Tag: M.W=100-150

Schweiger, K. published the artcileHeterocycles, 52. Reaction of 3,4,5,6-tetrahydro-6-hydroxy-4,4,6-trimethyl-1,3-thiazine-2-thione with secondary amines, Recommanded Product: 1,1-Dimethylthiourea, the publication is Monatshefte fuer Chemie (1977), 108(1), 243-55, database is CAplus.

The title compound reacted with secondary amines via the dialkylammonium-3-oxoalkyldithiocarbamate, either via isothiocyanates to 4-dialkylaminodihydro-2(1H)-pyridinethiones I (NRR1 = Et2N, piperidino, morpholino, 4-methyl-1-piperazinyl, etc.) or to dialkylammonium dithiocarbamates, depending on the amine used and the reaction conditions. Subsequently, 6-dialkylaminotetrahydro-1,3-thiazine-2-thiones II (NRR1 = morpholino, 4-methyl-1-piperazinyl) or tetrahydro-6-mercapto-1,3-thiazine-2-thione were formed. On being heated to reflux, II gave I and 4-dialkylaminodihydrothiopyranthione III. With secondary amines only dithiocarbamates were formed from tetrahydro-6-hydroxy-3,4,4,6-tetramethyl-1,3-thiazine-2-thione. The reaction of 5,6-dihydro-4,4,6-trimethyl-1,3-thiazine-2-thione with secondary amines gave N,N-dialkylthioureas or dialkylammonium thiocyanates; with dialkylformamides, 4-dialkylaminodihydropyridinethiones I were formed. 5,6-Dihyro-3,4,4,6-tetramethyl-1,3-thiazine-2-thione did not react with secondary amines or with dialkylformamides.

Monatshefte fuer Chemie published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C12H13NO3, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bahrampour, Niki published the artcileThe relationship between dietary sulfur amino acids intake and severity and frequency of pain in Iranian patients with musculoskeletal pains, 2020, Synthetic Route of 63-68-3, the publication is BMC Research Notes (2022), 15(1), 13, database is CAplus and MEDLINE.

Musculoskeletal pain conditions (MPs) are a widespread public problem that can affect 13.5% to 47% of the total population. Dietary changes can have strong effects on persons health; for instance, Sulfur amino acids (SAAs) can act as a precursor of neurotransmitters, antioxidative metabolic intermediates, such as glutathione, impact inflammation, and play a role in severity and frequency of MPs. We evaluated the relationship between dietary SAAs intake with severity and frequency of pain in patients with MPs. This cross-sectional study consisted of 175 men and woman. Anthropometric measurements and pain assessments were conducted via questionnaires. Dietary data were collected using 7 days 24-h recall. ANOVA and Spearman correlation coefficients were used to examine the relationship and correlation, resp., between exposure and outcome variables. There was a significant correlation between age, weight, waist circumference (WC), waist circumference to height (WHtR), body mass index (BMI), and severity and frequency of MPs among women. There was a correlation between age and severity of pain in men. The present study highlights a pos. association between the dietary SAAs and severity of pain, even after adjusting for confounding variables.

BMC Research Notes published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Synthetic Route of 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Li published the artcileToxicity evaluation of collagen hydrolysates from chrome shavings and their potential use in the preparation of amino acid fertilizer for crop growth, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Journal of Leather Science and Engineering (2022), 4(1), 2, database is CAplus.

Resource utilization of chrome shavings (CS) has attracted a lot of attention from scientists and technologists in leather industry. Especially, the collagen hydrolyzates extracted from CS are expected to find potential application values in agricultural field. However, there is no biotoxicity anal. of collagen hydrolyzates from CS. Herein, the collagen hydrolyzates with different mol. weights were produced from CS by three hydrolysis dechroming methods including alk. hydrolysis, enzymic hydrolysis and alk.-enzymic synergistic hydrolysis, and the optimal hydrolysis process of CS was designed and conducted. To evaluate their toxicity, the three collagen hydrolyzates were formulated into a nutrient solution for zebrafish development. The obtained results indicated that the hydrolyzates with low concentrations (less than 0.6 mg/mL) were safe and could promote the development for zebrafish embryos. Furthermore, the three collagen hydrolyzates were utilized as organic nitrogen sources and formulated into amino acid water-soluble fertilizers (AAWSF) including alk. type fertilizer (OH), enzymic type fertilizer (M) and alk.-enzymic type fertilizer (OH-M) for the early soilless seeding cultivation of wheat, soybean and rapeseed. It is worth mentioning that the chromium contents in the prepared AAWSF were less than 10 mg/kg, which is far less than the limit value in the standard (China, 50 mg/kg). The growth and development of seedlings (germination rate, plant height, fresh weight of leaves, soluble sugar content and chlorophyll content) were investigated. The corresponding results showed that the growth of seedlings watered with AAWSF was better compared with the other treatments, and the OH-M fertilizer had the best promoting effect on the seedlings growth and development, followed by the M and OH fertilizers. The safe toxicity assessment of the collagen hydrolyzates will expand their application scope, and the use of collagen hydrolyzates extracted from CS for seedlings growth also provides an effective and reasonable way to deal with the chromium-containing leather solid waste, which is an effective way to realize its resource utilization.

Journal of Leather Science and Engineering published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C6H5NO, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sala-Carvalho, Wilton R. published the artcileMetabolome of Ceratodon purpureus (Hedw.) Brid., a cosmopolitan moss: the influence of seasonality, Recommanded Product: 2-Methylbenzoic acid, the publication is Planta (2022), 255(4), 77, database is CAplus and MEDLINE.

Ceratodon purpureus showed changes in disaccharides, flavonoids, and carotenoids throughout annual seasons. These changes indicate harsher environmental conditions during the dry period, directing metabolic precursors to enhance the antioxidant system. Bryophytes are a group of land plants comprising mosses (Bryophyta), liverworts (Marchantyophyta), and hornworts (Antocerotophyta). This study uses the mol. networking approach to investigate the influence of seasonality (dry and rainy seasons) on the metabolome and redox status of the moss Ceratodon purpureus (Hedw.) Brid., from Campos do Jordao, Brazil. Samples of C. purpureus were submitted to three extraction methods: 80% methanol producing the soluble fraction (intracellular compounds), followed by debris hydrolysis using sodium hydroxide producing the insoluble fraction (cell wall conjugated compounds), both analyzed by HPLC-MS; and extraction using pre-cooled methanol, separated into polar and non-polar fractions, being both analyzed by GC-MS. All fractions were processed using the Global Natural Product Social Mol. Network (GNPS). The redox status was assessed by the anal. of four enzyme activities combined with the anal. of the contents of ascorbate, glutathione, carotenoids, reactive oxygen species (ROS), and malondialdehyde acid (MDA). During the dry period, there was an increase of most biflavonoids, as well as phospholipids, disaccharides, long-chain fatty acids, carotenoids, antioxidant enzymes, ROS, and MDA. Results indicate that C. purpureus is under harsher environmental conditions during the dry period, mainly due to low temperature and less water availability (low rainfall).

Planta published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mido, Yoshiyuki published the artcileInfrared and Raman spectra of N-methyl-N’-n-alkylthioureas, Synthetic Route of 6972-05-0, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (1988), 44A(4), 445-7, database is CAplus.

The IR and Raman spectra of solid CH₃NHCSNH(CH₂)_nCH₃ (n = 0-15) (MTUR’) and CH₃NDCSND(CH₂)_nCH₃ (n = 0-9) were examined The vibrational properties of N,N‘-disubstituted thioureas were studied on the basis of the spectral comparison among the series of compounds, the waveno. shift by N-deuteration, and a comparison with the vibrational properties of the urea analog. From the anal. of interactions between end-group vibrations and CH₂ band progression modes, MTUR’ mols. are in a skeletal planar structure with an extended n-alkyl chain.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Synthetic Route of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Su, Junqi published the artcileGeneration of oxyphosphonium ions by photoredox/cobaloxime catalysis for scalable amide and peptide synthesis in batch and continuous-flow, HPLC of Formula: 118-90-1, the publication is Angewandte Chemie, International Edition (2022), 61(5), e202112668, database is CAplus and MEDLINE.

Phosphine-mediated deoxygenative nucleophilic substitutions, such as the Mitsunobu reaction, are of great importance in organic synthesis. However, the conventional protocols require stoichiometric oxidants to trigger the formation of the oxyphosphonium intermediates for the subsequent nucleophilic additions Through dual catalysis of photoredox and cobaloxime, we realized a radical strategy for the catalytic formation of acyloxyphosphonium ions that enables direct amidation. The deoxygenative protocol exhibits a broad scope and has been used in the late-stage amidation of drug mols. In addition to batch reactions, a continuous-flow reactor was developed, enabling rapid peptide synthesis on gram scale. The successful assembly of a tetrapeptide on the solid support further demonstrated the versatility of this photocatalytic system. Moreover, exptl. and computational studies are consistent with the hypothesis of acyloxyphosphonium ions being formed as the key intermediates.

Angewandte Chemie, International Edition published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C4H6O3, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wieland, Theodor published the artcileAntagonists of the Lactobacillus bulgaricus factor and of pantothenic acid, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride, the publication is Chemische Berichte (1952), 1035-42, database is CAplus.

According to the present concept of the mechanism of the action of pantothenic acid (I) in the living cell, I is incorporated into the coenzyme A (II) and is present there as the thioethanolamide (III), the SH group of which acts as acyl transcarrier in biol. acylation of amines and alcs. Certain lactic acid bacteria, e.g., Lactobacillus helveticus V 80 (IV), show a faster growth with a scission product of II, the so-called Lactobacillus bulgaricus factor (LBF), than with I, especially at the beginning. From this it may be concluded that during the II synthesis in these micro?rganisms I is converted into pantetheine (V) which is then, as a whole, built into II. To test this theory, derivatives of III are synthesized, differing only slightly from III but in such a way that the synthesis of II can be stopped by the competition with V. Adding CH₂.CH₂.NH to MeSH in 20 cc. EtOH at -15¡ã and keeping the mixture overnight at 20¡ã give MeSCH₂CH₂-NH₂ (VI), b₇₆₀ 146-8¡ã (HCl salt m. 120¡ã); EtSCH₂CH₂NH₂ b₇₆₀ 163¡ã (HCl salt m. 147¡ã). Keeping 1.2 g. absolute dry Na D-pantothenate (VII) in 5 cc. anhydrous HCONMe₂ and 0.5 g. ClCO₂Et several hrs. at 0¡ã, adding 0.46 g. VI, keeping the mixture several hrs., evaporating the filtered solution in vacuo, and purifying the residue in BuOH by the countercurrent extraction (CCE) method give 40% S-methylpantetheine (VIII), very viscous pale yellow oil; S-Et homolog (IX) and S-Ph analog (X) have similar properties. Adding 1.5 cc. liquid NH₃ at -60¡ã to the filtered reaction mixture of 2.4 g. VII, 1 g. ClCO₂Et, and 15 cc. HCONMe₂, evaporating the NH₃ and the solvent, finally at 40¡ã in vacuo, and purifying the residue by CCE in BuOH and H₂O give 40% D-pantothenamide (XI), oil, very soluble in H₂O and BuOH, slightly soluble in C₆H₆ and ether. Saturating 5 g. HOCH₂CMe₂CH(OH)CN in 50 cc. ether with dry HCl and keeping the mixture overnight give almost 100% [O.CH₂.CMe₂.CH(OH).C:NH₂]⁺Cl^– which failed to give XI on treatment with CH₂:CHCONH₂. At low concentrations VIII-X possess little growth activity with IV which, at higher concentrations, is annulled by LBF, V, and I. Whereas with VIII and IX this stoppage is overcome after a few days, with X it is stable because of a true competitive process whereby 30-70 mols. inhibitor per 1 mol. growth-promoting substance (XII) stops the growth by 50%. XI possesses no inhibitory action and can, at a higher concentration, completely substitute for XII. The results of the microbiol. tests are given in several curves.

Chemische Berichte published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cabani, S. published the artcileVolume changes in the proton ionization of amines in water. 2. Amino alcohols, amino ethers, and diamines, COA of Formula: C3H12Cl2N2, the publication is Journal of Physical Chemistry (1977), 81(10), 987-93, database is CAplus.

From d. measurements (25¡ã) of aqueous solutions at various concentrations of solute, apparent molar volumes of some open-chain bifunctional primary, secondary and tertiary amines were determined; the compounds studied were X(CH2)nNH2 (X = HO, MeO, H2N; n = 2,3) and 2-XCH2CH2OH (X = MeNH, EtNH, Me2N, Et2N) and their mono- and dihydrochlorides, for which ¦¤V1¡ã and ¦¤V2¡ã for the 1st and 2nd steps of proton ionization were calculated from the limiting partial molar volumes Values ¦¤V1¡ã for the above bifunctional amines are compared with the corresponding values for monofunctional amines, and the difference in ¦¤V1¡ã caused by the introduction of the 2nd hydrophilic center is discussed. The volumes and entropies of ionization of the amines and carboxylic acids are compared, and the deviations of these functions from predictions based on simple electrostatic theories are considered.

Journal of Physical Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, COA of Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mirjalili, Mahtabalsadat published the artcilePharmacological agents for the prevention of colistin-induced nephrotoxicity, COA of Formula: C5H11NO2S, the publication is European Journal of Medical Research (2022), 27(1), 64, database is CAplus and MEDLINE.

Abstract: Background: Colistin is a polymyxin antibiotic which has been used for treatment of Gram-neg. infections, but it was withdrawn due to its nephrotoxicity. However, colistin has gained its popularity in recent years due to the reemergence of multidrug resistant Gram-neg. infections and drug-induced toxicity is considered as the main obstacle for using this valuable antibiotic. Results: In total, 30 articles, including 29 animal studies and one clin. trial were included in this study. These compounds, including aged black garlic extract, albumin fragments, alpha lipoic acid, astaxanthin, baicalein, chrysin, cilastatin, colchicine, curcumin, cytochrome c, dexmedetomidine, gelofusine, grape seed proanthocyanidin extract, hesperidin, luteolin, lycopene, melatonin, methionine, N-acetylcysteine, silymarin, taurine, vitamin C, and vitamin E exhibited beneficial effects in most of the published works. Conclusions: In this review, the authors have attempted to review the available literature on the use of several compounds for prevention or attenuation of colistin-induced nephrotoxicity. Most of the studied compounds were potent antioxidants, and it seems that using antioxidants concomitantly can have a protective effect during the colistin exposure.

European Journal of Medical Research published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hock, Katharina J. published the artcileDifluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions, Computed Properties of 421-49-8, the publication is Green Chemistry (2017), 19(4), 905-909, database is CAplus.

Herein, the applications of fluorinated diazoalkanes in cycloaddition reactions, with the emphasis on studying subtle differences between diverse fluorinated diazo compounds was reported. These differences led to two major synthetic protocols in batch and flow that allow the safe and scalable synthesis of fluoroalkyl-, sulfone-substituted pyrazolines.

Green Chemistry published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Computed Properties of 421-49-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia