Tag: M.W=100-150

Moriyama, Doris Ferreira published the artcileThe effects of temperature variation treatments on embryonic development: a mouse study, SDS of cas: 63-68-3, the publication is Scientific Reports (2022), 12(1), 2489, database is CAplus and MEDLINE.

Since the development of ART, embryos have been cultured at 37 ¡ãC in an attempt to mimic the in vivo conditions and the average body temperature of an adult. However, a gradient of temperatures within the reproductive tract has been demonstrated in humans and several other mammalian species. Therefore, the aim of this study was to evaluate the effects of temperature variation treatments on mouse embryo quality through morphokinetic events, blastocyst morphol., the relative gene expression of Igf2, Bax, Bcl2 and Apaf1 and the metabolomics of individual culture media. Study groups consisted of 2 circadian treatments, T1 with embryos being cultured at 37 ¡ãC during the day and 35.5 ¡ãC during the night, T2 with 38.5 ¡ãC during the day and 37 ¡ãC during the night and a control group with constant 37 ¡ãC. Our main findings are that the lower-temperature group (T1) showed a consistent neg. effect on mouse embryo development with “slow” cleaving embryos, poor-quality blastocysts, a higher expression of the apoptotic gene Apaf1, and a significantly different set of amino acids representing a more stressed metabolism On the other hand, our higher-temperature group (T2) showed similar results to the control group, with no adverse effects on blastocyst viability.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, SDS of cas: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hua, Xuewen published the artcileNovel Anthranilic Diamide Insecticides: Design, Synthesis, and Insecticidal Evaluation, Quality Control of 6950-53-4, the publication is Australian Journal of Chemistry (2014), 67(10), 1491-1503, database is CAplus.

Three series of new anthranilic diamide derivatives containing sulfide, N-cyanomethylsulfilimine, and N-cyanomethylsulfoximine groups were designed and synthesized by coupling the active substructures of anthranilic diamides and sulfoxaflor. The structures of the synthesized compounds were confirmed by IR spectroscopy, ¹H and ¹³C NMR, and elemental anal. Several unique structural characteristics were revealed via the crystal structure anal. of compound N-(2-(2-methyl-2-(methylthio)propylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide I. Bioassay results indicated that most of the synthesized compounds showed superior insecticidal activities against Mythimna separata and Plutella xylostella when compared with the pos. control cyantraniliprole. In particular, N-(2-(2-methyl-2-(N-cyanomethylsulfideimino)propylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide II showed excellent insecticidal activity against Mythimna separata, with a mortality rate of 100% at a concentration of 1¦Ìg?mL^-1. These results indicated that sulfide, N-cyanomethylsulfilimine, and N-cyanomethylsulfoximine moieties, as important active substructures, could improve or maintain the activity of the anthranilic diamide and promote novel pesticide development.

Australian Journal of Chemistry published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Quality Control of 6950-53-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Kyeojin published the artcileGlucal-conjugated sterols as novel vascular leakage blocker: Structure-activity relationship focusing on the C₁₇-side chain, Related Products of catalysis-chemistry, the publication is European Journal of Medicinal Chemistry (2014), 184-194, database is CAplus and MEDLINE.

A series of glucal-conjugated sterols as novel vascular leakage blocker were identified through design, synthesis and biol. evaluation. In addition, the structure-activity relationship (SAR) of the glucal-conjugated sterols focusing on the C₁₇-side chain was also established. The sterol analogs linked with the rigid C₁₇-side chain side chains exhibited potent cell survival activities. In particular, ((2R,3S)-3-Acetoxy-6-((3S,10R,13S,17S)-17-((E)-1-(cyclopentyloxyimino)ethyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy)3,6-dihydro-2H-pyran-2-yl)methyl acetate, which possesses a cyclopentyl oxime moiety, was shown to have excellent pharmacol. effects on retinal vascular leakage in a diabetic mouse model.

European Journal of Medicinal Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gazwi, Hanaa S. S. published the artcileAnalysis of the phytochemicals of Coriandrum sativum and Cichorium intybus aqueous extracts and their biological effects on broiler chickens, SDS of cas: 63-68-3, the publication is Scientific Reports (2022), 12(1), 6399, database is CAplus and MEDLINE.

Spices and herbs can be used as feed additives and viable alternatives to antibiotics in chicken production This study analyzed the phytochems., minerals, and antioxidant activity of aqueous extracts from Coriandrum sativum seeds and Cichorium intybus roots. The effects of different concentrations of C. sativum and C. intybus extracts on blood parameters, growth and carcass traits, biochem. parameters, and antioxidant activity of broiler chicks were also examined The results showed that C. sativum aqueous extract has relatively higher contents of total flavonoids and total phenolic acids than C. intybus aqueous extract Both extracts contain elevated mineral elements, especially iron, potassium, and sodium. Therefore, dietary supplementation of C. sativum seed and C. intybus root extracts could enhance broiler chicken growth performance, carcass characteristics, liver function, lipid profile, and antioxidant status. These extracts could be utilized as natural feed additives and growth promoters for broiler chickens.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, SDS of cas: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Barolli, Joao P. published the artcileHeteroleptic tris-chelate ruthenium(II) complexes of N,N-disubstituted-N’-acylthioureas: Synthesis, structural studies, cytotoxic activity and confocal microscopy studies, Product Details of C3H8N2S, the publication is Polyhedron (2017), 33-41, database is CAplus.

Ruthenium complexes were assessed as antitumor agents against cancer cells. In this project, new heteroleptic Ru(II) complexes [Ru(L)(bipy)(dppb)](PF₆) (L = N,N-disubstituted-N’-acylthiourea, bipy = 2,2′-bipyridine and dppb = 1,4-bis(diphenylphosphino)butane) were synthesized and characterized by elemental anal., IR and NMR (¹H and ³¹P{¹H}) spectroscopies, molar conductivity measurements and single crystal x-ray diffractometry. The IR and NMR data suggest the coordination of the ligands to the Ru(II) metal center through the thiocarbonyl and carbonyl groups. The structures of the new complexes were further studied by x-ray crystallog., which confirmed the coordination of the ligands with the metal through the S and O atoms, giving distorted octahedral complexes. The N,N-disubstituted-N’-acylthioureas and their complexes were screened with respect to their in vitro cytotoxicity. All compounds exhibited considerable antiproliferative activity against MCF-7 (human breast tumor cells ATCC HTB-26), DU-145 (human prostate tumor cells ATCC HTB-26), and relatively low toxicity against fibroblast L929 cells (health cell line from mouse ATCC CCL-1). A preliminary study regarding the mechanism of action of these compounds by confocal microscopy shows alterations of the actin filaments leading to modifications in cytoskeletal supporting the cell death and that the cell nucleus is not the main target of these complexes.

Polyhedron published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Product Details of C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Yifang published the artcileDesign and synthesis novel amide derivatives containing an 1,3,4-oxadiazole moiety as potential antibacterial agents, Category: catalysis-chemistry, the publication is Journal of Heterocyclic Chemistry (2022), 59(7), 1160-1168, database is CAplus.

To find new antibacterial agents, 25 novel amide derivatives containing an 1,3,4-oxadiazole moiety were designed and synthesized, and their antibacterial activity against Xanthomonas oryzae pv. oryzicola (Xoc) and Xanthomonas oryzae pv. oryzae (Xoo) were tested. Interestingly, all target compounds showed excellent antibacterial activities against Xoc and Xoo. The EC₅₀ values of compounds against Xoc and Xoo were 1.2-4.0 mg/L and 0.5-2.3 mg/L, resp., which were significantly superior to those of the thiodiazole copper (95.1 and 89.0 mg/L) and bismerthhibol (73.8 and 68.8 mg/L). For example, the EC₅₀ values of compound I against Xoc and Xoo were 1.7 and 0.5 mg/L, resp. Meanwhile, the curative and protection activity of compound I against rice bacterial leaf blight were 42.4% and 42.1%, resp., which were superior to the control of jiahuangxianjunzuo (34.1% and 32.6%) and thiodiazole copper (33.0% and 27.1%). In addition, compound I might suppress the cell growth of Xoo by inhibiting the production of extracellular polysaccharide, the formation of biofilm, changes the cell membrane permeability, and cell surface morphol.

Journal of Heterocyclic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Holte, Dane published the artcileEvaluation of PNU-159682 antibody drug conjugates (ADCs), Recommanded Product: 1,1-Dimethylthiourea, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(24), 127640, database is CAplus and MEDLINE.

PNU-159682 I is a highly potent secondary metabolite of nemorubicin belonging to the anthracycline class of natural products. Due to its extremely high potency and only partially understood mechanism of action, it was deemed an interesting starting point for the development of a new suite of linker drugs for antibody drug conjugates (ADCs). Structure-activity relationships were explored on the small mol. which led to six linker drugs being developed for conjugation to antibodies. Herein we describe the synthesis of novel PNU-159682 derivatives and the subsequent linker drugs as well as the corresponding biol. evaluations of the small mols. and ADCs.

Bioorganic & Medicinal Chemistry Letters published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Elenich, O. V. published the artcileSynthesis of nitrogen-containing heterocycles on the basis of 3-(4-acetylphenyl)-1-methylquinolin-2(1H)-one, Application In Synthesis of 6972-05-0, the publication is Russian Journal of Organic Chemistry (2016), 52(3), 373-378, database is CAplus.

The Meerwein reaction of 1-methylquinolin-2(1H)-one with 4-acetylbenzenediazonium chloride gave 3-(4-acetylphenyl)-1-methylquinolin-2(1H)-one which was brominated to 3-[4-(2-bromoacetyl)phenyl]-1-methylquinolin-2(1H)-one. The latter reacted with pyridine, 4-methylpyridine, quinoline, benzo[f]quinoline, and triphenylphosphine to afford the corresponding quaternary salts, and its reactions with thioacetamide, thiourea, 2-aminopyridine, and 2-aminopyrimidine led to the corresponding thiazole, imidazo[1,2-a]pyridine, and imidazo[1,2-a]pyrimidine derivatives containing a 2-oxoquinoline fragment. 3-(4-[2-[2-(arylmethylidene)-hydrazinyl]-1,3-thiazol-4-yl]phenyl)-1-methylquinolin-2(1H)-ones were obtained by condensation of 3-[4-(2-bromoacetyl)phenyl]-1-methylquinolin-2(1H)-one with thiosemicarbazide and aromatic aldehydes.

Russian Journal of Organic Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application In Synthesis of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Wen-Yang published the artcilePer- and polyfluoroalkyl substances target and alter human prostate stem-progenitor cells, Computed Properties of 118-90-1, the publication is Biochemical Pharmacology (Amsterdam, Netherlands) (2022), 114902, database is CAplus and MEDLINE.

Per- and polyfluorinated alkyl substances (PFAS) are a large family of widely used synthetic chems. that are environmentally and biol. persistent and present in most individuals. Chronic PFAS exposure have been linked to increased prostate cancer risk in occupational settings, however, underlying mechanisms have not been interrogated. Herein we examined exposure of normal human prostate stem-progenitor cells (SPCs) to 10 nM PFOA or PFOS using serial passage of prostasphere cultures. Exposure to either PFAS for 3-4 wk increased spheroid numbers and size indicative of elevated stem cell self-renewal and progenitor cell proliferation. Transcriptome anal. using single-cell RNA sequencing (scRNA-seq) showed 1) SPC expression of PPARs and RXRs able to mediate PFAS effects, 2) the emergence of a new cell cluster of aberrantly differentiated luminal progenitor cells upon PFOS/PFOA exposure, and 3) enrichment of cancer-associated signaling pathways. Metabolomic anal. of PFAS-exposed prostaspheres revealed increased glycolytic pathways including the Warburg effect as well as strong enrichment of serine and glycine metabolism which may promote a pre-malignant SPC fate. Finally, growth of in vivo xenografts of tumorigenic RWPE-2 human prostate cells, shown to contain cancer stem-like cells, was markedly enhanced by daily PFOS feeding to nude mice hosts. Together, these findings are the first to identify human prostate SPCs as direct PFAS targets with resultant reprogrammed transcriptomes and metabolomes that augment a preneoplastic state and may contribute to an elevated prostate cancer risk with chronic exposures.

Biochemical Pharmacology (Amsterdam, Netherlands) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gao, Yue published the artcileAnalysis of codon usage bias of WRKY transcription factors in Helianthus annuus, Related Products of catalysis-chemistry, the publication is BMC Genomic Data (2022), 23(1), 46, database is CAplus and MEDLINE.

The phenomenon of codon usage bias is known to exist in many genomes and is mainly determined by mutation and selection. Codon usage bias anal. is a suitable strategy for identifying the principal evolutionary driving forces in different organisms. Sunflower (Helianthus annuus L.) is an annual crop that is cultivated worldwide as ornamentals, food plants and for their valuable oil. The WRKY family genes in plants play a central role in diverse regulation and multiple stress responses. Evolutionary anal. of WRKY family genes of H. annuus can provide rich genetic information for developing hybridization resources of the genus Helianthus. Bases composition anal. showed the average GC content of WRKY genes of H. annuus was 43.42%, and the average GC3 content was 39.60%, suggesting that WRKY gene family prefers A/T(U) ending codons. There were 29 codons with relative synonymous codon usage (RSCU) greater than 1 and 22 codons ending with A and U base. The effective number of codons (ENC) and codon adaptation index (CAI) in WRKY genes ranged from 43.47-61.00 and 0.14-0.26, suggesting that the codon bias was weak and WRKY genes expression level was low. Neutrality anal. found a significant correlation between GC12 and GC3. ENC-plot showed most genes on or close to the expected curve, suggesting that mutational bias played a major role in shaping codon usage. The Parity Rule 2 plot (PR2) anal. showed that the usage of AT and GC was disproportionate. A total of three codons were identified as the optimal codons. Apart from natural selection effects, most of the genetic evolution in the H. annuus WRKY genome might be driven by mutation pressure. Our results provide a theor. foundation for elaborating the genetic architecture and mechanisms of H. annuus and contributing to enrich H. annuus genetic resources.

BMC Genomic Data published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia