Tag: M.W=100-150

Kost, A. N. published the artcileAcrylonitrile as a starting material for synthesis of amino nitriles and polyamines, SDS of cas: 10517-44-9, the publication is Uchenye Zapiski Moskov. Gosudarst. Univ. im. M. V. Lomonosova (1950), 39-97, database is CAplus.

cf. C.A. 41, 1609h; 42, 3722g. Dissertation at the University (1946) with complete exptl. details and bibliography of 169 references. A laboratory preparation of CH₂:CHCN (I) was developed as follows. To a hot saturated solution of 100 g. SnCl₂ was added 30 g. Zn dust with stirring and, after completion of reaction, the mixture was allowed to stand 2 hrs., decanted, washed with 10% AcOH, let stand overnight with 60 ml. 80-90% AcOH, filtered, washed with H₂O until neutral, and washed with EtOH and Et₂O, giving 30-35 g. Sn dust. All traces of Zn must be removed for good results with this catalyst. Heating 50 g. HOCH₂CH₂CN with 5 g. of the above Sn dust in a distillation apparatus with chilled receiver so that vapor temperature is below 110¡ã yields a 2-layer distillate; the upper layer after drying with CaCl₂ yields up to 90% I. If com. ethylene oxide is used in the preparation of the cyanohydrin, the product may be contaminated with MeCH:CHCN, H₂O, and NH₃; it is purified by 5-10 min. treatment with P₂O₅ and distillation (b₇₅₈ 78¡ã). Refluxing the cyanohydrin with silica gel, activated C, MgSO₄, Fe oxides, pieces of sheet Fe, Al foil, and Al₂O₃ gave but 0-30% yields of I. Passage of the cyanohydrin over Al₂O₃ at 200-20¡ã gave but 18-20% I. To 950 ml. aqueous NH₄OH (saturated in the cold) was added 95 g. I dropwise with cooling over 2 hrs. so that the mixture remained homogeneous; after 30 min. at room temperature, distillation gave 30% H₂NCH₂CH₂CN, b₁₄ 77-8¡ã, b₂₃ 89¡ã, n_D²⁰ 1.4390, d₂₀ 0.9584, which polymerized in several days in a sealed ampul even in darkness. Distillation of the higher-boiling residue gave 47% HN(CH₂CH₂CN)₂, b₁₄ 177-9¡ã, b₂₂ 209-11¡ã, n_D²⁰ 1.4630, d₂₀ 1.0196; HCl salt, m. 147-8¡ã (from MeOH); N-Bz derivative, m. 112¡ã (from MeOH). The free amine generated by addition of 50% aqueous Me₂NH to solid NaOH was fed into 106 g. I with ice cooling over 6-8 hrs., and the mixture distilled after 2 hrs. at room temperature yielding 80-1% Me₂NCH₂CH₂CN, b₇₅₀ 171¡ã, n_D²⁰ 1.4283, d₂₀ 0.8705; picrate, m. 151¡ã; HCl salt, m. 199¡ã (from MeOH). A mixture of 40 g. Et₂NH and 26.5 g. I gave a slight heat evolution after 5-10 min.; refluxed on a steam bath 2 hrs. (yellow color) and distilled, it yielded 89-95% Et₂NCH₂CH₂CN, b₂₀ 86-9¡ã. If the heating is done in sealed tubes 6-8 hrs. no yellow color is formed and the yield is nearly 100%; the pure product b₂ 65¡ã, b₉ 76¡ã, b₂₀ 87¡ã, b₄₅ 112¡ã, b₇₅₅ 197.3¡ã (corr.), d₂₀ 0.8761, n_D²⁰ 1.4380; HCl salt, m. 120¡ã; picrate, m. 85¡ã. This (3.1 g.) refluxed 4 hrs. with 4. g. 25% NaOH and evaporated gave the amorphous Na salt of the corresponding acid; refluxing 6.3 g. of the nitrile with 11 g. concentrated HCl, cooling, filtering, and evaporating repeatedly in vacuo gave an amorphous mass, which was freed in aqueous solution of Cl ion by Ag₂CO₃, the Ag ion removed with H₂S, and the filtrate evaporated, yielding 60% Et₂NCH₂CH₂CO₂H, m. 70-5¡ã. The best reaction conditions for piperidine and I are as follows: Piperidine (17 g.) and 11.1 g. I mixed with cooling in an ampul (cooled until the heat evolution stopped in 15-20 min.) and heated 4 hrs. on a steam bath, then let stand overnight, gave 96-7% (CH₂)₅NCH₂CH₂CN, b₁₈ 114-15¡ã; some 22% is formed by refluxing 5 g. piperidine with 5 g. HOCH₂CH₂CN 3 hrs. at 120-50¡ã; if Sn dust is added the yield is 52.5%. An extensive study showed that the reaction of I with PhNHEt is best carried out by heating in an ampul 100 hrs. on steam bath in the presence of 3% Ac₂O and a little hydroquinone, when 65-70% PhEtNCH₂CH₂CN, b₈ 158¡ã, b₁₁ 164-5¡ã, n_D²⁰ 1.5503, d₂₀ 1.0260, is obtained; HCl salt, hygroscopic solid; picrate, oil; the free base couples with diazotized sulfanilic acid even in acid medium and the coupling product, isolated as the Na salt, is a green solid, giving a brown color in acid solution Coupling with diazotized p-O₂NC₆H₄NH₂ gave a brown product, C₁₇H₁₇O₂N₅, while tetrazotized benzidine reacts only slowly in acidified solution, yielding a red-violet solution which turns yellow in neutral or basic solution; the free azo derivative is soluble in organic solvents. Hydrolysis of PhEtNCH₂CH₂CN is very slow with H₂O at 100¡ã in a sealed tube; concentrated HCl at room temperature acts slowly and incompletely even in 48 hrs., while heating at 110-20¡ã leads to loss of PhNHEt; heating with 30-40% H₂SO₄ gives an impure product. Alk. hydrolysis gives low yields of the corresponding acid. Refluxing 14 g. PhEtNCH₂CH₂CN and 20 g. KOH in 20 ml. H₂O and 70 ml. EtOH 15 hrs., acidifying with HCl, and repeatedly extracting with iso-BuOH, adding Et₂O to the extract gave 33.1% PhEtNCH₂CO₂H.HCl, a high-melting solid, giving a brown color with FeCl₃. This couples even in acid solution with diazotized sulfanilic acid, yielding a red azo derivative; p-O₂NC₆H₄N₂Cl also couples in acid medium, giving a red azo derivative PhEtNCH₂CH₂CN (4.5 g.) added slowly to 15 ml. concentrated H₂SO₄, and the mixture let stand 40 hrs., then diluted with H₂O (50 ml.), neutralized with concentrated NH₄OH, and let stand overnight giving a precipitate of PhEtNCH₂CH₂CONH₂, 68.5-76.5%, m. 55-8¡ã (crude), m. 67¡ã (from MeOH). I (35 g.) added to 20 g. dry (CH₂NH₂)₂ dropwise with cooling at 15-20¡ã over 2 hrs. the mixture shaken 2 hrs. at room temperature and let stand overnight in a stoppered flask gave 39.8% H₂NCH₂CH₂NHCH₂CH₂CN, b_1.5 101¡ã, n_D²⁰ 1.4727, d₂₀ 0.9912 (with MeZnI at room temperature only the primary amino group reacts, while at 100¡ã all active H can be determined) (the picrate and styphnate are oils, while HCl salt is a viscous mass), and 59.8% (CH₂NHCH₂CH₂CN)₂, b_1.5 174¡ã, b_3.5 191¡ã, n_D²⁰ 1.4793, d₂₀ 1.0256 [picrate and styphnate, oils; HCl salt, m. 184-7¡ã (decomposition)]. The structure of the latter appears confirmed by the improbability of reaction of I with a cyanoethylated group, and further by the reaction with MeZnI which indicates 1.94 active H atoms/mole at 100¡ã and 0.5 at room temperature Me₂NCH₂CH₂CN treated with MeI in C₆H₆ with cooling gave the methiodide, m. 153¡ã (from MeOH); EtI at room temperature yielded the ethiodide, m. 128.5¡ã (from MeOH); EtBr at 60¡ã yielded the ethobromide, m. 157¡ã (from Et₂O-MeOH); PrBr and CH₂:CHCH₂Cl at 80¡ã yielded the corresponding quaternary salts, m. 189¡ã (from Et₂O-MeOH), and 185-7¡ã (from MeOH), resp. Et₂NCH₂CH₂CN with MeI at room temperature gave the methiodide, m. 152¡ã (from MeOH), while EtI at 60¡ã gave the ethiodide, m. 168¡ã (from MeOH). (CH₂)₅NCH₂CH₂CN with MeI at 100¡ã gave the methiodide, m. 152¡ã (from MeOH), while EtI reacted slowly at 100¡ã yielding the ethiodide, m. 160-1¡ã (from MeOH). Reduction of H₂NCH₂CH₂CN with BuOH-Na gave variable yields when com. Na was used, because of traces of K (Dzirkal, C.A. 36, 2255.6); a 2% K-Na alloy gave high yields comparable to those obtained with pure Na. In the best procedure 30 g. of this alloy was rapidly treated with 14 g. H₂NCH₂CH₂CN in 450 ml. BuOH, and despite vigorous reaction the mixture was immediately heated in an oil bath at 140-50¡ã, cooled after 35-40 min., diluted with 130-50 ml. cold H₂O, steam-distilled 4-6 hrs. into the calculated amount of aqueous HCl, and the distillate evaporated, yielding 81% CH₂(CH₂NH₂)₂.2HCl, m. 242¡ã (from EtOH). Similar reduction of Me₂NCH₂CH₂CN gave 52-6% Me₂NCH₂CH₂ CH₂NH₂, b_128-30 70-80¡ã (crude), b₂₀ 44-5¡ã, b₇₄₈ 133¡ã, n_D²⁰ 1.4415, d₂₀ 0.8272; di-HCl salt, m. 184¡ã (from MeOH); picrate, C₁₇H₂₀N₈O₁₄, m. 211¡ã (from H₂O). The higher-boiling material yielded a little 3,3′-bis(dimethylamino)dipropylamine, b₂₀ 128-31¡ã, n_D²⁰ 1.4531 (HCl salt, hygroscopic solid; tripicrate, m. 200¡ã; chloroplatinate, 2C₁₀H₂₅N₃.3H₂PtCl₆, soluble in H₂O, insoluble in aqueous EtOH). Reduction of Et₂NCH₂CH₂CN with NaBuOH gave 38-63% diamine; a 2% K-Na alloy gave good consistent 60-70% yields; pure Et₂NCH₂CH₂CH₂NH₂, b₁₂ 61-2¡ã, b₇₀ 85-7¡ã, b₈₀ 99-100¡ã, b₇₅₅ 168-70¡ã, n_D²⁰ 1.4435, gave 2 active H with MeZnI at room temperature and at 100¡ã; picrate, m. 190.5¡ã (from MeOH); Bz derivative, oil. Refluxing this amine with an equimolar amount of oleic acid 2 hrs., adding a little amine, heating another hr., concentrating, and evaporating with C₆H₆ gave a product that formed extremely stable organic-aqueous emulsions. The higher-boiling fractions from the above reduction gave a little bis(diethylamino) dipropylamine, b₁₂ 148-50¡ã (picrate, m. 152¡ã), also obtained if the reduction is run with pure Na. Reduction of (CH₂)₅NCH₂CH₂CN with 2% K-Na in BuOH gave 57% 1-(3-aminopropyl)piperidine, b₄ 65-6¡ã, b₉ 79-81¡ã, n_D²⁰ 1.4729. COCl₂ with ROH gave the ClCO₂R: R =Et, b₇₅₂ 92-4¡ã; Pr, b₇₄₂ 114-16¡ã, n_D²⁰ 1.4036; iso-Pr, b₇₄₅ 101-2¡ã, n_D²⁰ 1.3996, d₂₀ 1.0777; Bu, b₁₆ 40-7¡ã, b₇₅₆ 138¡ã, n_D²⁰ 1.4128, d₂₀ 1.0513. COCl₂ with ROH in MePh in the presence of 5-8% quinoline gave the following ClCO₂R: iso-Bu, b₇₅₀ 123-7¡ã; iso-Am, b₇₅₄ 150-1¡ã, n_D²⁰ 1.4176, d₂₀ 1.0490; C₈H₁₇, b₅ 86.5¡ã, b₁₀ 96-7¡ã, b₁₅ 107¡ã, n_D²⁰ 1.4330, d₂₀ 0.9841; cyclohexyl, b₂₅ 80-5¡ã, n_D²⁵ 1.4628; 1-menthyl, b₅ 96¡ã, b₁₁ 108-9¡ã, n_D²⁰ 1.4712; PhCH₂, b₇ 85-7¡ã; with an equimolar amount of quinoline were obtained: sec-Bu, 72%, b₂₃ 30-1¡ã, b₇₄₈ 121-4¡ã, n_D²⁰ 1.4490; 1-methyl-2-cyclohexyl, b₃₀ 101.5¡ã, n_D²⁰ 1.4560; Ph, b₇ 64¡ã, n_D²⁰ 1.5162. The diamines (0.025 mole) in Et₂O were treated with 0.025 mole powd. potash, then 1.5-2 ml. H₂O, and RO₂CCl in Et₂O was added with cooling; the usual treatment gave the desired urethan derivatives: Me₂NCH₂CH₂CH₂NHCO₂Et, 55.8%, b₁₆ 137-7¡ã, n_D²⁰ 1.4480, d₂₀ 0.9653; l-menthyl ester, 51.8%, b₁ 164.5¡ã, n_D²⁰ 1.4706, d₂₀ 0.9557, m. 45¡ã; Et₂NCH₂CH₂CH₂NHCO₂Et, 66.7%, b₇ 130¡ã, n_D²⁰ 1.4503; iso-Pr ester, 53.2%, b_1.5 122-3¡ã, n_D³⁰ 1.4452, n_D²⁰ 1.4493, d₂₀ 0.9367; sec-Bu ester, 42.5%, b₅ 132¡ã, n_D²⁰ 1.4513, d₂₀ 0.9334; C₈H₁₇ ester, 63.3%, b₂ 181.5-2¡ã, n_D³⁰ 1.4528, n_D²⁰ 1.4577, d₂₀ 0.9168; cyclohexyl ester, 46.5%, b_1.5 165-7¡ã, n_D³⁰ 1.4725, n_D²⁰ 1.4752, d₂₀ 0.9765; 2-methylcyclohexyl ester, 81.5%, b₂ 177¡ã, n_D³⁰ 1.4693, n_D²⁰ 1.4723, d₂₀ 0.9679; l-menthyl ester, 88.2%, b₃ 173¡ã, n_D²⁰ 1.4719, d₂₀ 0.9482, m. 31¡ã; Ph ester, 33.6%, b₃ 196-201¡ã, n_D²⁰ 1.4770; PhCH₂ ester, 24%, b₃ 132-5¡ã, n_D²⁰ 1.5030. C₅H₅NCH₂CH₂CH₂NHCO₂Et, 78.3%, b₉ 150-3¡ã, n_D²⁰ 1.4742, d₂₀ 1.0070; Pr ester, 70.4%, b₁₈ 187-8¡ã, n_D²⁰ 1.4735, d₂₀ 0.9935; iso-Pr ester, 62.8%, b₈ 155-8¡ã, n_D²⁰ 1.4706, d₂₀ 0.9878; Bu ester, 62.8%, b₃ 146¡ã, b₅ 167-8¡ã, n_D²⁰ 1.4730, d₂₀ 0.9788; iso-Bu ester, 53.5%, b₂ 136.5-7¡ã, n_D²⁰ 1.4710, d₂₀ 0.9813; iso-Am ester, 66.2%, b₂ 159.5¡ã, n_D²⁰ 1.4712, d₂₀ 0.9749; C₈H₁₇ ester, 63.7%, b₉ 212-13¡ã, n_D²⁰ 1.4720, d₂₀ 0.9550.

Uchenye Zapiski Moskov. Gosudarst. Univ. im. M. V. Lomonosova published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, SDS of cas: 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lofberg, R. T. published the artcileGas-chromatographic analysis of aminothiol radioprotective compounds, Computed Properties of 10517-44-9, the publication is Analytical Letters (1971), 4(2), 77-86, database is CAplus.

A gas chromatog. method is described for aminothiols and disulfides. This method is based upon the formation of the trimethylsilyl derivatives and their separation by gas chromatog. The kinetics of the derivative formation were investigated. A synthetic method for C4 to C6 aminothiols is given.

Analytical Letters published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Computed Properties of 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Grudzinska, P. published the artcileReaction of cyanomethyl esters of carboxylic acids with arylhydrazines. IV. Synthesis of tolylhydrazides, Formula: C3H12Cl2N2, the publication is Lodz Towarz. Nauk., Wydzial III, Acta Chim. (1965), 75-83, database is CAplus.

cf. CA 59, 9969g. The reaction between tolylhydrazine (I) and cyanomethyl esters of carboxylic acids (in mole ratio 2:1) gave the following MeC₆H₄NHNHCOR (II) [R, m.p., and % yield (based on cyanomethyl ester) being given for the reactions conducted in AcOEt and without solvent resp.]: p-II: BZNHCH₂, 176-7¡ã, 95, 98.5; PhSO₂NHCH₂, 178-80¡ã, 95, 97; p-MeC₆H₄SO₂NHCH₂, 163-4¡ã, 97, 100; 4-pyridyl (as HCl salt), 239-41¡ã (decomposition), 73, 87; m-II: BZNHCH₂, 178-9¡ã, 92, 98; PhSO₂NHCH₂, 145-6¡ã, 95, 95; p-MeC₆H₄SO₂– NHCH₂, 158-9¡ã, 90, 94; 4-pyridyl, 161-2¡ã, 69, 81; o-II: Bz-NHCH₂, 172-3¡ã, 80, 89; PhSO₂NHCH₂, 145-6¡ã, 81, 85; p-MeC₆H₄SO₂NHCH₂, 164-5¡ã, 62, 79; 4-pyridyl, 209-10¡ã, 50, 85. The reaction mixture was usually kept 20 hrs. at room temperature In cases where no solid separated, either inoculation or distillation of the solvent in vacuo followed by addition of Et₂O initiated the crystallization

Lodz Towarz. Nauk., Wydzial III, Acta Chim. published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Grudzinski, S. published the artcileCyanomethyl esters. V. Reaction of cyanomethyl esters of carboxylic acids with cyanoethylhydrazine, Product Details of C3H12Cl2N2, the publication is Lodz Towarz. Nauk., Wydzial III, Acta Chim. (1965), 85-93, database is CAplus.

cf. CA 65, 681f. The appropriate cyanomethyl ester RCO₂CH₂CN{Alt}{179}(I) treated with H₂-NNH(CH₂)₂CN (II) furnished the following RCONHNH-(CH₂)₂CN (R, % yield) and m.p. (b.p.) given: Me (III), 73, (b_1.5 162-6¡ã); Et (IV), 73, (b_1.5 158-62¡ã); 4-O₂NC₆H₄, 55.5, 164.5-6¡ã; PhOCH₂, 73, 106-8¡ã; AcNHCH₂, 92.5, 108-11¡ã; BzNHCH₂ (V), 89.5, 132-4¡ã; 4-AcNHC₆H₄SO₂NHCH₂, 80, 152-4¡ã; 2-phenyl-4-quinolyl, 39.5, 165-6¡ã. V was prepared by using 20% excess of II, the others by using 100% excess of II. III and IV were prepared by keeping a mixture of the resp. I and II at room temperature 24 hrs. For the others an approx. 1-2M solution of I in a suitable solvent was left with II 24 hrs.

Lodz Towarz. Nauk., Wydzial III, Acta Chim. published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Product Details of C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ivanov, Evgeniy V. published the artcileVolumetric properties of some asymmetrically methyl-N-substituted thioureas in water between (278.15 and 318.15) K at ambient pressure, Application of 1,1-Dimethylthiourea, the publication is Journal of Molecular Liquids (2014), 426-431, database is CAplus.

Densities of dilute aqueous solutions of 1-monomethyl-2-thiourea and 1,1,3-trimethyl-2-thiourea have been measured using an Anton Paar DMA 5000 M vibrating-tube densimeter. The apparent molar volumes and expansibilities (down to infinite dilution) have been calculated from the obtained d. data. The experiments have been performed in the temperature range between (278.15 and 318.15) K, with a step of 10 K, at p ? 0.1 MPa. The influence of a nature of methyl-N-sited substituents on the structure-packing properties of aqueous thioureas has been discussed. A possibility to estimate the standard (limiting apparent or partial) molar volumes for asym. substituted 1,1-dimethyl-2-thiourea in water has been considered, too.

Journal of Molecular Liquids published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Filleux-Blanchard, Marie L. published the artcileDynamic magnetic resonance of carbon. IV. Application to the conformational study of thioureas, Safety of 1,1-Dimethylthiourea, the publication is Organic Magnetic Resonance (1977), 9(3), 125-6, database is CAplus.

The conformational equilibrium of RNR1CSNR2R3 (R = R1 = R2 = R3 = H, Me; R = Me, Ph, Ac, R1 = R2 = R3 = H; R = R2 = Me, CMe3, o-MeC6H4, R1 = R3 = H; R = R1 = Me, R2 = R3 = H; R = R1 = Me, R2 = p-MeC6H4, R3 = H) were studied by 13C NMR. Hindered rotation of CMe3 groups was observed Substituent effects were studied.

Organic Magnetic Resonance published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Safety of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Aledo, Juan Carlos published the artcilePhylogenies from unaligned proteomes using sequence environments of amino acid residues, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Scientific Reports (2022), 12(1), 7497, database is CAplus and MEDLINE.

Alignment-free methods for sequence comparison and phylogeny inference have attracted a great deal of attention in recent years. Several algorithms have been implemented in diverse software packages. Despite the great number of existing methods, most of them are based on word statistics. Although they propose different filtering and weighting strategies and explore different metrics, their performance may be limited by the phylogenetic signal preserved in these words. Herein, we present a different approach based on the species-specific amino acid neighborhood preferences. These differential preferences can be assessed in the context of vector spaces. In this way, a distance-based method to build phylogenies has been developed and implemented into an easy-to-use R package. Tests run on real-world datasets show that this method can reconstruct phylogenetic relationships with high accuracy, and often outperforms other alignment-free approaches. Furthermore, we present evidence that the new method can perform reliably on datasets formed by non-orthologous protein sequences, i.e., the method not only does not require the identification of orthologous proteins, but also does not require their presence in the analyzed dataset. These results suggest that the neighborhood preference of amino acids conveys a phylogenetic signal that may be of great utility in phylogenomics.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bargigia, Gianangelo published the artcileSynthesis of O-substituted hydroxylamines (RONH₂) from alcohols and isohydroxylamine monosulfonic acid, Safety of O-Isobutylhydroxylamine hydrochloride, the publication is Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti (1965), 39(1-2), 83-6, database is CAplus.

The process already described for the synthesis of RON₂ (CA 62, 8649h) was, studied in regard to several side and concomitant products. The alcs. used were Et, Pr, Bu, iso-Bu, sec-Bu, and benzyl alcs., and the products prepared were RONH₂ with R = EtO; PrO; iso-PrO; BuO; iso-BuO, sec-BuO, PhCH₂O. In each case, 12.5 g. dry H₂NOSO₃Na was suspended into 30 cc. absolute alc. and a cold solution of 3.2 g. Na in 40 cc. absolute alc. was added. The reaction mixture grew warm spontaneously after 15 min. under agitation until boiling occurred. After a 12-h. rest, the solid residue was removed and the salts were precipitated by acidification with concentrated HCl; the hydroxylamine-HCl was isolated in 27-49% yields by concentration to a small volume, filtration, and precipitation with ether. The purity of the products was controlled by gas chromatog.

Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Safety of O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Yiming published the artcileDirect sulfhydryl ligand derived UiO-66 for removal of aqueous mercury and its subsequent application as catalyst for transfer vinylation, COA of Formula: C8H8O2, the publication is Dalton Transactions (2022), 51(10), 4043-4051, database is CAplus and MEDLINE.

The treatment of mercury pollutants in water has been wide concern. Adsorption is a promising method for mercury removal that has been extensively studied. Nevertheless, the secondary application of the immobilized Hg is seldom investigated. In this paper, the Hg adsorption behavior of UiO-66 bearing sulfhydryl groups is studied. The research shows that the porous structure and sulfhydryl groups of UiO-66-SH can effectively promote the removal of mercury from water. In addition, this work also pushes forward the sequential application of the recovered adsorbent, which contains the adsorbed mercury that may cause secondary pollution. The recovered waste adsorbent, UiO-66-S-Hg, was successfully used as an efficient catalyst for transfer vinylation, which produces value-added products, vinyl benzoates. Eight vinyl esters have been successfully synthesized with a yield of up to 89%. This methodol. provides a promising way for not only the treatment of mercury contamination, but also secondary pollution protection and the resource utilization of immobilized Hg.

Dalton Transactions published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C17H18N3NaO3S, COA of Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Lei published the artcileLigand-Controlled NiH-Catalyzed Regiodivergent Chain-Walking Hydroalkylation of Alkenes, Computed Properties of 118-90-1, the publication is Angewandte Chemie, International Edition (2022), 61(30), e202204716, database is CAplus and MEDLINE.

A NiH-catalyzed migratory hydroalkylation of alkenyl amines with predictable and switchable regioselectivity is reported. By utilizing a ligand-controlled, directing group-assisted strategy, various alkyl units are site-selectively installed at inert sp³ C-H sites far away from the original C=C bonds. A range of structurally diverse ¦Á- and ¦Â-branched protected amines are conveniently synthesized via stabilization of 5- and 6-membered nickelacycles resp. This method exhibits broad scope and high functional group tolerance, and can be applied to late-stage modification of medicinally relevant mols.

Angewandte Chemie, International Edition published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C9H4F6O, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia