Tag: M.W=100-150

Yin, Sheng-Zhen published the artcileReaction of 3-iodo-4-oxo-4-H-1-benzopyran with thioureas, COA of Formula: C3H8N2S, the publication is Youji Huaxue (1996), 16(1), 34-7, database is CAplus.

Michael reaction of 3-iodo-4-oxobenzo-4H-pyran (I) with thioureas were reported. E.g, refluxing I with N,N-dimethylthiourea , K₂CO₃, and tetrabutylammonium chloride in benzene for 18 h gave 63% 1,3-dimethyl-2-thioxo-5-(2-hydroxybenzoyl)-4-imidazoline and 20% 3-methyl-2-methylimino-5-(2-hydroxybenzoyl)-4-thiazoline.

Youji Huaxue published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is Al2H32O28S3, COA of Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Long, Yang published the artcileNickel-Catalyzed Synthesis of an Aryl Nitrile via Aryl Exchange between an Aromatic Amide and a Simple Nitrile, Recommanded Product: 2-Methylbenzoic acid, the publication is ACS Catalysis (2022), 12(8), 4688-4695, database is CAplus.

A nickel-catalyzed synthesis of an aryl nitrile via aryl exchange between an aromatic amide and a simple nitrile was developed. By using cheap, easy-to-handle, and low-toxic 4-cyanopyridine as the cyanating source, cyanation of various aromatic amides afforded an assortment of aryl nitriles including bioactive drugs and organic luminescent mols. in good yields. The reaction exhibited wide substrate scope, good functional group tolerance, and unique selectivity that were complementary to traditional methods. Moreover, two key nickel complexes formed by oxidative addition to each substrate are obtained and determined by X-ray crystallog., which gave strong support for the mechanism elucidations.

ACS Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fang, Ze-Yu published the artcileDesign, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors, HPLC of Formula: 118-90-1, the publication is Chemistry & Biodiversity (2022), 19(6), e202200189, database is CAplus and MEDLINE.

A series of novel quinazolinone hydrazide derivatives were designed and synthesized as EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti-tumor cell proliferation and EGFR inhibitory activities. In the comprehensive anal. of all the tested compounds, the target compound 9c showed the best anti-tumor cell proliferation activity, (IC50=1.31 ¦ÌM for MCF-7, IC50=1.89 ¦ÌM for HepG2, IC50=2.10 ¦ÌM for SGC), and IC50=0.59 ¦ÌM for the EGFR inhibitory activity. Docking results showed that compound 9c could ideally insert the active site and interact with the critical amino acid residues (Val702, Lys721, Met769, Asp831) in the active site.

Chemistry & Biodiversity published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Yong-Jin published the artcileSynthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE, Related Products of catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(10), 2654-2660, database is CAplus and MEDLINE.

A series of N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)-butan-2-yl)benzamides, i.e. I, has been synthesized as BACE inhibitors. A variety of P2 and P3 substituents has been explored, and these efforts have culminated in the identification of several 1,3,5-trisubstituted phenylcarboxyamides with potent BACE inhibitory activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C25H23NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wen, Si published the artcileRuthenium(II)-catalyzed synthesis of CF₃-isoquinolinones via C-H activation/annulation of benzoic acids and CF₃-imidoyl sulfoxonium ylides, Safety of 2-Methylbenzoic acid, the publication is Organic Chemistry Frontiers (2022), 9(16), 4388-4393, database is CAplus.

A ruthenium(II)-catalyzed C-H activation/annulation reaction of benzoic acids and CF₃-imidoyl sulfoxonium ylides enabled by weak O-coordination was achieved. A series of 3-trifluoromethyl-isoquinolinones I [R = Ph, 2-MeC₆H₄, CH₂CH₂Ph, etc.; R¹ = 8-Me, 7-F, 6-I, etc.; R² = F, CF₂CF₃, CF₂CF₂CF₃] were synthesized in 37-75% yields under redox-neutral reaction conditions.

Organic Chemistry Frontiers published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C4H6BrFO2, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Yuanjing published the artcilePotassium tert-Butoxide Facilitated Amination of Carboxylic Acids with N,N-Dimethylformamide, SDS of cas: 118-90-1, the publication is Synthesis (2022), 54(16), 3595-3604, database is CAplus.

A practical and efficient potassium tert-butoxide (KO^tBu)-facilitated amination of carboxylic acids with N,N-dimethylamine was described. In the presence of catalytic amount of KO^tBu, a variety of aliphatic and aromatic carboxylic acids were transformed to N,N-dimethylamides using DMF as the dimethylamine reagent with the assistance of trimethylacetic anhydride. The applicability of this protocol was demonstrated by late-stage dimethylamidation of complex drug mols. A plausible reaction mechanism involving KO^tBu-facilitated in-situ amine generation from formamide decomposition and anhydride-mediated condensation was proposed on the basis of mechanistic investigations.

Synthesis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, SDS of cas: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Yuting published the artcileComparison of gut microbial communities, free amino acids or fatty acids contents in the muscle of wild Aristichthys nobilis from Xinlicheng reservoir and Chagan lake, Application of (S)-2-Amino-4-(methylthio)butanoic acid, the publication is BMC Microbiology (2022), 22(1), 32, database is CAplus and MEDLINE.

Fish is favored by consumers, while amino acids and fatty acids are the main nutrients of muscle. At present, it has been found that the gut microbial community may be involved in the regulation of host material anabolism. Juvenile and adult bighead carp (A. nobilis) from Chagan lake and Xinlicheng reservoir were selected, and divided into four groups to compare the differences of gut microbial communities, free amino acid and fatty acids in muscle. The results showed that fish in different lakes or ages contained specific microbiota, the gut microbial structure was similar, but the microbial content was significantly different. Gut microbial abundance of juvenile fish in Chagan lake was significantly higher than that of other groups. Phylum level anal. Proteobacteria was the dominant gut bacteria of fish in both adult and juvenile fish from two sep. lakes. Actinobacteria was another dominant bacterial phylum in juvenile fish in both lakes. Contents of free amino acids and fatty acids in muscle were detected, and the relationships between them and gut microbial communities were analyzed. Bighead carp grew from juvenile to adult, Actinobacteria abundance decreased (P < 0.05) and Proteobacteria increased (P < 0.05). Proteobacteria was pos. correlated with the contents of Thr, Lys, Pro, Asp, Gly and Glu, Actinobacteria was neg. correlated with Met and His. Meanwhile, EPA and DHA were pos. correlated with Proteobacteria, EPA and DHA were not significantly associated with Actinobacteria. It was speculated that the contents of free amino acids and fatty acids in muscle might be affected by the difference of gut microbiota, thus affecting the taste and nutritional quality.

BMC Microbiology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Application of (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ruan, Xiao-Yun published the artcilePhotoinduced and palladium-catalyzed hydrogen atom transfer triggered 1,2-difunctionalization of 1,3-dienes with hydroxamides, Computed Properties of 118-90-1, the publication is Science China: Chemistry (2022), 65(5), 863-869, database is CAplus.

The discovery of novel catalysis modes to generate a significant increase in structural complexity from readily available reactants is a fundamental goal in modern organic synthesis. Here, Authors report a photoinduced palladium-catalyzed hydrogen atom transfer triggered 1,2-difunctionalization of conjugated dienes. Without the employment of exogeneous photosensitizers and external oxidants, the cascade reaction realized the integration of remote functionalization of various C(sp³)-H bonds and selective difunctionalization of 1,3-dienes with 100% atom efficiency, allowing for the synthesis of structurally diverse amides with up to 90% yields. Given the prevalence of amides in pharmaceuticals and natural products, the current protocol has provided an efficient means to access highly functionalized amides from readily available carboxylic acid derivatives and 1,3-dienes.

Science China: Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zaitsev, S. Yu. published the artcileThin films with immobilized bis-crown-ether dye, Synthetic Route of 10517-44-9, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2011), 383(1-3), 120-124, database is CAplus.

Thin films based on photosensitive bis-crown-ether dye were prepared by Langmuir and “modified spreading” techniques. The maximal changes in the surface pressure – and surface potential-mol. area isotherms (the relative mol. area increase was about 16%), in the absorption (shifts of ¦Ë _max up to 9 nm) and fluorescence (shifts of ¦Ë _max up to 17 nm) spectra of these films in the presence of diaminoalkane dihydrochlorides in the aqueous subphase were found.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C12H15ClO3, Synthetic Route of 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zaitsev, Sergei Yu. published the artcileUltrathin chemosensory films with a photosensitive bis(crown ether) derivative, COA of Formula: C3H12Cl2N2, the publication is Mendeleev Communications (2008), 18(5), 270-272, database is CAplus.

The spectral and isotherm changes observed for a new photosensitive bis(crown ether) derivative assigned as optical mol. tweezers (OMT) in mixed monolayers with stearic acid by addition of ammonium and diammonium salts indicated the strongest complex formation between OMT and 1,3-diaminopropane dihydrochloride that may be of particular interest for design of chemosensory nanomaterials.

Mendeleev Communications published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C4Br2N2O4S, COA of Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia