Tag: M.W=100-150

Kraml, Michael published the artcileAgents affecting lipid metabolism. VIII. N,N’-Dibenzylethylenediamine, the key to a novel class of cholesterol biosynthesis inhibitors, Recommanded Product: Propane-1,3-diamine dihydrochloride, the publication is Journal of Medicinal Chemistry (1964), 7(4), 500-3, database is CAplus and MEDLINE.

cf. CA 58, 13786h; 60, 11242c. A number of mevalonic acid analogs and their N,N’-dibenzylethylenediamine (I) salts were tested for their effect on the incorporation of mevalonate-2-¹⁴C into cholesterol by rat liver homogenates. In contrast to the mevalonic acid analogs, their I salts exhibited an inhibitory property which was found to reside in I itself. The site of action of I is at the level of the conversion of 7-dehydrocholesterol to cholesterol. I was moderately effective in lowering serum sterols in hypercholesterolemic rats. Mol. modifications of I have resulted in compounds of increased potency, showing activity in vitro at a concentration of 10^-8M.

Journal of Medicinal Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Recommanded Product: Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

London, Clare published the artcileImidazopyridines: a novel class of hNa_v1.7 channel blockers, Related Products of catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(5), 1696-1701, database is CAplus and MEDLINE.

A series of imidazopyridines were evaluated as potential sodium channel blockers for the treatment of neuropathic pain. Several members were identified with good hNa_v1.7 potency and excellent rat pharmacokinetic profiles. Compound I had good efficacy (52% and 41% reversal of allodynia at 2 and 4 h post-dose, resp.) in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain when dosed orally at 10 mg/kg.

Bioorganic & Medicinal Chemistry Letters published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cui, Liu published the artcileRuthenium(II) complexes bearing chelating Carboxylate-anchored normal and abnormal Carbenes: Synthesis, characterizations and catalytic applications, Related Products of catalysis-chemistry, the publication is Polyhedron (2022), 115593, database is CAplus.

Functionalized abnormal/mesoionic NHC (NHC = N-heterocyclic carbene) complexes have been much less investigated in contrast to their normal NHC counterparts. In this work, a series of [C_carbene?_carboxylate]- and [C_carbene?’_phenyl]-type Ru(II) complexes bearing normal and abnormal NHCs have been synthesized. Their spectroscopic features, solid-state structure and aquation reactivity have also been reported. All the as-synthesized complexes have served as precatalysts to catalyze intramol. or intermol. carboxylic acid-to-alkyne addition reactions. It was found that the catalytic behavior of abnormal NHC complexes is superior to that of the normal NHC analogs. An anti-Markovnikov addition reactivity, leading to the formation of an E-type enol ester as the major product, was observed A few stoichiometric experiments have also been carried out to provide preliminary insight into the catalytic mechanism.

Polyhedron published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kuroda, Tokuyuki published the artcileSynthesis and biological activity of novel mitomycin C analogs derived from mitomycin A, Related Products of catalysis-chemistry, the publication is Journal of Heterocyclic Chemistry (1994), 31(1), 113-19, database is CAplus.

A variety of mitomycin C analogs were synthesized from mitomycin A and their biol. activities were studied. Mitomycin A (I) underwent nucleophilic displacement reactions involving intramol. hydrogen migrations upon treatment with nitrogen nucleophiles bearing mobile hydrogens, but the mode of hydrogen migration depended on the nature of the nucleophiles. The reaction with alkoxyamines gave oximes II (R = Me, CH₂CHMe₂). However, the reaction with hydroxylamine and benzohydrazine afforded imines III (R¹ = OH, NHBz). These products were converted into various types of mitomycin C derivatives by methylation with Me iodide or di-Me sulfate. The mechanistic features of these reactions are discussed. The in vitro and in vivo biol. activities were tested by using P388 leukemia and Sarcoma 180 tumor cells. Several of the synthesized compounds exhibited better activity than that of mitomycin C.

Journal of Heterocyclic Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mertens, Lucas published the artcileFluoroalkyl-Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines, Recommanded Product: 1,1,1-Trifluoropropan-2-amine, the publication is Chemistry – A European Journal (2016), 22(28), 9542-9545, database is CAplus and MEDLINE.

A novel continuous-flow approach for the synthesis of fluoroalkyl-substituted diazomethanes has been developed. Utilizing a cheap, self-made microreactor fluoroalkyl-substituted amines were transformed into the corresponding diazomethanes using tert-Bu nitrite and acetic acid as catalyst. These diazomethanes were employed in [2+3] cycloaddition reactions with olefins and alkynes, yielding valuable pyrazolines and pyrazoles, e.g. I, in good to excellent yields.

Chemistry – A European Journal published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Recommanded Product: 1,1,1-Trifluoropropan-2-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Coelho, Paula P. published the artcileEndosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation, Product Details of C5H11NO2S, the publication is Nature Communications (2022), 13(1), 3812, database is CAplus and MEDLINE.

Autophagy selectively targets cargo for degradation, yet mechanistic understanding remains incomplete. The ATG8-family plays key roles in autophagic cargo recruitment. Here by mapping the proximal interactome of ATG8-paralogs, LC3B and LC3C, we uncover a LC3C-Endocytic-Associated-Pathway (LEAP) that selectively recruits plasma-membrane (PM) cargo to autophagosomes. We show that LC3C localizes to peripheral endosomes and engages proteins that traffic between PM, endosomes and autophagosomes, including the SNARE-VAMP3 and ATG9, a transmembrane protein essential for autophagy. We establish that endocytic LC3C binds cargo internalized from the PM, including the Met receptor tyrosine kinase and transferrin receptor, and is necessary for their recruitment into ATG9 vesicles targeted to sites of autophagosome initiation. Structure-function anal. identified that LC3C-endocytic localization and engagement with PM-cargo requires the extended carboxy-tail unique to LC3C, the TBK1 kinase, and TBK1-phosphosites on LC3C. These findings identify LEAP as an unexpected LC3C-dependent pathway, providing new understanding of selective coupling of PM signalling with autophagic degradation

Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Product Details of C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Roe, Stephen P. published the artcileCorrelation of x-ray photoelectron spectroscopic core level binding energies with melting point for a series of diamine dihydrochlorides, HPLC of Formula: 10517-44-9, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (1985), 95(4), 397-408, database is CAplus.

XPS and DTA studies of a series of diamine dihydrochlorides showed that a linear relation exists between the Ni(1s) and Cl(2p_3/2) binding energy shifts and the m.ps. of these salts. A theor. model is presented to verify this empirical correlation. Such binding energy shifts and m.ps. are also dependent upon intrinsic electronic and bonding features of these salts such as quaternary N substituent inductive effects, charge delocalization within the cation, cation-anion interaction, and salt hydration.

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, HPLC of Formula: 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Jie published the artcileDual-enhancement on electrochemical performance with thioacetamide as an electrolyte additive for lithium-sulfur batteries, COA of Formula: C3H8N2S, the publication is Electrochimica Acta (2021), 138041, database is CAplus.

Li-S (Li-S) batteries with high theor. specific capacity and ascendancy of raw materials are considered as a potential candidate for next-generation energy storage system. However, some intractable challenges, such as low S use caused by the loss of active materials and surface passivation resulted from the deposition of insulating products, still hinder the practical application of Li-S batteries. Herein, various types of thioamides with different mol. structures were studied as electrolyte additives to enhance the electrochem. performance of Li-S cells by adjusting the solubility of the final product, Li₂S. The thioamides that contain H in primary-amine or secondary-amine groups are prone to generate recyclable active materials. Specifically, thioacetamide (TAA) as an electrolyte additive not only provides extra reversible capacity, but also boosts the solubility of Li₂S by intermol. H bonds, alleviating the passivation of the electrode and enhancing kinetics for the conversion of polysulfide to Li₂S. Therefore, the cells with TAA additive exhibit superior cycle performance and rate performance.

Electrochimica Acta published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, COA of Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jin, Ruitao published the artcileIon currents through Kir potassium channels are gated by anionic lipids, Name: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Nature Communications (2022), 13(1), 490, database is CAplus and MEDLINE.

Ion currents through potassium channels are gated. Constriction of the ion conduction pathway at the inner helix bundle, the textbook gate of Kir potassium channels, has been shown to be an ineffective permeation control, creating a rift in our understanding of how these channels are gated. Here we present evidence that anionic lipids act as interactive response elements sufficient to gate potassium conduction. We demonstrate the limiting barrier to K⁺ permeation lies within the ion conduction pathway and show that this gate is operated by the fatty acyl tails of lipids that infiltrate the conduction pathway via fenestrations in the walls of the pore. Acyl tails occupying a surface groove extending from the cytosolic interface to the conduction pathway provide a potential means of relaying cellular signals, mediated by anionic lipid head groups bound at the canonical lipid binding site, to the internal gate.

Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Name: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Baifan published the artcilePrediction and molecular field view of drug resistance in HIV-1 protease mutants, Product Details of C5H11NO2S, the publication is Scientific Reports (2022), 12(1), 2913, database is CAplus and MEDLINE.

Conquering the mutational drug resistance is a great challenge in anti-HIV drug development and therapy. Quant. predicting the mutational drug resistance in mol. level and elucidating the three dimensional structure-resistance relationships for anti-HIV drug targets will help to improve the understanding of the drug resistance mechanism and aid the design of resistance evading inhibitors. Here the MB-QSAR (Mutation-dependent Biomacromol. Quant. Structure Activity Relationship) method was employed to predict the mol. drug resistance of HIV-1 protease mutants towards six drugs, and to depict the structure resistance relationships in HIV-1 protease mutants. MB-QSAR models were constructed based on a published data set of Ki values for HIV-1 protease mutants against drugs. Reliable MB-QSAR models were achieved and these models display both well internal and external prediction abilities. Interpreting the MB-QSAR models supplied structural information related to the drug resistance as well as the guidance for the design of resistance evading drugs. This work showed that MB-QSAR method can be employed to predict the resistance of HIV-1 protease caused by polymorphic mutations, which offer a fast and accurate method for the prediction of other drug target within the context of 3D structures.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C12H17NO2, Product Details of C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia