Tag: M.W=200-250

Rajesh published the artcileManganese complexes of bis-benzimidazolyl ligand as novel quenchers of superoxide radical anion, Category: catalysis-chemistry, the publication is Polyhedron (1997), 16(20), 3511-3517, database is CAplus.

Mn^II/Mn^III complexes [Mn(DGB)X₂]^0/+ and [Mn(BBB)₂X]²⁺ were synthesized utilizing an exogenous anionic ligand (X = OAc, SCN) with tridentate bis(2-benzimidazolylmethyl)ether (DGB) and bidentate 1,2-bis(2-benzimidazolyloxamethyl)benzene (BBB) ligands. The visible spectra of the Mn^III compounds suggests pseudo C_4v symmetry, and the EPR data on the Mn^II complexes indicates a similar geometry. Cyclic-voltammetric studies reveal that the E_1/2 for the Mn^II/Mn^III couple shifts to a pos. value with acetate as an anionic ligand, implying that this anion stabilizes the Mn^II oxidation state while the E_1/2 data for SCN reveals that the anion stabilizes the Mn^III state. The reoxidation step of the superoxide formed in the cyclic-voltammetric experiments becomes irreversible in the presence of Mn complexes; suggesting that these complexes act as good quenchers for superoxide anion.

Polyhedron published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Biswas, Rima published the artcileAgNPs Immobilized over Functionalized 2D Hexagonal SBA-15 for Catalytic C-H Oxidation of Hydrocarbons with Molecular Oxygen under Solvent-Free Conditions, Related Products of catalysis-chemistry, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(15), 5856-5867, database is CAplus.

Activation of C-H bonds of hydrocarbons is one of the thrust areas of research over the years. Designing a robust catalyst, which can work efficiently under eco-friendly conditions for this reaction still remains a big challenge today. Highly dispersed aggregation-free silver nanoparticles (AgNPs) are immobilized over 2D hexagonally ordered functionalized mesoporous silica material via surface thioether functionalization, and the resulting supported AgNPs (AgMS) displayed environmentally benign selective oxidation of C-H bonds of the aliphatic and monocyclic hydrocarbons into their resp. carbonyl compounds The AgMS catalyst exhibited excellent activity toward liquid phase oxidation of C-H bonds under solvent-free and base-free neat conditions using mol. oxygen as the oxidant. This methodol. was successfully applied for the oxidation of substituted toluene, benzylic C-H bonds, and cycloalkanes with very good conversion and selectivity. Moreover, the hydrocarbon conversion and selectivity for the carbonyl products in this partial oxidation reaction have been retained after six reaction cycles. Therefore, immobilization of AgNPs at the surface of ordered mesoporous silica offers a very efficient route in designing a readily separable, reusable, very robust, and promising catalyst for C-H bond activation under eco-friendly reaction conditions.

ACS Sustainable Chemistry & Engineering published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Yuehui published the artcileGeneral and Selective Copper-Catalyzed Reduction of Tertiary and Secondary Phosphine Oxides: Convenient Synthesis of Phosphines, Product Details of C15H15OP, the publication is Journal of the American Chemical Society (2012), 134(23), 9727-9732, database is CAplus and MEDLINE.

Novel catalytic reductions of tertiary and secondary phosphine oxides to phosphines have been developed. Using tetramethyldisiloxane (TMDS) as a mild reducing agent in the presence of copper complexes, PO bonds are selectively reduced in the presence of other reducible functional groups (FGs) such as ketones, esters, and olefins. Based on this transformation, an efficient one pot reduction/phosphination domino sequence allows for the synthesis of a variety of functionalized aromatic and aliphatic phosphines in good yields.

Journal of the American Chemical Society published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Product Details of C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kundu, Sandip Kumar published the artcile6-(¦Á-Hydroxy-¦Á-aryl/naphthyl)methyl-3,4-dihydro-2,5-benzodiazocin-1(2H)-ones and diphenylmethanes from C-2 arylated 1,3-indandiones, HPLC of Formula: 457-68-1, the publication is Journal of Chemical Research (2004), 781-783, database is CAplus.

Stirring 2-hydroxy-2-aryl-1,3-indandiones in ethylenediamine at room temperature for 1-2 h produces benzodiazocinones I (R¹R² = benzo, R³ = R⁴ = H; R¹ = R² = H, R³R⁴ = benzo; R¹, R² = H, Me; R³ = H, Me, MeO, Cl; R⁴ = H) in 80-90% yields. Under similar reaction conditions 2,2-diaryl-1,3-indandiones furnish diphenylmethanes.

Journal of Chemical Research published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, HPLC of Formula: 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Vagner, Adrienn published the artcileA rigidified AAZTA-like ligand as efficient chelator for ⁶⁸Ga radiopharmaceuticals, Quality Control of 140-28-3, the publication is ChemistrySelect (2016), 1(2), 163-171, database is CAplus.

The new cyclohexane-fused CyAAZTA ligand was synthesized to increase the structural rigidity of the heptadentate chelator AAZTA with the aim of improving the overall stability of its Ga^III complex. The stability constant of Ga(CyAAZTA)^–, determined both by pH-potentiometry (logK_GaL=21.39) and by ⁷¹Ga NMR (logK_GaL=21.92), was found similar to that of GaAAZTA (logK_GaL=22.18). The kinetic inertness of Ga(CyAAZTA)^– was investigated by following its transmetallation and ligand exchange reactions with Cu²⁺ and human serum transferrin, resp. The formation of a hydroxido-complex near pH 7 decreases the half-life (t_1/2) of the dissociation reactions for Ga(CyAAZTA)^– compared to Ga(AAZTA)^– (8.5 h vs 21 h, pH 7.4). However, at pH < 7 the t_1/2 of Ga(CyAAZTA)^– is much longer (234 h at pH 6). Finally, CyAAZTA was successfully radiolabeled with ⁶⁸Ga in acetate buffer at pH 3.8, in 15 min at room temperature at [CyAAZTA]=10 ¦ÌM, with a labeling yield higher than 80 %. A 1 ¦ÌM solution of CyAAZTA was successfully labeled (L.Y.: 97.4 %) in 5 min at 90 ¡ãC. Stability tests in human serum and in the presence of 50 mM DTPA showed no significant decomposition of ⁶⁸GaCyAAZTA over 90 min.

ChemistrySelect published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C5H10N2OS, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Raynal, Noel J.-M. published the artcileRepositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome, Application In Synthesis of 38260-01-4, the publication is Molecular Cancer Therapeutics (2017), 16(2), 397-407, database is CAplus and MEDLINE.

Epigenetic drugs, such as DNA methylation inhibitors (DNMTi) or histone deacetylase inhibitors (HDACi), are approved in monotherapy for cancer treatment. These drugs reprogram gene expression profiles, reactivate tumor suppressor genes (TSG) producing cancer cell differentiation and apoptosis. Epigenetic drugs have been shown to synergize with other epigenetic drugs or various anticancer drugs. To discover new mol. entities that enhance epigenetic therapy, we performed a high-throughput screening using FDA-approved libraries in combination with DNMTi or HDACi. As a screening model, we used YB5 system, a human colon cancer cell line, which contains an epigenetically silenced CMV-GFP locus, mimicking TSG silencing in cancer. CMV-GFP reactivation is triggered by DNMTi or HDACi and responds synergistically to DNMTi/HDACi combination, which phenocopies TSG reactivation upon epigenetic therapy. GFP fluorescence was used as a quant. readout for epigenetic activity. We discovered that 45 FDA-approved drugs (4% of all drugs tested) in our FDA-approved libraries enhanced DNMTi and HDACi activity, mainly belonging to anticancer and antiarrhythmic drug classes. Transcriptome anal. revealed that combination of decitabine (DNMTi) with the antiarrhythmic proscillaridin A produced profound gene expression reprogramming, which was associated with downregulation of 153 epigenetic regulators, including two known oncogenes in colon cancer (SYMD3 and KDM8). Also, we identified about 85 FDA-approved drugs that antagonized DNMTi and HDACi activity through cytotoxic mechanisms, suggesting detrimental drug interactions for patients undergoing epigenetic therapy. Overall, our drug screening identified new combinations of epigenetic and FDA-approved drugs, which can be rapidly implemented into clin. trials. Mol Cancer Ther; 16(2); 397-407. ?2016 AACR.

Molecular Cancer Therapeutics published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ghirga, Francesca published the artcileUndecenyl resorc[4]arene in the chair conformation as preorganized synthon for olefin metathesis, Category: catalysis-chemistry, the publication is RSC Advances (2013), 3(38), 17567-17576, database is CAplus.

Tetramerization of (E)-2,4-dimethoxycinnamic acid ¦Ø-undecenyl ester with ethereal BF₃ gave three stereoisomers 1a, 1b, and 1c, which were assigned as the chair, cone, and 1,2-alternate conformations, resp. The chair conformation of 1a was confirmed by X-ray diffraction anal., which also showed a peculiar self-assembly behavior in the crystal lattice, forming intercalated hydrophilic and hydrophobic layers (6-7 ? thickness) as a consequence of strong CH-¦Ð interactions. Undecenyl resorc[4]arene 1a, which featured the simplest pattern of substituents, was submitted to olefin metathesis using the second-generation Grubbs complex as the catalyst. Depending on the reaction conditions, different products were isolated: a bicyclic alkene 2a (46%), a linear dimer 3a (5%), and a cross-linked homopolymer P1a (44%).

RSC Advances published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Berry, John F. published the artcileA molecular loop with interstitial channels in a chiral environment: exploration of the chemistry of Mo₂⁴⁺ species with chiral and non-chiral dicarboxylate anions, Category: catalysis-chemistry, the publication is Dalton Transactions (2003), 4297-4302, database is CAplus.

An enantiomerically pure chiral loop containing two units of cis-Mo₂(DAniF)₂²⁺ (DAniF = di-p-anisylformamidinate) was obtained by reacting cis-[Mo₂(DAniF)₂(NCMe)₄](BF₄)₂ with a chiral dicarboxylate easily prepared from p-, m-, and o-hydroquinone and Et (S)-lactate (H₂L1-H₂L3). The compound [cis-Mo₂(DAniF)₂]₂(L1)₂¡¤4CH₂Cl₂ (1) crystallizes in the noncentrosym. I222 space group with mols. stacking so as to form channels capable of hosting guest mols. such as CH₂Cl₂. These properties of 1, which was synthesized in high yield, makes it promising for applications in stereoselective catalysis. Similar reactions with H₂L2-3 and isomeric dicarboxylate linkers and some nonchiral ligands (HO₂CC(Me)₂O)₂-m-C₆H₄ and (HO₂CCH₂O)₂-o-C₆H₄ were studied. The nature of the products depends on the bite angle of the ligand.

Dalton Transactions published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Le Vaillant, Franck published the artcileRoom-Temperature Decarboxylative Alkynylation of Carboxylic Acids Using Photoredox Catalysis and EBX Reagents, Computed Properties of 1798-04-5, the publication is Angewandte Chemie, International Edition (2015), 54(38), 11200-11204, database is CAplus and MEDLINE.

The direct synthesis of alkynes from readily available carboxylic acids at room temperature under visible-light irradn was reported. The combination of an iridium photocatalyst with (alkynyl)benziodoxolone reagents allowed the decarboxylative alkynylation of carboxylic acids in good yields under mild conditions. The method was applied to silyl-, aryl-, and alkyl- substituted alkynes. It was particularly successful in the case of ¦Á-amino and ¦Á-oxo acids derived from biomass.

Angewandte Chemie, International Edition published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bishop, Peter T. published the artcileSubstituent dependence of the reactions of [RuCl₂(PPh₃)₃] with bulky aromatic thiols, SDS of cas: 22693-41-0, the publication is Dalton Transactions (2006), 1267-1270, database is CAplus and MEDLINE.

2,4,6-Trialkylbenzenethiols (alkyl = Me (tmt), Et (tet), Prⁱ (tipt)) react with [RuCl₂(PPh₃)₃] to give Ru products with the alkyl substituents forming M-C ¦Ò bonds, carbene, carbene with a S ¦Á-heteroatom, agostic H interaction or a simple tetrahedral Ru(II) species, depending on the substituent. Thus, the preparation and crystal structure of [Ru(SC₆H₂Me₂CH₂)(tmt)₂(PPh₃)] (1), [Ru(SC₆H₂Me₂CH)(tmt)(PPh₃)₂] (2), [Ru(SC₆H₂Me₂CSC₆H₂Me₃)(tmt)(PPh₃)₂] (3), [Ru(tet)₃(PPh₃)] (4) and [Ru(tipt)₂(PPh₃)₂] (5) are reported.

Dalton Transactions published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, SDS of cas: 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia