Tag: M.W=100-150

Cui, Shaoyu published the artcileDesign, synthesis and evaluation of wound healing activity for ¦Â-sitosterols derivatives as potent Na⁺/K⁺-ATPase inhibitors, Synthetic Route of 6084-58-8, the publication is Bioorganic Chemistry (2020), 103150, database is CAplus and MEDLINE.

¦Â-Sitosterols, is a common steroid that can be identified in a variety of plants and their efficacy in promoting wound healing has been demonstrated. Na⁺/K⁺-ATPase, more than a pump, its signal transduction function for involvement in cell growth regulation attracts widespread concern. The Na⁺/K⁺-ATPase/Src receptor complex can serve as a receptor involved in multiple signaling pathways including promoting wound healing pathways. To finding potent accelerating wound healing small mol., we choose the high inhibitory activity of Na⁺/K⁺-ATPase and non-cardiotoxic natural compound, ¦Â-sitosterol as the substrate. A series of ¦Â-sitosterol derivatives were designed, synthesized and evaluated as potential Na⁺/K⁺-ATPase inhibitors. Among them, some compounds showed improved inhibitory activity on Na⁺/K⁺-ATPase, with IC₅₀ value of 3.0¦ÌM, 3.4¦ÌM, 2.2¦ÌM, which are more potent than ¦Â-sitosterol with IC₅₀ 7.6¦ÌM. Especially, compound I can induce cell proliferation, migration and soluble collagen production in L929 fibroblasts. Compared to model, compound I can accelerate wound healing in SD rats. Further studies indicated that I can activate the sarcoma (Src), uptake the protein kinase B (Akt), extracellular signal-regulated kinase (ERK) proteins expression in a concentration dependent manner. Finally, binding mode of compound I with Na⁺/K⁺-ATPase was studied, which provides insights into the determinants of potency and selectivity. These results proved ¦Â-stitosterol derivative 49 can serve as an effective inhibitor of Na⁺/K⁺-ATPase and potential candidate for accelerating wound healing agents.

Bioorganic Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Synthetic Route of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Naskar, Gouranga published the artcileLigand-Enabled [3+2] Annulation of Aromatic Acids with Maleimides by C(sp³)-H and C(sp²)-H Bond Activation, Application of 2-Methylbenzoic acid, the publication is Chemistry – A European Journal (2022), 28(39), e202200778, database is CAplus and MEDLINE.

Synthesis of tricyclic heterocyclic mols. I [R = 5-F, 5-Me, 5-CF₃, etc.; R¹ = Me, Et, Bn, etc.] with a free carboxylic group in a high atom- and step-economical manner via palladium-catalyzed [3+2] annulation of substituted benzoic acids with maleimides was described. The reaction proceeded via a dual C-H bond activation such as C(sp³)-H at the benzylic position and C(sp²)-H bond activation at the meta position of substituted aromatics An external ligand (MPAA) was crucial for the success of present protocol. Further, the decarboxylation and esterification of the free carboxylic acid group of observed products were carried out.

Chemistry – A European Journal published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Application of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ramesh, Balu published the artcileRu(II)- or Rh(III)-Catalyzed Annulation of Aromatic/Vinylic Acids with Alkylidenecyclopropanes via C-H Activation, Name: 2-Methylbenzoic acid, the publication is Journal of Organic Chemistry (2022), 87(9), 5668-5681, database is CAplus and MEDLINE.

An efficient and new route for the synthesis of (E)-4-benzylideneisochroman-1-ones I [R¹ = 6-Me, 7-Cl, 8-MeO, etc.; Ar = Ph, 4-ClC₆H₄, 3-BrC₆H₄, etc.] through tandem cascade annulation of benzoic acids with alkylidenecyclopropanes using Ru(II) as a catalyst was demonstrated. It was important to note that the reaction delivers selectively E-stereoselective 4-benzylideneisochroman-1-one derivatives in moderate to good yields, which had completely diverse selectivity as compared with previous methods. Further, the annulation was explored with less-reactive ¦Â C-H activation of vinylic acids with alkylidenecyclopropanes, leading to the highly useful ¦Á-pyrone derivatives II [R³ = Me, CF₃, Ph, Bn; Ar= Ph, 3-MeC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄] in the presence of an Rh(III) catalyst.

Journal of Organic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Name: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ben-Abu, Yuval published the artcileMetabolome dynamics during wheat domestication, COA of Formula: C5H11NO2S, the publication is Scientific Reports (2022), 12(1), 8532, database is CAplus and MEDLINE.

One of the most important crops worldwide is wheat. Wheat domestication took place about 10,000 years ago. Not only that its wild progenitors have been discovered and phenotypically characterized, but their genomes were also sequenced and compared to modern wheat. While comparative genomics is essential to track genes that contribute to improvement in crop yield, comparative analyses of functional biol. end-products, such as metabolites, are still lacking. With the advent of rigorous mass-spectrometry technologies, it is now possible to address that problem on a big-data scale. In attempt to reveal classes of metabolites, which are associated with wheat domestication, we analyzed the metabolomes of wheat kernel samples from various wheat lines. These wheat lines represented subspecies of tetraploid wheat along primary and secondary domestications, including wild emmer, domesticated emmer, landraces durum, and modern durum. We detected that the groups of plant metabolites such as plant-defense metabolites, antioxidants and plant hormones underwent significant changes during wheat domestication. Our data suggest that these metabolites may have contributed to the improvement in the agricultural fitness of wheat. Closer evaluation of specific metabolic pathways may result in the future in genetically-engineered high-yield crops.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nakayama, Akira published the artcileDevelopment of insect juvenile hormone active oxime O-ethers and carbamates, Synthetic Route of 6084-58-8, the publication is Journal of Agricultural and Food Chemistry (1985), 33(6), 1034-41, database is CAplus.

Undecen-2-one oxime O-ethers and undecen-2-yl carbamates were prepared and their activities tested against Culex?pipiens (common mosquito), Chilo?suppressalis (rice stem borer), and Musca?domestica (housefly). Activities were comparable to that of naturally occurring juvenile?hormone?I??[13804-51-8]. To produce higher activities, the structures of the oxime O-ethers and the reportedly highly active 2-(4-phenoxyphenoxy)ethyl carbamates were hybridized to produce (4-phenoxyphenoxy)- and (4-benzylphenoxy)acetaldehyde oxime O-ethers and related compounds The activity of some of these substances against C. pipiens were comparable to the 90-100% inhibition of metamorphosis by methoprene??[40596-69-8], the most highly active of the juvenile hormone compounds

Journal of Agricultural and Food Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Synthetic Route of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Niwa, Atsushi published the artcileDevelopment of N,O-disubstituted hydroxylamines and N,N-disubstituted amines as insect juvenile hormone mimetics and the role of the nitrogenous function for activity, Computed Properties of 6084-58-8, the publication is Journal of Agricultural and Food Chemistry (1990), 38(2), 514-20, database is CAplus.

Insect juvenile hormone (JH) active N,O-disubstituted hydroxylamines were developed to examine the role of the nitrogenous function for high activity. They are O-alkyl-N-[(4-phenoxyphenoxy) and (4-benzylphenoxy)alkyl]hydroxylamines and reversely substituted N-alkyl-O-[(4-phenoxyphenoxy)alkyl]hydroxylamines. The activity against Culex?pipiens of the most potent member of each class was as high as that of the compounds known so far as the most active of JH mimics. When the overall length of the mols. is kept at the optimum, about 21 ?, suggested in earlier works, the compounds having a hydroxylamino N atom, rather than the O atom, at the ¦Ä-position from the central phenoxy O atom or at the 4-position (about 4.6 ?) from the alkyl end showed about 10 times higher activity than those having the N atom at position 1. The corresponding amine compounds showed this more clearly, but their activity was considerably lower than that of the hydroxylamines. The lower potency of the amines with pK_a ¡Ö10 was attributed to their quaternization at physiol. pH, preventing going to or binding with the action site.

Journal of Agricultural and Food Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Computed Properties of 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Eggleston, Drake S. published the artcileTetrasubstituted [14]-1,3,8,10-tetraeneN₄ macrocyclic complexes: synthesis, organic precursor, and template reaction mechanism, Computed Properties of 10517-44-9, the publication is Inorganic Chemistry (1980), 19(6), 1593-9, database is CAplus.

Template syntheses have been studied for macrocyclic complexes derived from 1,3-diaminopropane (DAP), 1-phenyl-1,2-propanedione (AB), and metal(II) acetate, where the metal is Fe, Co or Ni. The products were characterized by elemental analyses and conductivity and spectroscopic methods (IR, UV-visible, and ¹H and ¹³C NMR). The ¹³C NMR anal. indicated that the template synthesis is regiospecific, producing only one of the two possible isomeric products corresponding to the ligand 2,9-dimethyl-3,10-diphenyl-1,4,8,11-tetraazacyclotetradeca-1,3,8,10-tetraene, trans-MePhTIM. X-ray diffraction data for a crystal of [Co(MePhTIM)Cl₂]PF₆ are also consistent with a centrosym. trans isomer product. ¹H NMR studies of the 1:1 condensation of AB and DAP in the absence of metals indicates a mixture of products from which the major product was isolated and found to be 2-benzoyl-2-methylhexahydropyrimidine. Reaction of this compound with metal salts yields the isomerically pure trans-MePhTIM complexes. The synthetic results and ¹H NMR studies are consistent with a proposed template mechanism in which AB and DAP react first to form 2-benzoyl-2-methylhexahydropyrimidine in equilibrium with its open-chain Schiff-base tautomer. Subsequent condensation of two of the Schiff-base mols. under the influence of a metal ion leads exclusively to the trans-MePhTIM complex. Results of other experiments and syntheses using an unsym. substituted alkyl ¦Á-diketone indicate that the mechanism is also applicable to related systems.

Inorganic Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Computed Properties of 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Valandro, Silvano R. published the artcileAggregation-Enhanced Two-Photon Absorption of Anionic Conjugated Polyelectrolytes, Product Details of C3H12Cl2N2, the publication is Journal of Physical Chemistry Letters (2020), 11(19), 8292-8296, database is CAplus and MEDLINE.

The two-photon absorption properties of anionic poly(phenylene ethynylene)-type conjugated oligo- and polyelectrolytes are studied in molecularly dissolved and aggregated forms in aqueous solution Several different polyvalent cations are used to induce aggregation. It is found that both materials in the aggregated form exhibit enhanced two-photon excited fluorescence (2PEF) and two-photon cross section (¦Ò₂) compared with the molecularly dissolved structures. The 2PEF and ¦Ò₂ are unaffected by the nature of the polyvalent cation that is used to induce aggregation. The two-photon absorption cross section enhancement arises because of the increase in the difference dipole moment (¦¤¦Ì) in the aggregates of the conjugated materials, an effect that is attributed to the introduction of charge transfer character into the aggregate excited state.

Journal of Physical Chemistry Letters published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C12H15ClO3, Product Details of C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kinunda, Grace published the artcileUnderstanding the electronic and ¦Ð-conjugation roles of quinoline on ligand substitution reactions of platinum(II) complexes, Recommanded Product: 1,1-Dimethylthiourea, the publication is Transition Metal Chemistry (Dordrecht, Netherlands) (2014), 39(4), 451-459, database is CAplus.

A kinetic and mechanistic study of chloride substitution by thiourea nucleophiles, thiourea, N-methylthiourea, N,N-dimethylthiourea and N,N,N’,N’-tetramethylthiourea in the complexes chlorobis-(2-pyridylmethyl)amineplatinum(II) (Pt1), chloro N-(2-pyridinylmethyl)-8-quinolinamineplatinum(II) (Pt2), chloro N-(2-pyridinylmethylene)-8-quinolinamineplatinum(II) (Pt3) and chlorobis(8-quinolinyl)amineplatinum(II) (Pt4) was undertaken under pseudo-first-order conditions using UV-visible spectrophotometry. Lability of the chloro leaving group is dependent on the strength of ¦Ð-interactions between the filled d¦Ð-orbitals of the metal and the empty ¦Ð^*-orbitals of the chelating ligand in the following manner: Pt1 > Pt3 > Pt2 > Pt4. Introduction of the quinoline moiety within the nonlabile chelated framework of the Pt(II) complexes results in a more electron-rich metal center which retards the approach of the nucleophile through repulsion. Also, the net ¦Ò-effect of the ligand moiety plays a significant role in controlling the reactivity of the complexes. The exptl. results are interpreted with the aid of computational data obtained by d. functional theory (B3LYP(CPCM)/LANL2DZp//B3LYP/-LANL2DZp) calculations The mode of substitution remains associative as supported by neg. entropies and the dependence of the 2nd-order rate constants on the concentration of entering nucleophiles.

Transition Metal Chemistry (Dordrecht, Netherlands) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ongoma, Peter published the artcileThe ¦Ð-acceptor effect in the substitution reactions of tridentate N-donor ligand complexes of platinum(ii): a detailed kinetic and mechanistic study, Formula: C3H8N2S, the publication is Dalton Transactions (2012), 41(35), 10724-10730, database is CAplus and MEDLINE.

The nucleophilic substitution reactions of complexes [Pt{4′-(2”’-CH₃-phenyl)-2,2′:6′,2”-terpyridine}Cl]CF₃SO₃, [CH₃PhPtCl], [Pt{4′-(2”’-CH₃-phenyl)-6-(3”-isoquinoyl)-2,2’bipyridine}Cl]SbF₆, [CH₃PhisoqPtCl], [Pt{2-(2′-pyridyl)-1,10-phenanthroline}Cl]Cl, [pyPhenPtCl], and [Pt(terpyridine)Cl]⁺, [PtCl] with a series of nucleophiles: thiourea (TU), N,N-dimethylthiourea (DMTU), N,N,N,N-tetramethylthiourea (TMTU), I^–, Br^–, and SCN^– were studied in 0.1 M LiCF₃SO₃ in methanol (in the presence of 10 mM LiCl). The reactivity of the investigated complexes follows the order pyPhenPtCl > PtCl > CH₃PhPtCl > CH₃PhisoqPtCl. The lability of the chloride ligand is dependent on the strength of ¦Ð-backbonding properties of the spectator ligands around the platinum center. The exptl. data is strongly supported by DFT calculations The dependence of the second-order rate constants on concentration of the nucleophiles as well as the large neg. values reported for the activation entropy (¦¤S^?) confirmed an associative mechanism of substitution.

Dalton Transactions published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia