Tag: M.W=100-150

Li, Yinruizhi published the artcileTranscriptome profiling revealed candidate genes, pathways and transcription factors related to nitrogen utilization and excessive nitrogen stress in perennial ryegrass, COA of Formula: C5H11NO2S, the publication is Scientific Reports (2022), 12(1), 3353, database is CAplus and MEDLINE.

Ryegrass (Lolium perenne L.), a high-quality forage grass, is a good nutrient source for herbivorous livestock. However, improving nitrogen use efficiency and avoiding nitrate toxicity caused by excessive nitrogen are continual challenges in ryegrass production The mol. mechanism underlying the response of ryegrass to nitrogen, especially excessive nitrogen, remains unclear. In this study, the transcriptomic changes under different nitrogen levels were investigated in perennial ryegrass by high-throughput next-generation RNA sequencing. Phenotypic characterization showed that treatment with half of the standard N concentration (N0.5) led to a better growth state than the other three treatments. The treatments with the standard N concentration (N1) and treatments with ten times higher than the standard N concentration (N10) contained excessive nitrogen, which placed stress on plant growth. Anal. of differentially expressed genes indicated that 345 and 104 genes are involved in the regulation of nitrogen utilization and excessive nitrogen stress, resp. KEGG enrichment anal. suggested that “photosynthesis-antenna proteins” may respond pos. to appropriate nitrogen conditions, whereas “steroid biosynthesis”, “carotenoid biosynthesis” and “C5-branched dibasic acid metabolism” were identified as the top significantly enriched pathways in response to excessive nitrogen. Addnl., 21 transcription factors (TFs) related to nitrogen utilization were classified into 10 families, especially the AP2-EREBP and MYB TF families. Four TFs related to excessive nitrogen stress were identified, including LOBs, NACs, AP2-EREBPs and HBs. The expression patterns of these selected genes were also analyzed. These results provide new insight into the regulatory mechanism of ryegrass in response to nitrogen utilization and excessive nitrogen stress.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Chi-Tien published the artcileZinc complexes containing coumarin-derived anilido-aldimine ligands as catalysts for ring opening polymerization of L-lactide, Synthetic Route of 6950-53-4, the publication is Molecules (2015), 20(4), 5313-5328, database is CAplus and MEDLINE.

The coumarin-derived ligand precursors L¹H-L⁶H have been prepared Treatment of these ligand precursors with 1.2 equivalent of ZnEt₂ in toluene affords zinc Et complexes (LZnEt) 1-6 (where L = coumarin-derived ligands bearing different functional groups). Reaction of ligand precursor L³H with 1.5 equivalent of Zn[N(SiMe₃)₂]₂ in toluene affords the zinc amide complex, L³ZnN(SiMe₃)₂, 7. All these compounds were characterized by NMR spectroscopy and elemental anal. The mol. structures are reported for 1 and 7. The catalytic activities of complexes 1-7 towards the ring opening polymerization of L-lactide in the presence of 9-AnOH have been investigated.

Molecules published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Synthetic Route of 6950-53-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zuo, Dongxu published the artcileHighly Chemoselective Transamidation of Unactivated Tertiary Amides by Electrophilic N-C(O) Activation by Amide-to-Acyl Iodide Re-routing, Computed Properties of 118-90-1, the publication is Angewandte Chemie, International Edition (2022), 61(24), e202202794, database is CAplus and MEDLINE.

The challenging transamidation of unactivated tertiary amides has been accomplished via cooperative acid/iodide catalysis. Most crucially, the method provides a novel manifold to re-route the reactivity of unactivated N,N-dialkyl amides through reactive acyl iodide intermediates, thus reverting the classical order of reactivity of carboxylic acid derivatives This method provides a direct route to amide-to-amide bond interconversion with excellent chemoselectivity using equivalent amounts of amines. The combination of acid and iodide has been identified as the essential factor to activate the amide C-N bond through electrophilic catalytic activation, enabling the production of new desired transamidated products with wide substrate scope of both unactivated amides and amines, including late-stage functionalization of complex APIs (>80 examples). Authors anticipate that this powerful activation mode of unactivated amide bonds will find broad-ranging applications in chem. synthesis.

Angewandte Chemie, International Edition published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H15ClN2, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gu, Chengyihan published the artcileVisible-light-mediated amidation from carboxylic acids and tertiary amines via C-N cleavage, Quality Control of 118-90-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(39), 5873-5876, database is CAplus and MEDLINE.

Synthesis of tertiary amides RC(O)NR₁R₂ [R = Ph, 4-MeC₆H₄, 4-PhC₆H₄, etc.; R¹ = R² = Et, n-Pr; R¹R² = CH₂(CH₂)₃CH₂] via iridium photocatalyzed amidation of carboxylic acids and tertiary amines through C-N bond cleavage was reported. A wide scope of structurally diverse carboxylic acids participated smoothly in the reaction, providing the desired tertiary amides with moderate-to-good yields (up to 93% yield). This amidation strategy provided an alternative way to address the regioselectivity between nucleophilic functional groups, thus complementing the functional group compatibility of classical amidation protocols. Its synthetic robustness was also proved by the late-stage modification of several complex mols. and gram-scale applications.

Chemical Communications (Cambridge, United Kingdom) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Xin-yang published the artcileDiscovery of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer growth and angiogenesis, Formula: C8H8O2, the publication is Bioorganic Chemistry (2022), 105469, database is CAplus and MEDLINE.

Targeting EGFR and HER-2 is an essential direction for cancer treatment. Here, a series of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure was designed and synthesized to serve as EGFR/HER-2 dual-target inhibitors. The kinase assays verified that target compounds could inhibit the kinase activity of EGFR and HER-2 selectively. The results of CCK-8 and 3D cell viability assays confirmed that target compounds had excellent anti-proliferation ability against breast cancer cells (MCF-7 and SK-BR-3) and lung cancer cells (A549 and H1975), particularly against SK-BR-3 cells, while the inhibitory effect on healthy breast cells (MCF-10A) and lung cells (Beas-2B) was weak. Among them, the hit compound YH-9 binded to EGFR and HER-2 stably in mol. dynamics studies. Further studies found that YH-9 could induce the release of cytochrome c and inhibit proliferation by promoting ROS expression in SK-BR-3 cells. Moreover, YH-9 could diminish the secretion of VEGF and bFGF factors in SK-BR-3 cells, then inhibited tube formation and angiogenesis. Notably, YH-9 could effectively inhibit breast cancer growth and angiogenesis with little toxicity in the SK-BR-3 cell xenograft model. Taken together, in vitro and in vivo results revealed that YH-9 had high drug potential as a dual-target inhibitor of EGFR/HER-2 to inhibit breast cancer growth and angiogenesis.

Bioorganic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pfennig, Victoria S. published the artcileMechanochemical Grignard Reactions with Gaseous CO₂ and Sodium Methyl Carbonate, Formula: C8H8O2, the publication is Angewandte Chemie, International Edition (2022), 61(9), e202116514, database is CAplus and MEDLINE.

A one-pot, three-step protocol for the preparation of Grignard reagents from organobromides RBr [R = 2-naphthyl, 2-thienyl, 1-adamantyl, etc.] in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO₂) or sodium Me carbonate providing aryl and alkyl carboxylic acids RC(O)OH in up to 82% yield are reported. The preparation has the short reaction times and the significantly reduced solvent amounts [2.0 equivalent for liquid assisted grinding (LAG) conditions]. Unexpectedly, aryl bromides with methoxy substituents lead to sym. ketones such as 2,2′-dimethoxybenzophenone and 2,2′,5,5′-tetramethoxybenzophenone as major products.

Angewandte Chemie, International Edition published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mermer, Arif published the artcileBenzotriazole-oxadiazole hybrid Compounds: Synthesis, anticancer Activity, molecular docking and ADME profiling studies, Recommanded Product: 2-Methylbenzoic acid, the publication is Journal of Molecular Liquids (2022), 119264, database is CAplus.

Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized using both conventional method and ultrasound sonication (US) as an environmentally friendly method. It was observed that the US method provided an increase in reaction yields by reducing the reaction time approx. 3-fold. The synthesized compounds were investigated against PANC-1 cell line. All obtained compounds were characterized by FT-IR, ¹H NMR, ¹³C NMR and MS spectroscopic techniques. The compounds 1-{[5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}-1H1,2,3-benzotriazole and 1-{[5-(3,4-dietoksiphenyl)-1,3,4-oxadiazol-2-yl]methyl}-1H1,2,3-benzotriazole exhibited very promising anticancer activity results with IC₅₀ values of 117.5 ¡À 0.084 ¦ÌM and 87.82 ¡À 4.319 ¦ÌM, resp. Further, mol. docking studies to suggest how the synthesized compounds interact with the kinase domain of human DDR1 in complex of pancreatic Cancer proteins (PDB ID: 6HP9), and the crystal structure of PDEd of pancreatic Cancer proteins (PDB ID: 5E80). It was concluded from the docking studies that the compound 1-{[5-(3,4-dietoksiphenyl)-1,3,4-oxadiazol-2-yl]methyl}-1H1,2,3-benzotriazole demonstrated the highest binding score values for active site of both proteins. Afterwards, ADME calculations were performed to examine the drug properties of benzotriazole-oxadiazole hybrid compounds

Journal of Molecular Liquids published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Milosavljevic, Milutin M. published the artcileOptimization of the synthesis of N-alkyl and N,N-dialkyl thioureas from waste water containing ammonium thiocyanate, Computed Properties of 6972-05-0, the publication is Chemical Industry & Chemical Engineering Quarterly (2015), 21(4), 501-510, database is CAplus.

The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work. Thioureas synthesis was developed in two ways: Method I – reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II – reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, ¹H- and ¹³C-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatog. method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of byproducts and technol. applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacol. active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technol. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods.

Chemical Industry & Chemical Engineering Quarterly published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

de Almeida, Barbara Lucia published the artcileSynthesis and characterization of new ternary Cu(II)-polyamines-ATP complexes, Safety of Propane-1,3-diamine dihydrochloride, the publication is Inorganica Chimica Acta (2009), 362(7), 2447-2451, database is CAplus.

Four new complexes of Cu(II) of stoichiometry [Cu(ATP)(polyamine)] containing polyamines (PA) ethylenediamine, 1,3-diaminopropane, spermidine, or spermine and ATP were prepared from aqueous solution at pH 6. Synthesis, characterization, thermogravimetric, vibrational spectroscopy, and ESR analyses are described and show that these complexes have similar mol. structures. IR spectra and the thermal anal. are briefly discussed based on the peculiarities of the complexes. The IR spectra of the ligands and their copper complexes were used to assign the various groups and compare the shifts due to complexation. ESR parameters values for the complexes show that Cu(II) is complexed in a similar way in the four complexes. Similarity in the coordination mode of complexes in solid state has been determined and discussed. The data obtained suggest that the four complexes contain one water mol. of hydration and are complexed through two oxygen atoms from ATP and through two nitrogen atoms of each polyamine.

Inorganica Chimica Acta published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Safety of Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Utinan, M. F. published the artcileSynthesis and properties of 2-amino-5-(3,5,6-trichloro-1,4-benzoquinon-2-yl)thiazoles, Related Products of catalysis-chemistry, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1988), 692-8, database is CAplus.

Thiazoles (in the form of betaines) I (R² = Me, R³ = H, Me, Ph, allyl, Ac; R² = Et, R³ = Me) were prepared in 76-99% yields from benzoquinones II (R¹ = Et) via an intermediate coumaran III by treatment with appropriate thioureas in EtOH or from I (R¹ = Et) and thioureas in dioxane containing concentrated HCl.H₂O. Treating I with FeCl₃.6H₂O in aqueous DMF gave 75-95% benzoquinones IV.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C12H14O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia