Tag: M.W=100-150

Feigel, M. published the artcileA semiempirical AM1, MNDO and PM3 study of the rotational barriers of various ureas, thioureas, amides and thioamides, HPLC of Formula: 6972-05-0, the publication is Journal of Molecular Structure: THEOCHEM (1993), 33-48, database is CAplus.

AM1 was more than MNDO, or PM3 for calculating rotational barriers of compounds containing a RRN-CX-R linkage (amides, thioamides, ureas and thioureas). The barriers calculated with AM1 must be corrected using the equation ¦¤G_liquid^? = 1.6¦¤H_(AM1)^? + 4.5 kcal mol^-1 to obtain the best coincidence with exptl. values. Another equation, ¦¤H_ab?_initio^? = 1.35¦¤H_(AM1)^? + 2.05 kcal mol^-1 reproduces recent ab initio data well.

Journal of Molecular Structure: THEOCHEM published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, HPLC of Formula: 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mangion, Ian published the artcileDynamic kinetic asymmetric allylation of hydrazines and hydroxylamines, Synthetic Route of 6084-58-8, the publication is Organic Letters (2009), 11(15), 3258-3260, database is CAplus and MEDLINE.

Hydrazines and hydroxylamines have been found to be excellent nucleophiles for the palladium-catalyzed dynamic asym. allylic amination of vinyl epoxide, with good yields and enantioselectivities of up to 97% ee. This method is applicable to acyclic and heterocyclic amines and was applied toward a five-step synthesis of (R)-piperazic acid.

Organic Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Synthetic Route of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Schroth, W. published the artcileSynthesis of 1,3-thiazinium salts from ¦Â-chlorovinyl ketones and thio amide functionalized compounds, SDS of cas: 6972-05-0, the publication is Tetrahedron (1982), 38(7), 937-48, database is CAplus.

Thiocarbamoyl compounds reacted with ¦Â-chlorovinyl ketones to give 1,3-thiazinium salts via S-ketovinylthioimidium derivatives E.g., condensation reaction of Me₃CCSNH₂ with 4-MeC₆H₄COCH:CHCl in HClO₄ gave the intermediate 4-MeC₆H₄COCH:CHSC(:N⁺H₂)CMe₃ ClO₄^– which underwent acid-catalyzed cyclocondensation reaction to give 72% thiazinium salt I. The thiazinium salts react with nucleophilic reagents preferentially at position 6. E.g., substitution reaction of I with morpholine at -20¡ã gave 94% thiazine II. The scope of the cyclocondensation reaction is discussed.

Tetrahedron published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, SDS of cas: 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Schroth, Werner published the artcile1,3-Thiazine syntheses with ¦Â-diketones via enol phosphate, Related Products of catalysis-chemistry, the publication is Synthesis (1983), 827-30, database is CAplus.

RCOCH₂COR (R = Ph; 4-MeOC₆H₄, Me) were successively treated with Na or NaOMe, then (PhO)₂P(O)Cl in C₆H₆ or Et₂O to give 58-75% RCOCH:CROP(O)(OPh)₂ which were cyclized with H₂NC(S)R¹ (R¹ = Ph, Me, CMe₃, SEt, NH₂, NMe₂, morpholino, PhCH:NNH, MeEtC:NNH, 4-MeC₆H₄SO₂NHNH, 4-MeOC₆H₄) in AcOH containing POCl₃, with dropwise addition of 70% HClO₄ to give 39-97% thiazinium perchlorates I.

Synthesis published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Junior, Rubens Paula published the artcilePresence of human breast cancer xenograft changes the diurnal profile of amino acids in mice, Name: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Scientific Reports (2022), 12(1), 1008, database is CAplus and MEDLINE.

Human xenografts are extremely useful models to study the biol. of human cancers and the effects of novel potential therapies. Deregulation of metabolism, including changes in amino acids (AAs), is a common characteristic of many human neoplasms. Plasma AAs undergo daily variations, driven by circadian endogenous and exogenous factors. We compared AAs concentration in triple neg. breast cancer MDA-MB-231 cells and MCF10A non-tumorigenic immortalized breast epithelial cells. We also measured plasma AAs in mice bearing xenograft MDA-MB-231 and compared their levels with non-tumor-bearing control animals over 24 h. In vitro studies revealed that most of AAs were significantly different in MDA-MB-231 cells when compared with MCF10A. Plasma concentrations of 15 AAs were higher in cancer cells, two were lower and four were observed to shift across 24 h. In the in vivo setting, anal. showed that 12 out of 20 AAs varied significantly between tumor-bearing and non-tumor bearing mice. Noticeably, these metabolites peaked in the dark phase in non-tumor bearing mice, which corresponds to the active time of these animals. Conversely, in tumor-bearing mice, the peak time occurred during the light phase. In the early period of the light phase, these AAs were significantly higher in tumor-bearing animals, yet significantly lower in the middle of the light phase when compared with controls. This pilot study highlights the importance of well controlled experiments in studies involving plasma AAs in human breast cancer xenografts, in addition to emphasizing the need for more precise examination of exometabolomic changes using multiple time points.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Name: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Xiaotian published the artcileSNHG3 could promote prostate cancer progression through reducing methionine dependence of PCa cells, Application In Synthesis of 63-68-3, the publication is Cellular & Molecular Biology Letters (2022), 27(1), 13, database is CAplus and MEDLINE.

In recent years, morbidity and mortality of prostate cancer (PCa) have increased dramatically, while mechanistic understanding of its onset and progression remains unmet. LncRNA SNHG3 has been proved to stimulate malignant progression of multiple cancers, whereas its functional mechanism in PCa needs to be deciphered. In this study, our anal. in the TCGA database revealed high SNHG3 expression in PCa tissue. Further anal. in starBase, TargetScan, and mirDIP databases identified the SNHG3/miR-152-3p/SLC7A11 regulatory axis. FISH was conducted to assess the distribution of SNHG3 in PCa tissue. Dual-luciferase reporter gene and RIP assays confirmed the relationship among the three objects. Next, qRT-PCR and western blot were conducted to measure expression levels of SNHG3, miR-152-3p, and SLC7A11. CCK-8, colony formation, Transwell, and flow cytometry were carried out to assess proliferation, migration, invasion, methionine dependence, apoptosis, and the cell cycle. It was noted that SNHG3 as a mol. sponge of miR-152-3p stimulated proliferation, migration, and invasion, restrained methionine dependence and apoptosis, and affected the cell cycle of PCa cells via targeting SLC7A11. Addnl., we constructed xenograft tumor models in nude mice and confirmed that knockdown of SNHG3 could restrain PCa tumor growth and elevate methionine dependence in vivo. In conclusion, our investigation improved understanding of the mol. mechanism of SNHG3 modulating PCa progression, thereby generating novel insights into clin. therapy for PCa.

Cellular & Molecular Biology Letters published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C3H5BN2O2, Application In Synthesis of 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Scott, Jason A. published the artcileOptimization of a Pyrimidinone Series for Selective Inhibition of Ca²⁺/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain, Product Details of C8H8O2, the publication is Journal of Medicinal Chemistry (2022), 65(6), 4667-4686, database is CAplus and MEDLINE.

Adenylyl cyclase type 1 (AC1) is involved in signaling for chronic pain sensitization in the central nervous system and is an emerging target for the treatment of chronic pain. AC1 and a closely related isoform AC8 are also implicated to have roles in learning and memory signaling processes. Our team has carried out cellular screening for inhibitors of AC1 yielding a pyrazolyl-pyrimidinone scaffold with low micromolar potency against AC1 and selectivity vs. AC8. Structure-activity relationship (SAR) studies led to analogs with cellular IC₅₀ values as low as 0.25 ¦ÌM, selectivity vs. AC8 and other AC isoforms as well as other common neurol. targets. A representative analog displayed modest antiallodynic effects in a mouse model of inflammatory pain. This series represents the most potent and selective inhibitors of Ca²⁺/calmodulin-stimulated AC1 activity to date with improved drug-like physicochem. properties making them potential lead compounds for the treatment of inflammatory pain.

Journal of Medicinal Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C14H15BF3NO2, Product Details of C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pandeya, S. N. published the artcileSynthesis, anticonvulsant and analgesic activity of 1,2,4-dithiazoline derivatives, Recommanded Product: 1,1-Dimethylthiourea, the publication is Indian Journal of Pharmaceutical Sciences (1982), 44(2), 31-3, database is CAplus.

Iminodithiazolines I (R = 4-EtOC₆H₄NH, Me₂N; R¹ = Ph, 4-MeC₆H₄, PhCH₂, Me) were prepared by S-benzylating RCSNH₂, treating RC(:NH)SCH₂Ph with R¹NCS, and oxidative cyclization of R¹NHCSN:CRSCH₂Ph with Br₂. I (R = 4-MeC₆H₄, R¹ = CH₂Ph) was obtained as a by-product. At 10 mg/kg i.p. I (R = 4-EtOC₆H₄NH, R¹ = Ph, 4-MeC₆H₄; R = NMe₂, R¹ = 4-MeC₆H₄; R = 4-MeC₆H₄, R¹ = CH₂Ph) had 40-80% anticonvulsant activity in maximum electroshock test. I (R = 4-EtOC₆H₄NH, R¹ = 4-MeC₆H₄, PhCH₂; R = 4-MeC₆H₄, R¹ = CH₂Ph) had analgesic activity at 10 mg/kg i.p. in rats.

Indian Journal of Pharmaceutical Sciences published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Aziz, I. published the artcileSynthesis, Characterization, DNA Interaction Study, Antibacterial and Anticancer Activities of New Palladium(II) Phosphine Complexes, Category: catalysis-chemistry, the publication is Russian Journal of General Chemistry (2018), 88(3), 551-559, database is CAplus.

Palladium(II) complexes with N,N-dimethylthiourea and phosphines [tri-p-tolylphosphine (Tptp), benzyl(diphenyl)phosphine (Bdp), cyclohexyl(diphenyl)phosphine (Cdp)] were synthesized by the direct reaction of K₂[(PdCl₄)] with the corresponding phosphines and then with N,N-dimethylthiourea at a molar ratio of 1:2:2, resp. The general formula of these complexes is [Pd(L1)₂(L₂)₂]Cl₂, where L1 = N,N-dimethylthiourea (Dmtu), L2 = Tptp, Bdp, Cdp. The complexes were characterized by elemental analyses, multinuclear NMR (¹H, ¹³C, ³¹P), and FTIR. The complex with cyclohexyl(diphenyl)phosphine was also characterized by single crystal x-ray anal. The spectral and crystallog. data suggest monodentate coordination of dimethylthiourea through the S atom and of the phosphine ligand through the P atom and distorted square planar environment of Pd(II). The synthesized complexes were screened for DNA binding, antibacterial, cytotoxic, and antitumor activities. The complexes show interaction with DNA via intercalative mode. The complexes show good activity against both gram pos. and gram neg. bacteria as compared to that of a standard drug, Imipenem. Their antitumor activity against MCF7 tumor cell line is comparable with doxorubicin. MTT assay was used to study the cytotoxicity of the studied compounds

Russian Journal of General Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Srivastava, Santosh K. published the artcileThe effect of some oligoamines and -guanidines on membrane permeability in higher plants, Product Details of C3H12Cl2N2, the publication is Phytochemistry (Elsevier) (1982), 21(5), 997-1008, database is CAplus.

Diamines [NH₂(CH₂)_xNH₂] (x = ¡Ü10) decreased betacyanin efflux from beetroot disks, especially at x = 7. Triamines [NH₂(CH₂)_xNH(CH₂)₃NH₂] (x ¡Ü 8) had a similar effect, but increased total ion loss (x = 4-10). Tetraamines [NH₂(CH₂)₃NH(CH₂)_xNH(CH₂)₃NH₂] (x = 2-4) also reduced betacyanin efflux. Spermine potentiated the toxic effects of guazatine and dodine in beetroot disks, but with Ca reduced the induced ion efflux in swede disks, spinach leaves, and apple cells; putrescine, cadaverine, and spermidine did not have such an effect. Monoguanidines [NH₂C(=NH)NH(CH₂)_x-1Me], esp x = 10-12 and diguanidines [NH₂C(=NH)NH(CH₂)_xNHC(=NH)NH₂), especially x = 12, caused efflux of betacyanin and ions.

Phytochemistry (Elsevier) published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C7H8BNO4, Product Details of C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia