Tag: M.W=100-150

Jana, Debasish published the artcileMannich reaction of pyrrole and dimethylpyrrole with monoamines and diamines, Synthetic Route of 10517-44-9, the publication is Tetrahedron Letters (2019), 60(46), 151247, database is CAplus.

The Mannich reaction of pyrrole with ethylenediamine dihydrochloride and formaldehyde gave two compounds: N¹,N¹,N²,N²-tetrakis(pyrrol-2-ylmethyl)ethane-1,2-diamine and 1,3-bis(pyrrol-2-ylmethyl)imidazolidine in poor yields. Conversely, the reaction of pyrrole with propylenediamine dihydrochloride afforded macrocyclic compound I in 50% yield. The reaction of 2,5-dimethylpyrrole with methylamine hydrochloride and formaldehyde gave novel bicycle II. The reaction of 2,5-dimethylpyrrole with ammonium chloride gave the tripodal ligand tris(2,5-dimethylpyrrol-3-yl)methylamine in 62% yield. The structures of 1,3-bis(pyrrol-2-ylmethyl)imidazolidine, I and II were determined by single crystal X-ray diffraction studies.

Tetrahedron Letters published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Synthetic Route of 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Habyarimana, Ephrem published the artcileWhole-genome resequencing of Sorghum bicolor and S. bicolor x S. halepense lines provides new insights for improving plant agroecological characteristics, Computed Properties of 63-68-3, the publication is Scientific Reports (2022), 12(1), 5556, database is CAplus and MEDLINE.

Sorghum (Sorghum bicolor L. (Moench)) is the world’s fifth economically most important cereal and is a staple particularly in the semi-arid tropics of Africa and Asia. Genetic gains in this crop can benefit from wild relatives such as Sorghum halepense. Genome sequences including those from this wild species can boost the study of genome-wide and intraspecific variation for dissecting the genetic basis and improving important traits in sorghum. The whole-genome resequencing carried out in this work on a panel of 172 populations of S. bicolor and S. bicolor x S. halepense (SbxSh) advanced lines generated a total of 567,046,841 SNPs, 91,825,474 indels, 1,532,171 SVs, and 4,973,961 CNVs. Clearly, SbxSh accumulated more variants and mutations with powerful effects on genetic differentiation. A total of 5,548 genes private to SbxSh mapped to biol. process GO enrichment terms; 34 of these genes mapped to root system development (GO: 0022622). Two of the root specific genes i.e., ROOT PRIMORDIUM DEFECTIVE 1 (RPD1; GeneID: 8054879) and RETARDED ROOT GROWTH (RRG, GeneID: 8072111), were found to exert direct effect on root growth and development. This is the first report on whole-genome resequencing of a sorghum panel that includes S. halepense genome. Mining the private variants and genes of this wild species can provide insights capable of boosting sorghum genetic improvement, particularly the perenniality trait that is compliant with agroecol. practices, sustainable agriculture, and climate change resilience.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Computed Properties of 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lopez, S. published the artcileSpray pyrolysis deposition of Sn₂S₃ thin films, Name: 1,1-Dimethylthiourea, the publication is Semiconductor Science and Technology (1996), 11(3), 433-6, database is CAplus.

Ternary compound Sn^IISn^IVS₃ thin films were prepared on Pyrex glass substrates by the spray pyrolysis process using Sn chloride (SnCl₂) and n,n-dimethylthiourea as starting materials. The depositions were carried out at a substrate temperature of 320¡ã. The identification of the Sn₂S₃ phase was achieved by x-ray diffraction measurements. The optical reflectance and transmittance of the prepared films were used to obtain the variation of the refractive index and the extinction coefficient as a function of the wavelength. These calculated values were used to find the absorption coefficient and the optical bandgap and gave E_g = 1.16 eV. From measurements of the conductance as a function of T^-1, a dark activation energy was determined with a value of 1.02 eV.

Semiconductor Science and Technology published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Name: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mamalis, P. published the artcileAmino?xy derivatives. II. Some derivatives of N-hydroxybiguanide, Category: catalysis-chemistry, the publication is Journal of the Chemical Society (1960), 229-38, database is CAplus.

The preparation of some amino?xyalkanes and their corresponding biguanides, together with certain arylmethyl analogs, was described. A summary of bacteriostatic activities was included. Benzohydroxamates (I) were prepared by reaction of Na benzohydroxamate with an alkyl or arylmethyl halide. The following new I were obtained (substituent and m.p. or b.p. given): hexyl, 138-40¡ã/0.3 mm.; 4-methylbenzyl, 107-8¡ã; 4-chlorobenzyl, 162¡ã; 4-bromobenzyl, 176¡ã; 2-nitrobenzyl, 121¡ã; 3,4-dichlorobenzyl, 134¡ã; cinnamyl, 118-20¡ã; 1-naphthylmethyl, 140¡ã; 2-naphthylmethyl, 131¡ã; 2-methyl-1-naphthylmethyl, 150¡ã; 1-bromo-2-naphthylmethyl, 144¡ã; 8-quinolylmethyl, 133-4¡ã; 6-chloro-8-(1,3-benzodioxanylmethyl), 131-2¡ã. The required arylmethyl bromides were prepared by side chain bromination of toluenes and methylnaphthalenes with N-bromosuccinimide (II) in CCl₄ in the presence of Bz₂O₂. 4-BrC₆H₄CH₂Br, 1-(bromomethyl)naphthalene, and 1-bromo-(2-bromomethyl)naphthalene did not appear to have been prepared by this method. Bromination of 2-methylnaphthalene with II afforded 2-(bromomethyl)naphthalene, m. 48¡ã; in one run a substance, m. 128¡ã, was also obtained in low yield and shown to be 1-(dibromomethyl)naphthalene, since with refluxing H₂O it yielded 2-naphthaldehyde, leaflets, m. 57-8¡ã; semicarbazone m. 245¡ã (Me₂CO). The following I were prepared with properties in agreement with those in the literature: Me, Et, allyl, Bu, PhCH₂, and 4-nitrobenzyl. Cinnamyl benzohydroxamate (1 g.) in 15 ml. alc. and 15 ml. EtOAc shaken 3 min. with H and 10% Pd-C gave 0.88 g. crude product and distillation at 120-40¡ã 33 ¡Á 10^-5 mm. gave 3-phenylpropyl benzohydroxamate, m. 45-6¡ã. Benzohydroxamic acid (6.9 g.) and 2 g. NaOH in 50 ml. alc. refluxed 4 hrs. with 9-(chloromethyl)phenanthrene yielded 2.1 g. N-benzoyl-O,N-bis(9-phenanthrylmethyl)hydroxylamine, m. 209-10¡ã (aqueous HCONMe₂). Addition of H₂O to the original mother liquors precipitated 8.6 g. 9-phenanthrylmethyl benzohydroxamate, m. 160-1¡ã (EtOAc). K salt of hydroxyurethan and the alkyl bromides yielded alkyloxyurethans (III), colorless oils or low melting solids, purified by distillation or crystallization: (alkyl group and b.p./mm. or m.p. given): allyl, 123¡ã/28; isobutyl, 55¡ã/0.2; pentyl, 76¡ã/0.08; hexyl, 86¡ã/0.35; heptyl, 93¡ã/0.3; octyl, 98¡ã/0.04; nonyl, 103-4¡ã/0.3; decyl, 112¡ã/0.05; undecyl, 130¡ã/0.3; 2-methyldecyl, 128¡ã/0.2; tetradecyl, 39-40¡ã; hexadecyl, 40.5-1.5¡ã; octadecyl, 45-6¡ã. N-Decyl-N-decyloxyurethan was isolated as a by-product from the reaction of hydroxyurethan with decyl bromide, b_0.1 154¡ã, n_D¹⁸ 1.4490. A mixture of 5.6 g. NH₂OH.HCl, 12.5 g. anhydrous Na₂CO₃, and 37 ml. H₂O added dropwise at 15-20¡ã to 13.4 g. benzyl chloroformate, the mixture stirred 4 hrs., acidified, and the liberated oil extracted with Et₂O yielded 10.2 g. N-benzyloxycarbonylhydroxylamine (IV), m. 68-9¡ã (Et₂O-ligroine). NaOH (0.96 g.) in 25 ml. alc. treated with 4 g. IV, the Na salt separated, after addition of 3.4 g. MeI the mixture refluxed 4 hrs., H₂O added, the oily product isolated with Et₂O, and the solvent removed gave 3.3 g. oil. The oil left overnight at room temperature with 10 ml. 20% solution HBr in AcOH, evaporated, and the residual solid crystallized from alc.-Et₂O gave 1.5 g. amino?xymethane-HBr, plates, m. 102¡ã. Me benzohydroxamate (3 g.), 15 ml. concentrated HCl, and 15 ml. H₂O refluxed 2 hrs., 2.1 g. BzOH collected, and the filtrate evaporated gave 1.4 g. amino?xy methane-HCl, plates, m. 148-9¡ã (EtOAc-alc.). Aminooxyethane-HCl obtained from III (allyl) crystallized as plates, m. 172-4¡ã. The above HCl salt (5.0 g.) in 50 ml. alc. shaken with H and 10% Pd-C gave 4.8 g. 1-amino?xypropane-HCl (V), m. 150-1¡ã (EtOAc). III (Pr) (11.5 g.) and 60 ml. 6% alc.-HCl refluxed 1 hr. gave 6.4 g. V. III (Pr) (11.1 g.) and 100 ml. 17% HCl refluxed 2 hrs. (black oil separated), cooled, extracted with Et₂O, the aqueous layer evaporated, and the residual solid triturated with EtOAc-alc. gave 2.35 g. NH₄Cl; the Et₂O layer extracted with aqueous NaHCO₃ gave 4.8 g. BzOH. Evaporation of the Et₂O layer gave 2.95 g. material which on hydrolysis gave 2 g. BzOH and a little low boiling oil. III (Bu) (17 g.) and 80 ml. 6% alc.-HCl refluxed 2 hrs. gave 7.8 g. 1-amino?xybutane-HCl, plates, m. 155-6¡ã (EtOAc-alc.). 1-Amino?xypentane-HCl was similarly prepared as plates, m. 148¡ã. Amino?xyisobutane-HCl was prepared by alk. hydrolysis of the urethan as leaflets, m. 134-5¡ã (EtOAc). Amino?xyhexane-HCl similarly prepared, m. 151¡ã. 1-Amino?xyheptane-HCl separated as leaflets, m. 151-2¡ã (EtOAc-alc.). 1-Amino?xyoctane-HCl formed as plates, m. 147-9¡ã. 1-Amino?xynonane-HCl failed to crystallize and the crude material was used for the preparation of the biguanide. 1-Amino?xydecane-HCl crystallized as plates, m. 145.5-6.5¡ã (EtOAc-alc.), the HBr salt as plates, m. 135-6¡ã; the hydrochloride (2.1 g.) 1.25 g. salicylaldehyde, 0.4 g. NaOH in 2 ml. H₂O, and 15 ml. alc. refluxed 1 hr. gave 1.9 g. 1-salicylideneamino?xydecane, lemon-yellow oil, b_0.3 132¡ã. 1-Furfurylideneamino?xydecane was similarly prepared as a yellow oil, b_0.08 114¡ã. 1-Aminooxyundecane-HCl crystallized similarly, m. 145-6¡ã. 1-Aminooxytetradecane-HCl separated as leaflets, m. 137-8¡ã. The base crystallized as leaflets, m. 68-70¡ã (EtOAc-ligroine). 1-Amino?xyhexadecane-HCl was obtained as leaflets, m. 133-4¡ã; free base, leaflets, m. 45-7¡ã (ligroine). 1-Aminooxyoctadecane crystallized as needles, m. 50-2¡ã. I (PhCH₂) (4.3 g.) and 30 ml. 6% alc.-HCl refluxed 20 min. gave 2.7 g. amino?xymethylbenzene-HCl, m. 230-2¡ã. Similar preparations gave 88% p-amino?xymethyltoluene-HCl, leaflets, m. 233¡ã (alc.-H₂O);-chlorobenzene-HCl, leaflets, m. 243¡ã; -bromobenzene-HCl, plates, m. 246-7¡ã (alc.-Et₂0); and -nitrobenzene-HCl, leaflets, m. 216¡ã; o-amino?xymethylnitrobenzene-HCl, needles, m. 165-6¡ã; 4-amino?xymethyl-1,2-dichlorobenzene-HCl, leaflets, m. 197¡ã (EtOAc-alc.); 3-amino?xypropylbenzene-HCl, plates, m. 168-9¡ã (alc.-Et₂O); 1-amino?xymethylnaphthalene-HCl, needles, m. 198¡ã (EtOAc); 2-amino?xymethyl isomer, leaflets, m. 247¡ã (aqueous alc.) (N-benzyloxycarbonyl derivative, leaflets, m. 93-4¡ã); 1-amino?xymethyl-2-methylnaphthalene-HCl.H₂O, needles, m. 192-3¡ã (alc.-Et₂O); 2-amino?xymethyl-1-bromonaphthalene-HCl, needles, m. 199¡ã (alc.-H₂0); 9-amino?xymethylphenanthrene-HCl, needles, m. 216-17¡ã (alc.); and the 1-isomer, needles, m. 184-6¡ã. Chloromethylation of Tetralin gave a mixture, b₁₅ 142-8¡ã, of some 5- with 6-chloromethyl derivative of Tetralin. The mixture with Na benzhydroxamate gave mixed benzamido?xymethyl derivatives of Tetralin as a thick yellow oil. This (18 g.) refluxed 3 hrs. with 150 ml. 6% alc. HCl gave 6.8 g. 6-amino?xymethyl derivative -HCl of Tetralin, m. 190-1¡ã (alc.). 8-Amino?xymethyl-6-chloro-1,3-benzodioxan-HCl was prepared by alcoholysis of the benzohydroxamate as needles, m. 204-5¡ã (alc.-Et₂O). Benzohydroxamate (3.2 g.) with alc. HCl gave 2.3 g. 8-amino?xymethylquinoline-2HCl, m. 193¡ã. The amino?xy HCl salt (0.1 mole), 0.1 mole dicyandiamide, and 70 ml. alc. refluxed 2-4 hrs., filtered, the mixture evaporated, and treated with alc.-HCl and Et₂O gave the RONHC(:NH)(NHC(:NH)NH₂ (VI).2HCl, which usually crystallized and was collected and recrystallized VI.2HCl were often deliquescent and this precluded anal. results. These compounds were characterized by their picrates. The following results were thus obtained (substituent and derivative of VI, and m.p. given): Me, 2HCl, 183-4¡ã; Et, 2HCl, 180-1¡ã; Et, picrate, 235-6¡ã; Pr, 2HCl, 142-7¡ã; Pr, picrate, 219-20¡ã; Bu, 2HCl, 135-6¡ã; iso-Bu, 2HCl, 142-4¡ã; iso-Bu, picrate, 225¡ã; pentyl, 2HCl, 129-33¡ã;pentyl, 95-6¡ã; pentyl, picrate, 204-5¡ã; hexyl, 2HCl, 138-41¡ã; hexyl, picrate, 204-5¡ã; hexyl, -, 102-3¡ã; heptyl, 2HCl, 135-7¡ã; heptyl, picrate, 210¡ã; octyl, -, 99-100¡ã; octyl, picrate, 209¡ã; nonyl, 2HCl, 148-52¡ã; decyl, 2HCl, 123-30¡ã; decyl, -, 100-1¡ã; decyl, picrate, 204-5¡ã; undecyl, 2HCl, 145-8¡ã 2-methyldecyl, 2HCl, 108-11¡ã; dodecyl, 2HCl, 162-4¡ã; dodecyl, picrate, 207-8¡ã; tetradecyl, HCl, 140¡ã; tetradecyl, picrate, 210-12¡ã; hexadecyl, -, 101-3¡ã. Benzyloxybiguanide-2HCl (VII) crystallized as needles, m. 150-1¡ã (alc.-EtOAc); the base-formed as plates, m. 111¡ã (H₂O) [picrate, leaflets, m. 226-7¡ã (alc.-Me₂CO)]. VII (1.4 g.) in 15 ml. alc. shaken 15 min. with H and 10% Pd-C, the filtered solution evaporated, the gum triturated with Et₂O, and the product crystallized gave hydroxybiguanide-2HCl (VIII), m. 139-40¡ã (alc.-Et₂O). In a 2nd experiment the filtered hydrogenation solution seeded yielded the pure material directly. The aqueous solution of VIII with aqueous Li picrate gave the picrate, yellow prisms, m. above 300¡ã, which appeared to be guanylurea picrate. On prolonged storage VIII decomposed to guanylurea-HCl, m. 173-4¡ã. p-Amino?xymethyltoluene-HCl (8.5 g.), 4.1 g. dicyandiamide (IX), and 50 ml. alc. refluxed 2 hrs.. evaporated, treated with alc.-HCl, Et₂O, the 8 g. di-HCl salt dissolved in the min. amount of hot H₂O, and basified gave the base as leaflets, m. 177¡ã (EtOAc-alc.). Isonicotinonoylhydrazine (X) (1.35 g.), 0.84 g. IX, and 15 ml. MeOH refluxed 24 hrs. gave 1.92 g. prisms, m. 138-42¡ã. This substance with picric acid gave isonicotinoylhydrazine dipicrate-H₂O, m. 204-5¡ã. X (1.35 g.), 0.84 g. IX, 15 ml. MeOH, and 1 ml. concentrated HCl refluxed 1 hr. gave 1.86 g. isonicotinamidobiguanide-2HCl, m. 200¡ã (H₂O). The following RONHC(:NH)NHC(:NH)NH₂ were prepared (substituent, and derivative and m.p. given): p-ClC₆H₄CH₂, -; 175¡ã; o-BrC₆H₄CH₂, -, 188¡ã; p-O₂NC₆H₄CH₂, HCl, 216¡ã; o-O₂NC₆H₄CH₂. HCl, 179¡ã; 3,4-Cl₂C₆H₃CH₂, 2HCl, 171¡ã; 3-phenylpropyl, 2HCl.EtOH, 153-5¡ã; 1-naphthylmethyl, -, 145¡ã; 2-naphthylmethyl, -, 213¡ã; 1-methyl-2-naphthylmethyl, -, 1658¡ã; 1-bromo-2-naphthylmethyl, -, 158-60¡ã; 9-phenanthrylmethyl, H₂O, 107-8¡ã; 9-phenanthrylmethyl, -, 95-8¡ã; 1-phenanthrylmethyl, H₂O, 190¡ã; 6-tetrahydronaphthylmethyl, 2HCl, 138-41¡ã; 6-tetrahydronaphthylmethyl, -, 157-8¡ã; 6-chloro-8-(1,3-benzodioxanyl)methyl, -, 191-2¡ã. Benzohydrazide (20 g.), 12.5 g. IX, and 100 ml. alc. containing 5.1 g. dry HCl refluxed 3 hrs. gave 26.9 g. benzamidobiguanide-2HCl, m. 169-70¡ã (alc.-H₂O). 1-Amino?xydecane (XI) (1.32 g.), 0.64 g. IX, and 10 ml. alc. refluxed 20 hrs. gave 0.60 g. unchanged IX and 1.2 g. XI. 8-Amino?xymethyl-6-chloro-1,3-benzodioxan (1.24 g.), 0.48 g. IX, and 10 ml. MeOH refluxed 20 hrs. gave only unchanged materials. IX was recovered when refluxed 24 hrs. in MeOH. ¦Á-Amino?xyheptanoic acid-HCl (2 g.) refluxed 1 hr. with 20 ml. 5% MeOH-HCl and evaporated gave a gum, which refluxed 2 hrs. with 0.84 g. IX and 20 ml. alc., then 2 hrs. with 25 ml. N NaOH, the solvent removed, the product taken up in H₂O, brought to pH 6, and the solid collected gave 1.5 g. monohydrate, m. 127-8¡ã. Distillation with xylene gave 1-carboxyhexyloxybiguanide, m. 194¡ã. ¦Á-Amino?xyoctanoic acid (1 g.) in 20 ml. MeOH saturated with HCl refluxed 2 hrs., evaporated, the gum refluxed 2 hrs. with 0.48 g. IX, and 10 ml. alc., and hydrolyzed gave 0.5 g. 1-carboxyheptyloxybiguanide-H₂O, m. 129-31¡ã (aqueous alc.). ¦Á-Amino?xynonanoic acid (0.8 g.) treated as above gave 0.3. g. 1-carboxyoctyloxybiguanide-H₂O, m. 128-9¡ã. ¦Á-Amino?xydecanoic acid (1 g.) similarly gave 1.1 g. 1-carboxynonyloxybiguanide. H₂O, m. 122-5¡ã (aqueous alc.), and thence by use of xylene 1-carboxynonyloxy-biguanide, m. 187-8¡ã.

Journal of the Chemical Society published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Lijuan published the artcileBrown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE), HPLC of Formula: 63-68-3, the publication is Scientific Reports (2022), 12(1), 3693, database is CAplus and MEDLINE.

Both hyperthyroidism and elevated plasma branched chain amino acids (BCAA) are associated with insulin resistance. BCAA utilization and clearance relative to thyroid status changes remains unclear. We investigate amino acids changes, specifically BCAA, during the transition from hyperthyroidism to euthyroidism, and the impact of active brown adipose tissue (BAT) on the metabolic effects of BCAA. Newly diagnosed Graves disease participants were recruited. Hyperthyroidism was treated via a titration dosing regimen of thionamide anti-thyroid drug to establish euthyroidism over 12-24 wk. All underwent energy expenditure (EE) measurement within a chamber calorimeter, 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomog./magnetic resonance (PET/MR) imaging and plasma amino acids measurement during hyperthyroidism and euthyroidism. PET BAT maximum standardized uptake value (SUVmax), SUVmean and MR supraclavicular fat fraction (FF) quantified BAT activity. Twenty-two patients completed the study. Plasma BCAA level was significantly reduced in BAT-pos. but not in BAT-neg. patients during the transition from hyperthyroidism to euthyroidism. Plasma valine but not leucine and isoleucine correlated pos. with insulin and HOMA-IR in hyperthyroidism. Plasma valine, leucine and isoleucine correlated with insulin and HOMA-IR in euthyroidism. Plasma valine correlated with insulin and HOMA-IR in BAT-neg. but not in BAT-pos. participants in both hyperthyroid and euthyroid state. However, the change (i.e. decrease) in plasma valine concentration from hyperthyroid to euthyroid state was affected by BAT-status. BAT utilizes and promotes BCAA plasma clearance from hyperthyroid to euthyroid state. Active BAT can potentially reduce circulating BCAA and may help to ameliorate insulin resistance and improve metabolic health. Clin. trial registration: The trial was registered at clinicaltrials.gov as NCT03064542.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C10H16Br3N, HPLC of Formula: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Burger, Klaus published the artcileHexafluoroacetone as protective group and activating reagent in amino acid and peptide chemistry. 10. Synthesis of 3-(thiazol-4-yl)alanine and 3-(selenazol-4-yl)alanine derivatives from aspartic acid, Computed Properties of 6972-05-0, the publication is Synthesis (1992), 1145-50, database is CAplus.

3-(Thiazol-4-yl)alanines I (R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 2-furyl, NMe₂, 4-FC₆H₄, 2-thienyl, H, Me; R¹ = H, Me) and the 3-(selenazol-4-yl)alanine II were obtained from aspartic acid via 2,2-bis(trifluoromethyl)-4-(3-bromo-2-oxopropyl)-1,3-oxazolidin-5-one in a Hantzsch synthesis, using hexafluoroacetone as protective group.

Synthesis published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ferreira, Everton Geraldo Capote published the artcileRevealing potential functions of hypothetical proteins induced by genistein in the symbiosis island of Bradyrhizobium japonicum commercial strain SEMIA 5079 (= CPAC 15), HPLC of Formula: 63-68-3, the publication is BMC Microbiology (2022), 22(1), 122, database is CAplus and MEDLINE.

Bradyrhizobium japonicum strain SEMIA 5079 (= CPAC 15) is a nitrogen-fixing symbiont of soybean broadly used in com. inoculants in Brazil. Its genome has about 50% of hypothetical (HP) protein-coding genes, many in the symbiosis island, raising questions about their putative role on the biol. nitrogen fixation (BNF) process. This study aimed to infer functional roles to 15 HP genes localized in the symbiosis island of SEMIA 5079, and to analyze their expression in the presence of a nod-gene inducer. A workflow of bioinformatics tools/databases was established and allowed the functional annotation of the HP genes. Most were enzymes, including transferases in the biosynthetic pathways of cobalamin, amino acids and secondary metabolites that may help in saprophytic ability and stress tolerance, and hydrolases, that may be important for competitiveness, plant infection, and stress tolerance. Putative roles for other enzymes and transporters identified are discussed. Some HP proteins were specific to the genus Bradyrhizobium, others to specific host legumes, and the anal. of orthologues helped to predict roles in BNF. All 15 HP genes were induced by genistein and high induction was confirmed in five of them, suggesting major roles in the BNF process.

BMC Microbiology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, HPLC of Formula: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gaikwad, Mahadev published the artcileSynthesis, characterization and anti-microbial screening of novel substituted thiadiazole-5-aminotetrazoles, SDS of cas: 118-90-1, the publication is Chemistry & Biology Interface (2022), 12(1), 1-6, database is CAplus.

An efficient and green synthesis of substituted thiadiazole-5-aminotetrazoles I [R = Ph, benzyl, cinnamyl, etc.] were prepared in-situ by reaction of cyanogen bromide and sodium azide to generate a cyanogen azide as an intermediate in acetonitrile. The cyclization reaction of cyanogen azide and substituted thiadiazoles containing primary amines in acetonitrile-water solvent media, gave the intermediate 1-substituted 5-aminotetrazoles in good yield. In addition, to further evaluate the role of synthesized mols. for antimicrobial activities, and it’s found that compound I [R = 4-O₂NC₆H₄, 2-IC₆H₄] showed a good antimicrobial for broad range of bacterial and fungal pathogens.

Chemistry & Biology Interface published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, SDS of cas: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Syamal, A. published the artcileSyntheses of trimethylenedibiguanide sulfate and copper(II), nickel(II), palladium(II), and zinc(II) complexes of trimethylenedibiguanide, Formula: C3H12Cl2N2, the publication is Journal of Inorganic and Nuclear Chemistry (1978), 40(8), 1606-9, database is CAplus.

[M(H₂L)]Cl₂ (M = Cu, Ni, Pd; H₂L = trimethylenedibiguanide) and ZnL were prepared and characterized by elemental anal., magnetic, electronic, and IR spectral data. The dibiguanide acts as a quadridentate, neutral ligand in [M(H₂L)]Cl₂, and as a quadridentate dibasic ligand in ZnL. The ligand was prepared as H₂L.2H₂SO₄ by fusing [H₂N(CH₂)₃NH₂].2HCl, dicyandiamide, and CuSO₄.5H₂O at 140-145¡ã, and finally removing Cu as CuS.

Journal of Inorganic and Nuclear Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C14H31NO2, Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Verdirosa, Federica published the artcile1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-¦Â-Lactamase Inhibitors, SDS of cas: 118-90-1, the publication is ChemMedChem (2022), 17(7), e202100699, database is CAplus and MEDLINE.

Metallo-¦Â-lactamases (MBLs) are increasingly involved as a major mechanism of resistance to carbapenems in relevant opportunistic Gram-neg. pathogens. Unfortunately, clin. efficient MBL inhibitors still represent an unmet medical need. We previously reported several series of compounds based on the 1,2,4-triazole-3-thione scaffold. In particular, Schiff bases formed between diversely 5-substituted-4-amino compounds and 2-carboxybenzaldehyde were broad-spectrum inhibitors of VIM-type, NDM-1 and IMP-1 MBLs. Unfortunately, these compounds were unable to restore antibiotic susceptibility of MBL-producing bacteria, probably because of poor penetration and/or susceptibility to hydrolysis. To improve their microbiol. activity, we synthesized and characterized compounds where the hydrazone-like bond of the Schiff base analogs was replaced by a stable Et link. This small change resulted in a narrower inhibition spectrum, as all compounds were poorly or not inhibiting NDM-1 and IMP-1, but showed a significantly better activity on VIM-type enzymes, with Ki values in the ¦ÌM to sub-¦ÌM range. The resolution of the crystallog. structure of VIM-2 in complex with one of the best inhibitors yielded valuable information about their binding mode. Interestingly, several compounds were shown to restore the ¦Â-lactam susceptibility of VIM-type-producing E. coli laboratory strains and also of K. pneumoniae clin. isolates. In addition, selected compounds were found to be devoid of toxicity toward human cancer cells at high concentration, thus showing promising safety.

ChemMedChem published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C10H9NO, SDS of cas: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia