Catalysis-chemistry

Bijian, Krikor published the artcileNovel Aurora A and Protein Kinase C (¦Á, ¦Â1, ¦Â2, and ¦È) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity, Quality Control of 119-80-2, the publication is Journal of Medicinal Chemistry (2022), 65(4), 3134-3150, database is CAplus and MEDLINE.

Aurora kinases and protein kinase C (PKC) have been shown to be involved in different aspects of cancer progression. To date, no dual Aurora/PKC inhibitor with clin. efficacy and low toxicity is available. Here, we report the identification of compound 2e as a potent small mol. capable of selectively inhibiting Aurora A kinase and PKC isoforms ¦Á, ¦Â1, ¦Â2 and ¦È. Compound 2e demonstrated significant inhibition of the colony forming ability of metastatic breast cancer cells in vitro and metastasis development in vivo. In vitro kinase screening and mol. modeling studies revealed the critical role of the selenium-containing side chains within 2e, where selenium atoms were shown to significantly improve its selectivity and potency by forming addnl. interactions and modulating the protein dynamics. In comparison to other H-bonding heteroatoms such as sulfur, our studies suggested that these selenium atoms also confer more favorable PK properties.

Journal of Medicinal Chemistry published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Quality Control of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Eberl, H. Christian published the artcileChemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells, Formula: C3H8N2S, the publication is Scientific Reports (2019), 9(1), 1-14, database is CAplus and MEDLINE.

Kinobeads are a set of promiscuous kinase inhibitors immobilized on sepharose beads for the comprehensive enrichment of endogenously expressed protein kinases from cell lines and tissues. These beads enable chemoproteomics profiling of kinase inhibitors of interest in dose-dependent competition studies in combination with quant. mass spectrometry. We present improved bead matrixes that capture more than 350 protein kinases and 15 lipid kinases from human cell lysates, resp. A multiplexing strategy is suggested that enables determination of apparent dissociation constants in a single mass spectrometry experiment Miniaturization of the procedure enabled determining the target selectivity of the clin. BCR-ABL inhibitor dasatinib in peripheral blood mononuclear cell (PBMC) lysates from individual donors. Profiling of a set of Jak kinase inhibitors revealed kinase off-targets from nearly all kinase families underpinning the need to profile kinase inhibitors against the kinome. Potently bound off-targets of clin. inhibitors suggest polypharmacol., e.g. through MRCK alpha and beta, which bind to decernotinib with nanomolar affinity.

Scientific Reports published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Junping published the artcileA highly sensitive fluorescent probe for hydrogen sulfide based on dicyanoisophorone and its imaging in living cells, COA of Formula: C14H10O4S2, the publication is Sensors and Actuators, B: Chemical (2019), 141-147, database is CAplus.

Due to the importance of hydrogen sulfide (H₂S) in physiol. and pathol., the development of fluorescence probes for the detection of H₂S has attracted extensive attention of researchers. We developed a H₂S fluorescence probe (DCN-S) based on dicyanoisopentanone using dithioether and ester groups as the reaction sites. Under the nucleophilic substitution of H₂S, disulfide bond of DCN-S was broken. Then the probe changed into dicyanoisophorone derivative and emitted an orange fluorescence band from 530 nm to 700 nm (centered 580 nm). Upon response for H₂S, DCN-S exhibited high sensitivity (88 nM detection limit) and large stokes shift (155 nm). Importantly, the probe also was successfully used for endogenous and exogenous imaging of living cells.

Sensors and Actuators, B: Chemical published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C39H35N5O8, COA of Formula: C14H10O4S2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Yuchao published the artcileSilver-Catalyzed Radical Transformation of Aliphatic Carboxylic Acids to Oxime Ethers, Related Products of catalysis-chemistry, the publication is ACS Catalysis (2016), 6(10), 6465-6472, database is CAplus.

Oximes and oxime ethers are privileged building blocks and can be conveniently converted to ketones, amines, hydroxylamines, and nitriles. The authors describe the catalytic decarboxylation of aliphatic carboxylic acids to oxime ethers. With AgNO₃ as the catalyst, valuable oxime ethers bearing various substituents could be easily obtained. The broad substrate scope, easy accessibility of aliphatic carboxylic acids, and mild reaction conditions make this strategy immediately applicable to the synthesis, late-stage functionalization, and modification of biol. active compounds Exptl. studies show the reaction undergoes a radical process.

ACS Catalysis published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C8H11BO2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Caiyou published the artcileHighly stereoselective synthesis and application of P-chiral ferrocenyl bisphosphorus ligands for asymmetric hydrogenation, COA of Formula: C11H10O3, the publication is Organic Chemistry Frontiers (2017), 4(10), 2034-2038, database is CAplus.

New, efficient and highly stereoselective methods were developed for the synthesis/modification of Wudaphos type ligands. It was found that the “three hindered quadrant” model is crucial to ensure high enantiomeric control and that the substituents on the phosphine atom should be electron rich to increase the reactivity. Moreover, a new SPO-Wudaphos ligand was developed, which exhibited good to excellent enantioselectivities in the asym. hydrogenation of ¦Á-methylene-¦Ã-keto carboxylic acids.

Organic Chemistry Frontiers published new progress about 15732-75-9. 15732-75-9 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ketone, name is 2-Methylene-4-oxo-4-phenylbutanoic acid, and the molecular formula is C11H10O3, COA of Formula: C11H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Caiyou published the artcileA new ferrocenyl bisphosphorus ligand for the asymmetric hydrogenation of ¦Á-methylene-¦Ã-ketocarboxylic acids, Product Details of C11H10O3, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(70), 9785-9788, database is CAplus and MEDLINE.

New diphosphine-amine chiral ligand ^tBu-Wudaphos I was prepared and examined for chiral induction in rhodium-catalyzed asym. hydrogenation of ¦Á-methylene-¦Ã-ketocarboxylic acids, yielding ¦Á-methyl-¦Ã-ketocarboxylates with more than 98% ee and quant. conversion. Upon incorporation of a noncovalent ion pair interaction, a new chiral ferrocenyl bisphosphorus ligand t-Bu-Wudaphos was developed. t-Bu-Wudaphos can be easily synthesized with very high diastereoselectivity as a highly air stable solid. The new ligand exhibited excellent reactivities and enantioselectivities in the asym. hydrogenation of ¦Á-methylene-¦Ã-keto-carboxylic acids via an ion pair noncovalent interaction (up to >99% conversion, >99% ee).

Chemical Communications (Cambridge, United Kingdom) published new progress about 15732-75-9. 15732-75-9 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ketone, name is 2-Methylene-4-oxo-4-phenylbutanoic acid, and the molecular formula is C11H10O3, Product Details of C11H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tang, Lin published the artcileSolvent-Controlled Copper-Catalyzed Radical Decarboxylative Coupling for Alkenyl C(sp²)-P Bond Formation, Formula: C9H7NO4, the publication is Asian Journal of Organic Chemistry (2017), 6(11), 1683-1692, database is CAplus.

The first solvent-controlled copper-catalyzed oxidative decarboxylative coupling of alkenyl acids with P(O)H compounds for alkenyl C(sp²)-P bond formation by a free-radical process is reported. The reaction enables the highly chemo- and stereoselective synthesis of various (E)-alkenylphosphonates and (E)-alkenylphosphine oxides in moderate to good yields. On the basis of this catalytic system, styrenes and ¦Â-nitrostyrene as well as alkenyl acids can also give the corresponding products by cross-dehydrogenative coupling and denitration, resp. By altering the oxidant, the oxyphosphorylation of styrenes with P(O)H compounds readily yields ¦Â-ketophosphonates. The reaction described here enables a versatile and practical avenue for the formation of valuable C-P bonds.

Asian Journal of Organic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C6H12N2O, Formula: C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Zeshuai published the artcileSelective N-Monovinylation of Primary Aromatic Amides Using Calcium Carbide as an Alkyne Source, Quality Control of 118-90-1, the publication is ChemistrySelect (2022), 7(26), e202201463, database is CAplus.

An efficient method for the selective N-monovinylation of primary aromatic amides using calcium carbide as an alkyne source was described. A series of N-vinylbenzamides (enamides) RC(O)NHCH=CH₂ [R = Ph, 2-MeC₆H₄, 4-ClMeC₆H₄, etc.] were readily synthesized by this strategy. The salient features for this protocol were the use of inexpensive, easy-to-handle solid alkyne source, high chemoselectivity, transition metal catalyst-free, good functional group tolerance, and simple work-up procedures. These reactions was also be extended to the gram-scale level.

ChemistrySelect published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C18H23OP, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rau, Johannes H. published the artcileReactive fibers, Part III. Reactions of reactive fibers based on cyanuric cellulose with low-molecular-weight compounds, Computed Properties of 6972-05-0, the publication is Melliand Textilberichte (1979), 60(3), 258-63, database is CAplus.

Treatment of cotton fabrics with compounds containing various functional groups at 30-80¡ã in aqueous solutions at pH 3-9 showed that compounds containing primary and secondary amino groups, compounds containing phenolic OH groups, and thiourea and its derivatives were fixed on the fibers. Most compounds were sulfo acids or contained S in another form so bonding to the fiber could be measured by determination of S. The amount of compound bonded to the fibers fell between 0.3-9.7%; the yield, based on the amount of Cl contained in the reactive fiber, lay between 2.8 and 74%.

Melliand Textilberichte published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hyvonen, Mervi T. published the artcileMetabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N¹-acetyltransferase and thialysine acetyltransferase, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Drug Metabolism & Disposition (2013), 41(1), 30-32, database is CAplus and MEDLINE.

Triethylenetetramine (TETA; Syprine; Merck Rahway, NJ), a drug for Wilson’s disease, is a copper chelator and a charge-deficient analog of polyamine spermidine. We recently showed that TETA is metabolized in vitro by polyamine catabolic enzyme spermidine/spermine-N¹-acetyltransferase (SSAT1) and by thialysine acetyltransferase (SSAT2) to its monoacetylated derivative (MAT). The acetylation of TETA is increased in SSAT1-overexpressing mice compared with wild-type mice. However, SSAT1-deficient mice metabolize TETA at the same rate as the wild-type mice, indicating the existence of another N-acetylase respons 2ible for its metabolism in mice. Here, we show that siRNA-mediated knockdown of SSAT2 in HEPG2 cells and in primary hepatocytes from the SSAT1-deficient or wild-type mice reduced the metabolism of TETA to MAT. By contrast, 1,12-diamino-3,6,9-triazadodecane(SpmTrien), a charge-deficient spermine analog, was an extremely poor substrate of human recombinant SSAT2 and was metabolized by SSAT1 in HEPG2 cells and in wild-type primary hepatocytes. Thus, despite the similar structures of TETA and SpmTrien, SSAT2 is the main acetylator of TETA, whereas SpmTrien is primarily acetylated by SSAT1.

Drug Metabolism & Disposition published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia