immune escape and has emerged as a promising target for cancer immunotherapy. In this study, a novel series of bicyclic carboxylic acid derivatives were designed, synthesized and evaluated for inhibitory activities against IDO1. Among these, compound 9c exhibited strong IDO1 inhibitory activity (HeLa cellular IC₅₀ = 2.6 nM, THP-1 cellular IC₅₀ = 11.2 nM). Further anti-tumor studies in vivo have shown that compound 9c has a great inhibitory effect on tumor growth in mice CT26 model as a single agent or in combination with 5-fluorouracil (inhibition rate was 53.9% and 92.7%, resp.). These results indicate that compound 9c is a effective IDO1 inhibitor for further investigation.

Bioorganic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shen, Li published the artcileNovel hybrids from lamellarin D and combretastatin A4 as cytotoxic agents, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Medicinal Chemistry (2010), 45(1), 11-18, database is CAplus and MEDLINE.

A new series of hybrids of lamellarin D and combretastatin A4, 1,2-diphenyl-5,6-dihydropyrrolo[2,1-a]isoquinolines, was designed as cytotoxic agents based on principles of combination in medicinal chem. and taking the parent compounds’ different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids, e.g. I, were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC₅₀ ranges.

European Journal of Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H14BNO4S, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Jing published the artcileNew tetraphenylethene-based efficient blue luminophors: aggregation induced emission and partially controllable emitting color, Recommanded Product: Bis(4-fluorophenyl)methane, the publication is Journal of Materials Chemistry (2012), 22(6), 2478-2484, database is CAplus.

Two new TPE-based conjugated mols., constructed using tetraphenylethene (TPE) and carbazole or spirofluorene moieties, were successfully prepared They exhibited aggregation induced emission (AIE) properties, high thermal and morphol. stabilities, and low oxidation potential, making them promising properties for optoelec. materials. The fabricated nondoped multilayer OLEDs demonstrate that devices using these luminophors as the emitting layer show relatively good performance, and the device of SFTPE gives a maximum luminance and efficiency of 8196 cd m^-2 and 3.33 cd A^-1, resp., with the maximum emission wavelength at ?466 nm, thanks to the adjusted mol. structure and AIE characteristic of TPE.

Journal of Materials Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Recommanded Product: Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Xin Yi published the artcileConstruction of Supramolecular Fluorescent Probe by a Water-Soluble Pillar[5]arene and Its Recognition of Carbonate Ion, Category: catalysis-chemistry, the publication is Bulletin of the Chemical Society of Japan (2022), 95(1), 116-120, database is CAplus.

The interaction between pyridine pillar[5]arene (PyP5) and 2-naphthol with the former as the host mol. and the latter as the guest mol. is studied by fluorescence spectroscopy and NMR techniques, and the results show that PyP5 forms a 1:1 host-guest inclusion complex with 2-naphthol. Although free 2-naphthol has strong fluorescence, it is quenched in 2-naphthol@PyP5. Experiments were conducted with 2-naphthol@PyP5 as a fluorescent probe to detect different anions with results showing that only CO₃^2- causes a significant enhancement of the fluorescence of the fluorescent probe. Due to this high selectivity and high sensitivity, the fluorescent probe 2-naphthol@PyP5 may open up an effective way for the detection of CO₃^2-.

Bulletin of the Chemical Society of Japan published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C20H17ClN4O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia