Tag: M.W=100-150

Grawe, Thomas published the artcileSelf-Assembly of Ball-Shaped Molecular Complexes in Water, Related Products of catalysis-chemistry, the publication is Journal of Organic Chemistry (2002), 67(11), 3755-3763, database is CAplus and MEDLINE.

The authors present a simple and versatile access to spheroidal mol. assemblies with pronounced stability in highly polar solvents. These complexes are composed of doubly and triply charged complementary building blocks based on ammonium or amidinium cations and phosphonate anions. Their high thermodn. stability is best explained by the formation of a cyclic array of alternating pos. and neg. charges interconnected by a regular network of H bonds. Association constants reach 10⁶ M^-1 in methanol and often surpass 10³ M^-1 in water. The broad range of binding energies correlates well with the varying degree of preorganization of both complex partners. As a byproduct of these studies, new recognition motifs for histidine and arginine esters and the unsubstituted guanidinium ion are proposed. The addnl. introduction of Me groups in the 2-, 4-, and 6-positions of the central benzene ring in either cations or anions causes a marked drop in the corresponding K_a values of 1 order of magnitude; the related rotational barriers were estimated at 0.3-2.1 kcal/mol. Spontaneous formation of defined 2:1 complexes from three components also was observed

Journal of Organic Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yavari, Issa published the artcileA one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from thioamides or thioureas and 2-chloro-1,3-dicarbonyl compounds in an ionic liquid, Computed Properties of 6972-05-0, the publication is Monatshefte fuer Chemie (2009), 140(2), 209-211, database is CAplus.

A simple one-pot synthesis of functionalized Et 1,3-thiazole-5-carboxylates from the reaction of 2-chloro-1,3-dicarbonyl compounds with thioureas or thioamides in the presence of 1-butyl-3-methylimidazolium trifluoromethanesulfonate was described.

Monatshefte fuer Chemie published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C30H24BrCuN2P, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Thyne, Kevin M. published the artcileMetabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA), COA of Formula: C5H11NO2S, the publication is Scientific Reports (2022), 12(1), 5073, database is CAplus and MEDLINE.

Abstract: Methionine restriction (MR) extends lifespan and improves several markers of health in rodents. However, the proximate mechanisms of MR on these physiol. benefits have not been fully elucidated. The essential amino acid methionine plays numerous biol. roles and limiting its availability in the diet directly modulates methionine metabolism There is growing evidence that redox regulation of methionine has regulatory control on some aspects of cellular function but interactions with MR remain largely unexplored. We tested the functional role of the ubiquitously expressed methionine repair enzyme methionine sulfoxide reductase A (MsrA) on the metabolic benefits of MR in mice. MsrA catalytically reduces both free and protein-bound oxidized methionine, thus playing a key role in its redox state. We tested the extent to which MsrA is required for metabolic effects of MR in adult mice using mice lacking MsrA. As expected, MR in control mice reduced body weight, altered body composition, and improved glucose metabolism Interestingly, lack of MsrA did not impair the metabolic effects of MR on these outcomes. Moreover, females had blunted MR responses regardless of MsrA status compared to males. Overall, our data suggests that MsrA is not required for the metabolic benefits of MR in adult mice.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C6H12O2, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Toth, Balazs L. published the artcileZ-Selective Fluoroalkenylation of (Hetero)Aromatic Systems by Iodonium Reagents in Palladium-Catalyzed Directed C-H Activation, Related Products of catalysis-chemistry, the publication is Advanced Synthesis & Catalysis (2022), 364(2), 348-354, database is CAplus.

Herein, a stereoselective procedure for direct fluorovinylation of aromatic and heteroaromatic scaffolds is reported. This methodol. development has been realized by palladium-catalyzed ortho C-H activation reaction of a variety of aniline derivatives featuring the regioselectivity via directing groups such as secondary of tertiary amides, ureas or ketones. The application of non-sym. aryl(fluoroalkenyl)iodonium salts as fluoroalkenylating agents allowed mild reaction conditions in general for this transformation. The scope and limitations have been thoroughly investigated and the feasibility has been demonstrated by more than 50 examples.

Advanced Synthesis & Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C15H19BO2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kocabas, Erdal published the artcileA rapid and high-yielding synthesis of thiazoles and aminothiazoles using tetrabutylammonium salts, Category: catalysis-chemistry, the publication is Heterocycles (2010), 81(12), 2849-2854, database is CAplus.

A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of Bu₄NPF₆ at room temperature was developed. The products were formed rapidly within 15 min in high yields. The method is simple, rapid, and practical, generating thiazoles in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, ¹H NMR, ¹³C NMR, and elemental anal.

Heterocycles published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shechter, Yoram published the artcileNewly Designed Modifier Prolongs the Action of Short-Lived Peptides and Proteins by Allowing Their Binding to Serum Albumin, Name: Propane-1,3-diamine dihydrochloride, the publication is Bioconjugate Chemistry (2012), 23(8), 1577-1586, database is CAplus and MEDLINE.

We found that human serum albumin (HSA) contains a single binding domain for derivatives of long-chain fatty acid (LCFA)-like mols. in which the carboxylate is replaced by sulfonate. Accordingly, we have synthesized 16-sulfo-hexadecanoic acid-N-hydroxysuccinimide ester [HO₃S-(CH₂)₁₅-CONHS], an agent that reacts selectively with the amino side chains of peptides and proteins. A macromol. containing a single 16-sulfohexadecanoate moiety associating with albumin with a K_a value of 0.83¡À0.08¡Á10⁶ M^-1, a sufficient affinity to extend the actions in vivo of such short-lived peptides and proteins. S.c. administration of insulin-NHCO-(CH₂)₁₅-SO₃^– into mice facilitated a glucose-lowering effect 4.3 times in duration and 6.6 times in area under the curve (AUC) as compared to an in vitro equipotent amount of Zn²⁺-free insulin. Similarly, s.c. and i.v. administration of exendin-4-NHCO-(CH₂)₁₅-SO₃^– to mice yielded prolonged and stable reduction in glucose level, 5-9-fold longer than that of exendin-4. Also, a single s.c. administration of human interferon-¦Á2-[NH-CO-(CH₂)₁₅-SO₃^–]₃ to mice yielded circulating antiviral activity over a period of 40 h. In conclusion, a simple, hydrophilic reagent has been engineered, synthesized, and studied. Its linkage to peptides and proteins in a mono-modified fashion yielded hydrophilic, prolonged acting derivatives, due to their acquired ability to associate with serum albumin after administration.

Bioconjugate Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C20H28B2O4S2, Name: Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dwarakanath, K. published the artcileAssignments for the fundamental vibrations of N,N-dimethylthiourea and N,N-dimethylselenourea, Synthetic Route of 6972-05-0, the publication is Indian Journal of Pure and Applied Physics (1979), 17(3), 171-5, database is CAplus.

The IR spectra of Me₂NC(S)NH₂ (I) and Me₂NC(Se)NH₂ (II) and their N-deuterated and S-Me derivatives were measured between 4000 and 30 cm^-1. The fundamental frequencies of I and II were assigned and supported by normal coordinate calculations for the in-plane and out-of-plane modes of I–d₀ and –d₂. The coordinate treatment was extended to the in-plane vibrations of I–d₀ and –d₂ by introducing min. changes in transferring the force constants from I.

Indian Journal of Pure and Applied Physics published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Synthetic Route of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Murafuji, Hidenobu published the artcileDiscovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors, Application In Synthesis of 6084-58-8, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(23), 5272-5276, database is CAplus and MEDLINE.

Compound I, composed of a 1,3,6-trisubstituted 1,4-diazepane-7-one, was discovered as a novel human kallikrein 7 (KLK7, stratum corneum chymotryptic enzyme, SCCE) inhibitor, and its derivatives were synthesized and evaluated. Structure-activity relationship studies of the amidoxime unit and benzoic acid part of this new scaffold led to the identification of compounds II (R = CO₂H and R = Ms), which were more potent than the hit compound, I. The X-ray co-crystal structure of compound II (R = CO₂H) and human KLK7 revealed the characteristic interactions and enabled explanations of the structure-activity relationship.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Application In Synthesis of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kohno, Hiroyuki published the artcileEffects of intracerebroventricular administration of aliphatic diamines on ingestive behavior in the rat, HPLC of Formula: 10517-44-9, the publication is Japanese Journal of Pharmacology (1981), 31(2), 211-20, database is CAplus and MEDLINE.

The pharmacol. effects of intracerebroventricularly administered aliphatic diamines on ingestive behavior were measured in male rats adapted to a 4 h/day feeding and drinking schedule. 1,2-Ethanediamine-2HCl (ETD) [333-18-6], 1,3-propanediamine-2HCl (PRD) [10517-44-9], putrescine (PUT) [110-60-1], cadaverine-2HCl (CAD) [1476-39-7], and 1,6-hexanediamine-2HCl (HED) [6055-52-3] suppressed feeding and drinking behavior in a dose-dependent manner, but not unless a relatively high dose (>80 ¦Ìg) was given. The approx. anorectic potency was HED > CAD ¡Ö PUT > ETD > PRD. A sedation was also produced in fairly good parallel to these alterations in feeding and drinking behavior. Thus, there appears to be a relation between the length of the C chain and the potency of the pharmacol. action.

Japanese Journal of Pharmacology published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, HPLC of Formula: 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tsai, Cheng-Yu published the artcileHelical structure motifs made searchable for functional peptide design, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Nature Communications (2022), 13(1), 102, database is CAplus and MEDLINE.

The systematic design of functional peptides has technol. and therapeutic applications. However, there is a need for pattern-based search engines that help locate desired functional motifs in primary sequences regardless of their evolutionary conservation. Existing databases such as The Protein Secondary Structure database (PSS) no longer serves the community, while the Dictionary of Protein Secondary Structure (DSSP) annotates the secondary structures when tertiary structures of proteins are provided. Here, we extract 1.7 million helixes from the PDB and compile them into a database (Therapeutic Peptide Design database; TP-DB) that allows queries of compounded patterns to facilitate the identification of sequence motifs of helical structures. We show how TP-DB helps us identify a known purification-tag-specific antibody that can be repurposed into a diagnostic kit for Helicobacter pylori. We also show how the database can be used to design a new antimicrobial peptide that shows better Candida albicans clearance and lower hemolysis than its template homologs. Finally, we demonstrate how TP-DB can suggest point mutations in helical peptide blockers to prevent a targeted tumorigenic protein-protein interaction.

Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C3H9ClOS, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia