Catalysis-chemistry

Rakowitz, Dietmar published the artcileSynthesis and aldose reductase inhibitory activities of novel O-substituted hydroxyphenylacetic acid derivatives, Quality Control of 1860-58-8, the publication is Archiv der Pharmazie (Weinheim, Germany) (2006), 339(10), 547-558, database is CAplus and MEDLINE.

In continuation of our work aimed towards the preparation of novel aldose reductase inhibitors, several O-substituted hydroxyphenylacetic acid derivatives were investigated. The highest inhibitory activity was found for compounds 7b (3-(cyclohexylmethoxy)benzeneacetic acid) and 7c (4-(cyclohexylmethoxy)benzeneacetic acid). This result demonstrates that within these series, this moiety is a useful surrogate for the 4-bromo-2-fluorobenzyl residue which can be often found in potent aldose reductase inhibitors.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Quality Control of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Swain, Baijayantimala published the artcileNew coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry (2020), 28(15), 115586, database is CAplus and MEDLINE.

Two novel series of phenylacrylamide linked coumarins I [R = H, Me; Ar = Ph, 4-FC₆H₄, 4-MeOC₆H₄, etc.] and sulfocoumarins II [Ar¹ = 4-FC₆H₄, 3-F₃CC₆H₄, 4-NCC₆H₄, etc.] were synthesized and evaluated against four physiol. relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I, hCA II, hCA IX and hCA XII for their inhibitory action. Compounds I and II when screened for carbonic anhydrase inhibitory activity, they showned selective inhibition toward the tumor associated isoforms hCA IX and XII over CA I and II, with inhibition constants in the submicromolar to low nanomolar range. Compound I [R = H; Ar = 4-FC₆H₄] and II [Ar¹ = 4-NCC₆H₄] exhibited significant inhibition with low nanomolar potency against hCA IX, whereas I [R = H; Ar = 3,4-(OMe)₂C₆H₃] was effective against hCA XII. Compounds I [R = H; Ar = 4-FC₆H₄, 3,4-(OMe)₂C₆H₃] and II [Ar¹ = 4-NCC₆H₄] might be considered as lead mols. for future development of cancer therapeutics based on a novel mechanism of action.

Bioorganic & Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C19H14N2, Application of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Swain, Baijayantimala published the artcileNew coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation, COA of Formula: C11H12O4, the publication is Bioorganic & Medicinal Chemistry (2020), 28(15), 115586, database is CAplus and MEDLINE.

Two novel series of phenylacrylamide linked coumarins I [R = H, Me; Ar = Ph, 4-FC₆H₄, 4-MeOC₆H₄, etc.] and sulfocoumarins II [Ar¹ = 4-FC₆H₄, 3-F₃CC₆H₄, 4-NCC₆H₄, etc.] were synthesized and evaluated against four physiol. relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I, hCA II, hCA IX and hCA XII for their inhibitory action. Compounds I and II when screened for carbonic anhydrase inhibitory activity, they showned selective inhibition toward the tumor associated isoforms hCA IX and XII over CA I and II, with inhibition constants in the submicromolar to low nanomolar range. Compound I [R = H; Ar = 4-FC₆H₄] and II [Ar¹ = 4-NCC₆H₄] exhibited significant inhibition with low nanomolar potency against hCA IX, whereas I [R = H; Ar = 3,4-(OMe)₂C₆H₃] was effective against hCA XII. Compounds I [R = H; Ar = 4-FC₆H₄, 3,4-(OMe)₂C₆H₃] and II [Ar¹ = 4-NCC₆H₄] might be considered as lead mols. for future development of cancer therapeutics based on a novel mechanism of action.

Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C18H14BrNO3, COA of Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cox, Dezerae published the artcileHidden information on protein function in censuses of proteome foldedness, Safety of (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Nature Communications (2022), 13(1), 1992, database is CAplus and MEDLINE.

Methods that assay protein foldedness with proteomics have generated censuses of apparent protein folding stabilities in biol. milieu. However, different censuses poorly correlate with each other. Here, we show that the reason for this is that methods targeting foldedness through monitoring amino acid sidechain reactivity also detect changes in conformation and ligand binding, which can be a substantial fraction of the data. We show that the reactivity of only one quarter of cysteine or methionine sidechains in proteins in a urea denaturation curve of mammalian cell lysate can be confidently explained by a two-state unfolding isotherm. Contrary to that expected from unfolding, up to one third of the cysteines decreased reactivity. These cysteines were enriched in proteins with functions relating to unfolded protein stress. One protein, chaperone HSPA8, displayed changes arising from ligand and cofactor binding. Unmasking this hidden information using the approaches outlined here should improve efforts to understand both folding and the remodeling of protein function directly in complex biol. settings.

Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Safety of (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

De Simone, Filippo published the artcileCatalytic formal homo-Nazarov cyclization, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Organic Letters (2009), 11(4), 1023-1026, database is CAplus and MEDLINE.

The first catalytic method for the cyclization of vinyl-cyclopropyl ketones (formal homo-Nazarov reaction) is reported. Starting from activated cyclopropanes, heterocyclic, and carbocyclic compounds were obtained under mild conditions using Bronsted acid catalysts. Preliminary investigation of the reaction mechanism indicated a stepwise process.

Organic Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Votyakov, V. I. published the artcileEffect of some 1-aminoadamantane and 1,3,5-triaza-7-adamantylamine derivatives on viruses and rickettsiae, Synthetic Route of 14707-75-6, the publication is Fiziologicheski Aktivnye Veshchestva (1978), 88-92, database is CAplus.

Aminotriazaadamantanes I (R = H, 3-H₂N, 4-O₂N, 2-CO₂H) were prepared in 30-62.6% yields by acylation of the free amine with RC₆H₄CO₂Me. Reduction of I (R = 4-O₂N) gave 59.7% I (R = 4-H₂N). Triazaadamantanes II (R¹ = H, X = O, S; R¹ = N:CMe₂, N:CMePh, N:CHPh, X = O) were prepared in 43-77.8% yields by addition of PhNCX or H₂NCONHR¹ to the triazaadamantylamine. Addnl. obtained were 64.3-85.7% III (R² = 2-, 3-, 4-H₂N).

Fiziologicheski Aktivnye Veshchestva published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C8H7NO4, Synthetic Route of 14707-75-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Takayama, Toshio published the artcileSilicon-29 NMR chemical shifts of organosilicons as studied by the finite-perturbation theory CNDO/2 method, COA of Formula: C12H10F2Si, the publication is Bulletin of the Chemical Society of Japan (1987), 60(9), 3125-9, database is CAplus.

The ²⁹Si chem. shifts of silicon hydrides and fluorosilanes were calculated by means of the finite-perturbation theory method within the CNDO/2 framework. By a small revision of the formula for the off-diagonal elements of the core Hamiltonian matrix in the CNDO/2 method, the calculated results agree well with the gross trend of the exptl. values of the ²⁹Si chem. shifts in the literature. The relationship between the ²⁹Si chem. shift and the electronic structure was discussed.

Bulletin of the Chemical Society of Japan published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C14H10N2O, COA of Formula: C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huynh, Khoi published the artcileEnantioselective hydroamination/cyclization of aminoalkenes by (bis)-C₂ symmetric and (mono)-C₂ symmetric anionic tetraamide complexes of La(III), Related Products of catalysis-chemistry, the publication is Tetrahedron Letters (2015), 56(23), 3658-3661, database is CAplus.

Enantioselective hydroamination/cyclizations of several monosubstituted and disubstituted aminoalkenes were achieved, catalyzed by tetracoordinate anionic lanthanum(III) complexes with chiral (R)-N,N’-bis(dibenzosuberan-5-yl)-1,1′-binaphthalene-2,2′-diamine. Yttrium(III) complexes were also prepared, but the La(III) complexes showed higher activity and enantioselectivity.

Tetrahedron Letters published new progress about 928836-00-4. 928836-00-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain, name is 2,2-Diallylpent-4-en-1-amine, and the molecular formula is C11H19N, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jahn, Ullrich published the artcile3,3-dichloroprop-2-eniminium salts (vinylogous Viehe salts). A study of their reactivity towards nucleophiles, HPLC of Formula: 6972-05-0, the publication is Synthesis (1997), 573-588, database is CAplus.

The title compounds, [Cl₂C:CC:N⁺R₂]Cl^– [I; R₂ = Me₂, (CH₂)₄, (CH₂)₂O(CH₂)₂, (CH₂)₅] react regioselectively at either the 1- or 3-position depending on the reaction pattern. Chloro substitution affording new propene iminium salts is preferred e.g. in the reaction with mercaptans, amines, and some activated arenes and hetarenes. Nucleophilic attack at the 1-position providing in allyl or allylidene structure is observed e.g. in the reaction with H₂O, EtOH, trialkyl phosphite, Me₃SiCN, Grignard reagents, and acceptor activated methylene compounds Reaction at both positions with heterocyclization to 1,3-thiazine-6-thiones occurs with thioamide functions. The regiochem. depends on a complex interplay of several factors in contrast to the FMO predicted orientation. The utility of I and some consecutive products as versatile C₃-building blocks for further syntheses is foreseeable.

Synthesis published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, HPLC of Formula: 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rahimi, Fatemeh published the artcileNitrogen-rich silicon quantum dots: facile synthesis and application as a fluorescent ‘on-off-on’ probe for sensitive detection of Hg²⁺ and cyanide ions, Quality Control of 13822-56-5, the publication is Luminescence (2022), 37(4), 598-609, database is CAplus and MEDLINE.

The sensitive and reliable detection of Hg²⁺ and CN^– as harsh environmental contaminants are of great importance. In view of this, a novel ‘on-off-on’ fluorescent probe based on nitrogen-rich silicon quantum dots (NR-SiQDs) has been designed for sensitive detection of Hg²⁺ and CN^– ions in aqueous medium. NR-SiQDs were synthesized using a facile, one-step, and environment friendly procedure in the presence of 3-aminopropyl trimethoxysilane (APTMS) and ascorbic acid (AA) as precursors, with L-asparagine as a nitrogen source for surface modification. The NR-SiQDs exhibited strong fluorescence emission at 450 nm with 42.34% quantum yield, satisfactory salt tolerance, and superior photostability and pH stability. The fluorescence emission was effectively quenched using Hg²⁺ (turn-off) due to the formation of a nonfluorescent stable NR-SiQDs/Hg²⁺ complex, whereas after the addition of cyanide ions (CN-), Hg²⁺ ions could be leached from the surface of the NR-SiQDs and the fluorescence emission intensity of the quenched NR-SiQDs fully recovered (turn-on) due to the formation of highly stable [Hg(CN)₄]^2- species. After optimizing the response conditions, the obtained limits of detection were found to be 53 nM and 0.46μM for Hg²⁺ and CN^–, resp. Finally, the NR-SiQD-based fluorescence probe was utilized to detect Hg²⁺ and CN^– ions in water samples and satisfactory results were obtained, suggesting its potential application for environmental monitoring.

Luminescence published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Quality Control of 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia