Tag: M.W=200-250

Lobe, Maloba M. M. published the artcile3′,4′-Dihydro-2’H-spiro[indoline-3,1′-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Royal Society Open Science (2020), 7(1), 191316, database is CAplus and MEDLINE.

In the present study, 3′,4′-dihydro-2’H-spiro[indoline-3,1′-isoquinolin]-2-ones, designed as mol. hybrids of THIQ and OX, were synthesized and screened in-vitro against 59 cell lines in the NCI-60 screen. Twenty compounds displayed weak to moderate inhibition of cell proliferation; among them, three compounds displayed at least 50% inhibition of cell proliferation. The compounds appeared to target primarily renal cell cancer lines; however, leukemia, melanoma, non-small cell lung cancer, prostate, ovarian and even breast cancer cell lines were also affected. Therefore, this class of spirooxindoles may provide useful leads in the search for new anti-cancer agents.

Royal Society Open Science published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Yaxing published the artcileManganese(III) acetate catalyzed oxidative amination of benzylic C(sp³)-H bonds with nitriles, Application In Synthesis of 457-68-1, the publication is Organic & Biomolecular Chemistry (2017), 15(14), 2897-2901, database is CAplus and MEDLINE.

Mn-Catalyzed oxidative amination of benzylic C(sp³)-H bonds with nitriles was disclosed, which enabled the synthesis of a broad range of secondary amides I [R = Ph, 4-H₃CC₆H₄, 3-MeoC₆H₄, etc.; R¹ = Me, i-Pr, t-Bu, etc.; R² = Me, Ph, 4-ClC₆H₄, etc.] in moderate to excellent yields under mild conditions. The interaction between Mn(III) and DDQ facilitates the oxidation and makes it highly efficient and selective.

Organic & Biomolecular Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C6H13NO2, Application In Synthesis of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cheng, Ying published the artcileIron-Catalyzed Hetero-Cross-Dehydrogenative Coupling Reactions of Sulfoximines with Diarylmethanes: A New Route to N-Alkylated Sulfoximines, Safety of Bis(4-fluorophenyl)methane, the publication is Organic Letters (2014), 16(7), 2000-2002, database is CAplus and MEDLINE.

An efficient iron-catalyzed C-N bond formation by hetero-cross-dehydrogenative coupling (CDC) between sulfoximines and diarylmethanes is described. The reaction shows good functional group tolerance and provides N-alkylated sulfoximines in moderate to good yields.

Organic Letters published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Guo, Ju published the artcileSynthesis and cytotoxicity of 3-aryl acrylic amide derivatives of the simplified saframycin-ecteinascidin skeleton prepared from L-dopa, SDS of cas: 16909-09-4, the publication is European Journal of Medicinal Chemistry (2013), 670-676, database is CAplus and MEDLINE.

Twenty four compounds with diversified 3-arylacrylic amide side chains of the simplified saframycin-ecteinascidin pentacyclic skeleton were synthesized via a 14-step stereospecific route starting from L-dopa. The cytotoxicities of these compounds were tested against eight human tumor cell lines including HCT-8, BEL-7402, BGC-803, A549, A2780, MCF-7, MX-1, and MDA-MB-231. Most of these compounds exhibited potent antitumor activity, and a preliminary structure-activity relationship (SAR) was discussed. Compound I with 3-thiophenyl acrylic amide side chain exhibited selective cytotoxicity against MDA-MB-231 cell line with the IC₅₀ value of 50 nM.

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, SDS of cas: 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fan, Shuang published the artcileIn Situ-Induced Synthesis of Magnetic Cu-CuFe₂O₄@HKUST-1 Heterostructures with Enhanced Catalytic Performance for Selective Aerobic Benzylic C-H Oxidation, Category: catalysis-chemistry, the publication is ACS Catalysis (2017), 7(1), 243-249, database is CAplus.

The multifunctional design of heterogeneous catalysts which can realize the selective oxidation of C-H bonds with oxygen at low temperature is of crucial importance in the catalysis community. Here, we report the designed synthesis of Cu-CuFe₂O₄@HKUST-1 heterostructures that is highly active for the selective oxidation of benzylic C-H bonds under mild conditions (60 ¡ãC). In the synthetic process, the Cu(0) component of Cu-CuFe₂O₄ nanoparticles gradually released Cu²⁺ ions which were in situ transformed into the HKUST-1 shell. The high activity can be attributed to a rationally multifunctional design of Cu-CuFe₂O₄@HKUST-1 heterostructures, in which Cu-CuFe₂O₄ can provide multiple active sites while HKUST-1 attracts and preconcs. mol. oxygen. Notably, the catalytic performance under optimized reaction conditions (60 ¡ãC) was achieved in the oxidation of fluorene to fluorenone (conversion: > 99%, selectivity: > 99%). Furthermore, the Cu-CuFe₂O₄@HKUST-1 catalyst could be easily recovered by magnetic separation and reused for 10 times without significant loss of catalytic activity.

ACS Catalysis published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bellini, Clement published the artcileAlkaline-Earth-Catalyzed Cross-Dehydrocoupling of Amines and Hydrosilanes: Reactivity Trends, Scope and Mechanism, COA of Formula: C16H20N2, the publication is Chemistry – A European Journal (2016), 22(13), 4564-4583, database is CAplus and MEDLINE.

Alk.-earth (Ae = Ca, Sr, Ba) complexes catalyze the chemoselective cross-dehydrocoupling (CDC) of amines and hydrosilanes. Key trends were delineated in the benchmark couplings of Ph₃SiH with pyrrolidine or tBuNH₂. Ae{E(SiMe₃)₂}₂¡¤(THF)_x (E = N, CH; x = 2-3) are more efficient than [N?]Ae[E(SiMe₃)₂]¡¤(THF)_n (E = N, CH; n = 1-2) complexes ([N?]^– = [ArN(o-C₆H₄)C(H):NAr]^– with Ar = 2,6-iPr₂C₆H₃) bearing an iminoanilide ligand, and alkyl pre-catalysts are better than amido analogs. Turnover frequencies (TOFs) increase in the order Ca<Sr<Ba. Ba[CH(SiMe₃)₂]₂¡¤(THF)₃ displays the best performance (TOF up to 3600 h^-1). The substrate scope (>30 products) includes diamines and di(hydrosilane)s. Kinetic anal. of the Ba-promoted CDC of pyrrolidine and Ph₃SiH shows that 1: the kinetic law is rate = k[Ba]¹[amine]⁰[hydrosilane]¹, 2: electron-withdrawing p-substituents on the arylhydrosilane improve the reaction rate and 3: a maximal kinetic isotopic effect (k_SiH/k_SiD=4.7) is seen for Ph₃SiX (X = H, D). DFT calculations identified the prevailing mechanism; instead of an inaccessible ¦Ò-bond-breaking metathesis pathway, the CDC appears to follow a stepwise reaction path with N-Si bond-forming nucleophilic attack of the catalytically competent Ba pyrrolide onto the incoming silane, followed by rate limiting H-atom transfer to Ba. The participation of a Ba silyl species is prevented energetically. The reactivity trend Ca<Sr<Ba results from greater accessibility of the metal center and decreasing Ae-N_amide bond strength upon descending Group 2.

Chemistry – A European Journal published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Wen published the artcileChiral Squaramide-Catalyzed Highly Enantioselective Michael Addition of 2-Hydroxy-1,4-naphthoquinones to Nitroalkenes, Product Details of C10H11NO4, the publication is Advanced Synthesis & Catalysis (2011), 353(8), 1241-1246, database is CAplus.

A chiral squaramide-organocatalyzed, highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes has been developed. This reaction afforded the chiral naphthoquinones in excellent yields (up to 99%) and excellent enantioselectivity (up to 98% ee) under very low catalyst loading (0.25 mol%). This organocatalytic asym. Michael addition provides an efficient alternative route toward the synthesis of chiral functionalized naphthoquinones.

Advanced Synthesis & Catalysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C18H17NO8, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Wen published the artcileChiral squaramide-catalyzed highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Chemical Communications (Cambridge, United Kingdom) (2011), 47(47), 12706-12708, database is CAplus and MEDLINE.

An efficient highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes catalyzed by chiral squaramide catalyst has been developed. This organocatalytic reaction with a low catalyst loading (2 mol%) proceeded well to afford synthetically useful 1,3-dinitro compounds in high yields with high diastereoselectivities (up to 95:5 dr) and excellent enantioselectivities (up to 97% ee).

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C3H6BrNaO3S, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Liqiang published the artcileUse of organic ester as a high-performance spacer for the acidic preflush and hydraulic fracturing system, COA of Formula: C14H31NO2, the publication is Tianranqi Gongye (2012), 32(6), 43-45, database is CAplus.

The acidic preflush and hydraulic fracturing treatment has been widely applied to the stimulation of reservoirs at oil and gas fields. Although satisfactory stimulation effects have been obtained, the problem of gel breaking arises before the interactive touch between the prepad fluid and the fracturing fluid in the process of injection. In view of this, for the purpose of smooth operation and successful EOR treatment, the spacer is adopted to isolate the prepad fluid from the fracturing fluid. Through theor. anal. and exptl. research, the organic ester is used as the main agent to improve the performance of the prepad fluid and spacer for the developed acidic preflush and hydraulic fracturing system, and their formula and preparation methods are also presented herein. After a series of exptl. evaluation and anal., this developed acidic preflush and hydraulic fracturing system can not only meet the need of the technol., but effectively isolate the prepad fluid from the fracturing fluid, which helps improve the performance of the fracturing treatment.

Tianranqi Gongye published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C10H15NO, COA of Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zagidullin, R. N. published the artcileAmido-epichlorohydrin resins. Methods for their preparation and properties, Quality Control of 38260-01-4, the publication is Khimicheskaya Promyshlennost (St. Petersburg, Russian Federation) (2011), 88(5), 257-266, database is CAplus.

A new water soluble polyamide resins were prepared from epichlorohydrin, dicarboxylic acids, and various polyamines. All resin exhibited good adhesive properties in relationship to paper, metals, leather, plastics, wood, and glass. The resins were good flocculants.

Khimicheskaya Promyshlennost (St. Petersburg, Russian Federation) published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H12Br2, Quality Control of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia