Tag: M.W=200-250

Liu, Xue-Li published the artcileAsymmetric Synthesis of Functionalized Nitrophenols via a Copper(II)-Mediated Bromination/Debromination Aromatization Sequence, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Asian Journal of Organic Chemistry (2017), 6(8), 967-972, database is CAplus.

2″A stereospecific copper(II)-mediated bromination/debromination aromatization sequence leading to functionalized nitrophenols I (R¹ = H, 4-Me, 4-Et, 3-Me; R² = 3-methoxypheyl, 2-naphthyl, thiophen-2-yl, etc.) from corresponding ¦Ã-nitroketones II is described. This provides a simple methodol. for the construction of nitrophenols I in moderate to good yields and moderate to high enantioselectivities.

Asian Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yan, Gang published the artcileDivergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process, Synthetic Route of 140-28-3, the publication is Chemistry – A European Journal (2020), 26(11), 2486-2492, database is CAplus and MEDLINE.

A highly efficient 2-chloroquinazolin-4(3H)-one rearrangement was developed that predictably generated either twisted-cyclic or ring-fused guanidines in a single operation, depending on the presence of a primary vs. secondary amine in the accompanying diamine reagent. Exclusive formation of twisted-cyclic guanidines results from pairing 2-chloroquinazolinones with secondary diamines. Use of primary amine-containing diamines permited a domino quinazolinone rearrangement/intramol. cyclization gated through (E)-twisted-cyclic guanidines to afford ring-fused N-acylguanidines. This scalable, structurally tolerant transformation generated 55 guanidines and delivered twisted-cyclic guanidines with robust plasma stability and an abbreviated total synthesis of an antitumor ring-fused guanidine (4 steps, 55% yield).

Chemistry – A European Journal published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C11H22N2O4, Synthetic Route of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Han published the artcileSulfoximidations of Benzylic C-H bonds by Photocatalysis, Name: Bis(4-fluorophenyl)methane, the publication is Angewandte Chemie, International Edition (2018), 57(20), 5863-5866, database is CAplus and MEDLINE.

An efficient photocatalytic functionalization of compounds with benzylic C-H bonds by sulfoximidation in visible light is described. The mild reaction conditions allow the use of a broad array of substrates, including diarylmethane, alkyl arenes, arylacetonitrile, 2-arylacetate, and alkynyl aryl methanes. The sulfoximidation process is highly chemoselective and leads to the corresponding sulfoximines, e.g. I, in generally good yields. Mechanistic investigations suggested the intermediacy of sulfoximidoyl radicals.

Angewandte Chemie, International Edition published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C20H17FO4S, Name: Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Jinqing published the artcileSeparation of lithium and transition metals from the leachate of spent lithium-ion battery by extraction-precipitation with p-tert-butylphenoxy acetic acid, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Hydrometallurgy (2021), 105768, database is CAplus.

Unlike common solvent extraction and chem. precipitation, a novel extraction-precipitation process for the separation of Li and transition metals using p-tertylphenoxyacetic acid (POAA) is developed. Extraction-precipitation method refers to a method in which the extraction-precipitant can quant. extract the metal ions to form solid extracted complex without the requirement of organic solvent or carrier, and the extraction-precipitant can be stripped and recycled. In this study, the extraction-precipitation mechanism and thermodn. parameters between POAA and manganese (Mn), cobalt (Co), nickel (Ni) were analyzed. Subsequently, the equilibrium time and pH value of the separation process were optimized. Finally, the leach solution of LIB having Li, Ni, Co, Mn with concentration of 3.52 g/L, 7.93 g/L, 5.72 g/L, and 14.16 g/L, resp., was studied for the separation at pH 4.5. The results indicate that efficient separation of Li and transition metals was possible by one-step precipitation using 0.2 mol/L POAA solution (degree of saponification = 100%) when the ratio of n_POAA/n_Mn+Co+Ni was 2. The separation factor for the transition metals over lithium (¦¢_CoNiMn/¦¢_Li) reached as high as 133,014. After the transition metal-loaded POAA was stripped with 2 mol/L sulfuric acid, the stripped solution could be used for the production of ternary material precursor, and the regenerated POAA could be recycled for the extraction-precipitation process. The lithium in the solution was recovered in the form of lithium carbonate (Li₂CO₃) with a purity level of 97.7%. This high efficiency and sustainable process based on extraction-precipitation has shown potential application for spent LIB recovery.

Hydrometallurgy published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shi, Jiang-Ling published the artcileFe-Promoted Chlorobenzylation of Terminal Alkynes through Benzylic C(sp³)-H Bond Functionalization, SDS of cas: 457-68-1, the publication is Organic Letters (2016), 18(6), 1238-1241, database is CAplus and MEDLINE.

A chlorobenzylation of terminal alkynes through Fe(II)-promoted benzylic C(sp³)-H bond functionalization in the presence of NCS as a chloride source was developed. Compared with previous methods to prepare polysubstituted alkenyl halides, the present procedure provides an efficient alternative with high atom and step economy under mild conditions. The transformation was established to proceed through a single-electron transfer (SET) process with benzyl cations as key intermediates.

Organic Letters published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C15H10O2, SDS of cas: 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khachatryan, R. H. published the artcilePhase-transfer catalysis in synthesis of unsaturated phosphine oxides, SDS of cas: 4141-48-4, the publication is Khimicheskii Zhurnal Armenii (1999), 52(1-2), 77-84, database is CAplus.

Unsaturated tertiary phosphine oxides were prepared in 51-93% yields by reaction of R₂P(O)H (R = Ph, Et) with alkenyl or alkynyl halides, e.g., CH₂:CHCH₂Br, ClCH₂CH:CMe₂, ClCH₂CH:C(Me)Cl, ClCH₂Cú·CMe, ClCH₂Cú·CH, ClCH₂CH:CH₂, in C₆H₆ containing a catalytic amount of Katamine AB and excess KOH or K₂CO₃. The nature of the base affects the structure of the products obtained. Effective methods for synthesis of tertiary phosphine oxides with 1- and 2-propenyl, substituted 2-propenyl, 1,2-propadienyl, 1-propynyl and 2-butynyl groups were worked out. A higher tendency for isomerization of diphenyl-2-propynyl-phosphine oxide as compared with the di-Et analog was observed Use of phase-transfer catalysis for synthesis of unsaturated tertiary phosphine oxides is preferable to a superbasic medium.

Khimicheskii Zhurnal Armenii published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, SDS of cas: 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Alizadeh, N. published the artcileSpectroscopic studies of charge-transfer complexation of iodine with a new benzo-substituted macrocyclic diamide in chloroform, dichloromethane and their 1:1 mixture, Application In Synthesis of 5411-14-3, the publication is Journal of the Iranian Chemical Society (2008), 5(4), 610-616, database is CAplus.

Charge-transfer complexation of iodine with a new benzo-substituted macrocyclic diamide 5,6,7,8,9,10-hexahydro-2H-1,13,4,7,10-benzodioxatriazacyclopentadecine-3,11(4H,12H)-dione (L) with iodine was studied spectrophotometrically in chloroform, dichloromethane and their 1:1 (volume/volume) mixture The observed time dependence of the charge-transfer band and subsequent formation of I₃^– ion are related to the slow formation of the initially formed 1:1 L.I₂ outer complex to an inner electron donor-acceptor (EDA) complex, followed by fast reaction of the inner complex with iodine to form a triiodide ion, as follows:. L + I₂ ¡ú L.I₂ (outer complex), fast. L.I₂ (outer complex) ¡ú (L.I⁺)I^– (inner complex), slow. (L.I⁺)I^– (inner complex) + I₂ ¡ú (L.I⁺)I₃^–, fast. The pseudo-first-order rate constants for the transformation process were evaluated in different solvent systems. The stability constants of the resulting EDAr complexes were also evaluated and the solvent effect on their stability is discussed. The resulting complexes were isolated and characterized by FTIR and ¹H NMR spectroscopy.

Journal of the Iranian Chemical Society published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Application In Synthesis of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sharghi, Hashem published the artcileEfficient synthesis of some novel macrocyclic diamides using fast addition method, Category: catalysis-chemistry, the publication is Synthesis (2006), 999-1004, database is CAplus.

Synthesis of some new macrocyclic diamides based on catechol scaffold (I; X = (CH₂)₃, (CH₂)₆, CH₂CH₂NHCH₂CH₂, naphthalene-1,8-diyl, 3-nitro-1,2-phenylene, 3-methoxycarbonyl-1,2-phenylene, 3-pentyloxycarbonyl-1,2-phenylene, 3-octyloxycarbonyl-1,2-phenylene) and (II; X =3-methoxycarbonyl-1,2-phenylene, 3-pentyloxycarbonyl-1,2-phenylene, 3-octyloxycarbonyl-1,2-phenylene) by cyclization reactions between various diamines, i.e. 1,3-propanediamine, 1,6-hexanediamine, 3-aza-1,5-pentanediamine, 3-nitro-1,2-benzenediamine, Et 3,4-diaminobenzoate, pentyl 3,4-diaminobenzoate, or octyl; 3,4-diaminobenzoate, and 2-[2-(2-chloro-2-oxoethoxy)phenoxy]ethanoyl chloride using fast addition method has been described. The reactions were carried out in short reaction times and the expected macrocycles were obtained in good to high yields.

Synthesis published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C14H22O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yoshiji, Hitoshi published the artcileCombination of copper-chelating agent, trientine, and methotrexate attenuates colorectal carcinoma developmental and angiogenesis in mice, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Oncology Reports (2005), 14(1), 213-218, database is CAplus.

Recent studies have suggested that an antiangiogenic agent could improve the inhibitory effects of standard chemotherapeutic drugs against tumor development. We previously reported that the clin. used copper-chelating agent, trientine dihydrochloride (trientine), exerted strong anti-angiogenic activity and inhibited tumor growth. The aim of the current study was to examine the combined effect of trientine and methotrexate on the development and angiogenesis of xenograft human colorectal carcinoma (CRC) cells at clin. comparable low doses. When used individually, both trientine and methotrexate significantly suppressed CRC development along with inhibition of neovascularization in the tumor. A combination regimen of trientine and methotrexate exerted the most potent tumoricidal effect and led to ‘tumor dormancy.’. The combination of these agents also resulted in a marked suppression of the angiogenic factors, in particular the vascular endothelial growth factor and interleukin-8, and an increase of apoptosis in the tumor. In vitro studies revealed that neither trientine nor methotrexate was cytotoxic for tumor cells. On the other hand, the endothelial cell proliferation and tubular formation were significantly suppressed by these agents. The combined treatment of trientine and methotrexate at clin. comparable low doses could inhibit CRC development and angiogenesis, as well as suppress the angiogenic factors. Because both agents are widely used in clin. practice, the combination regimen may represent a potential new strategy for CRC therapy in the future.

Oncology Reports published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C3H5BN2O2, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saidalimu, Ibrayim published the artcileThe CF₃-DAST-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones/lactams/lactones and its extension to deacylative pentafluorophenylthiolation, COA of Formula: C9H9F5Si, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(63), 8761-8764, database is CAplus and MEDLINE.

A trifluoromethyl analog of diethylaminosulfur trifluoride (CF₃-DAST)-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones, lactams, and lactones that provide cyclic ¦Á-trifluoromethylthioketones, lactams, and lactones is reported. To the best of knowledge, this method represents the first example of the trifluoromethylthiolation of lactams. A corresponding deacylative pentafluorophenylthiolation using a pentafluorophenyl analog of diethylaminosulfur trifluoride (C₆F₅-DAST) was also attempted.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, COA of Formula: C9H9F5Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia